ライフサイエンスコーパス: N-terminal domain

1 er than the anticipated Rossmann fold of the N-terminal domain.

2 ous translocation of the carotenoid into the N-terminal domain.

3 A resolution crystal structure of the HiLpoA N-terminal domain.

4 rms interacting with beta-catenin through an N-terminal domain.

5 b by binding to a previously uncharacterized N-terminal domain.

6 160A) containing a catalytically inactivated N-terminal domain.

7 its intrinsically disordered regions in the N-terminal domain.

8 erved oligomerization interface in the mVP40 N-terminal domain.

9 A, is attached to the basal layer through an N-terminal domain.

10 f the dimeric 5'-UTR in complex with the RHA N-terminal domain.

11 not require cholesterol binding to NPC1L1's N-terminal domain.

12 NA recognition critically depends on the PB2 N-terminal domain.

13 dependent conformational changes outside the N-terminal domain.

14 an enzymatically active isoform lacking this N-terminal domain.

15 lyzed mainly by amino acid residues from the N-terminal domain.

16 to its truncated form eRF3c, which lacks the N-terminal domain.

17 is mediated by endonuclease activity in its N-terminal domain.

18 phiphilic alpha-helical structure within its N-terminal domain.

19 f Redbeta appear to reside solely within the N-terminal domain.

20 derstood region of the polymerase called the N-terminal domain.

21 o function than did similar mutations in the N-terminal domain.

22 tructured domains, including a beta-stranded N-terminal domain.

23 repression of Trio GEF activity by the Trio N-terminal domain.

24 tide in the catalytic barrel rather than the N-terminal domain.

25 ly conserved residue located within the PKD1 N-terminal domain.

26 aspases, cleave GSDMB at 88DNVD91 within the N-terminal domain.

27 rms makes extensive contacts with the folded N-terminal domain.

28 translate ADP binding into a movement of the N-terminal domain.

29 at the interface between the fingers and the N-terminal domains.

30 the full-length PB1-F2 (90 amino acids), its N-terminal domain (52 amino acids), expressed by current

31 vided into three linear domains: a conserved N-terminal domain, a hypervariable domain, and an acidic

32 have established that DnaB is composed of an N-terminal domain, a middle domain, and a C-terminal dom

33 Ligands binding to the N-terminal domain abolish the spontaneous ionic currents

34 le-vesicle fusion assay, suggesting that the N-terminal domain acts as an independent module within t

35 lutionary conserved sequence in the human GR N-terminal domain allows the formation of a GR-small ubi

36 rODA16 structure revealed a small 80-residue N-terminal domain and a C-terminal 8-bladed beta-propell

37 Galectin-3 has an intrinsically disordered N-terminal domain and a canonical CRD.

38 GDP-bound state, showing the characteristic N-terminal domain and a central G domain that are common

39 sed and purified, together with the isolated N-terminal domain and a mutant protein (KpsC D160A) cont

40 by the following two domains: a heme-binding N-terminal domain and a regulatory C-terminal domain bin

41 er, electron density was missing for the p59 N-terminal domain and for the linker connecting it to th

42 bic core with the conserved SAT motif of the N-terminal domain and I357 from the C-terminal domain, t

43 the presence of an L138P mutation in the VP1 N-terminal domain and identifying 52 additional mutation

44 genic Tau binds to synaptic vesicles via its N-terminal domain and interferes with presynaptic functi

45 skeletal muscle and has a large cytoplasmic N-terminal domain and smaller C-terminal pore-forming do

46 oteins Prp38, Snu23 and Spp381 bind the Prp8 N-terminal domain and stabilize U6 ACAGAGA stem-pre-mRNA

47 The peptide is clasped between the N-terminal domain and the transmembrane core of the rece

48 formational changes are detected both at the N-terminal domain and within the substrate portal nearly

49 how that PUB13 interacts with RabA4B through N-terminal domains and with phosphatidylinositol 4-phosp

