ライフサイエンスコーパス: O. volvulus

1 O. volvulus blisterase expressed in insect cells has max

2 namely, a Glu(124) (C. elegans) or Asp(123) (O. volvulus) residue present in a critical position.

3 eatment of Onchocerca volvulus infection, 40 O. volvulus-infected Ghanaians were randomized to receiv

4 In addition, O. volvulus contains the rickettsial endosymbiont Wolbac

5 The life expectancy of adult O. volvulus is reduced by approximately 50% and 70% afte

6 tonophoric activity was capable of affecting O. volvulus L3 molting and that the presence of both act

7 TLR4-mutant mice were immunized against O. volvulus with irradiated third-stage larvae, and it w

8 ding of an existing drug with impact against O. volvulus provides promise in the hunt for new therapi

9 ment of a protective immune response against O. volvulus in TLR4-mutant mice is not due to loss of Th

10 e colony-stimulating factor responses to all O. volvulus antigens unrelated to age.

11 by endosymbiotic Wolbachia in B. malayi and O. volvulus filaria are dependent on TLR2-TLR6 interacti

12 NETs and neutrophils were visualised around O. volvulus in nodules excised from untreated patients b

13 d with responses in 43 subjects with chronic O. volvulus infections.

14 ed immune response, the effect of concurrent O. volvulus infection on the immune response to tetanus

15 We describe O. volvulus genome variation in 27 isolates from the ear

16 reduction in the percentage of adult female O. volvulus positive for Wolbachia) is 91%-94% on averag

17 enzymes that are likely to be essential for O. volvulus viability.

18 negative for Mf: 16 (57%) were positive for O. volvulus DNA in the PCR-based assay.

19 xhibits high sensitivity and specificity for O. volvulus infection, and has great potential as a tool

20 aneously, and a soluble antigen extract from O. volvulus adult worms (OvAg) was injected into the cor

21 ransmitter-derived secretion metabolite from O. volvulus.

22 Importantly, the chitinase OvCHT1 from O. volvulus was recently discovered, however, its exact

23 ctive antitetanus response, although heavier O. volvulus infections are able to alter the magnitude o

24 In O. volvulus adult worms the Ov-SPI proteins are localize

25 Conversely, expression of ICAM-1 in O. volvulus-mediated keratitis was significantly reduced

26 To examine the role of IFN-gamma in O. volvulus keratitis, C57BL/6 and IFN-gamma(-/-) mice w

27 lso been found to be critical for molting in O. volvulus L3 larvae.

28 Targeting the Wolbachia in O. volvulus is effective in clearing microfilariae in th

29 esponse, and concurrent helminth infections (O. volvulus and intestinal helminths) may alter TT-speci

30 d for adaptive protective immunity to larval O. volvulus in mice.

31 o the corneal stroma, and that TLR2 mediates O. volvulus/Wolbachia-induced neutrophil activation and

32 for a better understanding of the biology of O. volvulus as well as for the identification of novel t

33 Here, we describe the chromosomes of O. volvulus and its Wolbachia endosymbiont.

34 is of the expressed sequence tag datasets of O. volvulus and other filariae identified four other mem

35 activation, we injected a soluble extract of O. volvulus containing Wolbachia bacteria into the corne

36 While the serum levels of O. volvulus-specific immunoglobulin G (IgG), IgG subclas

37 found also to completely inhibit molting of O. volvulus infective L3 stage larvae.

38 a humped pattern with host age, patterns of O. volvulus infection vary markedly with locality.

39 O. ochengi is the closest extant relative of O. volvulus and shares several key natural history trait

40 arasite representing the closest relative of O. volvulus.

41 tive immune response to the larval stages of O. volvulus in mice immunized with irradiated larvae.

42 nses to adult and infective larval stages of O. volvulus which are age related are consistent with th

43 ve, cytokine, and antibody response to TT of O. volvulus-infected subjects (n = 19) and comparable no

44 pact of each of its biological activities on O. volvulus L3 molting was investigated.

45 corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely

46 Other O. volvulus genes showed homology only to predicted gene

47 s (L3 and a recombinant L3-specific protein, O. volvulus ALT-1) which were significantly increased or

48 improved the specificity for cross-reactive O. volvulus patient sera (100% sensitivity and 100% spec

49 by antibodies directed against a recombinant O. volvulus L3 cysteine protease that was cloned and exp

50 Both recombinant O. volvulus and C. elegans cyclophilins were found to po

51 al ivermectin treatment in Ghana has reduced O. volvulus microfilarial intensity and prevalence, but

52 iving an intrastromal injection of a soluble O. volvulus extract.

53 tion and intracorneal injection with soluble O. volvulus Ags (OvAg), and that the inflammatory respon

54 sly and injected intrastromally with soluble O. volvulus antigens.

55 dicate that CD4(+) T cells mediate sustained O. volvulus keratitis by regulating eosinophil recruitme

56 e assays with fluorescent peptides show that O. volvulus blisterase requires a P4 arginine and a basi

57 Stratification of the O. volvulus-infected group into two groups representing

58 To determine whether in utero exposure to O. volvulus biases a child's subsequent immune responses

59 Thus, in utero exposure to O. volvulus has a long-term effect on the child's subseq

60 with age (equivalent to years of exposure to O. volvulus).

61 ore hypothesized that protective immunity to O. volvulus would not develop in C3H/HeJ mice which have

62 s capable of inducing protective immunity to O. volvulus.

63 ased significantly with age, although not to O. volvulus ALT-1, which may have unique L3-specific epi

64 hat may render the child more susceptible to O. volvulus infection postnatally.

65 Our results demonstrate that NATOG tracks O. volvulus metabolism in both worms and humans, and thu

66 but a small number of patients infected with O. volvulus, M. perstans, or W. bancrofti showed positiv

67 inal punch' to knockout human infection with O. volvulus altogether.

68 dies indicate that concurrent infection with O. volvulus can diminish the immune response to an unrel

69 ings indicate that concurrent infection with O. volvulus does not prevent the development of a protec

70 the individual level, between infection with O. volvulus microfilariae and bilateral blindness was ex