ライフサイエンスコーパス: L-serine

1 ntermediate at any concentration of O-acetyl-l-serine.

2 a decrease in the affinity of the enzyme for L-serine.

3 ed by the endogenous compound N-arachidonoyl l-serine.

4 ct acetate and of the external aldimine with l-serine.

5 approximately 10-fold lower Km for O-acetyl-l-serine.

6 and to aminoacylate total E. coli tRNA with L-serine.

7 tural similarities to the natural substrate, L-serine.

8 The mammalian enzymes are not inhibited by L-serine.

9 a model protein, by a pathway that required L-serine.

10 e > phosphatidylethanolamine >> phosphatidyl-l-serine.

11 ed in solutions weakly buffered by substrate L-serine.

12 pyrrolidines 4, 5, and 6, from either D- or L-serine.

13 e structure of the binding site complex with L-serine.

14 harge and specific interactions with phospho-l-serine.

15 s obtained in the forward half-reaction with L-serine.

16 in, stereoselective for sn-1, 2-phosphatidyl-L-serine.

17 -serine, or activated human neutrophils plus L-serine.

18 ivity and substrate inhibition with O-acetyl-L-serine.

19 e or oxindolyl-L-alanine, and, by inference, L-serine.

20 me catalyzing the formation of D-serine from L-serine.

21 lyzes the abstraction of the alpha-proton of L-serine.

22 tris-2,3-dihydroxybenzoyl-L-serine and acyl-L-serine.

23 f d-serine dependent on astrocytic supply of l-serine.

24 domain acts as a codomain for the action of L-serine.

25 moc-phospho(1-nitrophenylethyl-2-cyanoethyl)-L-serine 1, N-alpha-Fmoc-phospho(1-nitrophenylethyl-2-cy

26 ipid bilayer 2-dioleoyl-sn-glycero-3-phospho-L-serine/1-palmitoyl-2-oleoyl-sn-glycero-3-phosph oethan

27 modest inhibitor, whereas the dithiophospho-l-serine 10 was a somewhat weaker inhibitor.

28 Maximal inhibitory concentration of L-serine (10 mM) alone had a rather modest inhibitory ef

29 H2S precursor l-cysteine (10 mm) but not by l-serine (10 mm) or either amino acid in the presence of

30 The primary deuterium isotope effect using L-serine 2-D is one on (V/K)serine and V in the steady s

31 is no primary deuterium isotope effect with L-serine 2-D.

32 2 microM), taurine (5.5 +/- 2.1 microM), and l-serine (2.8 +/- 1.0 microM) were identified in the per

33 .2 microM), GABA (0.11 +/- 0.04 microM), and L-serine (23 +/- 4 microM) were measured.

34 ine-based cross-linker (N,O-bis-methacryloyl l-serine, 3), versus the aspartic-acid-based cross-linke

35 investigate the mechanisms mediating [(14)C]L-serine (a system L substrate) transport into human pla

36 -methyltetradecanoyl)oxy)hexadecanoyl)glycyl-l-serine, abbreviated as l-serine-(R+S)-Lipid 654, to de

37 O-Phospho-l-serine also prevented aggregation of the protein under

38 arachidonoyl glycine), NASer (N-arachidonoyl-l-serine), anandamide, NADA (N-arachidonoyl dopamine), N

39 otope effect of about 2 was measured on (V/K)L-serine and (V/K)ketomalonate and about 5.5 on V.

40 roxymalonyl-ACP from the primary metabolites l-serine and 1,3-bisphospho-d-glycerate.

41 ple, we find that Km(app) = 1.2+/-0.2 mM for L-serine and 5.6+/-2.2 mM for cysteamine, with kcat = 1.

42 his assay yielded Km(app) = 2.2+/-0.5 mM for L-serine and 6.6+/-2.2 for cysteamine, with kcat = 2.5+/

43 ar membranes formed from the condensation of L-serine and a long-chain acyl thioester.

44 cyclic lactone of tris-2,3-dihydroxybenzoyl-L-serine and acyl-L-serine.

45 famidates were synthesized in 60% yield from L-serine and allo-L-threonine, respectively.

46 s that are important for both recognition of l-serine and catalysis of ester formation.

