ライフサイエンスコーパス: OMP

1 OMP islands were distributed throughout the cell and con

2 OMPs are implicated in the maintenance of cell envelope

3 OMPs clustered to form approximately 0.5-mum diameter is

4 ve OMPs from the avian strain genome and 107 OMPs from the porcine strain genome with 83% overlap bet

5 ns serovar Copenhageni strain Fiocruz L1-130 OMP microarray containing all predicted lipoproteins and

6 stigated the transformation mechanisms of 20 OMPs during the methanogenic step of AD with a focus on

7 tral subunit of the BAM complex, accelerates OMP folding by lowering the kinetic barrier imposed by p

8 In the presence of activating OMP peptides, peptides corresponding to a region of CupB

9 gher cross-reactive immune responses against OMPs isolated from S. Choleraesuis and S. Enteritidis.

10 Moreover, the CupB5 peptide allowed OMP-activated AlgW cleavage of MucA in the presence of t

11 ight suggest the possibility of its being an OMP.

12 -depth characterization of methylation of an OMP at the molecular level and may lead to uncovering th

13 er membrane as well as the TM residues of an OMP determine its functional fold in vivo.

14 sults suggest that the folding process of an OMP is driven by the lipid-facing residues in its hydrop

15 Analysis of an OMP with a domain structure similar to that of LptD, Fhu

16 The TAM also consists of an OMP, designated TamA, and a single inner membrane (IM) p

17 These results reveal that OSNs undergo an OMP-dependent functional maturation process that coincid

18 in of BamA improve both bacterial growth and OMP biogenesis in a bamB bamE mutant and restore BamA le

19 A. baumannii infection, but monoclonal anti-OMP antibodies have not been developed, and their potent

20 the Wnt pathway with a monoclonal antibody, OMP-18R5.

21 ach is fast, efficient and applicable to any OMP.

22 At all ages studied, few VNNE cells are OMP reactive as view in coronal sections.

23 expand our earlier finding that few VSNs are OMP (+) in Saguinus geoffroyi to other species of the ge

24 Using fluorescent colicins as OMP-specific probes, in combination with ensemble and si

25 We use OMPBioM to assess OMP biogenesis mathematically in a global manner.

26 aid in the secretion of virulence-associated OMPs.

27 In the BamA(DeltaR44, A18S) background, OMP biogenesis improved dramatically, and this correlate

28 class of dual function, bipartite bacterial OMP.

29 vestigating the folding of several bacterial OMPs using membranes with naturally occurring Escherichi

30 cherichia coli, BamA is the core beta-barrel OMP and, together with four outer membrane lipoproteins,

31 ts expressing either a defective beta-barrel OMP assembly machinery (Bam) or assembly defective beta-

32 regulon in the event of aberrant beta-barrel OMP assembly, the expression of cpxP, the archetypal mem

33 velope stress caused by aberrant beta-barrel OMP assembly, with the Cpx regulon principally contribut

34 e of Delta cpxR in mutant Bam or beta-barrel OMP backgrounds was reversed by wild type DegP expressed

35 rotein complex consisting of the beta-barrel OMP BamA and lipoproteins BamB, -C, -D, and -E.

36 the Cpx regulon in the event of beta-barrel OMP mis-assembly, by utilizing mutants expressing either

37 sing a single assembly-defective beta-barrel OMP species.

38 to this process is the conserved beta-barrel OMP that belongs to the Omp85 superfamily.

39 ist folding and assembly of most beta-barrel OMPs except for TolC, which folds into a unique soluble

40 lowed by the archetypal trimeric beta-barrel OMPs, OmpF and LamB, and is dependent on POTRA 1.

41 nery (Bam) or assembly defective beta-barrel OMPs.

42 e subjected to degradation, but also because OMPs that assemble slowly can form dominant-negative int

43 ons, we established the mechanism for binary OMP partitioning.