50 on organization: a central GTPase domain, an N-terminal domain, and a C-terminal domain; the latter i

51 at this phosphorylation stabilizes fimbrin's N-terminal domain, and modulates actin filament binding

52 thway originating from the nucleation of the N-terminal domain, and that this pathway is the least li

53 th two tiers, an N-tier ring composed of the N-terminal domains, and a C-tier of C-terminal domains;

54 ains: (1) an intrinsically disordered acidic N-terminal domain; and (2) a folded C-terminal domain th

55 ssesses toxic nuclease activity, whereas the N-terminal domain appears to control toxin transport int

56 bed-ends of the arrays, achieved via a novel N-terminal domain, appears to be a critical aspect of it

57 e nine tyrosine residues in the fibromodulin N-terminal domain are O-sulfated, a posttranslational mo

58 esidues of two short regions within the NusG N-terminal domain are primarily responsible for recognit

59 that residues 115-125 within the yeast Top1p N-terminal domain are required for the complementation o

60 , and their interaction is mediated by their N-terminal domains as previously shown for gammaTuSCs.

61 The crystal structure of the N-terminal domain at 1.7 A resolution comprising residue

62 to the PSD membrane, with its palmitoylated, N-terminal domain at the membrane.

63 losteric Ras independently of the well-known N-terminal domain autoinhibition.

64 We show that both full-length GSDMB and the N-terminal domain bind to nitrocellulose membranes immob

65 mu1A C-terminal domain, but not the GST-mu1A N-terminal domain, bind to L-selectin tail peptide, and

66 a single JH III molecule is contained in the N-terminal domain binding pocket that is closed in an ap

67 nt fibromodulin fragments, we found that the N-terminal domain binds collagen.

68 In addition, the GSDMB N-terminal domain binds liposomes containing sulfatide.

69 The cleaved N-terminal domain binds phosphoinositides and cardiolipi

70 The unique DHX29 N-terminal domain binds to the ribosomal site near the m

71 at mature, cleaved, C-terminal AgRP, not the N-terminal domain, binds heparan sulfate.

72 inogenesis in vivo Phosphorylation of PKP1's N-terminal domain by RIPK4 is essential for their role i

73 The N-terminal domain can also interact independently with m

74 tent with the membrane-binding property, the N-terminal domain can be substituted by the influenza vi

75 Penetration of the N-terminal domain can bring the OCP carotenoid to within

76 Analyses of the variants unraveled that an N-terminal domain comprising a unique betabetabetaalphab

77 and characterized a novel, highly conserved N-terminal domain, comprising 92 amino acids, which medi

78 of a novel ATPase, Sulfolobus islandicusPilT N-terminal-domain-containing ATPase (SisPINA), encoded b

79 r X-ray crystallography and NMR results, the N-terminal domain contains four alpha-helices, 20 to 30

80 The N-terminal domain covers only a restricted area above th

81 ids A2-T704), MtTOP1-704t, that includes the N-terminal domains (D1-D4) and the first predicted C-ter

82 different GCPs are swapped, we show that the N-terminal domains define the functional identity of GCP

83 same well defined ubiquitin-like fold as the N-terminal domain, despite its reported aggregation and

84 a monoclonal mouse antibody specific for the N-terminal domain did not.

85 describe a schematic model of the unique Prf N-terminal domain dimer and its interaction with the eff

86 t an ADP-driven downward movement of the p97 N-terminal domain dislodges ataxin3 by inducing a steric

87 mediated by inhibitor-bridged contacts; the N-terminal domains do not participate and are structural

88 Surprisingly, the N-terminal domain does not appear to be required for any

89 Overexpression of NRP2 or its N-terminal domain enhances VSV-LUJV infection, and cells

90 ll-length TDP-43, association between folded N-terminal domains enhances the propensity of the intrin

91 sibility and shifted the conformation of the N-terminal domain from an extended structure to a compac

92 The structure of the TSC2 N-terminal domain from Chaetomium thermophilum and a hom

93 ains functionally complement the loss of the N-terminal domain from HgGLAND18.

