ライフサイエンスコーパス: N. meningitidis

1 N. meningitidis endotoxin was a potent agonist of both t

2 N. meningitidis has been considered a paradigmatic case

3 N. meningitidis MC58 NMB0419 encodes a Sel1-like repeat

4 N. meningitidis outbreak-related strains were distinguis

5 N. meningitidis strain 8047 was subjected to serial pass

6 N. meningitidis strains are divided into a number of ser

7 N. meningitidis subverts immune responses by hijacking a

8 ve species (58.0%), followed by GBS (18.1%), N. meningitidis (13.9%), H. influenzae (6.7%), and L. mo

9 fold-more Stase activity than extracts of 16 N. meningitidis clinical isolates, representing several

10 Of 25 N. meningitidis isolates obtained, 15 (60%) were nongrou

11 From 1997 to 2002, 1,298 N. meningitidis isolates, collected in the United States

12 in several Neisseria isolates showed that 5 N. meningitidis strains contain a 107-bp CREE in this re

13 93246, and the results were compared with 7 N. meningitidis strains, 13 N. polysaccharea strains, an

14 A N. meningitidis mutant with decreased expression of PorA

15 era mediated bactericidal activity against a N. meningitidis group C strain with human complement.

16 utant library was constructed in serogroup A N. meningitidis and screened for clones with increased p

17 mutability in a collection of 95 serogroup A N. meningitidis invasive isolates was determined.

18 ssay, (ii) for bactericidal activity against N. meningitidis serogroup C strain C11, and (iii) for th

19 ety of comparative sequence analyses against N. meningitidis reference genome sequences of known sero

20 liciting broadly protective immunity against N. meningitidis strains.

21 is vital for protecting individuals against N. meningitidis.

22 antigens to elicit broad protection against N. meningitidis serogroup B.

23 her species studied to date, and would allow N. meningitidis to generate a very large repertoire of p

24 We demonstrate here that although N. meningitidis fails to grow under strictly anaerobic c

25 , since both heme and Hb could complement an N. meningitidis hemA hemO double mutant for growth.

26 Similar studies established that an N. meningitidis luxS mutant also has metabolite pool cha

27 ratorian who had occupational exposure to an N. meningitidis isolate of the same serogroup within 14

28 he shared function of fHbp in N. cinerea and N. meningitidis and cross-reactive responses elicited by

29 experiments demonstrate that the E. coli and N. meningitidis protein homologs are functionally conser

30 In E. coli and N. meningitidis, the predominant lipid is a lysophosphat

31 r fractions of N. gonorrhoeae strain F62 and N. meningitidis strain MC58 not subset 3 (an acapsulate

32 e dca gene of N. gonorrhoeae strain FA19 and N. meningitidis strain NMB.

33 lation of LOS can protect N. gonorrhoeae and N. meningitidis from complement-mediated serum killing a

34 Stase expression between N. gonorrhoeae and N. meningitidis is due at least in part to differential

35 stream (5'lst) regions of N. gonorrhoeae and N. meningitidis revealed striking sequence differences c

36 lst transcript levels in N. gonorrhoeae and N. meningitidis revealed that N. gonorrhoeae strains exp

37 ng analysis revealed that N. gonorrhoeae and N. meningitidis use different promoters with different s

38 nockout strains of Neisseria gonorrhoeae and N. meningitidis were unable to use any heme source, whil

39 e, Neisseria spp. (Neisseria gonorrhoeae and N. meningitidis), Serratia marcescens, and other gram-ne

40 pecific pathogens, Neisseria gonorrhoeae and N. meningitidis, are Gram-negative bacteria that have so

41 s surface exposed in both N. gonorrhoeae and N. meningitidis.

42 tural analysis of LPS from H. influenzae and N. meningitidis strains where lpt6 had been insertionall

43 capsular polysaccharides from E. coli K1 and N. meningitidis group B and the heparosan-like capsular

44 Abs that can be protective against MenB and N. meningitidis group C strains.

45 of 95.7% and 85.7%, and L. monocytogenes and N. meningitidis were not observed in the study.