47 gle time point assay using 14C-(C-1)-labeled L-serine and cysteamine as substrates, counting the thia

48 intermediates 4 and 5 from N-Cbz- and N-Boc-l-serine and diastereoselective reduction of the enones.

49 t of a large number of microswimmers towards L-serine and elucidate the associated collective chemota

50 The dissociation constants for the enzyme.L-serine and enzyme.H4folate complexes were determined a

51 enzyme that catalyzes the interconversion of L-serine and glyoxylate to hydroxypyruvate and glycine.

52 n, ribonuclease A (RNase A), exposed to free L-serine and HOCl exhibits the biochemical hallmarks of

53 Monomers derived from l-serine and l-aspartic acid were synthesized and used t

54 The reactions of L-serine and L-cysteine with CBS resulted in the formati

55 a series of intermediates in the reaction of L-serine and L-homocysteine to form L-cystathionine.

56 strated increased maternal-fetal transfer of L-serine and L-leucine, but not glycine, following bolus

57 s, viscosities and enthalpies of dilution of l-serine and l-proline have been determined in water and

58 ges in taste quality and hydration number of l-serine and l-proline in the presence of the studied pr

59 The SstT protein functions to transport L-serine and L-threonine by sodium transport into the ce

60 alitatively similar to the taste of sucrose, L-serine and L-threonine generate distinctive percepts.

61 e able to reliably discriminate sucrose from L-serine and L-threonine.

62 utions of [l-Ser + M + H](+) (where l-Ser is l-serine and M is a given monosaccharide), [l-Phe-Gly +

63 a catalyzes an NAD(+)-dependent oxidation of l-serine and methyl-l-serine but exhibits low activity a

64 biosynthesis begins with the condensation of L-serine and palmitoyl-CoA catalyzed by the PLP-dependen

65 synthesis commences with the condensation of L-serine and palmitoyl-CoA to produce 3-ketodihydrosphin

66 tion of L-cysteine and acetate from O-acetyl-L-serine and sulfide.

67 ermediates in the forward half-reaction with L-serine and that the external aldimine of aminoacrylate

68 '-phosphate, while the beta-subunit utilizes L-serine and the indole produced at the alpha-site to fo

69 The coreceptor was inhibited by phospho-l-serine and to a lesser extent by phospho-d-serine but

70 S (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine) and neutral POPC (1-palmitoyl-2-oleoyl-sn-glyc

71 f the alpha-proton and the hydroxyl group of L-serine, and (3) that the rate of the overall reaction

72 e, L-vanyl-L-vanyl-L-valine, L-seryl-L-seryl-L-serine, and L-lysyl-L-lysyl-L-lysine at acid, neutral,

73 (SAT, EC 2.3.1.30), which produces O-acetyl-L-serine, and O-acetyl-L-serine sulfhydrylase (OASS, EC

74 ogenase has been solved with bound effector, l-serine, and substrate, hydroxypyruvic acid phosphate,

75 Once acetyl-CoA and l-serine are bound, an enzymic general base accepts a pr

76 L-lysine, L-glutamic acid, or diglycine with L-serine as a major component.

77 lmitoyltransferase uses l-alanine instead of l-serine as its amino acid substrate.

78 hough having no effect alone, N-arachidonoyl l-serine attenuated inhibition of human neutrophil migra

79 ding moieties are directly attached to a tri-l-serine backbone; although apparently minor, these stru

80 l differences seen in the native enzyme upon L-serine binding are not critical for inhibition, wherea

81 336V demonstrates that the minimal effect of L-serine binding leading to inhibition of enzyme activit

82 Pre-steady-state kinetic analysis of L-serine binding to lpLSD demonstrates that L-serine bin

83 main rotation of the subunits in response to L-serine binding.

84 of identical subunits that is inhibited when l-serine binds at allosteric sites between subunits.

85 L-serine binding to lpLSD demonstrates that L-serine binds to a second noncatalytic site and produce

86 In PGDH, L-serine binds to the ACT domain to inhibit catalytic ac

87 lusion chromatography) showed that O-phospho-l-serine binds to the phospholipid-binding region in the

88 C 1.1.1.95) is the first committed enzyme of l-serine biosynthesis in the phosphorylated pathway.

89 losis genome harbors all enzymes involved in l-serine biosynthesis including two PSP homologs: Rv0505

90 ur understanding of NLS as a disorder of the L-serine biosynthesis pathway and suggest that NLS repre

91 s in all three genes encoding enzymes of the L-serine biosynthesis pathway.