94 antibodies specific for FHbp epitopes in the N-terminal domain had higher binding affinity for the re

95 The structure of the MtTOP1 N-terminal domains has features that have not been obser

96 N-terminal domain homologs, the helical carotenoid prote

97 beta1-6A2V, which supports a role of Abeta's N-terminal domain in amyloid fibril formation.

98 e present two crystal structures of the MutY N-terminal domain in complex with either undamaged DNA o

99 The N-terminal domain in HgGLAND18 contains unique sequence

100 ction of APOBEC3G and suggest a role for the N-terminal domain in RNA editing.

101 sue of JBC, Brown and co-workers identify an N-terminal domain in SM that interconverts in a choleste

102 w mechanism highlights the importance of the N-terminal domain in substrate recognition, explains the

103 findings establish important roles for ELKS N-terminal domains in synaptic vesicle priming.

104 analysis of the structural model of the L142 N-terminal domain indicated significant homology with so

105 hen we overexpressed mutants lacking part of N-terminal domains, indicating that the IL1RAPL1 extrace

106 neurotoxic mutants of PrP, and the isolated N-terminal domain induces currents when expressed in the

107 tems (small unilamellar vesicle) through its N-terminal domain, inducing an important structural reor

108 was suppressed either by splicing the yeast N-terminal domain into the chimera, deleting the human N

109 Adjacent to the N-terminal domain is a flexible loop, followed by a C-te

110 and NMR analyses, we confirmed that the L142 N-terminal domain is a sugar acetyltransferase, catalyzi

111 eal that the alternative conformation of the N-terminal domain is caused by structural instability pr

112 s a truncated form lacking the 17- to 20-kDa N-terminal domain is completely inactive under identical

113 DNAs via its C-terminal domain, whereas the N-terminal domain is considered non-catalytic.

114 Thus, the N-terminal domain is critical for the full repertoire of

115 nd that this alternative conformation in the N-terminal domain is diminished in the presence of calci

116 by mutagenesis that membrane binding of the N-terminal domain is essential for activation of Ca(2+)-

117 ion K293 in humans (K310 in mice) within the N-terminal domain is indispensable for GC-induced evolut

118 Most importantly, the large proline-rich N-terminal domain is not exposed to the extracellular sp

119 The N-terminal domain is not necessary for acyltransferase a

120 cryoEM reveals that this occupancy-enhancing N-terminal domain is partially ordered.

121 The N-terminal domain is responsible for Prf homodimerizatio

122 isoform CUA-1.2 that lacks a portion of the N-terminal domain is targeted constitutively to the baso

123 Its N-terminal domain is the active part of the protein, and

124 Zinc binding to the N-terminal domain is thus crucial for HMA4 protein funct

125 to the native wild-type protein, whereas the N-terminal domain is unfolded and comprises an ensemble

126 This enhancing function of the Sec7 N-terminal domains is consistent with the high rate of A

127 ure, coupled with upward displacement of the N-terminal domain, is observed only when ATPgammaS is bo

128 nding site of the crystallized GluN1b/GluN2B N-terminal domains led to free binding energies, which c

129 ive against both EF and LF and recognize the N-terminal domain (LFN, EFN) of their target(s) with sub

130 subunit C-terminal domain (CTD) and not the N-terminal domain like other lineage A beta-CoVs to bind

131 n reported for the human TRPA1 ortholog, the N-terminal domain may tune the response but is not requi

132 dual PDE4 isoforms by targeting their unique N-terminal domains may provide a fruitful approach to pr

133 Subsequently, A3G forms N-terminal domain-mediated dimers, whose dissociation fr

134 The N-terminal domain mimics heparin, binding proteins with

135 Here we report crystal structure of the MshE N-terminal domain (MshEN1-145) from Vibrio cholerae in c

136 sion gene construction methodology to screen N-terminal domain mutations discovered in tumors that ar

