ライフサイエンスコーパス: IPAA

1 IPAA fail from 3% to 15% of the times, mainly due to tec

2 IPAA is an excellent option for patients with MUC, IC, F

3 IPAA was performed for ulcerative colitis in 73% of the

4 long-term results in a single cohort of 409 IPAA patients are unique and are likely a more accurate

5 After IPAA, 50 (31%) patients attempted to conceive.

6 After IPAA, quality of life improved promptly in both groups.

7 thrombi appear to be relatively common after IPAA surgery and are most likely segmental, multiple, an

8 t, no patient had a new cancer develop after IPAA.

9 ant), 5 had Crohn's disease (diagnosed after IPAA), 1 had indeterminate colitis, and 8 had familial a

10 nd pouch survival rates are equivalent after IPAA for IndC and UC, there is an increase in some compl

11 Early function after IPAA is good for most patients.

12 here is no data on the quality of life after IPAA for IndC.

13 a delayed fashion at median 36 months after IPAA in 87(43%).

14 red for reconstruction (mean 68 months after IPAA).

15 time and ageing on long-term outcomes after IPAA.

16 nancy on long-term functional outcomes after IPAA.

17 significantly higher in older patients after IPAA for CUC compared with younger patients.

18 Fifteen patients attempted pregnancy after IPAA, of which 11 (73%) were able to conceive, resulting

19 as time to first spontaneous pregnancy after IPAA.

20 Eighty-five women who became pregnant after IPAA had pouch function, which was comparable with women

21 Short-term function and QoL after IPAA is good.

22 The mean follow-up after IPAA was 68 +/- 33 months (range 6-136).

23 atients followed annually for 15 years after IPAA.

24 matory or fistulizing Crohn's disease and an IPAA performed for diagnosis of ulcerative colitis were

25 ds of 7 patients with Crohn's disease and an IPAA treated with infliximab were reviewed.

26 t patients with Crohn's disease involving an IPAA who are refractory to conventional therapies.

27 ence (P = .02) rather than to creation of an IPAA at the first operation (P = .55).

28 to divert in patients with CUC undergoing an IPAA.

29 years; range, 12-66 years) who underwent an IPAA between 1987 and 2002 (mean follow-up, 33.6 months;

30 ced CT after a total proctocolectomy with an IPAA.

31 colectomy with ileal pouch-anal anastamosis (IPAA) after diagnosis of severe ulcerative colitis (UC)

32 transabdominal ileal pouch-anal anastomoses (IPAA) redo surgery for a failed initial IPAA.

33 octectomy, and ileal pouch anal anastomoses (IPAA) with a protective ileostomy.

34 ry training in ileal pouch-anal anastomosis (IPAA) and identify possible differences in the learning

35 vely collected ileal pouch-anal anastomosis (IPAA) database was reviewed retrospectively to identify

36 ate results of ileal pouch-anal anastomosis (IPAA) done for patients with familial adenomatous polypo

37 colectomy with ileal-pouch anal anastomosis (IPAA) for an original diagnosis of ulcerative colitis.

38 colectomy and ileal pouch-anal anastomosis (IPAA) for ulcerative colitis, familial colonic polyposis

39 colectomy with ileal pouch-anal anastomosis (IPAA) has substantially reduced the risk for ulcerative

40 the results of ileal pouch-anal anastomosis (IPAA) in patients in whom the anal mucosa is excised by

41 colectomy with ileal pouch anal anastomosis (IPAA) is associated with tubal factor infertility in fem

42 performance of ileal pouch-anal anastomosis (IPAA) is controversial in CD.

43 Ileal pouch anal anastomosis (IPAA) is the treatment of choice for chronic, medically

44 patients with ileal pouch-anal anastomosis (IPAA) may be due to inflammatory conditions, including p

45 double-stapled ileal pouch-anal anastomosis (IPAA) or a mucosectomy and hand-sewn anastomosis, and wh

46 colectomy with ileal pouch-anal anastomosis (IPAA) substantially reduces the risk of colorectal cance

47 ts who undergo ileal pouch-anal anastomosis (IPAA) surgery for ulcerative colitis (UC) or indetermina

48 s common after ileal pouch-anal anastomosis (IPAA) surgery for ulcerative colitis (UC).

49 PALGA) to identify all patients with IBD and IPAA in The Netherlands from January 1991 to May 2012.

50 We identified 1200 patients with IBD and IPAA; 25 (1.83%) developed pouch neoplasia, including 16

51 range, 5-170 months) had proctocolectomy and IPAA at Mayo Medical Center in Rochester, Minnesota.