92 e involved in the first and limiting step in L-serine biosynthesis, were recently identified as the c

93 ansferase, the enzyme for the second step in L-serine biosynthesis.

94 hosphatase, which catalyzes the last step of L-serine biosynthesis.

95 e that catalyzes the first committed step of l-serine biosynthesis.

96 LS-linked mutants was dysregulation of the d/l-serine biosynthetic pathway, previously linked to both

97 opanol phosphate bound to the alpha-site and L-serine bound to the beta-site (alpha D60N-IPP-Ser), an

98 )-dependent oxidation of l-serine and methyl-l-serine but exhibits low activity against beta-hydroxyi

99 so be induced by the external application of l-serine but not glycine to the Arabidopsis wild type, s

100 e sensitivity of the enzyme to inhibition by L-serine but not the extent of inhibition.

101 Pyruvate activation is competitive with L-serine, but activation of the enzyme is not compatible

102 cluding d-alanine, beta-alanine, glycine and l-serine, but not d-serine, triggered similar depolarizi

103 cement of the beta-acetoxy group of O-acetyl-l-serine by a thiol to give l-cysteine.

104 D-Serine, formed from L-serine by serine racemase (SR), is a physiologic coago

105 A receptor and is created by conversion from L-serine by serine racemase.

106 endogenous ligand for NMDARs generated from l-serine by the enzyme serine racemase (Srr).

107 agonist, D-serine, which is synthesized from L-serine by the neuronal enzyme serine racemase (SR).

108 led from 2,3-dihydroxybenzoate (2,3-DHB) and l-serine by the nonribosomal peptide synthetases EntB an

109 our sites for dicaproyl-sn-glycero-3-phospho-L-serine (C(6)PS, a soluble form of PS); the heavy and l

110 E), and 1, 2-dihexanoyl-sn-glycero-3-phospho-L-serine (C6PS) at concentrations below their correspond

111 ylserine, 1,2-dicaproyl-sn-glycero-3-phospho-l-serine (C6PS), binds to discrete sites on FXa, FVa, an

112 act infection (UTI), but loss of both D- and L-serine catabolism results in attenuation.

113 lH4, and condensation of the 15N-indole with L-serine, catalyzed by tryptophan synthase.

114 binds AI-2 in the periplasm, and Tsr is the l-serine chemoreceptor.

115 titers were lower for factor VIII-O-phospho-l-serine complex compared with factor VIII alone.

116 r results suggest that factor VIII-O-phospho-l-serine complex may be beneficial to increase the physi

117 immunogenicity of the factor VIII-O-phospho-l-serine complex was evaluated in hemophilia A mice.

118 f important neuromessengers including D- and L-serine, D- and L-asparate, glutamate, GABA, serotonin,

119 We report here the characterization of L-serine deaminase from Escherichia coli, which is the p

120 L-Serine deaminases catalyze the deamination of L-serine

121 we show that deletion of the genes encoding L-serine deaminases SdaA and SdaB resulted in a mutant t

122 formation, pyridoxal 5'-phosphate-dependent l-serine decarboxylase (SDC) activity was readily detect

123 The L-serine dehydratase from Legionella pneumophila (lpLSD)

124 SDH (L-serine dehydratase, EC 4.3.1.17) catalyzes the pyridox

125 Bacterial L-serine dehydratases differ from mammalian L- and D-ser

126 reveals striking kinetic differences between L-serine dehydratases from Bacillus subtilis (bsLSD, typ

127 ence homology to be present in all bacterial L-serine dehydratases that utilize an Fe-S catalytic cen

128 solved in the presence and in the absence of L-serine demonstrated a clustering of significant angle

129 Under these conditions, we observed both L-serine-dependent and L-serine-independent pathways of

130 rocyclic cores allowed the identification of l-serine derived macrocycle 32 (Ki* = 3 nM, EC90 = 30 nM

