ライフサイエンスコーパス: LTA

1 LTA might be one way of increasing the power of genetic

2 LTA synthase (LtaS) polymerizes polyglycerol-phosphate f

3 LTA synthesis in Staphylococcus aureus and other microbe

4 LTA was a significant risk factor both for graft loss an

5 LTA was detected on the surface of 80% of the strains, a

6 LTA(+252) may influence predisposition to severe sepsis,

7 LTA(4)H also possesses aminopeptidase activity with unkn

8 LTA(4)H knockdown limited the formation of leukotriene B

9 LTA-exposed T cells did not proliferate and did not prod

10 against E. faecalis LTA also bind to type 1 LTA from other gram-positive species and opsonized Staph

11 at C-8, indicative of the formation of 14,15-LTA(4).

12 that the LTB(4) precursors leukotriene A(4) (LTA(4)) and 5-hydroperoxyeicosatetrenoic acid (5-HPETE)

13 om 5-lipoxygenase(-/-) and leukotriene A(4) (LTA(4)) hydrolase(-/-) mice, we demonstrate that FLSs ge

14 the addition of exogenous leukotriene A(4) (LTA(4); the precursor of LTB(4)) to retinas resulted in

15 there would be 240 SLK transplants and 9,426 LTAs.

16 ntly reduced 54 (Cowan), 38 (Wood), and 83% (LTA), whereas anti-CD14 alone significantly reduced 23,

17 donic acid hydroperoxide to a leukotriene A (LTA) type epoxide by specific lipoxygenase (LOX) enzymes

18 Abnormal LTA or ATP secretion test results were identified in 58%

19 ediated by staphylococcal lipoteichoic acid (LTA) and acts selectively on keratinocytes triggered thr

20 rial cell wall components lipoteichoic acid (LTA) and peptidoglycan (PGN) induced similar expression

21 choic acid (TA) polymers, lipoteichoic acid (LTA) and wall teichoic acid (WTA), which are proposed to

22 e that is responsible for lipoteichoic acid (LTA) biosynthesis in Lactobacillus acidophilus (NCK2025)

23 that plays a key role in lipoteichoic acid (LTA) biosynthesis in Lactobacillus acidophilus NCFM (NCK

24 rived cell-wall component lipoteichoic acid (LTA) governs the second phase of immune responses when h

25 s peptidoglycan (PGN) and lipoteichoic acid (LTA) induced the secretion of proinflammatory mediators

26 e, we show that S. aureus lipoteichoic acid (LTA) inhibits platelet aggregation caused by physiologic

27 Lipoteichoic acid (LTA) is a Gram-positive cell surface molecule that is fo

28 Lipoteichoic acid (LTA) is a major component of the cell wall of Gram-posit

29 Lipoteichoic acid (LTA) is an important cell wall component of Gram-positiv

30 Lipoteichoic acid (LTA) is an important cell wall component required for pr

31 Lipoteichoic acid (LTA) is an important cell wall polymer found in gram-pos

32 Lipoteichoic acid (LTA) is an important cell wall polymer in Gram-positive

33 Lipoteichoic acid (LTA) is an important cell wall polymer in gram-positive

34 Type 1 lipoteichoic acid (LTA) is present in many clinically important gram-positi

35 (ATP) and the TLR2 ligand lipoteichoic acid (LTA) selectively and synergistically induced expression

36 by pulp fibroblasts under lipoteichoic acid (LTA) stimulation.

37 /6 agonist staphylococcal lipoteichoic acid (LTA) was abolished only in the index case individual, th

38 levan, and a glucosylated lipoteichoic acid (LTA) was identified in a micellar fraction.

39 Lipoteichoic acid (LTA), a cell wall polymer of gram-positive bacteria, con

40 Lipoteichoic acid (LTA), a cell wall ribitol polymer from Gram-positive org

41 Lipoteichoic acid (LTA), a glycerol phosphate polymer, is a component of th

42 fferentiation factor, and lipoteichoic acid (LTA), a Toll-like receptor 2 ligand.