44 Here, we provide evidence that the borrelial OMP P66, a known adhesin with pore-forming activity, for

45 en of the nasal airway was positive for both OMP and the disease-specific isoform of the prion protei

46 e in the OMPs and greater divergence in both OMP sequences and the encoding locus structure between t

47 atment that leads to apoptosis of ORNs, both OMP and prion proteins were present in nasal lavage samp

48 c antibodies are borreliacidal and that both OMPs are immunogenic during nonhuman primate infection.

49 verall similarity, it is plausible that both OMPs have similar or overlapping functions in this patho

50 chanism for allosteric activation of DegS by OMP-peptide binding.

51 e complex folding environment encountered by OMPs in the periplasm and demonstrate the key role of Sk

52 K (TP0897), an extensively studied candidate OMP, and TP0136, a lipoprotein recently reported to be s

53 el assembly machinery (BAM), which catalyzes OMP insertion into the outer membrane.

54 ically necessary for the assembly of certain OMPs.

55 e of the beta barrel of the Escherichia coli OMPs OmpLA and EspP creates an energy barrier that imped

56 Here we compared OMP (+) VSN density in five species of Saguinus (a genus

57 and deletion mutants revealed two competing OMP assembly pathways, one of which is followed by the a

58 tissue specific knock-out mouse by crossing OMP-Cre transgenic mice to Ric-8b floxed mice.

59 outer membrane localization and discriminate OMPs by structure or function.

60 Thus, the complexes of these OPRTs distort OMP part of the way toward the transition state.

61 ust be precisely aligned to ensure efficient OMP insertion.

62 ole for Skp in the assembly of the essential OMP LptD.

63 ertion in clusters, driving the pre-existing OMP clusters towards cell poles for long-term storage.

64 OMP) deposition and the fate of pre-existing OMPs are still enigmatic despite numerous concerted effo

65 hat antibiotic resistant bacteria expressing OMP TolC could spread more widely within sandy aquifers.

66 parallel chaperone pathways that facilitate OMP assembly.

67 If primates with relatively few OMP (+) VSNs have a functional vomeronasal system, OMP i

68 facilitate the transfer of partially folded OMPs to the soluble POTRA (polypeptide-transport-associa

69 imeric protein encapsulates partially folded OMPs, protecting them from the aqueous environment until

70 ntities of 86.4% for Tr1, 45.9% to 46.3% for OMP-1X, and 55.0% to 56.9% for P44/Msp2.

71 ce identities of 73.1% for Tr1/Tr, 39.8% for OMP-1X/OMP1, and 41.5% to 42.1% for P44/Msp2.

72 inery, the previously identified complex for OMP assembly.

73 the conserved RGF residues are critical for OMP biogenesis.

74 The C1' distortion for OMP happens in two steps, half upon binding and half on

75 tide transport-associated (POTRA) domain for OMP reception and assembly.

76 l outer membrane protein (OMP) essential for OMP biogenesis.

77 uter membrane-based lipoprotein required for OMP assembly.

78 here the molecular features responsible for OMP targeting to the mycomembrane of Corynebacterium glu

79 eting to the mycomembrane and sufficient for OMP assembly into mycolic acid-containing lipid bilayers

80 TM site sequence analysis from C. glutamicum OMP and other O-acylated proteins in bacteria and eukary

81 As the [1'-(3)H]OMP k(cat)/K(m) KIEs are approximately 1.20, half of the

82 Other secretion systems have OMP components which use transmembrane alpha-helices and

83 Most Hop and Hom OMPs were susceptible to proteolysis, whereas Hor and Ho

84 model for BamA function, which explains how OMP assembly can be conserved between prokaryotes and eu

85 d this organization lies at the heart of how OMPs are turned over in the membrane.

86 However, OMP biogenesis occurred as a gradient that was highest a

87 y, BamA beta-barrel alterations also improve OMP biogenesis in cells lacking the major periplasmic ch

88 In contrast, in OMP knock-out mice, odorant exposure reduced the number

89 zymes of the AD process are also involved in OMP biotransformation.

