ライフサイエンスコーパス: CRF

1 CRF (30 ng) facilitated strategy set-shifting performanc

2 CRF constricts the small bowel and increases fructose ma

3 CRF dose-dependently impaired working memory performance

4 CRF injection caused a significant increase in salivary

5 CRF is strongly, inversely, and independently associated

6 CRF is the first endogenous neuropeptide that can be sho

7 CRF mediates numerous stress-related endocrine, autonomi

8 CRF-enriched CEA-DA projections are positioned to influe

9 CRF-producing neurons and CRF in the CeA are required fo

10 a corticotropin-releasing factor receptor 1 (CRF-R1)-dependent mechanism, and that these CRF1 and NE

11 receptors (GPCRs) known as type-1 and type-2 CRF receptors.

12 ed nucleus vs central nucleus divisions; (2) CRF content of the CEA-DA path; and (3) striatal subregi

13 ons at 5-HT2C receptors (5-HT2CRs), engage a CRF(BNST) inhibitory microcircuit that silences anxiolyt

14 of low dopamine tone that is dependent on a CRF-induced decrease in midbrain dopamine activity.

15 Recently, a CRF-related peptide, termed PD-sauvagine, was isolated f

16 mediates anxiogenic responses by activating CRF type 1 (CRF1) receptors in limbic brain regions.

17 Adding CRF to standard risk factors resulted in a net reclassif

18 min to 135 min was significantly lower after CRF compared with saline [mean difference: 5911 mL . min

19 ending colon volume rose significantly after CRF.

20 ith their respective high-affinity agonists, CRF+urocortin2, resulted in approximately twofold increa

21 Dorsal amygdala CRF overexpression significantly increased AT and metabo

22 ons for understanding how discrete amygdalar CRF pathways modulate longer-lasting fear in anxiety- an

23 ficant interaction was found between age and CRF in each trajectory, indicating that CRF was more str

24 s recruited into the anterior VTA (aVTA) and CRF tone is increased in both subregions.

25 le, performed better than traditional CH and CRF parameters in differentiating forme fruste KC from n

26 or presence of corneal abnormalities, CH and CRF readings were available for 382 Indian persons.

27 The percentage of change of CH and CRF were found to be significantly higher in group II.

28 Interestingly, the increases in CH and CRF were greater in Group 2 than in Group 1 (P > .05).

29 The CH and CRF were measured with the Ocular Response Analyzer (Rei

30 sed to investigate the association of CH and CRF with potential risk factors.

31 th Edition, Clinical Modification codes, and CRF profile (hypertension, diabetes mellitus, hyperchole

32 hat corticotropin-releasing factor (CRF) and CRF receptors are prominent in the PFC, the cognitive ef

33 bled generating atomistic models of CRF- and CRF(12-41)-bound CRF1R, further explored by molecular dy

34 Corneal hysteresis and CRF.

35 CRF-producing neurons and CRF in the CeA are required for discriminative fear, but

36 The central actions of NPY and CRF have opposing functions in the regulation of emotion

37 tra-VTA antagonism of CRF-R1 in the pVTA and CRF-R2 in the aVTA during each social defeat prevented e

38 (Ucn1) and two receptor subtypes, CRF-R1 and CRF-R2, in primary human articular chondrocytes (AC) and

39 Our hybrid analysis approach (CRF-GSEA) proved successful in predicting SSc patient IL

40 rotein (CRF-BP) was originally recognized as CRF sequestering protein.

41 THODS AND Between 1987 and 2014, we assessed CRF in 21 080 HF-free subjects (58.3+/-11 years) at the

42 thcare expenditures with optimal and average CRF profile were $5946 and $3731 less compared with thos

43 increased activation of pVTA CRF-R1 and aVTA CRF-R2.

44 he VTA and antagonism of pVTA CRF-R1 or aVTA CRF-R2 reverses cocaine seeking.