46 magnitude than N. meningitidis organisms and N. meningitidis PorB (published elsewhere as Nme PorB).

47 been switched between N. lactamica PorB and N. meningitidis PorB, we identified residues in loop 5 a

48 2 copies in N. meningitidis strain Z2491 and N. meningitidis strain MC58, respectively) than 105- to

49 ved > or =0.031 micro g of human infant anti-N. meningitidis serogroup C PS IgG, 75 (94.9%) had a > o

50 relationship between concentrations of anti-N. meningitidis serogroup C PS-specific IgG and serum SB

51 Each pool was assayed (i) for the anti-N. meningitidis serogroup C capsular polysaccharide (PS)

52 It was concluded that the anti-N. meningitidis serogroup C PS IgG antibody induced by t

53 s who were not previously immunized with any N. meningitidis serogroup C vaccine served as a negative

54 This isolate was identified as N. meningitidis by biochemical identification methods bu

55 ed allelic patterns in urethritis-associated N. meningitidis strains may reflect genetic diversity in

56 mouse intranasal challenge model for group B N. meningitidis to evaluate potential vaccine candidates

57 eactive with heterologous strains of group B N. meningitidis.

58 ed with the two different strains of group B N. meningitidis.

59 is a potential vaccine candidate for group B N. meningitidis.

60 y, the transcriptome of adherent serogroup B N. meningitidis strain MC58 was determined at intervals

61 xygenase (HO), from the pathogenic bacterium N. meningitidis(NmHO), which secures host iron, shares m

62 ygenase, HO, from the pathological bacterium N. meningitidis have been investigated to assess the pro

63 share the same loci) and differences between N. meningitidis strains and N. gonorrhoeae FA1090 (only

64 egions that allow for discrimination between N. meningitidis and N. gonorrhoeae.

65 scents is due largely to interaction between N. meningitidis and other members of the upper respirato

66 inical isolate described here expresses both N. meningitidis and N. gonorrhoeae 16S rRNA genes, as sh

67 sseriae, as a target for C4b and C3b on both N. meningitidis and N. gonorrhoeae.

68 actamica is not associated with disease, but N. meningitidis occasionally invades the host, causing m

69 enital colonization and urethritis caused by N. meningitidis are possible across a range of meningoco

70 no cases of meningococcal disease caused by N. meningitidis B were reported among vaccinated student

71 Meningococcal disease caused by N. meningitidis serogroup B (MenB) has been endemic in B

72 revention of meningococcal disease caused by N. meningitidis serogroup B (NmB).

73 andidate for prevention of disease caused by N. meningitidis.

74 may explain adolescent/adult colonization by N. meningitidis.

75 A and B, outer membrane porins expressed by N. meningitidis, do not contribute significantly to fH b

76 ommon pathogen detected (n = 17) followed by N. meningitidis (n = 13).

77 The decreased release of PG monomers by N. meningitidis relative to N. gonorrhoeae is partly due

78 s surface localized, cleaved and secreted by N. meningitidis.

79 ow that the utilization of carbon sources by N. meningitidis determines its ability to withstand comp

80 Binding to serogroups A, B, and C N. meningitidis strains was detected by FACS and Far Wes

81 ant with the polyST genes from groups B or C N. meningitidis and the control E. coli K92 polymerase g

82 We have identified three serogroup C N. meningitidis (MenC) isolates recovered from patients

83 effect of purified PorB in vitro, a chimeric N. meningitidis strain expressing N. lactamica PorB indu

84 om complement attack achieved by circulating N. meningitidis therefore depends on the relative levels

85 with S. pneumoniae, S. agalactiae, E. coli, N. meningitidis, or H. influenzae in combination with ce

86 exposure to droplets or aerosols containing N. meningitidis.

