ライフサイエンスコーパス: N-acetyltransferase

1 ated from serotonin by AANAT (arylalkylamine N-acetyltransferase).

2 d by the need for large amounts of arylamine N-acetyltransferase.

3 polyamine bound in an allosteric site of an N-acetyltransferase.

4 ounds were tested against purified serotonin N-acetyltransferase.

5 e 1 and Serratia marcescens aminoglycoside 3-N-acetyltransferase.

6 ransferase activity active site on serotonin N-acetyltransferase.

7 tly attached leader peptides and a GNAT-type N-acetyltransferase.

8 minoazobenzene-4'-sulfonic acid by arylamine N-acetyltransferase.

9 he defining member of a large superfamily of N-acetyltransferases.

10 alogous to motifs A, B and D, found in other N-acetyltransferases.

11 s homologous to several microbial antibiotic N-acetyltransferases.

12 otein shows similarity to a diverse group of N-acetyltransferases.

13 AT as a member of the GCN5-related family of N-acetyltransferases.

14 isubstrate analogs with other aminoglycoside N-acetyltransferases.

15 adopt a fold similar to that of GCN5-related N-acetyltransferases.

16 pression of HBP enzyme glucosamine-phosphate N-acetyltransferase 1 (GNPNAT1) is found to be significa

17 Human arylamine N-acetyltransferase 1 (NAT1), a polymorphic xenobiotic m

18 ng single-nucleotide polymorphisms (SNPs) in N-acetyltransferase 1 (NAT1), NAT2, and epoxide hydrolas

19 The latter was catalyzed by N-acetyltransferase 1 alone as normal human epidermal ke

20 s as selective inhibitors of human arylamine N-acetyltransferase 1 and mouse arylamine N-acetyltransf

21 ferase M1, glutathione-S-transferase T1, and N-acetyltransferases 1 and 2.

22 Currently there is much interest in the N-acetyltransferase-1 (NAT1) genetic polymorphism and it

23 melatonin due to mutation of arylalkylamine N-acetyltransferase 2 (aanat2) to show that melatonin is

24 ne 6 (TMPRSS6), transferrin receptor (TFR2), N-acetyltransferase 2 (arylamine N-acetyltransferase) (N

25 The presence of a nonsynonymous variant of N-acetyltransferase 2 (NAT2) [rs1208 (803A>G, K268R)] wa

26 cleotide polymorphism in the human arylamine N-acetyltransferase 2 (Nat2) gene has recently been iden

27 A role for the N-acetyltransferase 2 (NAT2) genetic polymorphism in can

28 N-acetyltransferase 2 (NAT2) is the only known locus inf

29 Mutations in N-acetyltransferase 2 (NAT2), a highly polymorphic enzym

30 and 259 control subjects were genotyped for N-acetyltransferase 2 (NAT2), which codes for a polymorp

31 ion between the slow acetylator genotype for N-acetyltransferase 2 and familial PD.

32 ne N-acetyltransferase 1 and mouse arylamine N-acetyltransferase 2 are described.

33 The slow acetylator frequency for N-acetyltransferase 2 for sporadic PD was between that f

34 The N-acetyltransferase 2 gene (NAT2) product is an enzyme i

35 We also investigated N-acetyltransferase 2 in 100 blood samples from patients

36 Phenotypically slow acetylators (N-acetyltransferase 2 index <0.37) had an odds ratio of

37 The slow acetylator genotype for N-acetyltransferase 2 was more common in the familial PD

38 phenotyped for cytochrome P4501A2 (CYP1A2), N-acetyltransferase 2, and sulfotransferase 1A1 enzyme a

39 ome P-4501A2 (CYP1A2), xanthine oxidase, and N-acetyltransferase 2--by measuring levels of caffeine m

40 ermal keratinocytes did not express mRNA for N-acetyltransferase 2.

41 ase, glutathione transferases M1 and T1, and N-acetyltransferase 2.

42 haplotyping of 11 SNPs within exon 2 of the N-acetyltransferase-2 (NAT2) gene, which expresses an im

43 N-acetyltransferase-2 (NAT2) is an important enzyme that

44 NAT8L (N-acetyltransferase 8-like) catalyzes the formation of N

45 by constitutive genetic disruption of Nat8l (N-acetyltransferase-8 like) permits normal CNS myelinati

46 ch encodes the neuronal NAA-synthetic enzyme N-acetyltransferase-8-like.