52 Risk for neoplasia in patients with UC and IPAA is small and not eliminated by colectomy or mucosec

53 not appear to justify the decision to avoid IPAA creation at the first operation provided that it is

54 Half of them already had a child before IPAA.

55 CD diagnosis was before IPAA (intentional) in 20(10%), from postoperative histop

56 Transanal resection of an elongated IPAA spout was performed on 58 patients; abdominoperinea

57 going transabdominal redo surgery for failed IPAA between 1983 and 2014 were evaluated.

58 fe (QOL) outcomes of redo surgery for failed IPAA, especially in large series of patients.

59 In UC patients with failing IPAA, partial or complete pouch reconstruction can be do

60 ne sequencing data from paired biopsies from IPAA patients with UC and familial adenomatous polyposis

61 Female patients older than 18 years that had IPAA under the age of 41 were eligible for inclusion (n

62 Of those patients who had IPAA at our institution, pouch failure occurred in 197 p

63 o either endorectal mucosectomy and handsewn IPAA or to double-stapled IPAA, which spared the anal tr

64 s of fecal incontinence compared to handsewn IPAA, which excises the mucosa.

65 ith IndC should not be precluded from having IPAA surgery.

66 ision, and monitoring, the learning curve in IPAA surgery may be reduced even further.

67 ainee staff demonstrated a learning curve in IPAA surgery.

68 M) model was used for monitoring outcomes in IPAA surgery.

69 ses (IPAA) redo surgery for a failed initial IPAA.

70 The initial IPAA was constructed at our institution in 32 patients a

71 LAP-IPAA is equivalent to open IPAA in terms of safety and f

72 LAP-IPAA patients had shorter median time to regular diet (3

73 This report describes 100 LAP-IPAA patients case matched to 200 open IPAA patients.

74 (range, 16-34 kg/m) underwent IPAA (100 LAP-IPAA, 200 open IPAA).

75 In addition, LAP-IPAA provides significant improvements in short-term rec

76 Between 1998 and 2004, 100 consecutive LAP-IPAA patients (75 laparoscopic assisted, 25 hand assiste

77 s nil, and readmission rates were equal (LAP-IPAA = 21%, open IPAA = 22%).

78 .Postoperative morbidity was equivalent (LAP-IPAA = 33%, open IPAA = 37%), mortality was nil, and rea

79 Outcomes of laparoscopic IPAA (LAP-IPAA) have been incompletely characterized.

80 Reoperation was required in 3% of LAP-IPAA and 6.5% of open IPAA patients (P < 0.2) during the

81 Median operative time was longer for the LAP-IPAA group (333 minutes versus 230 minutes, P < 0.0001).

82 d a higher pregnancy rate after laparoscopic IPAA (log-rank, P = 0.023).

83 However, fertility after laparoscopic IPAA has never been assessed.

84 rate appears to be lower after laparoscopic IPAA than after open surgery.

85 are significantly higher after laparoscopic IPAA.

86 , pregnancy, pouch salvage, and laparoscopic IPAA.

87 Outcomes of laparoscopic IPAA (LAP-IPAA) have been incompletely characterized.

88 patients who underwent a total laparoscopic IPAA between 2000 and 2011 and were aged 45 years or les

89 open and 27 (54%) had undergone laparoscopic IPAA.

90 e identified from a prospectively maintained IPAA database.

91 Reports on the outcome of IPAA for IndC have been inconclusive because of the smal

92 ing performance during the learning phase of IPAA surgery.

93 were identified and case matched to 200 open IPAA control patients by age, operation, gender, date of

94 0 LAP-IPAA patients case matched to 200 open IPAA patients.

95 kg/m) underwent IPAA (100 LAP-IPAA, 200 open IPAA).

96 ssion rates were equal (LAP-IPAA = 21%, open IPAA = 22%).

97 rbidity was equivalent (LAP-IPAA = 33%, open IPAA = 37%), mortality was nil, and readmission rates we

98 required in 3% of LAP-IPAA and 6.5% of open IPAA patients (P < 0.2) during the first 3 months.

99 LAP-IPAA is equivalent to open IPAA in terms of safety and feasibility.

100 es or enteric leaks occurred in 23 patients; IPAA function was excellent in 19 of these patients (2 h

101 and chart review of 3707 consecutive primary IPAA cases.

102 and median follow-up 7.4 years) with primary IPAA were included.

103 ame procedure again, and 98% would recommend IPAA to others with IndC.