87 ime PCR assays have been developed to detect N. meningitidis ctrA, H. influenzae hpd, and S. pneumoni

88 Y synF showed 100% specificity for detecting N. meningitidis species, with high sensitivity (serogrou

89 nsitive as conventional methods in detecting N. meningitidis (13.2% versus 5.7%; P < 0.0001).

90 Here, we analyzed the genomes of 39 diverse N. meningitidis isolates associated with urethritis, col

91 onal activity against 10 genetically diverse N. meningitidis serogroup B strains.

92 of properdin do not bind directly to either N. meningitidis or N. gonorrhoeae but play a crucial rol

93 on against bacteremia caused by encapsulated N. meningitidis strains expressing GNA1870 subvariant 1

94 s to study the geographic spread of epidemic N. meningitidis strains or other microbes of clinical im

95 To assess ongoing risk, we evaluated N. meningitidis carriage among US travelers to the 2001

96 Finally, N. meningitidis contains more genes that undergo phase v

97 gesting fluorescently labeled, ethanol-fixed N. meningitidis organisms (phagocytic activity) in the p

98 clonal antibody (MAb) B5 is bactericidal for N. meningitidis strain 8047 when PEtn is present in the

99 erogroup-specific genes in the cap locus for N. meningitidis serogroups A, B, C, W135, X, and Y.

100 This was particularly relevant for N. meningitidis, as only 1/13 cases was culture positive

101 om 0.18 to 17.31 micro g of IgG specific for N. meningitidis serogroup C PS per ml.

102 ection of a few DNA copies per LAMP zone for N. meningitidis, S. pneumoniae and Hib were achieved wit

103 ccines are available to protect against four N. meningitidis serogroups, there is currently no commer

104 ructure of an ADEP-ClpP complex derived from N. meningitidis was solved.

105 the second highest incidence of disease from N. meningitidis.

106 The Cas9 RNA-guided endonuclease from N. meningitidis (NmCas9) recognizes a 5'-NNNNGATT-3' pro

107 All four opa genes from N. meningitidis strain H44/76 were sequentially disrupte

108 structure by complementation with kdtA from N. meningitidis or Escherichia coli.

109 suggest that phosphoryl moieties of LA from N. meningitidis and N. gonorrhoeae LOSs play an importan

110 rsible "aging" of native heme oxygenase from N. meningitidis, NmHO.

111 and chimeric forms of the IgA1 protease from N. meningitidis strain NMB.

112 he interactions between 11 Pil proteins from N. meningitidis.

113 Comparison of PG fragment release from N. meningitidis and N. gonorrhoeae showed that meningoco

114 Furthermore, N. meningitidis, unlike enteric Gram-negative bacteria,

115 ave functional activity against heterologous N. meningitidis strain, as demonstrated via bactericidal

116 ntibody responses to a panel of heterologous N. meningitidis strains than did a control multicomponen

117 One hundred N. meningitidis samples were typed by comparing MALDI-TO

118 ex real-time PCR assays for detection of (i) N. meningitidis ctrA, H. influenzae hpd, and S. pneumoni

119 pd, and S. pneumoniae lytA (NHS assay); (ii) N. meningitidis serogroups A, W135, and X (AWX assay); a

120 groups A, W135, and X (AWX assay); and (iii) N. meningitidis serogroups B, C, and Y (BCY assay).

121 In N. meningitidis, a weak sigma 70 promoter at the 3' term

122 In N. meningitidis, NalP is secreted at distinct sites arou

123 NO inhibits oxidase activity in N. meningitidis with an apparent Ki NO = 380 nM measured

124 d lgt-1 in strain 93246, were the same as in N. meningitidis.

125 pid A indicates that lipid A biosynthesis in N. meningitidis can proceed without the addition of Kdo

126 manno-octulosonic acid (Kdo) biosynthesis in N. meningitidis.