45 In this report, behavioral CRFs were obtained in humans (both males and females) by

46 knowledge related to the association between CRF and health outcomes, increase awareness of the added

47 e is known regarding the association between CRF and incidence of heart failure (HF).

48 s was to investigate the association between CRF and incident AF in a large, multiracial cohort that

49 However, the relationship between CRF and atrial fibrillation (AF) is less clear.

50 drinking; 2) inhibiting VTA-projecting BNST CRF neurons attenuates binge-like drinking; and 3) binge

51 ctions from the CeAL clustered around BNSTDL CRF cells.

52 ) neurons in the CeA is potently enhanced by CRF and that CRFR1 signaling in the CeA is critical for

53 ity exhibit hyperalgesia that is mediated by CRF-CRFR1 signaling in CeA.

54 Intra-CeA CRF infusion mimicked stress-induced hyperalgesia.

55 Our results highlight how CeAL CRF neurons and projections to the BNSTDL consolidate lo

56 p009 (CRF-ArchT) to examine the role of CeAL CRF neurons and projections to the BNSTDL during the acq

57 Optogenetic silencing of CeAL CRF neurons during contextual fear acquisition disrupted

58 Silencing CeAL CRF projections in the BNSTDL during contextual fear acq

59 ted into the amygdala was restricted to CeAL CRF neurons.

60 (i) first-order to higher-order linear-chain CRFs, and from (ii) first-order to higher-order semi-Mar

61 The results indicate that chronic CRF overexpression in primates not only increases AT but

62 In contrast, CRF-BP and CRF2alphaR colocalized when both proteins are

63 ; Marfan syndrome CRF 9.77 +/- 1.65, control CRF 11.03 +/- 1.72, P = .01) and corneas were flatter in

64 ing acute defeat, but, with repeated defeat, CRF is recruited into the anterior VTA (aVTA) and CRF to

65 d the HPA axis response to the dexamethasone-CRF test, but left alcohol craving unaffected.

66 axis were evaluated using the dexamethasone-CRF test.

67 rminalis and central amygdala, and dopamine, CRF, kappa/dynorphin, and glutamate transmission in othe

68 ic transmission in the CeA, and dysregulated CRF-FAAH facilitates stress-induced increases in glutama

69 udies examined the influence of dysregulated CRF and FAAH systems in altering excitatory transmission

70 y stressed rats continue to express elevated CRF tone within the VTA and antagonism of pVTA CRF-R1 or

71 caine taking, and that persistently elevated CRF tone in the VTA may drive later cocaine seeking thro

72 ditional studies examined whether endogenous CRF modulates working memory.

73 nsistent with a mechanism whereby the excess CRF that characterizes stress-related diseases initiates

74 hestrates the stress response, and excessive CRF is thought to contribute to the pathophysiology of t

75 on and interaction of heterologous expressed CRF-BP and CRF2alphaR in yeast, human embryonic kidney 2

76 n known that corticotropin-releasing factor (CRF) and CRF receptors are prominent in the PFC, the cog

77 neuropeptide corticotropin releasing factor (CRF) and its receptors (CRF-R1, CRF-R2) are located in t

78 europeptides corticotropin-releasing factor (CRF) and orexin-A in the ventral tegmental area (VTA) pl

79 The corticotropin-releasing factor (CRF) family of peptides includes CRF and three urocortin

80 ion, reduced corticotropin-releasing factor (CRF) immunodensity in the paraventricular nucleus of the

81 g a role for corticotropin-releasing factor (CRF) in the IC during craving and relapse, a subsequent

82 Corticotropin-releasing factor (CRF) is expressed in the Ce, has a role in stress, and i

83 Corticotropin-releasing factor (CRF) mediates anxiogenic responses by activating CRF typ

84 opulation of corticotropin-releasing factor (CRF) neurons in the bed nucleus of the stria terminalis

