ライフサイエンスコーパス: -switched

1 We have used 20 capsule-switched variants of strain TIGR4 to investigate whether

2 Median FH binding was high in capsule-switched mutant strains expressing more invasive serotyp

3 wild-type serotype 3 strain and the capsule-switched mutant behaved similarly, whereas in the lungs

4 e 3 strain was virulent, whereas the capsule-switched mutant was avirulent.

5 neutrophil association for the TIGR4 capsule-switched strains.

6 A chain-switched Fab fragment containing the M77 Fd fragment and

7 Class-switched and nonswitched GC B cells emerged contemporane

8 Class-switched anti-RNP autoantibody-producing cells were also

9 Class-switched memory B cells showed: accumulation of FAS-muta

10 with a lentiviral construct encoding a class-switched anti-HIV IgA (b12-IgA) into the humanized bone

11 st be exquisitely controlled because a class-switched B cell cannot revert back to the parent isotype

12 onal germinal center activity and of a class-switched memory B-cell compartment.

13 mma H chains, which is indicative of a class-switched response.

14 vo and isolated 24 h later initiated a class-switched, Ag-specific Ab response in naive animals.

15 High-affinity class-switched Abs and memory B cells are products of the germ

16 ant mice fail to produce high-affinity class-switched antibodies and generate memory B and long-lived

17 response, which produces high affinity class-switched antibody made by long-lived plasma cells.

18 specific GC B cells, and high-affinity class-switched antibody production.

19 in B cells that express high-affinity class-switched IgG.

20 ined by the formation of high-affinity class-switched memory B cells and long-lived antibody-secretin

21 on and the generation of high-affinity class-switched plasma and memory B cells.

22 responses that generate high-affinity, class-switched Ab in vivo.

23 However, the number of high-affinity, class-switched Ab-forming cells was severely decreased in the

24 nduce B cells secreting high-affinity, class-switched antibodies during germinal center (GC) reaction

25 s for the generation of high-affinity, class-switched antibodies during T cell-dependent antibody res

26 bited the production of high-affinity, class-switched antibodies, but not the production of low-affin

27 or B cell production of high-affinity, class-switched antibodies.

28 ial in the induction of high-affinity, class-switched antibodies.

29 orting the induction of high-affinity, class-switched antibody responses, long-lived plasma cells, an

30 (Tfh) cells potentiate high-affinity, class-switched antibody responses, the predominant correlate o

31 excessive production of high-affinity, class-switched autoantibodies and to the high incidence of B c

32 IgG, but not IgM secretion by already class-switched B cells.

33 Although class-switched virus-specific Abs were initially generated in

34 Both CD8(+) T cells and class-switched Ab responses have been detected from patients w

35 provide help for germinal centers and class-switched Ab responses.

36 e, B cell-deficient, Ab-deficient, and class-switched Ab-deficient mice with attenuated Salmonella an

37 proliferation markers (Ki-67(+)), and class-switched B cells (IgG(+)); and (5) both TNFRSF17 mRNA an

38 cytidine deaminase was expressed, and class-switched B cells were present.

39 d numbers of marginal zone B cells and class-switched cells, and were associated with decreased antib

40 ronment essential for GC formation and class-switched Ig responses.

41 This may imply that CD4 T cells and class-switched IgG antibodies are more relevant for generating

42 oted homeostatic production of IgM and class-switched IgG antibodies to microbial capsular polysaccha

43 +) B cells, including IgM(+) naive and class-switched IgG memory B cells, with a concomitant increase

44 Numbers of total memory (CD27(+)) and class-switched memory B cells (IgM(-)) were significantly redu

45 d circulating natural killer cells and class-switched memory B cells were reduced.

46 molecule expression between naive and class-switched memory B cells, indicating their potential to i

47 ive, mature CD5(+), IgM(+) memory, and class-switched memory B cells.

48 erse compartment of IgM(+)(IgD(+)) and class-switched memory B cells.

49 s-associated, somatically mutated, and class-switched pathogenic autoantibodies are generated in spon

50 in germinal center B cells as well as class-switched high-affinity Ab-secreting cells.