137 53G, in common with the previously described N-terminal domain mutations Q31L and L100P in mice, and

138 ts, TAP1 and TAP2, each of which contains an N-terminal domain (N-domain) in addition to a conserved

139 Each protein has two N-terminal domains, N1 and N2, structurally related to t

140 addition to the stabilization of either Rrn7 N-terminal domain near Pol I wall or the tandem winged h

141 The structure shows that the NusG N-terminal domain (NGN) binds at the central cleft of RN

142 micellar structures, where the very soluble N-terminal domain (NT) forms the shell.

143 N-methyl-d-aspartate (NMDA) receptor GluN2B N-terminal domain (NTD) aims for the treatment of variou

144 The helical bundle sequentially folded in an N-terminal domain (NTD) and a C-terminal domain (CTD) se

145 ffecting the FAD binding site located at the N-terminal domain (NTD) and accelerating proteasomal deg

146 A flexible linker connecting the N-terminal domain (NTD) and C-terminal domain (CTD) of A

147 eceptor, and consists of the membrane-distal N-terminal domain (NTD) and ligand-binding domain (LBD),

148 The N-terminal domain (NTD) flexible-loop (FL) region is one

149 The highly conserved spidroin N-terminal domain (NTD) is a pH-driven self-assembly dev

150 Controlled dimerization of the spidroin N-terminal domain (NTD) is crucial to this process.

151 TDP-43's N-terminal domain (NTD) is important for these activitie

152 ults of in vitro experiments showed that the N-terminal domain (NTD) is intrinsically disordered and

153 Its N-terminal domain (NTD) is responsible for interaction w

154 Tyr(30), Tyr(64), and Tyr(86) in the N-terminal domain (NTD) of beta-catenin.

155 bound to DnaB alters the conformation of the N-terminal domain (NTD) of DnaB to impair the ability of

156 The N-terminal domain (NTD) of HBc is sufficient for capsid

157 es through direct interaction of EAF and the N-terminal domain (NTD) of MED26.

158 tacoronavirus (beta-CoV) in group A uses the N-terminal domain (NTD) of S protein to bind to its rece

159 s being extensively studied, the role of the N-terminal domain (NTD) of STING remains an important su

160 These proteins have sequence homology to the N-terminal domain (NTD) of the Orange Carotenoid Protein

161 The crystal structure of the N-terminal domain (NTD) of YabA solved at 2.7 A resoluti

162 Here, we investigate the impact of the PHF1 N-terminal domain (NTD) on the Tudor domain interaction

163 vide biochemical evidence that the conserved N-terminal domain (NTD) plays a significant role in the

164 Here, we show that Cet1's N-terminal domain (NTD) promotes the recruitment of FACT

165 domain (CTD) that deaminates cytidine, and a N-terminal domain (NTD) that binds to ssDNA.

166 This protein has an N-terminal domain (NTD) that has been shown to bind to s

167 mic conformational equilibrium involving the N-terminal domain (NTD) with implications for the bindin

168 We characterized an Mcm10 mutant at the N-terminal Domain (NTD), Mcm10-4A, defective for self-in

169 slices, we show that the extracellular AMPAR N-terminal domain (NTD), which projects midway into the

170 the structure of the functionally important N-terminal domain (NTD).

171 in (MLD) and transfers cholesterol to NPC1's N-terminal domain (NTD).

172 phatidylserine binds to an integral-membrane N-terminal domain (NTD); however, how the NTD activates

173 he role of the PrP(c) amino-terminal domain (N-terminal domain [NTD], amino acids [aa] 23 to 90) in c

174 that the effect was more pronounced when the N-terminal domains (NTDs) of both RelA and p50 were pres

175 Recent studies established that the N-terminal domains (NTDs) of cMyBP-C (e.g., C0, C1, M, a

176 Previously, we have shown that the sHSP N-terminal domains (NTDs), which have a high degree of i

177 raction to the CARD domains of RIG-I and the N terminal domain of La.

