ライフサイエンスコーパス: CFAE

1 CFAE ablation did not confer incremental benefit when pe

2 CFAE-targeted ablation of AF is effective in maintaining

3 d at non-DE LA sites, followed by 41 +/- 12% CFAE at patchy DE and 11 +/- 6% at dense DE regions (p =

4 .005 and p = 0.008, respectively); 19 +/- 6% CFAE sites occurred at border zones of dense DE.

5 tionated atrial electrogram (CFAE) ablation (CFAE arm) in patients with persistent AF.

6 For group I, all CFAE regions with an interval confidence level >7 were a

7 ions showed mixed electrogram amplitudes and CFAE grades that did not differ from surrounding atrium

8 However, peaks in wall stress and CFAE were found at 88% of PV ostia.

9 by roof and mitral isthmus ablation, before CFAE ablation in the CFAE arm.

10 sources were not consistently surrounded by CFAE (P=0.67).

11 Continuous CFAE (CFEmean [NavX algorithm that quantifies Egm fracti

12 CFE-mean <80 ms was considered as continuous CFAE.

13 AF, the EGM voltage was higher at continuous CFAE sites than at non-CFAE sites (0.53 mV (Q1, Q3: 0.33

14 A minority of continuous CFAE sites displayed EGM fractionation in SR (15+/-4%) a

15 Ninety percent of continuous CFAE sites occur at non-DE and patchy DE LA sites.

16 Radiofrequency duration during CFAE ablation was significantly less in group II (23+/-2

17 0.01), more complex fractionated atrial Egm (CFAE) extent (54 +/- 16 cm(2) vs. 28 +/- 15 cm(2), p = 0

18 ion+complex fractionated atrial electrogram (CFAE) ablation (CFAE arm) in patients with persistent AF

19 by complex fractionated atrial electrogram (CFAE) mapping in 674 high-risk AF patients.

20 ed complex fractionated atrial electrograms (CFAE) ablation versus a selective CFAE ablation strategy

21 Complex fractionated atrial electrograms (CFAE) are targets of atrial fibrillation (AF) ablation.

22 2) complex fractionated atrial electrograms (CFAE), using CFAE mean (the mean interval between deflec

23 ng complex fractionated atrial electrograms (CFAE).

24 of complex fractionated atrial electrograms (CFAEs) after antral pulmonary vein isolation (APVI) furt

25 ng complex fractionated atrial electrograms (CFAEs) are commonly employed to identify and eliminate t

26 of complex fractionated atrial electrograms (CFAEs) has been proposed as a strategy to improve outcom

27 esis that complex fractionated electrograms (CFAEs) recorded during atrial fibrillation (AF) could be

28 ith CFAEs was performed, aiming to eliminate CFAE and/or convert to sinus rhythm.

29 The carbohydrate fatty acid esters (CFAE) obtained showed good emulsifying properties in W/O

30 fibrillation patients who would benefit from CFAE ablation.

31 ia are significantly lower using generalized CFAE ablation+PVI.

32 studies are required to define and identify CFAEs more accurately, in a standardized manner, to enha

33 both P<0.0001) and with absence of CFAE (ie, CFAE mean <120 ms; P<0.0001).

34 For both group I and II, CFAE ablation prolonged AF cycle length (25+/-33 versus

35 s in wall stress were not associated with LA CFAE, the PV ostia may respond differently.

36 ccess off antiarrhythmic drugs at 12 months (CFAE: 30/65 [46%] versus control: 37/65 [57%]; P=0.29) a

37 Most CFAE (48 +/- 14%) occurred at non-DE LA sites, followed

38 Most CFAE sites lie remote from AF sources and are not suitab

39 higher at continuous CFAE sites than at non-CFAE sites (0.53 mV (Q1, Q3: 0.33 to 0.83) versus 0.30 m

40 <0.05 mV; both P<0.0001) and with absence of CFAE (ie, CFAE mean <120 ms; P<0.0001).

41 procedures showed no incremental benefit of CFAE ablation (OR, 0.80; 95% CI, 0.46-1.38; P=0.42).

42 atrial fibrillation, there is no benefit of CFAE ablation in paroxysmal atrial fibrillation.

43 The anatomic distribution of CFAE sites was assessed, quantified, and correlated betw

44 We aimed to assess the impact of CFAE ablation in addition to pulmonary vein isolation (P

45 The role of CFAE ablation in addition to PVI should be questioned an

46 Up to 2 h of additional ablation of CFAEs after APVI does not appear to improve clinical out

47 Ablation of CFAEs has been reported to eliminate persistent AF.

48 l fibrillation terminated during ablation of CFAEs in 9 of 50 patients (18%) in Group C.

49 oversion (Group B, n = 50) or to ablation of CFAEs in the left atrium or coronary sinus for up to 2 a

50 Additional ablation of CFAEs resulted in no improvement in mid-term procedural

51 ping of AF in humans has shown that areas of CFAEs correlate with areas of slowed conduction and pivo

52 We hypothesized that such areas of CFAEs could be identified in patients with AF and might

53 derstanding regarding the origin and role of CFAEs in atrial fibrillation continues to evolve, there

54 physiology, distribution and significance of CFAEs in atrial fibrillation.

55 There was no effect on CFAE mean across quartiles of wall stress.

56 For group II, only CFAE sites with continuous electric activity were ablate

57 PVI+CFAE ablation versus PVI alone did not improve the overa

58 analysis of studies comparing PVI versus PVI+CFAE ablation.

59 ctrograms (CFAE) ablation versus a selective CFAE ablation strategy targeting areas of continuous ele

60 [57%]; P=0.29) and multiprocedural success (CFAE: 51/65 [78%] versus control: 52/65 [80%]; P=1.0) we

61 ophysiology as well as the role of targeting CFAEs in catheter ablation of atrial fibrillation.

62 ion, different ablation strategies targeting CFAEs have been compared with the standard pulmonary vei

63 spite the apparent safety of this technique, CFAE ablation did not improve freedom from AF/atrial tac

64 edure times were significantly longer in the CFAE arm (70+/-20 versus 55+/-17; 201+/-35 versus 152+/-

65 At the first redo procedure, patients in the CFAE arm had a higher incidence of organized atrial tach

66 sthmus ablation, before CFAE ablation in the CFAE arm.

67 actionated atrial electrograms (CFAE), using CFAE mean (the mean interval between deflections).

68 Whereas CFAE ablation in addition to standard pulmonary vein iso

69 ltage characteristics poorly correlated with CFAE.

70 Radiofrequency ablation of the area with CFAEs was performed, aiming to eliminate CFAE and/or con

71 Areas with CFAEs represent a defined electrophysiologic substrate a

72 Ablations of the areas associated with CFAEs resulted in termination of AF without external car

73 created during AF, and areas associated with CFAEs were identified.