90 amA to the outer membrane and is involved in OMP insertion.

91 Methylation in OMP remains poorly understood.

92 t specificity in this adaptive plasticity in OMP knock-out mice suggests a potential role for this pr

93 FhaC counterpart, play an important role in OMP and/or BamA biogenesis.

94 bserved may correspond to distinct stages in OMP assembly.

95 to require a consensus C-terminal signal in OMPs characterized by terminal F or W residues.

96 Last, OMP also steepens the dose-response relation to improve

97 screen for interactions between leptospiral OMPs and fibronectin (Fn).

98 by utilizing two transgenic reporter lines: OMP-ZsGreen mice which express bright green fluorescent

99 in vitro folding kinetics observed for many OMPs.

100 ermodynamic and kinetic parameters maximizes OMP folding flux and minimizes aggregation and unnecessa

101 trations of several organic micropollutants (OMPs) in sewage sludge.

102 wever, a Deltaskp mutant displays only minor OMP assembly defects, and no OMPs have been shown to req

103 resulted in the accumulation of misassembled OMPs.

104 We examined the features of misfolded OMPs with respect to their ability to generate envelope

105 complex, on the folding kinetics of a model OMP (tOmpA) using fluorescence spectroscopy, native mass

106 atural substrate orotidine 5'-monophosphate (OMP) for orotidine 5'-monophosphate decarboxylase (OMPDC

107 carboxylation of orotidine 5'-monophosphate (OMP) in 50/50 (v/v) HOH/DOD catalyzed by orotidine 5'-mo

108 ions of [1'-(3)H]orotidine 5'-monophosphate (OMP) with the catalytic sites of Plasmodium falciparum a

109 Moreover, OMP speeds up signal transduction for ORNs to better syn

110 Moreover, OMPs, previously known only to activate DegS, also gener

111 k can also be extended to the synthesis of N-OMP/SiO2 nanocomposites, mesoporous SiO2 , crystalline m

112 itrogen-doped ordered mesoporous polymers (N-OMPs) is developed, which is realized by mixing polymer

113 The synthesized N-OMPs and their derived catalysts are found to exhibit co

114 barrel and promote insertion of the nascent OMP.

115 um with sequence homology to a Gram-negative OMP, belongs to the BamA family of proteins essential fo

116 data from previous reports, however, neither OMP was found to bind human factor H or to be required f

117 regions as the primary entry points for new OMP insertion in clusters, driving the pre-existing OMP

118 splaced to the poles of growing cells as new OMPs take their place.

119 lays only minor OMP assembly defects, and no OMPs have been shown to require Skp for their assembly.

120 cal control over the spontaneously occurring OMP folding reaction in the periplasm.

121 the transition state for decarboxylation of OMP provided by OMPDC represents the sum of 11.8 and 10.

122 (obs) for OMPDC-catalyzed decarboxylation of OMP, and the 4 kcal/mol of binding energy, which is util

123 The density of OMP (+) vomeronasal sensory neurons (VSNs) in the VNNE w

124 g., owl monkey) had a similar low density of OMP (+) VSNs as in Saguinus.

125 his research, we investigated the effects of OMP TolC on E. coli transport within saturated sands thr

126 l intrinsic phosphodianion binding energy of OMP is divided between the 8 kcal/mol of binding energy,

127 Lack of OMP increases basal cAMP, thus abolishing differences in

128 Our sample indicates that the number of OMP (+) VSNs in primates varies from ubiquitous to few w

129 ent to this loop, with the phosphodianion of OMP was probed by determining the kinetic parameters k(c

130 The process of OMP biogenesis has been studied in vivo, and each of its

131 The kinetic retardation of OMP folding places a strong negative pressure against sp

132 The scarcity of OMP (+) cells in some primate VNOs reflects a lower numb

133 C1' distortion at the TS is equal to that of OMP.

134 In sum, OMPBioM provides a global view of OMP biogenesis that yields unique insights into this ess

135 urce and the high stability and abundance of OMPs.