51 (healthy donors) MHC-II expression as class-switched memory B cells and intermediate costimulatory m

52 ng T cells and significantly augmented class-switched HSV-specific antibody responses compared with t

53 etic mechanisms, valproic acid blunted class-switched and hypermutated T-dependent and T-independent

54 systemic autoimmunity characterized by class-switched anti-nuclear Abs.

55 memory compartments, characterized by class-switched IgG and high-affinity Abs, are the basis for su

56 in the immunoglobulin (Ig)D(-)CD27(+) (class-switched) memory B-cell compartment that normally arises

57 of somatic mutations in CD19+IgD-CD27+ class-switched memory B cells in RV-specific memory B cells, s

58 ligand gene, do not have a classical, class-switched memory B-cell population (IgD(-) CD27(+)).

59 In contrast, class-switched antibodies specific to S. aureus are common, im

60 tingly, in the absence of conventional class-switched memory B cells, the circulating EBV load was co

61 In addition, it decreased class-switched and hypermutated autoantibodies, ameliorated di

62 Frequencies of AF DENV(+) class-switched memory B cells (IgD(-)CD27(+) CD19(+) cells) re

63 high titers of specific IgM and early class-switched antibodies.

64 lipopolysaccharide effectively elicits class-switched NP-specific IgG3 and IgG2b in mice.

65 e hypothesized that clonally expanded, class-switched IgG4-positive B cells and plasma cells could be

66 germinal centers and is necessary for class-switched Ab responses.

67 iple MHC disparities, cognate help for class-switched alloantibody may also be provided by CD4 T cell

68 te activity, and provision of help for class-switched antibody responses.

69 ive repertoire are apparent mainly for class-switched B cells and not for IgM germinal center, IgM me

70 response to different stimuli than for class-switched memory cell development.

71 spontaneous germinal center formation, class-switched autoantibodies, renal histopathology, and early

72 t1/2 of pre-established Ag-induced Ig class-switched and IgM-positive memory B cells over 402 d.

73 By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflam

74 ion to enhancing mucosal immunity, IgD class-switched B cells enter the circulation to 'arm' basophil

75 ing the recall response by CD27(+) IgG class-switched human memory B cells, total IgG secreted is a f

76 ii) germinal-center B cells, and (iii) class-switched B cells.

77 irment in production of immunoglobulin class-switched antibodies, which is possibly contributed to by

78 rexpressing MiR-210 exhibited impaired class-switched Ab responses, a finding confirmed in wild-type

79 at Sox2 may regulate AID expression in class-switched B cells to suppress genomic instability associa

80 gs are considered to largely reside in class-switched CD27(+) cells.

81 ciated with a significant reduction in class-switched IgG, and anti-nucleosomal IgG-secreting B cells

82 ic failure and the severe reduction in class-switched memory B cells, while gathering longitudinal la

83 2 anti-parasite mechanisms, including class-switched antibodies, activated leukocytes and innate def

84 assumes multiple cell fates, including class-switched B cells, antibody-secreting plasma cells, and m

85 om infants who survived RSV infection, class-switched antiviral and antinucleosomal antibodies were d

86 c B1a cells, which differentiated into class-switched CD138(+) IgG-secreting B1a cells.

87 to promote B cell differentiation into class-switched plasmablasts and led to downregulation of chemo

88 tiation of WASp-deficient B cells into class-switched plasmablasts in vitro, suggesting that WASp-dep

89 In addition, anti-P. murina class-switched Abs were increased in BL/6 Stat4(-/-) mice, but

90 ge B-cell clones, especially among non-class-switched memory B cells.

91 hat are essential for the synthesis of class-switched Ab.

92 Ab formation, decreases production of class-switched Abs targeting nonnuclear Ags, and limits system

93 1), are critical for the generation of class-switched and hypermutated (mature) Ab and autoantibody r

94 Greater apoptotic depletion of class-switched and IgM memory cells was associated with phosph

95 magglutinin leads to the production of class-switched anti-MOG antibodies, dependent on the presence

96 ponse that increases the generation of class-switched antibodies and the frequency of somatic hypermu

97 the events that lead to production of class-switched antibodies during T. gondii infection have not

98 ght be useful to enhance production of class-switched antibodies following vaccination.