43 . pneumoniae, TLR2 ligand lipoteichoic acid (LTA), and TLR4 ligand pneumolysin (PLY) stimulated BMDCs

44 popolysaccharide (LPS) or lipoteichoic acid (LTA), histones are released from the droplets and kill b

45 rt exposure times to LPS, lipoteichoic acid (LTA), thymidine homopolymer phosphorothioate oligonucleo

46 ll as S. aureus cell wall lipoteichoic acid (LTA), were incubated in thrombin-inhibited human whole b

47 ing SlpA, SlpB, SlpX, and lipoteichoic acid (LTA), which interact with pattern recognition receptors

48 opolysaccharide (LPS) and lipoteichoic acid (LTA).

49 ved cell wall components (lipoteichoic acid [LTA] and peptidoglycan [PGN]), which are essential for t

50 to membrane glycolipids (lipoteichoic acid, LTA).

51 The data show that the L. acidophilus LTA-negative in LTA (NCK2025) not only down-regulated IL

52 Lipoteichoic acids (LTA) are polymers of alternating units of a polyhydroxy

53 Lipoteichoic acids (LTAs) are membrane-anchored molecules in the cell envelo

54 i, and staphylococci, and antibodies against LTA have been shown to opsonize nonencapsulated Enteroco

55 The effectiveness of rabbit antibody against LTA suggests that this conserved bacterial structure cou

56 Light transmission aggregometry (LTA) is used worldwide for the investigation of heritabl

57 ys included light transmission aggregometry (LTA), VerifyNow P2Y12 (VN), and vasodilator-associated s

58 ys included light transmission aggregometry (LTA), VerifyNow P2Y12 (VN-P2Y12), and vasodilator-associ

59 arison with light transmission aggregometry (LTA).

60 who received either liver transplant alone (LTA) or CLKT between 2002 and 2008.

61 and life years after liver transplant alone (LTA) or SLK transplant.

62 ion compared to liver transplantation alone (LTA) has also increased.

63 trate a critical role for lymphotoxin alpha (LTA) in the pathogenesis of Sjogren's disease in IL14alp

64 TNF -308G>A (rs1800629), lymphotoxin-alpha (LTA) 252A>G (rs909253), IL10 -3575T>A (rs1800890, rs1800

65 proinflammatory cytokine lymphotoxin-alpha (LTA) is thought to contribute to the pathogenesis of ath

66 a variant in intron 1 of lymphotoxin-alpha (LTA), a gene adjacent to TNF, was associated with erythe

67 and desorption in cation-free zeolites AlPO-LTA.

68 Although LTAs and WTAs are synthetically lethal, we report that t

69 ts and an increase of 4,971 life years among LTA recipients.

70 a support a model whereby Lmo0644 acts as an LTA primase LtaP and transfers the initial glycerolphosp

71 ide LTA synthases while YvgJ functions as an LTA primase, as indicated by the accumulation of a GroP-

72 a: OR(allelic) = 1.35, P(trend) = 0.004) and LTA 252G carriers (DLBCL: OR(allelic) = 1.12, P(trend) =

73 B -511, IL6 -174, IL10 -1082, TNFA -308, and LTA +252) and markers of nutritional status among patien

74 l genes such as GZMB, PRF1, INFG, IL-32, and LTA, carbohydrate and lipid metabolism-related genes suc

75 lved in glycolipid (lmo2555 and lmo2554) and LTA backbone (lmo0644 and lmo0927) synthesis.

76 Thermo nanoimprinting of LPS and LTA micelles to Epon 1002F films exhibits excellent sens

77 unt for the highly polar moieties of LPS and LTA, we evaluate different resist and stamp materials of

78 Using Optimul and LTA, concentration-response curves were generated for ar

79 oposed to guide the decision between SLK and LTA, but their poor predictive value has limited their u

80 proteins as novel antimicrobial targets, and LTA mutant strains as improved probiotics are highlighte

81 causal polymorphisms regulating the TNF and LTA responses may be located some distance from the gene

82 required, the numbers of SLK transplants and LTAs would be 648 and 9,065, respectively.