85 injection of corticotropin-releasing factor (CRF) on fructose malabsorption and the resulting volume

86 Corticotropin-releasing factor (CRF) orchestrates the stress response, and excessive CRF

87 by increased corticotropin releasing factor (CRF) receptor-1 expression and signalling, which modulat

88 Corticotropin-releasing factor (CRF) receptors-which bind the hormone CRF as well as rel

89 europeptide, corticotropin-releasing factor (CRF) regulates the dorsal raphe nucleus-serotonin (DRN-5

90 Corticotropin-releasing factor (CRF) signaling at the CRF1 receptor (CRF1R) in the ventr

91 The corticotropin releasing factor (CRF) system in the central amygdala (CeA) has been impli

92 The corticotropin releasing factor (CRF) system in the central amygdala (CeA) has been impli

93 The corticotropin-releasing factor (CRF) system, which is involved in stress, addiction, and

94 blockade of corticotropin-releasing factor (CRF) type 1 receptors (CRFR1s) reduces stress-induced th

95 Corticotropin releasing factor (CRF) within the ventral tegmental area (VTA) has emerged

96 tigated how corticotrophin releasing factor (CRF), a critical stress response mediator, influences am

97 ly expresses corticotropin-releasing factor (CRF), an important modulator of stress responses.

98 o vertebrate corticotropin-releasing factor (CRF), and its receptor, Dh44R1.

99 municate via corticotropin-releasing factor (CRF), but studies have yet to examine its function in fe

100 volvement of corticotropin-releasing factor (CRF), noradrenaline, dopamine, glutamate, kappa/dynorphi

101 Y (NPY) and corticotropin-releasing factor (CRF).

102 neuropeptide corticotropin-releasing factor (CRF).

103 vestigate whether corneal resistance factor (CRF) and central corneal thickness (CCT) differ between

104 steresis (CH) and corneal resistance factor (CRF) between Indian and Chinese populations.

105 steresis (CH) and corneal resistance factor (CRF) in both groups postoperatively.

106 steresis (CH) and corneal resistance factor (CRF) were decreased (Marfan syndrome CH 9.45 +/- 1.62, c

107 act of favorable cardiovascular risk factor (CRF) profile on healthcare expenditure and resource util

108 steresis [CH] and corneal resistance factor [CRF]), and corneal wavefront aberrations were assessed b

109 cations [i.e., chromatin regulatory factors (CRF)] and genes encoding histone proteins harbor recurre

110 The cytokinin response factors (CRFs) are a group of related AP2/ERF transcription facto

111 We show that the CYTOKININ RESPONSE FACTORS (CRFs), transcription factors downstream of cytokinin per

112 Chronic renal failure (CRF) is a major public health problem worldwide.

113 Cancer-related fatigue (CRF) remains one of the most prevalent and troublesome a

114 Favorable CRF profile is associated with significantly lower medic

115 ealth expenditures were noted with favorable CRF profile across CVD status.

116 nsistent with a role in discriminative fear, CRF neurons undergo plasticity following threat conditio

117 hopeptides that were more abundant in female CRF-OE mice were overrepresented in an Alzheimer's disea

118 Controlled-release fertilizers (CRFs) can change the release kinetics of the fertilizer

119 tworks (DCNN) and conditional random fields (CRF); it can model not only complex sequence-structure r

120 rary implementing conditional random fields (CRFs), a class of probabilistic graphical models, for ro

121 hat low levels of cardiorespiratory fitness (CRF) are associated with a high risk of cardiovascular d

122 Cardiorespiratory fitness (CRF) as assessed by formalized incremental exercise test

123 Poor cardiorespiratory fitness (CRF) is an independent risk factor for cardiovascular mo

124 established that cardiorespiratory fitness (CRF) is inversely associated with cardiovascular and all

125 n between LTL and cardiorespiratory fitness (CRF), an enduring trait influenced by chronic habituatio

126 zed, with impairment observed only following CRF infusions into the caudal dorsomedial PFC (dmPFC).