47 Serotonin N-acetyltransferase, a member of the GNAT acetyltransfer

48 0- to 100-fold increases in pineal serotonin N-acetyltransferase (AA-NAT) activity.

49 old rhythm in the activity of arylalkylamine N-acetyltransferase (AA-NAT; EC 2.3.1.87) controls the r

50 erotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AA-NAT]).

51 erotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT, HGMW-approved symbol AANAT;

52 erotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT; EC 2.3.1.87), the penultima

53 The aminoglycoside 3-N-acetyltransferase AAC(3)-IV from Escherichia coli exhi

54 The 2'-N-acetyltransferase [AAC(2')-Ia] in Providencia stuartii

55 ovidencia stuartii contains a chromosomal 2'-N-acetyltransferase [AAC(2')-Ia] involved in the O acety

56 The chromosomally encoded aminoglycoside N-acetyltransferase, AAC(2')-Ic, of Mycobacterium tuberc

57 the chromosomally encoded aminoglycoside 6'-N-acetyltransferase, AAC(6')-Iy, of Salmonella enterica

58 cits in enzymatic activity of arylalkylamine N-acetyltransferase (AANAT) and N-acetylserotonin O-meth

59 Arylalkylamine N-acetyltransferase (AANAT) catalyzes the N-acetylation

60 Arylalkylamine N-acetyltransferase (aaNAT) catalyzes the transacetylati

61 Serotonin N-acetyltransferase (AANAT) controls the daily rhythm in

62 hormone melatonin, is catalyzed by serotonin N-acetyltransferase (AANAT) in a reaction requiring acet

63 Arylalkylamine N-acetyltransferase (AANAT) is the penultimate and key r

64 inding sites in the 3"-UTR of arylalkylamine N-acetyltransferase (Aanat) mRNA, the penultimate enzyme

65 erotonin N-acetyltransferase (arylalkylamine N-acetyltransferase (AANAT)) is a critical enzyme in the

66 s for tryptophan hydroxylase, arylalkylamine N-acetyltransferase (AANAT), and hydroxyindole-O-methylt

67 regulated by the activity of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme in t

68 otonin in the pineal gland by arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme in t

69 synthesized from serotonin by arylalkylamine N-acetyltransferase (AANAT), which is predominantly expr

70 melatonin-synthesizing enzyme arylalkylamine N-acetyltransferase (AANAT).

71 yme in melatonin synthesis is arylalkylamine N-acetyltransferase (AANAT).

72 erotonin N-acetyltransferase [arylalkylamine N-acetyltransferase (AANAT)] is a key circadian rhythm e

73 Arylalkylamine N-acetyltransferase (AANAT, serotonin N-acetyltransferas

74 nzyme in melatonin synthesis, arylalkylamine N-acetyltransferase (AANAT; serotonin N-acetyltransferas

75 After overexpression of arylalkylamine N-acetyltransferase (AANAT; the enzyme regulating melato

76 aluated the (1) expression of arylalkylamine N-acetyltransferase (AANAT; the rate-limiting enzyme for

77 erotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) in the pineal gland control

78 erotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) is a member of the GCN5 N-ac

79 erotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) mRNA in the chicken pineal g

80 rylalkylamine N-acetyltransferase (serotonin N-acetyltransferase, AANAT, EC ) is the penultimate enzy

81 erotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT, EC 2.3.1.87) is the first en

82 erotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT, EC 2.3.1.87) is the penultim

83 tyltransferase (also known as arylalkylamine N-acetyltransferase; AANAT) bound to a potent bisubstrat

84 mRNA level of arylalkylamine-N-acetyltransferase (AANAT2), a key enzyme of melatonin

85 This binding activates N-acetyltransferase activity in the C-terminal GCN5-rela

86 Agmatine N-acetyltransferase (AgmNAT) catalyzes the formation of

87 The structure of serotonin N-acetyltransferase (also known as arylalkylamine N-acet

88 Serotonin N-acetyltransferase, also called the melatonin rhythm en

89 lex structure with those of 14-3-3:serotonin N-acetyltransferase and 14-3-3:heat shock protein beta-6

90 protein, which turns on the transcription of N-acetyltransferase and inducible cAMP early repressor,

91 ction of recombinant chicken liver arylamine N-acetyltransferase and optimization of its use in minia

92 to this previously uncharacterized family of N-acetyltransferases and also provide a molecular framew

93 a member of the superfamily of GCN5-related N-acetyltransferases and catalyzes the covalent attachme

94 beta1-AR-driven increase in cAMP, serotonin N-acetyltransferase, and melatonin production.