127 y a genomic island (the prp gene cluster) in N. meningitidis that enables this species to utilize pro

128 f 154- to 156-bp CREE (163 and 152 copies in N. meningitidis strain Z2491 and N. meningitidis strain

129 Novel aspects of the methylcitrate cycle in N. meningitidis include a propionate kinase which was pu

130 t such a system has not been demonstrated in N. meningitidis.

131 ntrol point for sialic capsule expression in N. meningitidis.

132 DsbA-catalysed oxidative protein folding in N. meningitidis.

133 similar to pacA and pacB were also found in N. meningitidis and N. lactamica strains, and an inserti

134 nces a wide range of biological functions in N. meningitidis either directly or via intermediate regu

135 of the iron-activated nspA and secY genes in N. meningitidis occur by Fur-dependent and -independent

136 studies have identified a number of genes in N. meningitidis that are iron and Fur activated, demonst

137 o be associated with phase variable genes in N. meningitidis.

138 lons (phasevarions), have been identified in N. meningitidis.

139 fication is a pathway of major importance in N. meningitidis.

140 be lst, whereas this promoter is inactive in N. meningitidis.

141 coding the CMP-Kdo synthetase (kpsU/kdsB) in N. meningitidis resulted in expression of a lipooligosac

142 ence of Fur-regulated small RNA molecules in N. meningitidis MC58.

143 t response regulator, encoded by NMB0595, in N. meningitidis strain NMB resulted in the loss of all P

144 d all 13 N. polysaccharea strains but not in N. meningitidis and N. gonorrhoeae strains.

145 patterns of MAb reactivity were observed in N. meningitidis by Western blot, depending on the relati

146 ide consists of polyhexosamine phosphates in N. meningitidis serogroups A and X.

147 s study is the first report of small RNAs in N. meningitidis and the first to use a bioinformatics ap

148 uptake via GltT-GltM plays multiple roles in N. meningitidis internalization into HBMEC.

149 r1 transposon mutant library was screened in N. meningitidis serogroup A strain IR4162.

150 e for the lack of -35 consensus sequences in N. meningitidis.

151 he regulation of LOS inner core structure in N. meningitidis through an environmental sensing two-com

152 ne, resulted in loss of functional traits in N. meningitidis and E. coli Our study indicates that the

153 endent, iron-activated gene transcription in N. meningitidis.

154 olonizers of the human nasopharynx increased N. meningitidis switching frequencies, indicating that h

155 duction are observed aerobically, indicating N. meningitidis can act as an aerobic denitrifier.

156 fhbp genes were obtained from 1837 invasive N. meningitidis serogroup B (MnB) strains from the Unite

157 In susceptibility testing of invasive N. meningitidis isolates from the Active Bacterial Core

158 identify the recognition site for three key N. meningitidis methyltransferases: ModA11 (exemplified

159 f human C3 complement on the surface of live N. meningitidis bacteria and greater passive protective

160 Neisseria meningitidis (N. meningitidis), Streptococcus pneumoniae (S. pneumonia

161 is-causing bacteria, Neisseria meningitidis (N. meningitidis).

162 In all infected mice, N. meningitidis targeted the human vasculature, leading

163 Recombinant native N. meningitidis FBA was purified and used in a coupled e

164 At baseline, natural N. meningitidis carriage in the control group was 22.4%

165 orA P1.2 mAb to the surface of eight of nine N. meningitidis serogroup B strains tested with the P1.2

166 suggest that strain 93246 is nonencapsulated N. meningitidis but has the ability to produce extracell

167 ain 93246 identical to other nonencapsulated N. meningitidis strains.