127 and validated as a high-affinity ligand for CRF receptor studies.

128 was seen when the analysis was repeated for CRF and CCT.

129 Analysis was repeated for CRF and CCT.

130 e 4 most commonly recommended treatments for CRF-exercise, psychological, combined exercise and psych

131 l interventions as first-line treatments for CRF.

132 mbinants, and circulating recombinant forms (CRFs) currently in circulation worldwide.

133 (33.14%), 20 circulating recombinant forms (CRFs; 11.63%), and 20 unclassified (11.63%) sequences we

134 and the TrKB systems, and independently from CRF.

135 tics and mechanisms of nutrient release from CRFs.

136 Mapping contrast response functions (CRFs) has allowed (neuro)scientists to gain important in

137 ed by measuring contrast response functions (CRFs).

138 Furthermore, CRF axonal projections from the CeAL clustered around BN

139 hese results reveal an essential 5-HT(DRN)-->CRF(BNST) circuit governing fear and anxiety, and provid

140 nosed as having cancer at Medicare age, high CRF in midlife was associated with an adjusted 32% (HR,

141 al, and prostate cancers among men with high CRF were 0.45 (95% CI, 0.29-0.68), 0.56 (95% CI, 0.36-0.

142 Avoiders exhibited higher CRF peptide levels in CeA that did not appear to be loca

143 These findings suggest that higher CRF is associated with longer LTL.

144 ons that are activated by the stress hormone CRF.

145 actor (CRF) receptors-which bind the hormone CRF as well as related peptides-are important regulators

146 These experiments explore how CRF is released and interacts with its receptors in spec

147 These experiments explore how CRF release and the activation of its receptors within t

148 , we show that Abeta species can hyperexcite CRF neurons, providing a mechanism by which Abeta influe

149 It implements CRFs models, that is discriminative models from (i) firs

150 0.26; 95% CI, 0.13-0.38; P < .001) improved CRF during and after primary treatment, whereas pharmace

151 exercise training had significantly improved CRF (mL/kg per min; weighted mean difference, 2.72; 95%

152 is study used a phosphoproteomic approach in CRF-overexpressing (CRF-OE) mice to test the proof of pr

153 hift cognitive processing through changes in CRF neurotransmission in the DRN and the association of

154 Elevations in CRF-CRF1 signaling dysregulate FAAH activity, and this g

155 aled salutary effects of rhubarb extracts in CRF.

156 bitory synaptic transmission specifically in CRF neurons via a previously unknown Gi-mediated, PKA-de

157 udy the role of constitutive upregulation in CRF systems on amygdalar eCB function and persistent anx

158 n this review, we discuss DNA alterations in CRFs and how these influence tumor chromatin structure a

159 ing factor (CRF) family of peptides includes CRF and three urocortins, which signal through two disti

160 analyzing lines with decreased and increased CRF function.

161 nd the consequences of chronically increased CRF in the Ce region.

162 metabolites associated with adenine-induced CRF.

163 ated withdrawal-induced anxiety; whereas IPN CRF infusion in mice increased anxiety.

164 ow that excitability of genetically isolated CRF-receptive (CRFR1) neurons in the CeA is potently enh

165 s, CRF1 and CRF2 , and two of their ligands, CRF and urocortin 3, respectively, in African mole-rat s

166 These data collectively link CRF to increased Abeta through gamma-secretase and provi

167 Chemogenetic inhibition of local CRF neurons in the VTA did not alter binge-like ethanol

168 e and accurate available tool for localizing CRF receptors in rodent brain.

169 5% CI, 0.16-0.64) compared with men with low CRF in midlife.

170 Compared with men with low CRF, the adjusted hazard ratios (HRs) for incident lung,

171 First, attention lowered CRFs, whereas consciousness raised them.

172 opeptides that distinguished female and male CRF-OE mice were overrepresented in unique pathways that

173 (ii) first-order to higher-order semi-Markov CRFs (semi-CRFs).