104 edo surgery, 101 (n = 20%) patients had redo IPAA failure.

105 oning pouch, and 46 patients (1.2%) had redo IPAA.

106 Repeat IPAA can often salvage pelvic pouches in patients with M

107 ad a functioning pouch 6 months after repeat IPAA.

108 or "poor." All said they would choose repeat IPAA surgery again.

109 Patients who had successful repeat IPAA surgery often report functional problems but would

110 Foundation patients who had undergone repeat IPAA surgery after septic complications from previous pe

111 Patients with retained IPAA at follow-up had near-perfect/perfect continence (7

112 The learning curve for hand-sewn IPAA surgery was quantified only for senior staff who at

113 the learning curve for stapled and hand-sewn IPAA surgery.

114 n failure rate between stapled and hand-sewn IPAA, but there is no literature that evaluates the diff

115 Two-stage vs 3-stage IPAA procedures for active ulcerative colitis.

116 Stapled IPAA, which preserves the mucosa of the anal transition

117 Two hundred one patients underwent a stapled IPAA since May 1989, 192 as a one-stage procedure withou

118 the authors performed 126 additional stapled IPAA procedures for ulcerative colitis and familial aden

119 ctomy and handsewn IPAA or to double-stapled IPAA, which spared the anal transition zone.

120 The triple-stapled IPAA without temporary ileal diversion has a relatively

121 case mix, trainee staff undertaking stapled IPAA surgery showed an improvement in the pouch failure

122 Ta-IPAA for UC is a safe procedure, resulting in fewer pati

123 f transanal ileal pouch-anal anastomosis (ta-IPAA) with transabdominal minimal invasive approach in u

124 Overall, ta-IPAA led to lower CCI scores.

125 ve morbidity were 0.52 times lower in the ta-IPAA group (95% confidence interval [0.29; 0.92] P = 0.0

126 Ninety-seven patients (male: 52%) with ta-IPAA were compared to 119 (male: 53%) with transabdomina

127 These data support the conclusion that IPAA is a durable operation for patients requiring proct

128 The IPAA eradicates the risk of colorectal cancer in patient

129 at 3, 6, 9, 12, 18, and 24 months after the IPAA and yearly thereafter.

130 We conclude that the IPAA confers a good quality of life.

131 We use the IPAA model of IBD to associate mucosal host gene express

132 oing major reconstructive revisions of their IPAA at our institution between 1981 and 2005.

133 pared to 119 (male: 53%) with transabdominal IPAA.

134 nine hundred and eleven patients undergoing IPAA for Ind and UC from 1983 to 1999 were evaluated.

135 vision in this series of patients undergoing IPAA is due to a policy of aggressive correction when pa

136 were collected from 1965 patients undergoing IPAA surgery by 12 surgeons in a single center between 1

137 r risk stratification of patients undergoing IPAA surgery.

138 We evaluated 87 patients who had undergone IPAA for inflammatory bowel disease.

139 dex of 23 kg/m (range, 16-34 kg/m) underwent IPAA (100 LAP-IPAA, 200 open IPAA).

140 Of the 1,454 patients who underwent IPAA for CUC between 1981 and 1994, 1,386 were part of t

141 In contrast, early colectomy with IPAA accrued a discounted lifetime cost of $147,763 per

142 iate clinical settings, early colectomy with IPAA after diagnosis of severe UC reduces health care ex

143 th IPAA was necessary for the colectomy with IPAA strategy to be cost-ineffective.

144 age or death, comparing early colectomy with IPAA strategy to the standard medical therapy strategy.

145 , while QALY-gained for early colectomy with IPAA was 20.72.

146 value of less than 0.7 after colectomy with IPAA was necessary for the colectomy with IPAA strategy

147 Quality-of-life after colectomy with IPAA was the most sensitive variable impacting cost-effe

148 Making the diagnosis of CD in patients with IPAA can be difficult, but it is important for prognosti

149 For CD patients with IPAA, when the diagnosis is established preoperatively o

150 this test in the management of patients with IPAA.

151 y diagnostic features of CD in patients with IPAA.

152 for evaluation of symptomatic patients with IPAA.

153 e underwent restorative proctocolectomy with IPAA from 1984 to 2009 at the Cleveland Clinic.

154 The restorative proctocolectomy with IPAA has become the procedure of choice for patients wit

155 Total proctocolectomy with IPAA is known to be associated with postoperative infert

156 nce in quality of life, or satisfaction with IPAA surgery.

157 Sixty consecutive subjects with IPAA for inflammatory bowel disease had measurements of