83 n, a tailoring modification of both WTAs and LTAs, becomes essential when the former, but not the lat

84 Anti-LTA mAb also rescued the macrophage response in mice lac

85 Thus, acquired anti-LTA Abs rescue TLR2-dependent immunity to staphylococcal

86 Combined TIRAP and anti-LTA Ab deficiencies underlie staphylococcal disease in t

87 se 4 (IRAK-4)-deficient individuals, by anti-LTA monoclonal antibody (mAb).

88 cologic interference of the large T antigen (LTA) may represent an effective therapeutic approach for

89 he GF microbiome's effect on MCs by applying LTA to the skin of GF mice.

90 glycolipid anchor, and Lmo0927 functions as LTA synthase LtaS, which extends the glycerolphosphate b

91 owing a proinflammatory potency of S. aureus LTA.

92 nd indicates that pneumococcal and S. aureus LTAs differ not only in their structure but also in thei

93 in statistical power with long-term average (LTA) as compared to single-visit BP association studies.

94 nce, only a single conformer was found (BEA, LTA and MFI).

95 itioning of septa, suggesting a link between LTA synthesis and the cell division process.

96 Inactivation of both LTA and WTA is lethal and comparison of the individual m

97 unexpected discovery that cells lacking both LTAs and WTAs lose their ability to form Z rings and can

98 hil-driven inflammation, PGP was degraded by LTA(4)H, which facilitated the resolution of inflammatio

99 or-mediated inflammatory response induced by LTA plus PGN.

100 Median MPA by LTA for prasugrel 5 mg in LBW patients was noninferior t

101 vation of both the TLR2 and TLR4 pathways by LTA plus Hb leads to an enhanced innate immune response.

102 within the dermis through SCF production by LTA-stimulated keratinocytes.

103 e genes that are most highly up-regulated by LTA plus Hb activation compared to LTA alone are cytokin

104 PD response by LTA, VN-P2Y12, and VASP during all treatments appeared s

105 The NGF secretion by LTA-stimulated pulp fibroblasts, which is negatively reg

106 L2 significantly increases BDNF secretion by LTA-stimulated pulp fibroblasts.

107 icated in the modulation of NGF secretion by LTA-stimulated pulp fibroblasts.

108 itive result was not always substantiated by LTA (specificity, 67%; positive predictive value, 77%).

109 l responses were significantly suppressed by LTA.

110 Assessment of LTA gene transcription by LTA promoter-luciferase construct indicated that LTA lev

111 in neutrophil clearance/apoptosis (C10orf54, LTA), adhesion (TNXB), or centrosome and microtubule str

112 14 Ab 18D11 significantly reduced 92 (Cowan, LTA) and 85% (Wood) of these markers.

113 g antibodies revealed that S. aureus-derived LTA and PGN-induced chemokine expression requires IL-1RI

114 ic monoclonal antibodies were used to detect LTA in the envelope of B. anthracis strain Sterne (pXO1(

115 review provides an overview of the different LTA types and their chemical structures and synthesis pa

116 ated roles in elongation (WTA) and division (LTA).

117 e have concluded that the presence of either LTAs or WTAs on the cell surface is required for initiat

118 plained by modulation of the virally encoded LTA.

119 esistant or -sensitive) or their endotoxins (LTA + PGN) or exotoxins (TSST-1).

120 overall results render the copper-exchanged LTA zeolite attractive as a viable substitute for Cu-SSZ

121 lining-are competent to metabolize exogenous LTA(4) into LTB(4) ex vivo.

122 IL14alphaTG mice express LTA mRNA in their salivary glands and spleen and produce

123 m LTA(4) and transfer it to cells expressing LTA(4) hydrolase (LTA(4)H) or LTC(4) synthase (LTC(4)S)

124 we show that antibodies against E. faecalis LTA also bind to type 1 LTA from other gram-positive spe

125 n with rabbit antibodies against E. faecalis LTA promoted the clearance of bacteremia by E. faecalis

126 ormations involving the framework types FAU, LTA, EMT, GIS, SOD, ANA, CAN, and JBW.