178 The N-terminal domain of A3G (A3G-CD1) is responsible for ol

179 Original work proposed that the N-terminal domain of AgRP facilitates this interaction.

180 charges of acetylable lysine residues in the N-terminal domain of APE1 are essential for chromatin as

181 sitive charges of the lysine residues in the N-terminal domain of APE1 induces a conformational chang

182 This suggests that the N-terminal domain of ApoA1 actively participates in the

183 pecific interactions between residues in the N-terminal domain of ArfA and RF2 help RF2 to adopt a ca

184 f the archaeal flagellin is a homolog of the N-terminal domain of bacterial type IV pilin, showing on

185 del is proposed illustrating the role of the N-terminal domain of BnaDGAT1 as a positive and negative

186 Here, we report that the hydrophilic N-terminal domain of Brassica napus DGAT1 (BnaDGAT11-113

187 interacts with a novel binding motif in the N-terminal domain of CaV1 LTCC alpha1 subunits that is n

188 Densin binds to the N-terminal domain of Cav1.2, but not that of Cav1.3, and

189 this loop controls interactions between the N-terminal domain of CDC20 and APC1 and APC8.

190 lded central domain of CENP-C and the folded N-terminal domain of CENP-N that becomes rigidified 1,00

191 The N-terminal domain of complexin is important for activati

192 Membrane binding of the N-terminal domain of complexin therefore cooperates with

193 at the C-terminal beta-propeller but not the N-terminal domain of CrODA16 is required for the interac

194 aliana cryptochrome 2 (CRY2) protein and the N-terminal domain of cryptochrome-interacting basic-heli

195 Fn binding by CshA, in which the disordered N-terminal domain of CshA acts to "catch" Fn, via format

196 This suggests that Ca(2+) affinity of the N-terminal domain of cTnC in isolation is insufficient t

197 ractions that begins with the opening of the N-terminal domain of cTnC, followed by cTnC binding the

198 This cleavage site preceded the N-terminal domain of decorin that controls muscle growth

199 The N-terminal domain of DENV NS5 has guanylyltransferase an

200 an alteration of the helical hairpins in the N-terminal domain of DnaB, presumably occluding this reg

201 The N-terminal domain of dynein intermediate chain (N-IC) is

202 x to the ribosome, via interactions with the N-terminal domain of eRF3a which itself has an active ro

203 The N-terminal domain of FbiB is homologous to CofE with an

204 ucleotidyl-transferase core of GLD-2 and the N-terminal domain of GLD-3, and determined its structure

205 Cleavage releases the N-terminal domain of GSDMD, causing it to form cytotoxic

206 Complex formation requires the N-terminal domain of Hook proteins, which resembles the

207 aled that this inhibitory compound binds the N-terminal domain of Hsp90 close to its ATP-binding site

208 t prevents the specific interaction with the N-terminal domain of Hsp90 required for catalysis.

209 Here, we report the crystal structure of the N-terminal domain of human Apc1 (Apc1N) determined at 2.

210 -specific apparent rates at 2500 bar for the N-terminal domain of L9 (NTL9), and rates at atmospheric

211 other biophysical methods, we show that the N-terminal domain of LCN2-R is a soluble extracellular d

212 The regulatory N-terminal domain of LPL contains a consensus Mst1 phosp

213 l and microscopic analyses revealed that the N-terminal domain of M1 protein binds and inactivates hi

214 P/DNA complex, AsiA /sigma(70) Region 4, the N-terminal domain of MotA [MotA(NTD)], and the C-termina

215 linking was not prevented by deletion of the N-terminal domain of NPC1, which contains the initial bi

216 on within liquid-like droplets formed by the N-terminal domain of NPM1 and R-motif peptides, thus pro