131 BS-protected propargylic ethers 25 and 32 to l-serine-derived aldehyde 26, respectively, afforded oxa

132 ium reagent (7a or 25a, respectively) to the L-serine-derived aldehyde 4, followed by hydrolysis of t

133 The synthesis features the use of an L-serine-derived E-selective modified Julia olefination

134 Conversely, the binding of l-serine did not have a significant effect on the stoich

135 mprising either acidic DL-alpha-phosphatidyl-L-serine, dipalmitoyl (DPPS) or zwitterionic L-alpha-pho

136 show that 1,2-dioleoyl-sn-glycero-3-[phospho-L-serine] (DOPS) small unilamellar vesicles (SUVs) drama

137 sphoglycerol (DPPG), and dipalmitoyl phospho-l-serine (DPPS).

138 e C133W SPTLC1 mutant linked to HSAN1, a 10% L-serine-enriched diet reduced dSL levels.

139 One of the compounds, the l-serine ester serine biphenyl-4-carboxylate reversibly

140 H) reveals that the physiological inhibitor, l-serine, exerts its effect on at least two steps in the

141 e was observed in the progress curve for the L-serine external aldimine formation, indicating a hyste

142 esis was not detected in the T148A-catalyzed L-serine external aldimine formation.

143 d sulfate in preventing the formation of the L-serine external aldimine.

144 The enzyme is highly selective toward L-serine, failing to racemize any other amino acid teste

145 These analogues were Fmoc-L-tyrosine, Fmoc-L-serine, Fmoc-L-phenyalanine, Fmoc-glycine (Fmoc-Gly),

146 Alternatively, elaboration of l-serine gave the corresponding enantiopure N,N-dibenzyl

147 LP enzymes were observed with the substrates L-serine, glyoxylate, and hydroxypyruvate.

148 icantly more persistent when it moves up the L-serine gradient than when it travels down the gradient

149 strong heading preference for moving up the L-serine gradient, while their speed does not change con

150 L-serine had no significant effect on hyperglycemia, bod

151 he well known role of d-serine in the brain, l-serine has recently been implicated in breast cancer a

152 ipids 2-10 having choline, ethanolamine, and l-serine headgroups were synthesized, and the inhibitory

153 of the external aldimines with L-cysteine or L-serine; (ii) chloride and sulfate increase the externa

154 ation of k-OptForce to the overproduction of L-serine in E. coli and triacetic acid lactone (TAL) in

155 The reaction of the enzyme with L-serine in the absence of L-homocysteine produced the a

156 e report that l-threonine may substitute for l-serine in the beta-substitution reaction of an enginee

157 enantioselectively esterify citric acid with l-serine in the first committed step of achromobactin bi

158 the nonionic urea stabilizes the aldimine of L-serine in the presence, but not in the absence, of NaC

159 tation by abstraction of the alpha proton of L-serine in the SGAT reaction.

160 acteria, but contains L-theronine instead of L-serine in the trilactone backbone.

161 ons, we observed both L-serine-dependent and L-serine-independent pathways of CML formation.

162 rence for d-glucose compared with isocaloric l-serine independently of the perception of sweetness.

163 is found to contain homochiral L-alanine and L-serine indicating the presence of extant or recently e

164 must be bound to the anion-binding site for l-serine inhibition, providing a potential mechanism for

165 L-Serine inhibits the catalytic activity of Escherichia

166 cine (L-pHPG) into positions 1, 3, and 5 and L-serine into position 4.

167 ion, the inhibition of enzymatic activity by L-serine is also cooperative with Hill coefficients grea

168 at the formation of the external aldimine of L-serine is faster than the formation of the aminoacryla

169 nzyme that predominates when the aldimine of L-serine is formed and shifts the equilibrium in favor o

170 The second, noncatalytic site for L-serine is likely to be the ASB domain (beta domain) of

171 Whereas l-serine is not transported, serine racemase, the synthe

172 a coli d-3-phosphoglycerate dehydrogenase by l-serine is positively cooperative with a Hill coefficie

173 O-acetyl-L-serine, suggesting that O-phospho-L-serine is the likely substrate in vivo.

174 When L-serine is the substrate, HOCl generates high yields of

175 serine-O-phosphate (L-SOP), the precursor of L-serine, is a potent agonist against the group III meta

176 racemase (SR), which generates D-serine from L-serine, is physiologically inhibited by phosphatidylin

177 vation can be eliminated by higher levels of L-serine, it may be that this second site is actually a

178 phosphono-butyric acid (L-AP4) and O-phospho-L-serine (L-SOP) both caused a concentration-dependent d

179 f a number of amino acids including glycine, L-serine, L-alanine, and L-cysteine, as well as their D-

180 threonine, l-arginine, l-glycine, l-proline, l-serine, l-alanine, and l-glutamic acid.