127 ting that these three proteins are bona-fide LTA synthases while YvgJ functions as an LTA primase, as

128 42, 249, and 16 genes were downregulated for LTA, LPS, Poly(dT), and Poly(I:C), respectively, with at

129 nce of posttransplantation RF was higher for LTA patients at 6 months and 3 years of follow-up (P<0.0

130 hrough the PI3K-Akt pathway is necessary for LTA-induced VEGF expression in pulp cells.

131 tative lipoteichoic acid ligase required for LTA assembly.

132 lycolipid production, and LtaS, required for LTA backbone synthesis, interact with one another.

133 138, 1013, and 22 genes were upregulated for LTA, LPS, Poly(dT), and Poly(I:C), and 12, 142, 249, and

134 : cells expressing 5-lipoxygenase (5LO) form LTA(4) and transfer it to cells expressing LTA(4) hydrol

135 retinal glial cells synthesized LTB(4) from LTA(4), whereas mRECs produced both LTB(4) and the cyste

136 Bone marrow cells from LTA(4)H(-/-) or LTC(4)S(-/-) mice injected into 5LO(-/-)

137 Furthermore, LTA reduced hemostasis in a mouse tail-bleed assay.

138 actor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attention as candidate genes fo

139 rast, trophic forms suppressed beta-glucan-, LTA-, and LPS-induced IL-1beta, IL-6, and TNFalpha produ

140 egative associations with the TNF haplotype, LTA+252A/TNFhtSNP1(-308)G/TNFhtSNP2(-238)G/TNFhtSNP3(+48

141 Hence, LTA is important for S. pneumoniae to establish systemic

142 We studied leukotriene A(4) hydrolase (LTA(4)H) as a relevant target in pancreatic cancer.

143 Leukotriene A(4) hydrolase (LTA(4)H) is a proinflammatory enzyme that generates the

144 fer it to cells expressing LTA(4) hydrolase (LTA(4)H) or LTC(4) synthase (LTC(4)S) to produce LTB(4)

145 The leukotriene A(4) hydrolase (LTA(4)H) protein is regarded as a relevant target for ca

146 imilarities between the production of type I LTA and osmoregulated periplasmic glucans in gram-negati

147 The physiological functions of type I LTA are discussed in the context of inhibitors that bloc

148 ances in the biosynthesis pathway for type I LTA, d-alanylated polyglycerol-phosphate linked to di-gl

149 Our findings identify LTA(4)H as a functionally important target for mediating

150 Both IL14alpha and IL14alpha/LTA(-/-) mice had similar B cell responses to T-dependen

151 However, both IL14alphaTG and IL14alphaTG.LTA(-/-) mice produced similar amounts of IFN-alpha and

152 crossed with LTA(-/-) mice, the IL14alphaTG.LTA(-/-) mice retained normal salivary gland secretions

153 s known on the effects of AMPK activation in LTA-triggered innate immune responses.

154 s of 5LO-derived products were comparable in LTA(4)H(-/-) and WT mice, but were reduced in LTC(4)S(-/

155 expressing a truncated P2Y(2)R deficient in LTA secretion.

156 twork connecting WTAs with genes involved in LTA synthesis, peptidoglycan synthesis, surface protein

157 We show that both proteins are involved in LTA synthesis.

158 show that the L. acidophilus LTA-negative in LTA (NCK2025) not only down-regulated IL-12 and TNFalpha

159 Two paralogues have a redundant role in LTA synthesis during sporulation and their absence gives

160 role of TLR2, PI3K/Akt, and IKK signaling in LTA-induced VEGF expression was evaluated.

161 of FLNa in FLNa RNAi SMC rescued UTP-induced LTA expression.

162 Given that lipoproteins also inhibit LTA- and LPS-mediated inflammation, these results sugges

163 atidylglycerol binding to LtaS and inhibited LTA synthesis in S. aureus and in Escherichia coli expre

164 e development of COPD, selectively inhibited LTA(4)H aminopeptidase activity, which led to the accumu

165 independent cancer cell growth by inhibiting LTA(4)H activity in HCT116 colorectal cancer cells.