174 re is an inverse association between midlife CRF and incident lung and colorectal cancer but not pros

175 preciable phenotypes, disruption of multiple CRFs results in larger rosettes, delayed leaf senescence

176 Mutated CRFs have now been identified in most types of cancer an

177 Neither CRF nor CH differed significantly between the groups.

178 s of the release processes and to design new CRFs in a shorter time and with relatively lower cost.

179 rtance for the design and development of new CRFs.

180 tra-dmPFC administration of the nonselective CRF antagonist, D-Phe-CRF, dose-dependently improved wor

181 These findings demonstrate a novel CRF gain-control circuit and show separable pathways for

182 Importantly, the ability of CRF antagonists to improve working memory is identical t

183 The working memory actions of CRF in the PFC were topographically organized, with impa

184 se of this statement is that the addition of CRF for risk classification presents health professional

185 diabetes mellitus, but that the addition of CRF to traditional risk factors significantly improves t

186 Amelioration of CRF with the three rhubarb extracts was associated with

187 Intra-VTA antagonism of CRF-R1 in the pVTA and CRF-R2 in the aVTA during each so

188 Antagonism of CRF-R1 with CP-154526 caused an accumulation of intracel

189 d to estimate the independent association of CRF with incident AF.

190 We analyzed the colocalization of CRF-BP and CRF2R in cultured rat mesencephalic neurons,

191 Inclusion criteria consisted of CRF severity as an outcome and testing of exercise, psyc

192 alamus to DRN-driven serotonergic control of CRF levels in the amygdala may contribute to the transit

193 hift from MRN-driven serotonergic control of CRF levels in the hypothalamus to DRN-driven serotonergi

194 L-carnitine metabolism in the development of CRF.

195 rs GR expression leading to disinhibition of CRF.

196 iographic studies to map the distribution of CRF receptor binding sites in the mouse brain.

197 Although the cellular distribution of CRF receptor expression has been well characterized at t

198 hifting performance, whereas higher doses of CRF and urocortin II that would interact with CRF2 were

199 is unclear whether chronic dysregulation of CRF systems induces maladaptive changes in amygdalar eCB

200 ominent in the PFC, the cognitive effects of CRF action within the PFC are poorly understood.

201 s-induced changes in the cellular effects of CRF in the DRN translate to changes in cognitive effects

202 translate to changes in cognitive effects of CRF.

203 n nonstressed rats by intra-BLA infusions of CRF (200 ng/0.5 mul), but not by repeated NE infusions (

204 light recent advances in the interactions of CRF receptors with other GPCRs and non-GPCR proteins and

205 ircuitry studies indicate the involvement of CRF and noradrenaline transmission in bed nucleus of str

206 Knockdown of CRF synthesis in the VTA prevented IPI activation and an

207 ion, chronic stress did not induce a loss of CRF-induced EPSCs in basal dendrites, thereby creating a

208 inistration in rats.In vivo microdialysis of CRF in the VTA demonstrated that CRF is phasically relea

209 utanol extracts of rhubarb in a rat model of CRF with adenine-induced chronic tubulointerstitial neph

210 data enabled generating atomistic models of CRF- and CRF(12-41)-bound CRF1R, further explored by mol

211 However, the nature of CRF release in the VTA during acute and repeated stress,

212 better assess the translational potential of CRF antagonists, we examined the cognitive effects of sy

213 The proportion of CRF+ outputs is >50%, and mainly targets the A10 parabra

214 were classified by age-specific quintiles of CRF.