181 ty and chemotactic responses to L-aspartate, L-serine, L-leucine, and Ni(2+) of WT and chemotactic-mu

182 regulating seven of those polar metabolites (L-serine, L-leucine, glucose, fructose, myo-inositol, ci

183 nsor is high over other amino acids, such as L-serine, L-leucine, L-aspartic acid, L-glutamic acid, h

184 aldimine dissociation constants for O-acetyl-L-serine, L-methionine, and 5-oxo-L-norleucine; (iii) ch

185 some difficulty discriminating sucrose from L-serine, L-threonine, maltose, fructose, and glucose.

186 A mechanism whose overall effect is to keep L-serine levels from accumulating to high levels while n

187 te-limiting step in the reaction at limiting l-serine levels is likely formation of the tetrahedral i

188 fferent amounts, but only the (R)-isoform of l-serine-Lipid 654.

189 Two PSMA-I&T-derived inhibitors with all-L-serine- (MAS3) and all-D-serine- (mas3) chelating moie

190 based on the initial amount of the starting L-serine material.

191 ide (12) and sulfone (18) derived from N-Boc-L-serine methyl ester acetonide (9), affording two novel

192 o aziridinomitosenes had been developed from l-serine methyl ester hydrochloride.

193 ting from commercial N-tert-butyloxycarbonyl-L-serine methyl ester is described.

194 esis of (+)-saxitoxin in 14 steps from N-Boc-l-serine methyl ester.

195 3,4-bis(acetyloxy)phenyl] -1-oxo-2-propenyl]-L-serine methyl ester; compound 1] that selectively modi

196 The enzyme binds 4 L-serine molecules at two interfaces formed by the nonco

197 Products of the CysE enzyme (OAS, N-acetyl-L-serine [NAS], O-acetyl-L-threonine, and N-acetyl-L-thr

198 dent degradation of the isoindole derivative L-serine-NDA-beta-mercaptoethanol was found to follow ps

199 r 1-palmitoyl-2-oleoyl-sn-glycero-3-[phospho-L-serine] (negatively charged, POPS) or 1-palmitoyl-2-ol

200 sphatidylserine synthase (CDP-diacylglycerol:l-serine O-phosphatidyltransferase, EC 2.7.8.8) is one o

201 oic acid (2-PMPA), quisqualic acid (QA), and L-serine O-sulfate (L-SOS), at 1.72, 1.62, and 2.10 A re

202 L-serine-O-phosphate (L-SOP), the precursor of L-serine,

203 t binds weakly to another endogenous ligand, L-serine-O-phosphate (L-SOP), which antagonizes the effe

204 reported previously, the clear exception is L-serine-O-phosphate (L-SOP), which strongly activates g

205 R agonists l-2-amino-4-phosphonobutyrate and l-serine-O-phosphate or the physiological ligand l-gluta

206 avor of l-serine over the normally preferred l-serine-O-sulfate ( approximately 1200-fold change in k

207 nding and properly positioning the l-THA and l-serine-O-sulfate substrates and the l-erythro-beta-hyd

208 es the synthesis of l-cysteine from O-acetyl-l-serine (OAS) and inorganic bisulfide.

209 cement of the beta-acetoxy group of O-acetyl-L-serine (OAS) by a thiol to give L-cysteine.

210 in which the beta-acetoxy group of O-acetyl-L-serine (OAS) is replaced by bisulfide to give L-cystei

211 tution of the beta-acetoxy group of O-acetyl-l-serine (OAS) with inorganic bisulfide.

212 entrations of glutathione, Cys, and O-acetyl-l-serine (OAS), in shoot tissue, are strongly correlated

213 talyzes the conversion of serine to O-acetyl-L-serine (OAS).