166 del of human pancreatic cancer by inhibiting LTA(4)H activity.

167 imply that therapeutic strategies inhibiting LTA(4)H to prevent LTB(4) generation may not reduce neut

168 In conclusion, AMPK activation inhibits LTA-induced lung inflammation in mice.

169 The LTA primase LtaP(Lm) initiates LTA synthesis by transferring the first glycerolphosphat

170 -hybrid approach, we show that the three key LTA synthesis proteins, YpfP and LtaA, involved in glyco

171 Pneumococcal mutants deficient in TacL lack LTA and show attenuated virulence in mouse models of acu

172 e individual, the only family member lacking LTA-specific antibodies (Abs).

173 S. aureus mutants lacking LTA are enlarged and show aberrant positioning of septa,

174 a substrate by 5-LO to form the initial LT, LTA(4).

175 ociated with a reduced expression of the MCV LTA as well as an increased expression of promyelocytic

176 d Rho activation and consequent Rho-mediated LTA secretion.

177 TLR2 and the generation of ROS/RNS mediates LTA-induced barrier dysfunction in PMEM.

178 oinflammatory role of LTA and the ability of LTA-deficient L. acidophilus to regulate inflammation an

179 ndicate that the mere presence or absence of LTA cannot account for cell division and sporulation def

180 Western blot analysis of LTA produced by ltaS(BS) , yfnI, yqgS and yvgJ single, t

181 Assessment of LTA gene transcription by LTA promoter-luciferase constr

182 Characterization of LTA mRNAs isolated from primary and from transformed hum

183 immune responses when high concentrations of LTA access T cells directly through disrupted skin.

184 Transcellular delivery of LTA(4) from marrow-derived cells to retinal cells result

185 The effect of LTA on lung endothelial permeability is not known.

186 We have characterized the key enzyme of LTA synthesis in Bacillus subtilis, LTA synthase (LtaS).

187 4) 3-fold without inducing the expression of LTA(4) hydrolase protein.

188 s than bestatin, an established inhibitor of LTA(4)H activity, and the inhibitory effects of resverat

189 l chemistry effort to optimize inhibitors of LTA(4)H.

190 At low levels of LTA, the presence of Hb can result in a 200-fold increas

191 The occurrence and mechanisms of LTA modifications with D-alanyl, glycosyl, and phosphoch

192 iene B(4) (LTB(4)), the enzymatic product of LTA(4)H, and suppressed anchorage-independent growth of

193 he same operon resulted in the production of LTA with an altered structure.

194 iver allograft and patient survival rates of LTA patients were significantly lower compared with CLKT

195 stimulates a strong and sustained release of LTA from WT but not P2Y(2)R(-/-) SMC.

196 activation signals on subsequent removal of LTA.

197 is study reveals the proinflammatory role of LTA and the ability of LTA-deficient L. acidophilus to r

198 on defects, underscoring the pivotal role of LTA in this gram-positive pathogen.

199 Although the exact role of LTA is unknown, mutants display significant growth and p

200 y, these findings indicate a crucial role of LTA(4)H in cancer and also support the anticancer effica

201 g that P2Y(2)R/filamin-mediated secretion of LTA is independent of the endoplasmic reticulum/Golgi se

202 ause the skin microbiome is a rich source of LTA, a Toll-like receptor 2 ligand, we mimicked the GF m

203 cancer efficacy of [6]-gingerol targeting of LTA(4)H for the prevention of colorectal cancer.

204 Here we review four different types of LTA that can be distinguished on the basis of their chem

205 essary for Rho signaling pathway upstream of LTA release and subsequent stimulation of ICAM-1 express

206 The presence of D-alanine on LTA is necessary for the full inhibitory effect.

207 Research on LTA structure and function represents a large frontier t

208 ue transcript variants (TVs), including one (LTA TV8) that initiated within a polypyrimidine tract ne

209 r ltaS4 did not display defects in growth or LTA synthesis.