95 andidate tumor suppressor, Charlatan, and an N-acetyltransferase, ARD1.

96 gulatory systems that control arylalkylamine N-acetyltransferase are a circadian clock and environmen

97 Bisubstrate analogs for the aminoglycoside N-acetyltransferases are nanomolar inhibitors of Enteroc

98 Here, we show that the N-acetyltransferase arrest-defect 1 protein (ARD1) funct

99 Serotonin N-acetyltransferase (arylalkylamine N-ace-tyltransferase

100 ated by changes in the activity of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase

101 Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase

102 Large changes in the activity of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase,

103 The abundance of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase,

104 Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase,

105 Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase,

106 rcadian changes in the activity of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase,

107 Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase,

108 Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase,

109 Serotonin N-acetyltransferase [arylalkylamine N-acetyltransferase

110 ne for the NAA biosynthetic enzyme aspartate N-acetyltransferase (Asp-NAT).

111 thetase (BACS) and bile acid-CoA: amino acid N-acetyltransferase (BAT) are induced by FXR in rat live

112 in its biosynthesis is catalyzed by PerB, an N-acetyltransferase belonging to the left-handed beta-he

113 (GNAT), Serratia marcescens aminoglycoside 3-N-acetyltransferase, bound to coenzyme A (CoA) has been

114 in is similar to those of other GCN5-related N-acetyltransferases but the carboxy-terminal domain is

115 mical analyses indicate that PaiA is a novel N-acetyltransferase capable of acetylating both spermidi

116 hibition is suggested to involve a serotonin N-acetyltransferase-catalyzed alkylation reaction betwee

117 eficiency of acetyl-CoA: alpha-glucosaminide N-acetyltransferase causes lysosomal accumulation of hep

118 functions as the noncatalytic subunit of the N-acetyltransferase complex B (NatB) to maintain the num

119 Arylalkylamine N-acetyltransferase controls daily changes in melatonin

120 acterized circadian rhythm enzyme, serotonin N-acetyltransferase, displayed significant FRET, indicat

121 oxal phosphate binding domain is fused to an N-acetyltransferase domain related to the general contro

122 rase activity in the C-terminal GCN5-related N-acetyltransferase domain, which is required for GlcNAc

123 lamine N-acetyltransferase (AANAT, serotonin N-acetyltransferase, EC ) plays a unique transduction ro

124 lamine N-acetyltransferase (AANAT; serotonin N-acetyltransferase, EC ).

125 d the N-terminal domain of an aminoglycoside N-acetyltransferase, encoded by a plasmid-borne antibiot

126 Spermidine N-acetyltransferase, encoded by the gene speG, catalyzes

127 ion is introduced by bacterial Gcn-5-related N-acetyltransferase enzymes and can be removed by bacter

128 ns that show no sequence conservation within N-acetyltransferase enzymes, is implicated by cross-spec

129 his is the first structure of a Gcn5-related N-acetyltransferase family member with demonstrated acti

130 50 and NHERF1) and NAT9, a new member of the N-acetyltransferase family.

131 KAT2A) is a member of the GNAT (Gcn5-related N-acetyltransferase) family of HATs.

132 ed that the two enzymes share a Gcn5-related N-acetyltransferase fold but differ in their respective

133 pite the established function as a bona fide N-acetyltransferase, FrbF shows no sequence similarity t

134 GAT is an N-acetyltransferase from Bacillus licheniformis that was

135 We have solved the structure of arylamine N-acetyltransferase from M. smegmatis at a resolution of

136 ins at least one tumour suppressor gene, the N-acetyltransferase functions of Fus-2 may be relevant t

137 Consistent with other N-acetyltransferases, Fus-2 localizes to the cytoplasm,

138 and discovered enzymes exhibiting glyphosate N-acetyltransferase (GAT) activity.

139 expression of 3OST2 in the night pineals on N-acetyltransferase gene expression and melatonin produc

140 e best characterized are the Gcn5-containing N-acetyltransferase (GNAT) complexes.

141 A central GCN5-related N-acetyltransferase (GNAT) domain bears bifunctional dec

142 MEC-17 core adopts a canonical Gcn5-related N-acetyltransferase (GNAT) fold that is decorated with e

143 ltransferase, AANAT) is a member of the GCN5 N-acetyltransferase (GNAT) superfamily and catalyzes the

144 The Gcn5-related N-acetyltransferase (GNAT) superfamily is a large group

145 eron, a divergent member of the Gcn5-related N-acetyltransferase (GNAT) superfamily of enzymes whose

146 Hpa2 is a member of the Gcn5-related N-acetyltransferase (GNAT) superfamily, a family of enzy

147 AcuA protein is a member of the Gcn5-related N-acetyltransferase (GNAT) superfamily, the AcuC protein

148 ce similarity to any member of the GCN5-like N-acetyltransferase (GNAT) superfamily.