217 LUJV GP binds the N-terminal domain of NRP2, while CD63 stimulates pH-acti

218 Carotenoid Proteins [HCPs]), paralogs of the N-terminal domain of OCP, were described.

219 In this process, the N-terminal domain of p30 released from GSDMD acts as an

220 Cdk5/p25 activity, we propose that the "p10" N-terminal domain of p35, absent in p25, spares Cdk5/p35

221 yloid oligomers, whereas full-length and the N-terminal domain of PB1-F2 aggregate to amorphous struc

222 Both full-length and N-terminal domain of PB1-F2 are soluble at pH values </=

223 We show that the entire N-terminal domain of Pol3, containing polymerase and pro

224 sical techniques, we show that the flexible, N-terminal domain of PrP(C) functions as a powerful toxi

225 The crystal structure of the N-terminal domain of pyoS2 (pyoS2(NTD)) bound to FpvAI (

226 y, we initially present the structure of the N-terminal domain of QseB, the response regulator respon

227 The structural data confirm that the N-terminal domain of RapZ possesses a kinase fold, where

228 The most N-terminal domain of Reck binds to the leucine-rich repe

229 a novel bipartite degradation signal in the N-terminal domain of RGS2.

230 ing to the SEPT6 and SEPT7 groups and to the N-terminal domain of septins from the SEPT3 group.

231 PTEN interacts with the N-terminal domain of SRF and PTEN-SRF interaction promot

232 ross-linking and mass spectrometry, that the N-terminal domain of Streptococcus pneumoniae protein Ps

233 Although the N-terminal domain of SuiB adopts a typical RRE (RiPP rec

234 binding with TATA-box DNA, and also with the N-terminal domain of TAF1 previously implicated in TATA-

235 However, it has been understood that the N-terminal domain of the archaeal flagellin is a homolog

236 dings by showing that DNA-binding by the MCM N-terminal domain of the archaeal organism Pyrococcus fu

237 separately with CTD and the latter with the N-terminal domain of the C-subunit.

238 tion within the compound-binding site in the N-terminal domain of the CA protein.

239 rystal structure of CypA in complex with the N-terminal domain of the HIV-1 capsid protein (CA) has b

240 We suggest that the N-terminal domain of the OCP burrows tightly into the PB

241 Preferential interactions at the N-terminal domain of the peptide hormone were manifested

242 ntains a 197-amino-acid (aa) deletion in the N-terminal domain of the spike (S) protein.

243 H-pyrimido[4,5-b]indole scaffold against the N-terminal domain of the topoisomerase IV E subunit from

244 VP90(71-415) encompasses the conserved N-terminal domain of the viral CP.

245 Here, we report the structures of the N-terminal domain of Tps2 (Tps2NTD) from Candida albican

246 Crystal structures of the free catalytic N-terminal domain of TrmJ show a 2-fold symmetrical dime

247 ar antigen 1 (EBNA1) that interacts with the N-terminal domain of USP7 (USP7-NTD).

248 The soluble, cleaved N-terminal domain of V-ATPase a2 isoform is associated w

249 Moreover, the delivery of the N-terminal domain of VDAC1 as a synthetic peptide (VDAC1

250 VP90(71-415) encompasses the conserved N-terminal domain of VP90 but lacks the hypervariable do

251 nylated version of Rab1 bound directly to an N-terminal domain of WHAMM in vitro.

252 ld be partially replaced by RBR fused to the N-terminal domain of XND1.

253 presented SAXS analysis it is found that the N-terminal domains of ApoA1-POPC-cholesterol particles a

254 However, the N-terminal domains of CPEBs are distinct and contain spe

255 binding, with important roles played by the N-terminal domains of Csn2 and Csn4 and the RING domain

256 Here we solve the crystal structures of the N-terminal domains of PHF1 and MTF2 with bound CpG-conta

257 e to freeze one transient state in which the N-terminal domains of SNARE proteins are assembled.