210 ns (in four loci) uniquely identified by our LTA analyses included those of SBP and MAP at 2p23 (rs12

211 sponded very poorly to all TLR2/6 (PAM2CSK4, LTA, FSL-1), TLR1/2 (PAM3CSK4), and TLR4 (LPS, MPLA) ago

212 Polyanionic LTAs have fundamentally important roles in divalent cati

213 enzyme responsible for polyglycerolphosphate LTA synthesis is LtaS, first described in Staphylococcus

214 ong the six single nucleotide polymorphisms, LTA (+252) was most overrepresented in the septic patien

215 o effect on IL-23 production, it potentiated LTA induced IL-23 production to the same level as that o

216 ing YfnI in the absence of LtaS(BS) produced LTA of retarded mobility, presumably caused by an increa

217 s oxygenation, whereas lack of O(2) promotes LTA epoxide synthesis.

218 ggested by a structural analysis of purified LTA.

219 o shed light on the distribution of putative LTA biosynthetic genes among bacteria.

220 ied the potency of AMPK activation to reduce LTA-induced inflammation in vitro and in lungs in vivo.

221 In vivo, AMPK activation reduced LTA-induced neutrophil influx, as well as protein leak a

222 fter delivery of a monomeric ADP-ribosylase (LTA) and its pentameric carrier B subunit (LTB).

223 r ions when fully exchanged into high-silica LTA zeolites are demonstrated to exhibit excellent activ

224 Furthermore, local production of soluble LTA in the salivary glands of IL14alphaTG mice is necess

225 livary glands and spleen and produce soluble LTA protein in their salivary secretions.

226 Staphylococcal LTA inhibits both inflammatory cytokine release from ker

227 s with high similarity to the staphylococcal LTA synthase LtaS, which is responsible for polyglycerol

228 ue TLR2-dependent immunity to staphylococcal LTA in individuals with inherited TIRAP deficiency, acco

229 bility of exogenous nucleotides to stimulate LTA production was evaluated in VSMC by ELISA.

230 In addition, we found that UTP-stimulated LTA secretion is not sensitive to brefeldin A, which blo

231 nzyme of LTA synthesis in Bacillus subtilis, LTA synthase (LtaS).

232 th ltaS1 and ltaS2 were unable to synthesize LTA and exhibited reduced viability, altered envelope mo

233 anthracis employs LtaS enzymes to synthesize LTA, an envelope component that promotes bacterial growt

234 (wall TA (WTA)) or to the membrane (lipo-TA (LTA)).

235 Therefore, D-alanine-tailored LTAs are required for survival when WTAs are absent.

236 nservation (2 substitutions identified) than LTA allele variants (22 substitutions identified).

237 The decision to perform SLK rather than LTA is an important one because the benefits to the live

238 anges in platelet function more readily than LTA.

239 We also demonstrate that LTA is increased in the salivary gland secretions and se

240 We tested the hypothesis that LTA from Staphylococcus aureus induces alterations in th

241 promoter-luciferase construct indicated that LTA levels are controlled at the level of transcription.

242 ve bacteria are highlighted, indicating that LTA should perhaps be compared to these polymers rather

243 We observed that LTA potently suppressed T-lymphocyte activation in a Tol

244 co shape similarity algorithm predicted that LTA(4)H might be a potential target of resveratrol.

245 ith the current literature, and propose that LTA biosynthesis in Actinobacteria might be fundamentall

246 ing a reverse-docking approach revealed that LTA(4)H might be a potential target of [6]-gingerol.

247 Here, we show that LTA exhibits a different linkage conformation compared t

248 We show that LTA is needed for divalent cation homoeostasis and that

249 triple and the quadruple mutant, showed that LTA production was only abolished in the quadruple and t

250 These studies suggest that LTA plays a critical role in the local rather than syste

251 he hypothesis underlying this study was that LTA induces VEGF expression in dental pulp cells through

252 The LTA 252A>G/TNF -308G>A haplotype containing the LTA/TNF

253 The LTA downstream segment was found to be required for, and

254 The LTA primase LtaP(Lm) initiates LTA synthesis by transfer

255 trengthen previous results for DLBCL and the LTA 252A>G/TNF -308A locus and provide robust evidence t

256 ) subunit onto the glycolipid anchor and the LTA synthase LtaS(Lm) extends the polymer by the repeate

257 252A>G/TNF -308G>A haplotype containing the LTA/TNF variant alleles was strongly associated with DLB

258 These results confirm that variation in the LTA/TNF gene cluster modifies a major skin manifestation

259 Interestingly, the LTA downstream segment alternate core promoter was activ

260 Additionally, modification of the LTA backbone structure can provide protection against ca

261 known to interfere with the function of the LTA.