99 Expression of class-switched antibodies from Ara h 2-positive cells confirms

100 The titers of class-switched antibodies in immunized CD4 T-cell- and MHC cla

101 ter reaction and for the production of class-switched antibodies in response to thymus-independent an

102 Secretion of class-switched antibodies requires additional stimulation by B

103 s naive B cells, higher frequencies of class-switched antibodies were detected in cocultures of CXCR5

104 The production of class-switched antibodies, particularly immunoglobulin (Ig) G1

105 licular CD4 T cells, and production of class-switched antibody, together with expansion of B1 B cells

106 c infections through the generation of class-switched antibody-secreting cells (ASCs) in germinal cen

107 Complete absence of class-switched B cells was a sensitive predictor of AID defici

108 I compound AZD8055 increased titers of class-switched high-affinity antibodies to a hapten-protein co

109 rminal center formation, production of class-switched Ig, and development of memory B cells.

110 ro and produced high concentrations of class-switched IgG2b and IgG2c, including anti-RNA antibodies.

111 e observed reductions in expression of class-switched isotypes in OCA-B-/- mice may be due in part to

112 ediated recombination, the tracking of class-switched memory B and plasma cells in vivo.

113 lymphopenia, decreased frequencies of class-switched memory B cells and hypogammaglobulinemia due to

114 er of iNKT cells and the percentage of class-switched memory B cells and propensity to lymphoprolifer

115 us toxin, whereas the proliferation of class-switched memory B cells is suppressed by Stichodactyla h

116 controls revealed that frequencies of class-switched memory B cells were increased in the patients,

117 uencies ranging from 0.01% to 0.11% of class-switched memory B cells.

118 nal center and ensure replenishment of class-switched memory CD27(+) B cells from Ag-experienced prec

119 ry repertoire is distinct from that of class-switched memory.

120 ficient mice by blocking production of class-switched pathogenic IgG autoantibodies.

121 nted the age-dependent accumulation of class-switched resting memory B cells.

122 esponses, especially the generation of class-switched, antigen-specific antibody responses.

123 es the T cell-dependent development of class-switched, autoreactive memory B cells and plasma cells/p

124 diseases are marked by the presence of class-switched, high-affinity autoantibodies with pathogenic p

125 ith B cells but lacking secreted Ab or class-switched Ab had little deficiency in resistance to Salmo

126 -transgenic mice spontaneously produce class-switched autoantibodies ex vivo.

127 inii-specific IgM, but did not produce class-switched IgG or IgA.

128 munoglobulin were activated, producing class-switched autoantibody in vivo despite the apparently nor

129 r CD40 expression on B cells producing class-switched Ig in response to a T-dependent Ag.

130 B cells to generate GCs and productive class-switched antibody responses.

131 h the periphery and produce protective class-switched Abs after Borrelia burgdorferi infection.

132 In contrast, quiescent class-switched memory B cells express high levels of Kv1.3 ( a

133 The rapid, class-switched amAb response indicates that B cells in female

134 e without memory T cells recapitulated class-switched recall alloantibody responses.

135 o those patients with severely reduced class-switched memory B cells and an elevated level of CD21(lo

136 ted with recurrent infections, reduced class-switched memory B cells, and hypogammaglobulinemia.

137 D8alpha(-) DCs in mice leads to robust class-switched antibody (Ab) responses to a T cell-dependent (

138 cripts, and reduced titers of secreted class-switched IgG1, IgG3, and IgA antibodies, without alterat

139 ed with a rapid decline in Ag-specific class-switched Ab.

140 nhanced production of antigen-specific class-switched antibodies in vivo.

141 n reported to produce antigen-specific class-switched human antibodies, with some demonstrating neutr

142 ell as increased levels of Ag-specific class-switched Ig production following immunization with OVA t

143 sequencing of the BCR from E2-specific class-switched memory B cells sorted from two independent part

144 HCV-specific class-switched memory B cells were detected in 3 out of 7 part

145 Here we report strong class-switched, high avidity humoral immune responses elicited

146 oproliferative disease (XLP) lack such class-switched memory B cells but are highly susceptible to EB

147 Our data demonstrate that class-switched MBC can respond to variants of the original pat

148 In this study, we showed that the class-switched IgG autoantibody response in MRL/Fas(lpr/lpr) a

149 /CDR3 sequences from those seen in the class-switched response to oxazolone that we have also analyze

150 High titer, class-switched autoantibodies are a hallmark of systemic lupus

151 Epithelial cells (ECs) transport class-switched immunoglobulin G (IgG) and IgA antibodies acros

152 production of Ag-specific IgM, whereas class-switched isotypes are decreased by approximately 80-90%

153 surface models to derive the electric-field-switched low-symmetry structures of new TTF- and PMDI-ba

154 rrelation (HETCOR) experiment with frequency-switched Lee-Goldburg (FSLG) irradiation is performed on

155 enon of passively Q-switched ~3 mum and gain-switched ~2 mum pulses in a shared cavity was demonstrat

156 arget a segment of membrane IgE on human IgE-switched B cells that is not present in serum IgE.