215 To determine the potential role of CRF projections from the bed nucleus of the stria termin

216 stochemical techniques to assess the role of CRF-CRFR1 signaling in CeA in stress-induced hyperalgesi

217 Severity of CRF was the primary outcome.

218 mized, placebo-controlled crossover study of CRF compared with saline injection in 11 male and 10 fem

219 es, increase awareness of the added value of CRF to improve risk prediction, and suggest future direc

220 etric analysis of release characteristics of CRFs is of paramount importance for the design and devel

221 In contrast, overexpression of CRFs generally results in the opposite phenotypes.

222 Continued research on CRF mutations will be critical for our future understand

223 ements of CH (10.6+/-1.6 mmHg; P = 0.670) or CRF (10.3+/-1.7 mmHg; P = 0.103) between the ethnic grou

224 Expression of our CRF-ArchT vector injected into the amygdala was restrict

225 phoproteomic approach in CRF-overexpressing (CRF-OE) mice to test the proof of principle that when CR

226 ive AD pathogenesis, which directly perturbs CRF signaling, thereby enhancing chronic PTSD symptoms w

227 te neuroadaptive changes in tonic and phasic CRF with repeated stress, that CRF release during stress

228 on of the nonselective CRF antagonist, D-Phe-CRF, dose-dependently improved working memory performanc

229 4.7%) had average, and 2728 (17.4%) had poor CRF profile, translating to 54.2, 64.1, and 24.9 million

230 and $3731 less compared with those with poor CRF profile.

231 There is evidence that CRF-BP potentiates CRF and urocortin 1 actions through CRF type 2 receptors

232 l drinking, but inhibition of VTA-projecting CRF neurons from the BNST significantly reduced intake.

233 ticotropin releasing factor binding protein (CRF-BP) was originally recognized as CRF sequestering pr

234 seeking through increased activation of pVTA CRF-R1 and aVTA CRF-R2.

235 F tone within the VTA and antagonism of pVTA CRF-R1 or aVTA CRF-R2 reverses cocaine seeking.

236 ha)MeLeu(27,40),Glu(30),Lys(33)]-acetyl-h /r-CRF(9-41)}.

237 sing factor (CRF) and its receptors (CRF-R1, CRF-R2) are located in the VTA and influence dopaminergi

238 in releasing factor (CRF) and its receptors (CRF-R1, CRF-R2) are located in the VTA and influence dop

239 ike LgA cocaine self-administration, reduced CRF immunodensity in the central nucleus of the amygdala

240 cal interventions are effective for reducing CRF during and after cancer treatment, and they are sign

241 order to higher-order semi-Markov CRFs (semi-CRFs).

242 Deviations relative to the standard CRF, i.e., gain functions, describe the strength of sign

243 bute to CORT regulation of GR and subsequent CRF expression in the CeA.

244 urocortin1 (Ucn1) and two receptor subtypes, CRF-R1 and CRF-R2, in primary human articular chondrocyt

245 CH 11.24 +/- 1.21, P = .01; Marfan syndrome CRF 9.77 +/- 1.65, control CRF 11.03 +/- 1.72, P = .01)

246 d viral-based strategy to selectively target CRF neurons with the optogenetic silencer archaerhodopsi

247 in the bed nucleus of the stria terminalis (CRF(BNST)) in mice.

248 se results are the first to demonstrate that CRF acts in the PFC to regulate PFC-dependent cognition.

249 dialysis of CRF in the VTA demonstrated that CRF is phasically released in the posterior VTA (pVTA) d

250 We previously demonstrated that CRF receptor 1 (CRF1) neurons comprise a specific compon

251 results were validated by demonstrating that CRF overexpression in females was associated with increa

252 There is evidence that CRF-BP potentiates CRF and urocortin 1 actions through C

253 Here we found that CRF induces EPSCs in PFC layer V cells and that ketamine

254 relapse, a subsequent experiment found that CRF receptor-1 (CRF1) blockade in the AId similarly redu

255 We hypothesized that CRF-BP binds to CRF2R, exerting an escort protein role.

256 We hypothesized that CRF-CRFR1 signaling in central amygdala (CeA) mediates s

257 ple mutant is embryo lethal, indicating that CRF function is essential for embryo development.