262 ted against either novel heteroglycan or the LTA reduced bacterial load in mouse liver or kidney tiss

263 nt alternate core promoter that produces the LTA TV8 transcript most likely consists of a stimulating

264 Further investigation determined that the LTA downstream segment alternate core promoter that prod

265 ined PafR antagonist, demonstrating that the LTA inhibitory signal occurs via PafR.

266 fluorescence approach, we show here that the LTA polymer is not surface exposed in S. aureus, as it c

267 ociated haplotype (P = 0.00085), whereas the LTA+252AA/TNFhtSNP2GG haplotype was protective (P = 0.00

268 TFII-I, and RNA polymerase II) bind to this LTA region in vivo.

269 Thus LTA exposure resulted in temporary functional T-cell par

270 Thus, LTA biosynthesis provides an attractive target for the d

271 However, no TNF/LTA polymorphisms were found to be associated with SM in

272 s and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium,

273 which catalyzes the transformation of AA to LTA(4) in a two-step reaction.

274 we found that resveratrol directly bound to LTA(4)H in vitro and in cells and suppressed proliferati

275 e analyzed the direct exposure of T cells to LTA in vitro.

276 ulated by LTA plus Hb activation compared to LTA alone are cytokines, chemokines, receptors and inter

277 This finding was quite in contrast to LTA of the Staphylococcus aureus SA113Deltalgt mutant, w

278 In this study, the contribution to LTA transcriptional regulation of the region between the

279 aenoic acid; 5S-HPETE) almost exclusively to LTA(4), the model enzyme, soybean LOX-1, normally produc

280 rentiated pulp cells (OD-21) were exposed to LTA from Streptococcus sanguis, and the role of TLR2, PI

281 hepatorenal syndrome, CLKT is preferable to LTA because it improves liver allograft and patient surv

282 nse to Cowan and Wood, and 12 in response to LTA.

283 Lastly, current efforts to use LTAs as vaccine candidates, synthesis proteins as novel

284 Using LTA analysis, we identified genetic loci influencing BP.

285 rate that detailed phenotypic analysis using LTA and ATP secretion is a powerful tool for the diagnos

286 As a result, the rate of SLK versus LTA differs significantly between transplant centers.

287 s of resveratrol were reduced in cells where LTA(4)H was suppressed by shRNA-mediated knockdown.

288 These data support a model whereby LTA backbone synthesis proceeds in S. aureus at the divi

289 n-beta mRNA is present after activation with LTA plus Hb, suggesting that the TRIF/TRAM-dependent pat

290 of IL-6 secretion following activation with LTA plus Hb.

291 When IL14alphaTG mice were crossed with LTA(-/-) mice, the IL14alphaTG.LTA(-/-) mice retained no

292 evels increase upon platelet incubation with LTA, an effect which inhibits platelet activation.

293 Similar results were observed with LTA.

294 , which presented with normal responses with LTA.

295 ibitor, IkappaBalpha, after stimulation with LTA plus Hb.

296 Hemoglobin (Hb) can synergize with LTA, a TLR2 ligand, to potently activate macrophage inna

297 box 1 protein (HMGB1), which synergized with LTA to increase secretion of IL-6.

298 AMP-dependent pathways acted in synergy with LTA to enhance IL-23, only inhibition of the cAMP-depend

299 Treatment with LTA or the TLR2 agonist Pam((3))CSK((4)) induced signifi

300 Here we report that oral treatment with LTA-deficient NCK2025 normalizes innate and adaptive pat