157 erstanding of the origin and fate of the IgE-switched B cell has been markedly improved by studies in

158 The immediate precursor of the IgE-switched B cell is either a relatively naive nonswitched

159 ely naive nonswitched B cell or a mature IgG-switched B cell.

160 In normal mice, self-reactive IgG2a-switched B cells were deleted, leading to the selective

161 Phospholipase A2-specific IgG4-switched memory B cells expanded after bee venom exposur

162 Isotype-switched B cells were only detected in the peritoneum.

163 st immune responses, T helper type 1 isotype-switched antibodies, and gamma interferon (IFN-gamma)-se

164 plasma cells secreting high-affinity isotype-switched Abs in mice immunized with T cell-dependent Ags

165 te the development of high-affinity, isotype-switched Abs, and immunological memory; consequently, ma

166 er (GC) reactions and high affinity, isotype-switched antibody responses.

167 e dominant pathway of high-affinity, isotype-switched autoantibody production in the MRL/MpJ-Fas(lpr)

168 uction of high-titer, high-affinity, isotype-switched IgG autoantibodies directed against nucleic aci

169 The genes were all isotype-switched and somatically mutated.

170 noclonal antibody (MAb) 9d8 (2a), an isotype-switched variant of the immunoglobulin G3 (IgG3) MAb 9d8

171 major IgMD-expressing subsets and an isotype-switched variant, each developing from distinct B-cell p

172 fic flow sorting express mutated and isotype-switched antibodies.

173 and B220(+) lymphocytes, IgM(+) and isotype-switched IgG(+) and IgA(+) B cells, antigen presenting c

174 CPS is able to induce potent IgM and isotype-switched IgGs in mice and pigs, yielding functional acti

175 rminal center B cells, more antibody isotype-switched germinal center B cells, more memory B cells, a

176 In blood, isotype-switched B cells constitute the major viral reservoir.

177 d by CD138(-) IgD(-) IgM(+) B cells, isotype-switched CD138(-) IgD(-) IgM(-) memory B cells (B(mem)),

178 Human memory B cells comprise isotype-switched and nonswitched cells with both subsets display

179 ulation of memory B cells containing isotype-switched (IgG and IgA) and IgM-only cells and lacking ex

180 We propose that germline-encoded, isotype-switched B cells in newborn piglets differentiate to Ab-

181 erated B memory cells that expressed isotype-switched immunoglobulins (swIg) or retained IgM.

182 Interestingly, the F240 isotype-switched variants IgG3 and IgG4, also expressed in CHO c

183 These data reveal a role for isotype-switched antibodies in promoting basophil expansion and

184 We have found a unique role for isotype-switched antibodies in promoting helminth-induced basoph

185 switch recombination (CSR) generates isotype-switched Abs with distinct effector functions.

186 e earliest Ag-driven events in human isotype-switched, IgG-expressing MBCs and compare them with thos

187 ansfer of variable region-identical, isotype-switched, LPS-specific, murine immunoglobulin M (IgM) an

188 l for immunoglobulin (Ig) G1 and IgE isotype-switched antibody responses.

189 as not affected by the deficiency in isotype-switched antibodies, suggesting a direct effect on basop

190 68 latency is predominantly found in isotype-switched memory B cells.

191 onses, we found a marked decrease in isotype-switched, A. fumigatus-specific antibodies in sera of mi

192 F59 was highly effective in inducing isotype-switched IgG antibodies and long-term protective immune

193 the differentiation of B cells into isotype-switched B cells and plasma cells.

194 tially maintained in the long-lived, isotype-switched CD40(+) B cells.