168 bacterium and contributes to the ability of N. meningitidis to avoid complement-mediated killing in

169 spect to the nearby regions; the analysis of N. meningitidis serogroup B shows two new large regions

170 into the commensal and virulence behavior of N. meningitidis can be gleaned from the genome, in which

171 ltransferase responsible for biosynthesis of N. meningitidis group B capsule was detected in strain 9

172 CoA to decorate the D-mannosamine capsule of N. meningitidis serogroup A.

173 The capsule of N. meningitidis serogroup B, (alpha2-->8)-linked polysia

174 al regulation of the sialic acid capsules of N. meningitidis.

175 Natural carriage of N. meningitidis and related bacteria leads to the develo

176 Carriage of N. meningitidis serogroup W-135 increased significantly

177 Carriage of N. meningitidis was investigated by using three differen

178 Lst rabbit antiserum bound to whole cells of N. meningitidis MC58 not subset 3 and wild-type N. gonor

179 odology required for the characterization of N. meningitidis and highlights its usefulness for public

180 e were representatives of invasive clones of N. meningitidis.

181 , hyperendemic lineages (invasive clones) of N. meningitidis as well as did MLST.

182 ed to construct all possible combinations of N. meningitidis strains deficient in one, two, three, or

183 ngs may be useful in assessing components of N. meningitidis as potential vaccine candidates.

184 These data show that non-LPS components of N. meningitidis induce DC maturation, but that LPS in th

185 Thus, the observed growth defect of N. meningitidis pfs and luxS mutants is not due to quoru

186 The limit of detection of N. meningitidis is about 3 copies per LAMP zone within 4

187 proach for fast instrument-free diagnosis of N. meningitidis in resource-limited settings.

188 Neisseria, shortly before the divergence of N. meningitidis and Neisseria gonorrhoeae.

189 which binds to an inner core LPS epitope of N. meningitidis.

190 ransferase (Stase) activity than extracts of N. meningitidis strain MC58 [symbol: see text]3 a serogr

191 d LPS extracted from an LPS mutant (galE) of N. meningitidis strain MC58 (B:15:P1.7,16:L3).

192 ciated genomes from the 4 carried genomes of N. meningitidis, which is far more than can be expected

193 Rapid and reliable identification of N. meningitidis serogroups is crucial for judicious and

194 We screened 126 isolates of N. meningitidis and found the GGI in 17.5% of strains, w

195 n disease-associated and carried isolates of N. meningitidis at the level of individual nucleotide va

196 n disease-associated and carried isolates of N. meningitidis may provide critical insight into mechan

197 The strains tested included isolates of N. meningitidis serogroups A, B, C, W135, and Y, Neisser

198 disease-associated and 4 carried isolates of N. meningitidis to search for SNPs that show mutually ex

199 length of which differs between isolates of N. meningitidis, suggesting that dca is phase variable i

200 isk diffusion method for testing isolates of N. meningitidis.

201 surface outer membrane protein 85 (OMP85) of N. meningitidis as an immobilized selective layer.

202 Cn, which are homologous to Class II pili of N. meningitidis, they did not react with anti-ChoP antib

203 t phenotypes and hence invasive potential of N. meningitidis strains.

204 y as single elements in the 5'lst regions of N. meningitidis isolates.

205 In addition, the 5'lst regions of N. meningitidis strains have 105-bp transposon-like Corr

206 island is absent from the close relative of N. meningitidis, the commensal Neisseria lactamica, whic

207 (I)] moiety of LOS influenced sialylation of N. meningitidis LOS in vitro and in vivo.

208 Last, we revisit the species status of N. meningitidis, N. gonorrheae, and N. lactamica in the

209 f wild-type and NMB0573 knock-out strains of N. meningitidis has shown that NMB0573 is associated wit

210 first time, that PorB2-expressing strains of N. meningitidis regulate the AP of baby rabbits and rats

211 available vaccine for serogroup B strains of N. meningitidis, this kind capsule-switching event could

212 e GGI has also been found in some strains of N. meningitidis.

