ライフサイエンスコーパス: N-myc gene

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1 uadruplex formation within the intron of the N-myc gene.

2 ressed in cells carrying extra copies of the N-myc gene.

3 ors the expression pattern of the endogenous N-myc gene.

4 vels even as cells show amplification of the N-myc gene.

5 ells with chromosomally integrated amplified N-myc genes.

6 of naturally metastatic cells with amplified N-myc genes.

7 neuroblastoma selects for cells that amplify N-myc genes.

8 Mutation of the cell cycle regulator N-myc gene also leads to an apparently identical phenoty

9 on may be a better prognostic indicator than N-myc gene amplification in neuroblastoma.

10 frequently in human B lymphoid tumors, while N-myc gene amplification is frequent in human neuroblast

11 the XRCC4/p53-deficient MBs have high-level N-myc gene amplification, often intrachromosomally in th

12 ich the physically linked cad and endogenous N-myc genes are coamplified.

13 HV is insertional activation of the cellular N-myc gene by integrated viral DNA.

14 lls downregulate expression of the amplified N-myc gene, concurrent with the arrest of cell prolifera

15 trate that modulating HuD expression affects N-myc gene copy number as well as expression.

16 Thus, N-myc gene copy number is modulated by alteration of HuD

17 N-myc gene copy numbers and transcription rates are simi

18 ients (95%), DNA index (ploidy) in 18 (90%), N-myc gene expression in 14 (70%), and cytogenetic analy

19 Therefore, post-transcriptional control of N-myc gene expression must differ between these cell typ

20 s virus is associated with the activation of N-myc gene expression, usually by viral DNA integration

21 nvestigate mechanisms of regulation of human N-myc gene expression, we observed that N-myc promoter-c

22 acetylcholinesterase activity, and decreased N-myc gene expression.

23 of Tbx20 led to increased Tbx2 and decreased N-myc gene expression.

24 ich DNA oligonucleotide originating from the N-myc gene folds into G-quadruplex structures in the pre

25 t in 73% of animals, either the c-myc or the N-myc genes had been disrupted and deregulated.

26 the transfected promoter and the endogenous N-myc gene in single-copy, but not amplified lines.

27 Enhanced expression of the amplified N-myc gene in the tumor cells may be associated with poo

28 Amplification of the N-myc gene is a significant adverse prognostic factor in

29 lear run-on analyses, we determined that the N-myc gene is actively transcribed in all cell types exa

30 The N-myc gene is overexpressed due to genomic amplification

31 The human N-myc gene normally is expressed in only a subset of fet

32 In mice, complete disruption of the N-myc gene results in fetal death on the first day of re

33 those whose tumors had amplification of the N-myc gene (RR = 0.26; P = .112; EFS, 67% v 0%).

34 The c- and N- myc genes showed three general classes of sequence co

35 ial evidence implicates amplification of the N-myc gene with aggressive tumor growth and poor outcome

36 varied size and/or position relative to the N-myc gene, with DDX1 representing at least one other ge

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