149 X-ray structure of a canonical GCN5-related N-acetyltransferase (GNAT), Serratia marcescens aminogly

150 ylation reactions belong to the Gcn5-related N-acetyltransferase (GNAT; PF00583) family, named after

151 eled by a downregulation of the GCN5-related N-acetyltransferases (GNAT) p300/CBP-associated factor a

152 GCN5-type N-acetyltransferases (GNATs) are enzymes that catalyse t

153 Gcn5-related N-acetyltransferases (GNATs), named after their founding

154 me is a member of the GCN5-related family of N-acetyltransferases (GNATs), which share four conserved

155 with the coenzyme-bound forms of the related N-acetyltransferases, HAT1 (yeast histone acetyltransfer

156 Histone N-acetyltransferases (HATs) are a group of enzymes which

157 omoters of pineal-selective enzymes, such as N-acetyltransferase, hydroxyindole-O-methyl transferase,

158 in A in the active site of aminoglycoside 6'-N-acetyltransferase-Ii [AAC-(6')-Ii].

159 The results suggest that leptin activates a N-acetyltransferase in POMC neurons, leading to increase

160 h for genes involved in regulation of the 2'-N-acetyltransferase in Providencia stuartii, a mini-Tn5C

161 Normal induction of spermidine/spermine N-acetyltransferase in Q19 lines regulating back-convers

162 rapidly induced the enzymatic activity of a N-acetyltransferase in the hypothalamus of mice.

163 structure among the microbial and eukaryotic N-acetyltransferases in the region corresponding to the

164 A shares recognizable sequence homology with N-acetyltransferases, including those that can acetylate

165 tructurally conserved among a superfamily of N-acetyltransferases, including yeast histone acetyltran

166 Comparison with related N-acetyltransferases indicates a conserved structural fr

167 eficiency of acetyl-CoA: alpha-glucosaminide N-acetyltransferase involved in the lysosomal catabolism

168 Arylalkylamine N-acetyltransferase is also expressed in the retina, whe

169 Serotonin N-acetyltransferase is the enzyme responsible for the di

170 cs mediated by regioselective aminoglycoside N-acetyltransferases is the predominant cause of bacteri

171 -dependent phosphorylation of arylalkylamine N-acetyltransferase, leading to formation of a regulator

172 erved glutamate residue seen in Gcn5-related N-acetyltransferase-like acyltransferases.

173 A different enzyme from arylalkylamine N-acetyltransferase mediated this reaction, as this gene

174 In serotonin N-acetyltransferase, motif A adopts an alpha/beta confor

175 , and glutathione S-transferase (GST) M1 and N-acetyltransferase (NAT) 2 polymorphisms that may influ

176 One such enzyme is homologous to arylamine N-acetyltransferase (NAT) and has been identified in Fus

177 ns of two pineal-specific enzymes: serotonin N-acetyltransferase (NAT) and hydroxyindole-O-methyltran

178 ns, an amino acid kinase (AAK) domain and an N-acetyltransferase (NAT) domain connected through a 10-

179 like fold but lacking kinase activity and an N-acetyltransferase (NAT) domain homologous to other GCN

180 Arylamine N-acetyltransferase (NAT) enzymes are widespread in natu

181 nogenic heterocyclic amines are activated by N-acetyltransferase (NAT) enzymes, encoded by NAT1 and N

182 The activity of pineal serotonin N-acetyltransferase (NAT) exhibits a large circadian rhy

183 bolism of benzidine and N-acetylbenzidine by N-acetyltransferase (NAT) NAT1 and NAT2.

184 s feature ultrathin films containing DNA and N-acetyltransferase (NAT) on pyrolytic graphite (PG) ele

185 tivated by mycobacterial and human arylamine N-acetyltransferase (NAT).

186 phate farnesyltransferase (FDFT1), arylamine N-acetyltransferase (NAT-1), lipoprotein lipase (LPL), a

187 Arylamine N:-acetyltransferase (NAT) was first identified as the i

188 droxylation followed by O-acetylation by the N-acetyltransferases NAT1 and NAT2.