213 found throughout the population structure of N. meningitidis (genetic distance, >0.425), whereas exl2

214 Here we report the crystal structures of N. meningitidis heme oxygenase (nm-HO) in the Fe(II), Fe

215 e vital to molecular epidemiology studies of N. meningitidis, including outbreak investigations and p

216 PorB is located on the surface of N. meningitidis and can be recognized by receptors of th

217 polysialic acid expressed on the surface of N. meningitidis and in the absence of specific antibody

218 LP2086 is localized on the outer surface of N. meningitidis.

219 nding protein, are essential for survival of N. meningitidis group B strain H44/76 in normal human se

220 tance of binding of human fH for survival of N. meningitidis in vitro and in vivo.

221 Both enzymes are necessary for survival of N. meningitidis under oxidative stress and during bloods

222 ive damage, are not required for survival of N. meningitidis under oxidative stress.

223 The mismatch repair system of N. meningitidis was found to play an important role in d

224 tide resolution the primary transcriptome of N. meningitidis strain 8013.

225 contribute to the evolution and virulence of N. meningitidis.

226 ultures grown overnight doubled the yield of N. meningitidis carriage isolates compared with conventi

227 d, showed that the Mu SGS and the E. coli or N. meningitidis sequences allowed an enhancement of proc

228 ccus-like and distinguishing them from other N. meningitidis strains.

229 ngitidis serogroups) or endogenous (in other N. meningitidis serogroups) sources of 5'-cytidinemonoph

230 istance, and virulence in the human pathogen N. meningitidis.

231 cantly increases detection of S. pneumoniae, N. meningitidis, and H. influenzae in CSF, and that appl

232 s that were qPCR positive for S. pneumoniae, N. meningitidis, and H. influenzae, only 10 were culture

233 The expression of HemO also protected N. meningitidis cells against heme toxicity.

234 in (fHbp), a virulence factor which protects N. meningitidis from innate immunity by binding the huma

235 We examined the ability of purified N. meningitidis PorB to induce maturation of murine sple

236 iliar with current recommendations regarding N. meningitidis.

237 ther than sequences from the closely related N. meningitidis.

238 Ps of the pathophysiologically less relevant N. meningitidis serogroup L, is one of the smallest know

239 Three representative N. meningitidis strains (8047, M986, and 2996) were inve

240 Ciprofloxacin-resistant N. meningitidis has emerged in North America.

241 To assess local carriage of resistant N. meningitidis, we conducted a pharyngeal-carriage surv

242 nous (in all N. gonorrhoeae strains and some N. meningitidis serogroups) or endogenous (in other N. m

243 nied by increased overall mutability in some N. meningitidis isolates including strains shown to be m

244 The pathogenic Neisseria species N. meningitidis and N. gonorrhoeae possess an outer memb

245 it biochemically from the pathogenic species N. meningitidis.

246 s Neisseria contains two pathogenic species (N. meningitidis and N. gonorrhoeae) in addition to a num

247 genomes of two pathogenic Neisseria species, N. meningitidis (Nm) and N. gonorrhoeae (Ng).

248 The capsular polysaccharide surrounding N. meningitidis is a major virulence factor.

249 beta-galactosidase (beta-gal) activity than N. meningitidis 5'lst::lacZ fusions in a host-independen

250 flammatory responses of lower magnitude than N. meningitidis organisms and N. meningitidis PorB (publ

251 eae strains express more lst transcript than N. meningitidis strains.