258 and CRF in each trajectory, indicating that CRF was more strongly associated with the aging trajecto

259 clinical evidence demonstrates not only that CRF is a potentially stronger predictor of mortality tha

260 We showed previously that CRF receptor 1-expressing (CRF1+) neurons in the CeA are

261 Here we show that CRF-BP physically interacts with the CRF2alphaR but not

262 Our results showed that CRF-BP and CRF2R naturally colocalize in the neurites of

263 ogous expression of each protein showed that CRF-BP was localized mainly in secretory granules and CR

264 ic and phasic CRF with repeated stress, that CRF release during stress may contribute to later escala

265 These observations suggest that CRF antagonists may represent a novel approach for the t

266 Results also suggest that CRF treatment effectiveness was associated with cancer s

267 tion in different brain nuclei suggests that CRF-BP may have additional functions.

268 Significant changes were found between the CRF and control groups representing characteristic pheno

269 o-associated virus serotype 2 containing the CRF construct.

270 owing body of work that links changes in the CRF system with social behavior.

271 mpared the telencephalic distribution of the CRF receptors, CRF1 and CRF2 , and two of their ligands,

272 ttle is known about the role of CRF2R or the CRF neurocircuitry involved.

273 apamycin complex 1 synaptogenic pathway; the CRF-induced EPSCs required an intact BLA input and were

274 These results indicate that the CRF transcription factors play important roles in multip

275 This effect could only be removed using the CRF-R1 selective antagonist CP-154526, suggesting Ucn1 a

276 to predict the release of nutrients from the CRFs to elucidate fundamental understanding of the dynam

277 Here we explore the role of the CRFs in Arabidopsis thaliana growth and development by a

278 Disruption of the CRFs results in partially insensitivity to cytokinin in

279 Furthermore, we demonstrate that this CRF(BNST) inhibitory circuit underlies aversive behaviou

280 entiates CRF and urocortin 1 actions through CRF type 2 receptors (CRF2R).

281 nist CP-154526, suggesting Ucn1 acts through CRF-R1 when promoting chondrocyte survival.

282 Thus, CRF-BP emerges as a GPCR escort protein increasing the u

283 9, 12-15, 18, 19, 22-26, 28, 31) had k(i) to CRF receptors in the high picomolar and low nanomole ran

284 eide breath test and the adrenal response to CRF was assessed by serial salivary cortisol measurement

285 opulation of rats 5-HT neuronal responses to CRF have been demonstrated to shift from CRF1-mediated i

286 optogenetic silencer archaerhodopsin tp009 (CRF-ArchT) to examine the role of CeAL CRF neurons and p

287 ion modes may be more effective for treating CRF at different points in the cancer treatment trajecto

288 increased gamma-secretase accumulation upon CRF treatment.

289 e self-administration in a 24 h "binge." VTA CRF continues to influence cocaine seeking in stressed a

290 Binge-induced changes in VTA CRF system protein and messenger RNA were also assessed

291 hese acute and persistent changes to the VTA CRF system may lead to better therapeutic interventions

292 of binge-like ethanol consumption on the VTA CRF system were assessed following drinking-in-the-dark

293 at ethanol-induced activation of BNST-to-VTA CRF projections is critical in driving binge-like ethano

294 s of the stria terminalis (BNST) to the VTA, CRF neurons in this circuit were chemogenetically inhibi

295 in and messenger RNA associated with the VTA-CRF system.

296 When CRF was considered as a binary variable (unfit/fit), low

297 ice to test the proof of principle that when CRF is in excess, sex-biased CRF1 coupling translates in

298 fe course in adults and to determine whether CRF modifies the age-associated trajectory of lipids and

299 The current studies examined whether CRF receptor activation in the PFC modulates cognitive f

300 nting characteristic phenotypes of rats with CRF.