1                                      Crigler-Najjar syndrome (CN) is a very rare genetic disorder cha

2                                      Crigler-Najjar syndrome is a recessively inherited disorder char

3                                      Crigler-Najjar syndrome type 1 (CN-1) is a recessively inherited

4                                      Crigler-Najjar syndrome type I is characterized by unconjugated

5 in the UGT1A1 (HUG-Br1) isozyme of a Crigler-Najjar (CN) Type I patient.

6 c bilirubin glucuronidation, causing Crigler-Najjar syndrome type 1 or 2, respectively.

7                         In contrast, Crigler-Najjar syndrome types I and II are rare genetic disorder

8 he risk of bilirubin encephalopathy (Crigler-Najjar syndrome).

9                                  For Crigler-Najjar syndrome, an inherited disorder that results in f

10 cult, is now accepted management for Crigler-Najjar type I disease but remains controversial for the

11 rubinemia in humans that suffer from Crigler-Najjar type I disease results from lesions in the UGT1A1

12 r type II patients and, recently, in Crigler-Najjar type I patients treated with human hepatocyte cel

13                                   In Crigler-Najjar type II patients and, recently, in Crigler-Najjar

14 lirubinemia in the Gunn rat model of Crigler-Najjar syndrome can be achieved with one injection of HD

15 perbilirubinemic Gunn rats (model of Crigler-Najjar syndrome type 1) resulted in hUGT1A1 expression i

16 transplantation in the management of Crigler-Najjar syndrome, type 1.

17  rat is an excellent animal model of Crigler-Najjar syndrome, type 1.

18  both alleles, whereas patients with Crigler-Najjar syndrome are homozygous for a defect that yields

19  report describes a young adult with Crigler-Najjar syndrome type II in whom kernicterus developed af

20 nduced levels noted in patients with Crigler-Najjar type 1 disease, is fatal in neonatal Ugt1(-/-) mi

21 s (n = 3), and patients (n = 4) with Crigler-Najjar type I (CN-I) syndrome.