252 data are at odds with this proposal and that N. meningitidis fits the criteria that we have proposed

253 These data demonstrate that N. meningitidis targets human endothelial cells in vivo

254 de several lines of supporting evidence that N. meningitidis colonization is correlated with propioni

255 We found that N. meningitidis recycles PG fragments via the selective

256 In this study, we show that N. meningitidis binds fH to its surface.

257 The N. meningitidis isolate described must have obtained N.

258 bactericidal assay using MAb B5 against the N. meningitidis MC58 galE mutant in the presence of huma

259 Because the N. meningitidis serogroup L capsule polymer consists of

260 The translated amino acid sequences from the N. meningitidis and H. influenzae lpt6 genes have conser

261 u derivative lacking the SGS, those from the N. meningitidis prophages allowed a small enhancement, a

262 its distinct protospacer adjacent motif, the N. meningitidis CRISPR-Cas machinery increases the seque

263 we report a 1.44 A crystal structure of the N. meningitidis major pilin PilE and a approximately 6 A

264 Analysis of the N. meningitidis strain MC58 genome for foreign DNA sugge

265 the ratio of species-specific sequences, the N. meningitidis strain seems to have replaced one of its

266 e P1.14 monoclonal antibodies and showed the N. meningitidis L1(8) lipo-oligosaccharide immunotype.

267 en-Probe Aptima assays cross-react with this N. meningitidis isolate.

268 However, most of the time N. meningitidis is carried as a commensal not associated

269 prp genes provides a metabolic advantage to N. meningitidis in the adult oral cavity, which is rich

270 e an important determinant of MBL binding to N. meningitidis and can modulate complement-dependent ki

271 Binding to N. meningitidis was specific for human fH (low for chimp

272 ingitidis group C, none of the MAbs bound to N. meningitidis groups A, C, and Y.

273 We show that these proteins bind directly to N. meningitidis Cas9 (NmeCas9) and can be used as potent

274 ed with common homozygotes after exposure to N. meningitidis.

275 like Neisseria gonorrhoeae, binding of fH to N. meningitidis was independent of sialic acid on the ba

276 difies cellular TNF secretion in response to N. meningitidis and may influence susceptibility to meni

277 ontogeny of the murine anti-CpsB response to N. meningitidis could determine key parameters regarding

278 talyze the synthesis of the complex trimeric N. meningitidis serogroup L capsule polymer repeating un

279 n of CREE lengths is similar between the two N. meningitidis genomes, with a greater number of 154- t

280 p CREE also shows similarity between the two N. meningitidis strains (15 copies share the same loci)

281 bination of vaccines prepared from wild-type N. meningitidis and recombinant protein.

282 ne or an OMV vaccine prepared from wild-type N. meningitidis or a combination of vaccines prepared fr

283 as much lower than that within the wild-type N. meningitidis strain only upon HBMEC infection and was

284 nterleukin 8 (IL-8) secretion than wild-type N. meningitidis, suggesting a role for PorB in induction

285 crete sequences were obtained; 92 (76%) were N. meningitidis sequences, and 29 (24%) were N. gonorrho

286 toskeleton linker, were more pronounced when N. meningitidis formed larger colonies on HBMEC under ph

287 findings on the diverse mechanisms by which N. meningitidis avoids complement-mediated killing, and

288 er mechanism toward our understanding of why N. meningitidis is strictly a human pathogen.

289 With N. meningitidis and Haemophilus, higher levels of recove

290 m developing bacteremia after challenge with N. meningitidis serogroup B strain 8047 (surface binding

291 ed abundance of SNO during coincubation with N. meningitidis, S. enterica, or E. coli.

292 Conflicting data with N. meningitidis indicate that Omp85 functions either in

293 of cytokines produced during infection with N. meningitidis and may be involved in the inflammatory

294 mice were then challenged intranasally with N. meningitidis strain H355 or M982, and the colonizatio

295 ethal intraperitoneal challenge of mice with N. meningitidis serogroup B, and sera raised against the

296 Except for HmenB5, which cross-reacted with N. meningitidis group C, none of the MAbs bound to N. me

297 However, strain 93246 reacted with N. meningitidis serotype 4 and serosubtype P1.14 monoclo

298 In contrast to previous reports with N. meningitidis, loss of phosphoethanolamine attached to

299 drophobic agent resistance mechanisms within N. meningitidis.

300 Serogroup X N. meningitidis (NmX) dominated in both vaccinated and u