214 cts on the rates of different reactions with L-serine or beta-chloro-L-alanine in the presence or abs

215 ndicate that PvSHMT can bind first to either L-serine or H4folate.

216 MurM is an aminoacyl ligase that adds l-serine or l-alanine as the first amino acid of a dipep

217 MurM, an aminoacyl-tRNA ligase that attaches L-serine or L-alanine to the stem peptide lysine of Lipi

218 ino acid derivatives which are prepared from L-serine or L-aspartic acid, respectively.

219 Supplementation with l-serine or removal of l-alanine independently restored

220 he myeloperoxidase-H2O2-chloride system plus L-serine, or activated human neutrophils plus L-serine.

221 limination substrate specificity in favor of l-serine over the normally preferred l-serine-O-sulfate

222 r actions, alleviates negative regulation of L-serine:palmitoyl-CoA acyltransferase, upregulating pro

223 In the presence of N-palmitoyl L-serine phosphoric acid, a competitive inhibitor for th

224 Moreover, TNFalpha enhanced FLIP(L) serine phosphorylation, which was increased by activa

225 gh levels while not completely depleting the L-serine pool in the bacterial cell is proposed.

226 nd 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS) 3:1 mol/mole and at neutral pH, the pept

227 C)/1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (POPS)) (2:1) but not from liposomes composed o

228 nd 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (POPS), a negatively charged phospholipid, was

229 e, 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine (POPS), and cholesteryl hemisuccinate (CHS).

230 PC), POPC, 1-palmitoyl-2-oleoyl-phosphatidyl-L-serine (POPS), or POPS mixed with 1-palmitoyl-2-oleoyl

231 erine deaminases catalyze the deamination of L-serine, producing pyruvate and ammonia.

232 Membranes containing phosphatidyl-L-serine (PS) and phosphatidylethanolamine (PE) greatly

233 The anionic phospholipid, phosphatidyl-L-serine (PS), is sequestered in the inner layer of the

234 Lactadherin is a phosphatidyl-L-serine (Ptd-L-Ser)-binding protein that decorates memb

235 L-aspartate but not on the key C3 compounds L-serine, pyruvate and L-lactate, showing that CanB is c

236 hexadecanoyl)glycyl-l-serine, abbreviated as l-serine-(R+S)-Lipid 654, to develop a method that combi

237 As oral L-serine reduces the severity of neuropathy in the mouse

238 tment of the dithionite-reduced protein with L-serine results in a slight broadening of the feature a

239 III administered as a complex with O-phospho-l-serine retained in vivo activity in hemophilia A mice.

240 ion, transport experiments with radiolabeled l-serine reveal that the sloR operon is required for rap

241 CI, Garofalo and colleagues report that oral L-serine reverses the accumulation of deoxysphingolipids

242 zymic general base accepts a proton from the l-serine side chain hydroxyl as it undergoes a nucleophi

243 S (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-serine (sodium salt)), and ganglioside GM1.

244 (DOPG)</=1,2-dioleoyl-sn-glycero-3-[phospho-l-serine] sodium salt (DOPS), indicating that the anioni

245 p-(hydroxyphenyl)glycine (pHPG) residues and L-serine, some where the latter is O-phosphorylated, O-a

246 ate to bind GLA domains by providing phospho-L-serine-specific and phosphate-specific interactions, r

247 The model invokes a single "phospho-L-serine-specific" interaction and multiple "phosphate-s

248 iral chromatographic analysis confirmed that L-serine sublimation produced DL-alanine, glycine, and e

249 contrast to wild-type mALAS2, is active with L-serine, suggest that active site Thr-148 modulates ALA

250 ter for O-phospho-L-serine than for O-acetyl-L-serine, suggesting that O-phospho-L-serine is the like

251 ng frames with identities to either O-acetyl-L-serine sulfhydrylase (OASS) or homocysteine synthase,

252 ich produces O-acetyl-L-serine, and O-acetyl-L-serine sulfhydrylase (OASS, EC 2.5.1.47), which conver

253 L-serine supplementation also improved measures of motor

254 hysiology of HSAN1 and raise the prospect of l-serine supplementation as a first treatment option for

255 d in patients with type 2 diabetes mellitus, L-serine supplementation could also be a therapeutic opt

256 lved in the pathology of DN and that an oral L-serine supplementation could be a novel therapeutic op

257 creased plasma 1-deoxySL concentrations, and L-serine supplementation lowered 1-deoxySL concentration

258 In a pilot study with 14 HSAN1 patients, L-serine supplementation similarly reduced dSL levels.

259 Oral L-serine supplementation suppressed the formation of 1-d

260 t accumulates higher intracellular levels of L-serine than CFT073.