195 ignant tumor of somatically mutated, isotype-switched plasma cells (PC), usually arises from a common

196 First, we examined circulating non-isotype-switched (IgD(+)CD27(+)) memory cells, a population that

197 d is preceded by accumulation of non-isotype-switched IgD(+) and IgM(+) B cells.

198 notypes characteristic of naive, non-isotype-switched, memory (Bmem) cells and antibody-secreting cel

199 imately, the quality and quantity of isotype-switched Abs produced in Icos(-/-) mice declined over ti

200 abaudi AS infection or production of isotype-switched Abs, but it is necessary for maintenance of a s

201 a cell development, and secretion of isotype-switched anti-Id Abs.

202 -dependent, as was the production of isotype-switched anti-Sm/RNP autoantibodies.

203 le as helper cells for production of isotype-switched antibodies.

204 ggesting that defective apoptosis of isotype-switched autoreactive B cells is central to Fas mutation

205 The life history of isotype-switched B cells is unclear, in part, because of an inab

206 intained in two different subsets of isotype-switched B cells, germinal center and memory B cells.

207 from the circulating compartment of isotype-switched B cells.

208 a driving force for accumulation of isotype-switched B(mem) and ASC.

209 out and we also raise the subject of isotype-switched CLL, which, despite its rarity, contributes int

210 e follicle and for the generation of isotype-switched IgG autoantibodies.

211 etected only very low frequencies of isotype-switched IgG-secreting cells in mouse spleens, until at

212 body sequences by deep sequencing of isotype-switched memory B cells or in IgG antibodies elicited ag

213 equired to inhibit the production of isotype-switched pathogenic Abs and the evolution of joint infla

214 ls, GC reactions, and development of isotype-switched, flu-specific antibody responses.

215 A (miR)-155 for normal production of isotype-switched, high-affinity antibodies and for a memory resp

216 plasma cells, but down-regulated on isotype-switched plasma cells in vivo.

217 fferentiated directly into IgM(+) or isotype-switched (sw) Ig(+) memory B cells in a GC-independent f

218 e IFN-gamma-producing CD4 T cells or isotype-switched Salmonella-specific Ab responses.

219 dent antigens, eliciting protective, isotype-switched antibodies in the absence of conventional TCR a

220 nd to be highly effective in raising isotype-switched IgG antibodies to a T-dependent influenza virus

221 Cs) are long-lived sources of rapid, isotype-switched secondary antibody-forming cell (AFC) responses

222 These cells engendered rapid, isotype-switched secondary plasmablast responses upon restimulat

223 rminal center (GC) B cell reactions, isotype-switched Ab responses, parasite control, and host surviv

224 located in both cycling and resting isotype-switched B cells.

225 not production, of parasite-specific isotype-switched Abs.

226 DCs was dependent on virus-specific, isotype-switched antibodies (Abs) that facilitated the capture a

227 ayed accumulation of virus-specific, isotype-switched ASC requires CD19-dependent GC formation in CLN

228 results in the generation of strong, isotype-switched antibody responses, which are protective.

229 Here we demonstrate that isotype-switched plasma cells expressed major histocompatibility

230 ost by preferentially colonizing the isotype-switched (IgD(-)CD27(+)) memory B-cell pool.

231 -TT conjugate vaccine conform to the isotype-switched (IgG(+)CD27(+)) rather than the IgM memory (IgM

232 VH sequences similar to those of the isotype-switched plasma cell.

233 ells ranging from early-activated to isotype-switched differentiation stages is both temporally and s

234 nstrated a steady ratio of IgM(+) to isotype-switched GC B cells and a persistent population of GC B

235 tumors are rare variants of typical isotype-switched multiple myeloma with a similar disease outcome

236 e immediately before that of typical isotype-switched myeloma.

237 Whereas isotype-switched memory had the highest viral loads by quantitat

238 ardtii has been shown to be a directly light-switched cation-selective ion channel, which employs 11-

239 Low-affinity FcgammaR locus-switched mice represent an unprecedented model of cognat

240 The NBD-switched complexes, T1MT2C/T2MT1C, TAP1/T2MT1C, and TAP2

241 +)CD27(+) cells (commonly referred to as non-switched memory) in infected cord blood cell cultures, a

242 icited larger LAN and LPC amplitude than non-switched words.

