ライフサイエンスコーパス: CQA

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1 e classified as critical quality attributes (CQAs).

2 hods to monitor critical quality attributes (CQAs).

3 e and also demonstrated no impact on product CQAs.

4 vely by the quinic or caffeic acid moiety of CQAs.

5 and pulp, namely 3-O-caffeoylquinic acid (3-CQA), 4-p-coumaroylquinic acid (HC1), 4-O-caffeoylquinic

6 the content of chlorogenic acid derivates (3-CQA, 4-CQA and 5-CQA) and caffeine using the high perfor

7 uinic acid (HC1), 4-O-caffeoylquinic acid (4-CQA), 5-O-caffeoylquinic acid (5-CQA), derivative of p-c

8 ant variability from 89 to 571 mg/100g for 5-CQA and 48 to 486 mg/100g for 1,5-DCQA in dry material.

9 tent of chlorogenic acid derivates (3-CQA, 4-CQA and 5-CQA) and caffeine using the high performance l

10 on and quantification of chlorogenic acid (5-CQA) and 1,5-dicaffeoylquinic acid (1,5-DCQA) as main co

11 the synthesis of mainly chlorogenic acid (5-CQA) and 3,5-dicaffeoylquinic acid.

12 lorogenic acid derivates (3-CQA, 4-CQA and 5-CQA) and caffeine using the high performance liquid chro

13 be an important critical quality attribute (CQA), and several analytical approaches have been propos

14 r assisting the critical quality attributes (CQAs) assessment of antibodies.

15 Compounds composed by one or two CQAs covalently linked with pentose (Pent) residues (1-1

16 nic acid (4-CQA), 5-O-caffeoylquinic acid (5-CQA), derivative of p-coumaroylquinic acid (HC2) and 3,5

17 of samples ranged from 3.93 to 14.13 g of 5-CQA equivalent/100g dry weight (DW).

18 Lineweaver-Burk plots indicated that 5-CQA exerts a mixed type inhibition as km increased and V

19 icated the presence of caffeoylquinic acids (CQA), feruloylquinic acids (FQA) and dicaffeoylquinic ac

20 ILIS is a valuable methodology in addressing CQAs for the QbD paradigm.

21 e esterase hydrolyzed all chlorogenic acids (CQAs, FQAs) and their corresponding lactones (CQALs, FQA

22 CGA; subsequent relative quantities were: 4-CQA>3-CQA>5-FQA>4-FQA>diCQA (sum of 3,4, 3,5 and 4,5-diC

23 subsequent relative quantities were: 4-CQA>3-CQA>5-FQA>4-FQA>diCQA (sum of 3,4, 3,5 and 4,5-diCQA).

24 A higher proportion of 5-CQA in the phenolic mixture was responsible for an incre

25 With the exception of Desiree, TPC and 5-CQA levels decreased after cooking.

26 Significant increases in TSP, AC and 5-CQA levels were observed for each sample following UV-B

27 CQA levels were reduced through processing but to a grea

28 The most abundant hydroxycinnamic acid was 5-CQA (neochlorogenic acid) with 259.12-481.4mg/kgf.w. in

29 strengthen the use of on-line LC to monitor CQAs of a mAb continuously with various PAT IEX analytic

30 ely measure the critical quality attributes (CQAs) of the drug product.

31 genic acid isomer 5-O-caffeoylquinic acid (5-CQA) on digestion of potato starch by porcine pancreatic

32 Total chlorogenic acids (CQAs) ranged from 43 to 953mg/100g dw and were more conc

33 Co- and pre-incubation of PPAA with 5-CQA significantly reduced PPAA activity in a dose depend

34 Chlorogenic acid (CQA), the ester of caffeic acid with quinic acid supplie

35 sis, a mixture of 5-O-caffeoylquinic acid (5-CQA), the most abundant chlorogenic acid in green coffee

36 phenolics (TSP), 5-O-caffeoylquinic acid (5-CQA), total carotenoids, AC, and phenylalanine ammonia-l

37 5-CQA was present at the highest levels, between 25 and 30

38 Levels of CQA were significantly (p<0.05) lower in some industrial

39 Critical quality attributes (CQAs) were examined for mAbs purified with different Pro

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