189 Arylamine N-acetyltransferases (NAT1 and NAT2) acetylate and detox

190 ion followed by phase II O-esterification by N-acetyltransferase (NAT2) are generally regarded as act

191 The enzymes cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2) are principally implicated in

192 tor (TFR2), N-acetyltransferase 2 (arylamine N-acetyltransferase) (NAT2), ABO blood group (ABO), and

193 Arylamine N -acetyltransferases (NATs) catalyse the acetylation fr

194 Arylamine N-acetyltransferases (NATs) are a homologous family of e

195 Arylamine N-acetyltransferases (NATs) are cytosolic enzymes that c

196 Arylamine N-acetyltransferases (NATs) catalyze an acetyl group tra

197 Arylamine N-acetyltransferases (NATs) catalyze an acetyl group tra

198 Arylamine N-acetyltransferases (NATs) catalyze the acetylation of

199 ect of apocynin on the activity of arylamine N-acetyltransferases (NATs) in excised liver samples was

200 Arylamine N-acetyltransferases (NATs), a class of xenobiotic-metab

201 Arylamine N-acetyltransferases (NATs; E.C 2.3.1.5) N-acetylate ary

202 Although previously characterized as the N-acetyltransferase of S5, our data indicate that RimJ,

203 conserved domain corresponding to a putative N-acetyltransferase or thioltransferase catalytic site.

204 activities of a C4''-transaminase (Pam), a 4-N-acetyltransferase (Pdi), a UDP-hydrolase (Phy), an enz

205 zymatic activity in vitro, this GCN5-related N-acetyltransferase region is critical for the solubilit

206 with a previously unidentified GCN5-related N-acetyltransferase region.

207 l control non-derepressible 5 (GCN5)-related N-acetyltransferase regions.

208 Arylalkylamine N-acetyltransferase (serotonin N-acetyltransferase, AANA

209 lies lacking one such enzyme, arylalkylamine N-acetyltransferase, show increased rest after rest depr

210 The spermidine N-acetyltransferase SpeG is a dodecameric enzyme that ca

211 SmAAT (Serratia marcescens aminoglycoside 3-N-acetyltransferase), suggests the mode of substrate bin

212 structural similarity to other Gcn5-related N-acetyltransferase superfamily members.

213 ution and found that PaiA is a member of the N-acetyltransferase superfamily of enzymes.

214 ures have a common fold core of GCN5-related N-acetyltransferase superfamily proteins, along with a u

215 amily 9, isoform 3 regulatory factor), NAT9 (N-acetyltransferase superfamily), and RAPTOR (rapamycin

216 icant similarity of Nut1 to the GCN5-related N-acetyltransferase superfamily.

217 c structure for a member of the Gcn5-related N-acetyltransferase superfamily.

218 It is a member of the GNAT (GCN-5-related N-acetyltransferase) superfamily of enzymes, which catal

219 T) and is a member of the GNAT (GCN5 related N-acetyltransferases) superfamily.

220 ation is on the enzyme QdtC, a CoA-dependent N-acetyltransferase that catalyzes the last step in the

221 One of these, referred to as WlbB, is an N-acetyltransferase that converts UDP-2-acetamido-3-amin

222 lic mobile element (ACME) encoding a Spm/Spd N-acetyltransferase that is necessary and sufficient for

223 regulation patterns of 3OST2 with serotonin N-acetyltransferase, the enzyme controlling the melatoni

224 d pineal-specific transcription of serotonin N-acetyltransferase, the rate-limiting enzyme in melaton

225 g histone acetyltransferases, aminoglycoside N-acetyltransferases, thioesterases, and enzymes involve

226 When applied to N-acetyltransferases, this reveals sequence and structur

227 ponses, photic suppression of arylalkylamine-N-acetyltransferase transcript, and acute suppression of

228 cAMP early repressor, the major inhibitor of N-acetyltransferase transcription.

229 y, isoniazid acetylator status determined by N-acetyltransferase type 2 genotype was associated with

230 a enterica aac(6')-Iy-encoded aminoglycoside N-acetyltransferase, we demonstrate that a series of bis

231 ly annotated as an aminoalkylphosphonic acid N-acetyltransferase which is able to acetylate a range o

232 Arylamine N-acetyltransferases which acetylate and inactivate ison

233 rium tuberculosis possess a single arylamine N-acetyltransferase whose gene is predicted to occur wit

234 zymes, such as epoxide hydrolase, glyphosate N-acetyltransferase, xylanase and phosphotriesterase, in