261 is more than 500-fold greater for O-phospho-L-serine than for O-acetyl-L-serine, suggesting that O-p

262 cytes affect d-serine levels by synthesizing l-serine that shuttles to neurons to fuel the neuronal s

263 herichia coli is allosterically inhibited by L-serine, the end product of its metabolic pathway.

264 he hypothesis that complexation of O-phospho-l-serine, the head group of phosphatidylserine, with the

265 By incorporating L-alanine in place of L-serine, the mutant HSAN1-associated serine palmitoyltr

266 kinase C alpha to activate the conversion of l-serine to d-serine by serine racemase.

267 d the most strongly associated locus for the L-serine to D-serine ratio in CSF.

268 cytic glia that ensheathe synapses, converts L-serine to D-serine, an endogenous ligand of the NMDA r

269 by serine racemase, which directly converts L-serine to D-serine.

270 me that catalyzes the direct racemization of L-serine to D-serine.

271 ne racemase (SR) is the enzyme that converts L-serine to D-serine.

272 tylation of the side chain hydroxyl group of l-serine to form O-acetylserine, as the first step of a

273 c enzyme involved in conversion of O-phospho-l-serine to l-serine, was characterized in this study.

274 The binding of L-serine to phosphoglycerate dehydrogenase from E. coli

275 tack of the enzyme-bound citryl adenylate by l-serine to produce the homochiral ester.

276 atalyzes a hydroxymethyl group transfer from L-serine to tetrahydrofolate (H4folate) to yield glycine

277 show a shift from their canonical substrate L-serine to the alternative substrate L-alanine.

278 5'-phosphate (PLP)-dependent dehydration of L-serine to yield pyruvate and ammonia.

279 However, O-phospho-L-serine (to 1 mM) had no effect on the binding of PtdSe

280 ely 2, whereas the binding of the inhibitor, l-serine, to the apoenzyme displays positive cooperativi

281 n difluoride)undecanoyl-sn-glycero-3-phospho-L-serine (TopFluor-PS), a synthetic fluorescent PS analo

282 es of system L were distributed to MVM, with L-serine transport attributed to LAT2.

283 tive framework to test the 2 hypotheses that l-serine transport occurs by either obligate exchange or

284 nes of both siderophores, while only the tri-l-serine trilactone is a substrate of Fes.

285 l could only account for experimental [(14)C]L-serine uptake data when the transporter was not exclus

286 anobilayers in which PS headgroups contained l-serine versus d-serine.

287 hat valanimycin is derived from l-valine and l-serine via the intermediacy of isobutylamine and isobu

288 hat valanimycin is derived from L-valine and L-serine via the intermediacy of O-(L-seryl)isobutylhydr

289 When instead of glycine, L-serine was reacted with ALAS, a lag phase was observed

290 olved in conversion of O-phospho-l-serine to l-serine, was characterized in this study.

291 uses l-alanine over its canonical substrate l-serine, we also investigated the effects of substrate

292 ese residues are necessary for inhibition by l-serine when it binds to the regulatory domain.

293 he pyridoxal phosphate-dependent reaction of L-serine with indole to form L-tryptophan.

294 The enzyme catalyzes the reaction of L-serine with L-homocysteine to form L-cystathionine thr

295 a-synthase (CBS) effects the condensation of l-serine with l-homocysteine to form l-cystathionine.

296 tion of tryptophan synthase, the reaction of L-serine with pyridoxal 5'-phosphate at the beta-site to

297 could be observed for glycine, d-serine, and l-serine with statistical confidence.

298 termediate can be formed from l-cysteine and l-serine with the S272A,D mutant enzymes, but not with t

299 H that it is very sensitive to inhibition by L-serine, with an I(0.5) = 30 microm.

300 , while in the presence of hydrogen sulfide, L-serine yielded L-cysteine.