243 Platform-switched implants showed greater crestal bone preservati

244 alatal/lingual implant position; 2) platform-switched abutments; 3) flapless approach; 4) bone grafts

245 hic bone changes around customized, platform-switched abutments placed according to the "one-abutment

246 crestal bone preservation than non-platform-switched implants.

247 ral blood mononuclear cells (PBMCs) with PLY-switched strains and assessed dendritic cell and CD4(+)

248 These polymerase-switched strains initially grow very slowly, but subsequ

249 We particularly show that electrically pre-switched devices in low-resistive states comprise reduce

250 Q-switched operation at 1480 nm and 1840 nm is achieved wi

251 A Q-switched Nd:YAG laser at 355 nm was used to ablate a hig

252 hly focused nanosecond laser pulses from a Q-switched Nd:YAG laser at lambda = 532 nm to generate cav

253 sing focused laser pulses of 532 nm from a Q-switched Nd:YAG laser.

254 We have demonstrated that a Q-switched neodymium:yttrium-aluminum-garnet dermatology l

255 diagnosis of CALM and were treated with a Q-switched or picosecond laser.

256 ied by modulating the magnetization, and a Q-switched pulse output with a pulse width of 5 ns and pea

257 We have proposed and demonstrated a Q-switched Thulium doped fibre laser (TDFL) with a 'Yin-Ya

258 eveloped a photoacoustic probe that uses a Q-switched, frequency-doubled Nd:YAG (neodymium, yttrium,

259 produced using a single laser pulse from a Q-switched, frequency-quadrupled Nd:YAG laser that was mod

260 from a nanotube polymer composite SA based Q-switched Thulium doped fibre laser.

261 by residents (41 of 52 [79%]), followed by Q-switched Nd:YAG (30 of 52 [58%]).

262 een investigated using a frequency doubled Q-switched (10 Hz) Nd:YAG laser at 532 nm.

263 ptic Q-switch, we demonstrate an efficient Q-switched laser with a repetition rate of 200 kHz.

264 e of an inexpensive, small, and "turn-key" Q-switched 532-nm Nd:YAG laser as a source for nonlinear,

265 (Yb) and an erbium (Er)-doped fiber laser Q-switched by a solution processed, optically uniform, few

266 e picosecond laser, Q-switched ruby laser, Q-switched alexandrite laser, or Q-switched 1064-nm Nd:YAG

267 with 755-nm alexandrite picosecond laser, Q-switched ruby laser, Q-switched alexandrite laser, or Q-

268 t repetition rate achieved so far in a LGS Q-switched laser and it can provide a practical Q-switched

269 lifetime as the gain medium, a stable LGS Q-switched laser was designed with average output power of

270 A 10-mm cavity length magnetooptically Q-switched Nd:GdVO4 laser was demonstrated using a single-

271 by laser, Q-switched alexandrite laser, or Q-switched 1064-nm Nd:YAG laser.

272 ees well with the experiments of passively Q-switched lasers using Ti3 CN at wavelengths of 1558 and

273 se experiments is a diode-pumped passively Q-switched microchip laser operating at 266 nm.

274 techniques, a new phenomenon of passively Q-switched ~3 mum and gain-switched ~2 mum pulses in a sha

275 tched laser and it can provide a practical Q-switched laser with a tunable high repetition rates for

276 Previously, we reported Q-switched lasers incorporating rare-earth substituted iro

277 is LRD technique utilizes an Er:YAG rotary Q-switched laser with an output wavelength of lambda = 2.9

278 ed laser cavities, we obtain self-starting Q-switched pulses with microsecond duration and kilohertz

279 al-band fiber ring laser with synchronized Q-switched pulses at wavelengths of 1480 nm and 1840 nm, a

280 he most extensively studied device was the Q-switched Nd:YAG laser, which has shown promising results

281 ecorded in the range of 200-975nm by using Q-switched Nd:YAG laser at 532nm (4ns, 10Hz) attached to e

282 Clinicians using Q-switched or picosecond lasers to treat CALMs can use mor

283 switching strategy known as the Sequentially-Switched Delay Line (SSDL) is proposed.

284 l and functional characterization of subtype-switched Epa1 variants shows that specificity is governe

285 ncreased frequency of CD19+IgD+CD27+ unclass-switched memory B cells and a low frequency of somatic m