258 l analysis suggested that differences in the N-terminal domains of these polymerases are responsible

259 ed nucleic acid binding domains, mediated by N-terminal domain oligomerization, as structural feature

260 a transmembrane orientation with a lipidated N-terminal domain on the cell surface and a periplasmic

261 Mutations in the CaV1.3 alpha1 subunit N-terminal domain or in the CaMKII catalytic domain that

262 The P protein consists of three domains, the N-terminal domain (P(N)), the oligomerization domain (P(

263 The p150 subunit of human CAF-1 contains an N-terminal domain (p150N) that is dispensable for histon

264 ts phosphorylation at S54 and S73 within the N-terminal domain (Pdc-ND) followed by association with

265 e show that p31(comet) binding to the TRIP13 N-terminal domain positions the disordered MAD2 N-termin

266 However, the Hop1 C-terminal but not the N-terminal domain possesses strong i-motif binding activ

267 homologous scaffold proteins with different N-terminal domains, possessing either a palmitoylation s

268 Rad51 directly interacts with the Pol alpha N-terminal domain, promoting Pol alpha and delta binding

269 he full-length protein (Redbeta(FL)) and the N-terminal domain (Redbeta(177)) to different lengths of

270 the presence of ATP, VAT with its regulatory N-terminal domains removed unfolds other VAT complexes a

271 We show that the disordered N-terminal domain (residues approximately 20-100) intera

272 domain of three zinc fingers and a variable N-terminal domain responsible for recruiting cofactors.

273 Four independent crystal structures of the N-terminal domain reveal several distinct open and close

274 rystal structures of the GluA2/3 and GluA2/4 N-terminal domains reveal a novel compact conformation w

275 The N-terminal domain shortened the collagen fibril formatio

276 mutations in p97 deregulate dynamics of the N-terminal domain that binds adaptor proteins involved i

277 Cdc48 consists of an N-terminal domain that binds UN and two stacked hexameri

278 transcription factors are located in the ID N-terminal domain that contains a powerful activation fu

279 structure of CteB also reveals an accessory N-terminal domain that has high structural similarity to

280 class B GPCRs, binds to its receptor via its N-terminal domain, thereby activating the pathway to thi

281 set of protein complexes through its unique N-terminal domain, thereby leading to targeted degradati

282 We also found the N-terminal domain to be necessary and sufficient for imm

283 ng ESCRT-III until it encounters the ordered N-terminal domain to destabilize the ESCRT-III lattice.

284 oplasmic form of CCN3 interacted with the AR N-terminal domain to sequester AR in the cytoplasm of pr

285 o identify and characterize mutations in the N-terminal domain to understand its function.

286 ating chloroplast transit peptide (cTP), and N-terminal domains to the ATPase, Rubisco recognition an

287 ne these mechanochemical interactions by its N-terminal domains transiently interacting with actin an

288 Although N-terminal domain truncation was necessary for crystal f

289 anonical tyrosine integrase (Int) lacking an N-terminal domain typically associated with binding to a

290 oes a major conformational change within its N-terminal domain upon binding to the egg-surface recept

291 enoid translocation and separation of C- and N-terminal domains upon transition from the basic orange

292 ysyl-ubiquitination sites in the cytoplasmic N-terminal domain were mutated to alanine protected SNAT

293 The N-terminal domains were embedded in an asymmetric model

294 helix via lateral interactions between their N-terminal domains, whereas the C-terminal domains media

295 consistent with unfolding of the 25 residue N-terminal domain, which exposes the beta-scaffold of th

296 a catalytically inactive dioxygenase-related N-terminal domain, which is important for MCM loading, b

297 Although SGTA's N-terminal domain, which mediates homodimerization and r

298 fining feature of ERFVIIs is their conserved N-terminal domain, which renders them oxygen- and nitric

299 Interestingly, a flexible region within the N-terminal domain, which undergoes beta-strand-to-alpha-

300 Deletion of the Hsp104 N-terminal domain yields a hypomorphic disaggregase, Hsp