136 ch the Bam complex catalyzes the assembly of OMPs is not known.

137 lex has been implicated in the biogenesis of OMPs.

138 rm bacteria assist in assembly and export of OMPs.

139 ressure against spontaneous incorporation of OMPs into inner bacterial membranes, which would dissipa

140 am complex, which catalyses the insertion of OMPs in the outer membrane.

141 mer that catalyzes the membrane insertion of OMPs.

142 Given its role in the production of OMPs for survival and pathogenesis, BAM represents an at

143 oducts and to foster the complete removal of OMPs via operational strategies, remain unclear.

144 The identification of this core set of OMPs is consistent with the hypothesis that "subdominant

145 etermined by the differential stabilities of OMPs in the asymmetrical outer membrane.

146 The cumulative effect is to push old OMP islands towards the poles of growing cells, leading

147 e passive and binary in nature, in which old OMPs are displaced to the poles of growing cells as new

148 ; and 4) periodontal disease followed by OM (OMP).

149 Despite extensive studies on OMP biogenesis, it is unclear why OMPs require assembly

150 This role may be compensated for by other OMP assembly proteins; in the absence of both Skp and Fk

151 le with mutations in genes that encode other OMP assembly factors leads to severe synthetic phenotype

152 Other OMPs, including LamB, are less affected in the Deltaskp

153 icted by promiscuous interactions with other OMPs.

154 ne-embedded BamA beta-barrel domain overcome OMP biogenesis defects that occur at the POTRA domain of

155 ms Visual oligonucleotide modeling platform (OMP) and ThermoBLAST.

156 the membrane, the ability of Skp to prevent OMP aggregation was investigated.

157 key role of Skp in holding aggregation-prone OMPs prior to their direct or indirect delivery to the m

158 earance of mature, olfactory marker protein (OMP) (+) olfactory neurons as compared to empty vector.

159 ledge, we examined olfactory marker protein (OMP) expression in a sample of twenty-three non-human pr

160 We found that olfactory marker protein (OMP), a protein expressed in mature ORNs, controls both

161 terozygous for the olfactory marker protein (OMP), this adaptive plasticity was strongest in the popu

162 enetic ablation of olfactory marker protein (OMP), which is exclusively expressed in mature OSNs.

163 sotoxic treatment, olfactory marker protein (OMP), which is specific for ORNs, was not detected in na

164 mediates beta-barrel outer membrane protein (OMP) assembly.

165 Borrelia burgdorferi outer membrane protein (OMP) BB0406 and found that the gene encoding this OMP wa

166 a severe beta-barrel outer membrane protein (OMP) biogenesis defect.

167 Outer membrane protein (OMP) biogenesis is critical to bacterial physiology beca

168 ssential beta-barrel outer membrane protein (OMP) biogenesis machinery in Gram-negative bacteria, chl

169 rily for its role in outer membrane protein (OMP) biogenesis, during which the jellyfish-like trimeri

170 The sites of new outer membrane protein (OMP) deposition and the fate of pre-existing OMPs are st

171 of BamA, an integral outer membrane protein (OMP) essential for OMP biogenesis.

172 The outer membrane protein (OMP) from Neisseria meninigitidis, PorB, is a naturally

173 olyticus isolates by outer membrane protein (OMP) P6 gene sequencing is complicated by sequence varia

174 The outer membrane protein (OMP) TolC is the cell surface component of several drug

175 Two outer membrane protein (OMP) transport systems in diderm bacteria assist in asse

176 s (p44ES/msp2ES) and outer membrane protein (OMP), using DNA isolated from the blood of four naturall

177 on of three putative outer membrane protein (OMP)-encoding genes.

178 alyze methylation of outer membrane protein (OMP).

179 Efficient OM protein (OMP) folding and insertion appears to require a consensu

180 ists in complexes with beta-barrel proteins (OMPs) allowing it to adopt a transmembrane orientation w

181 ntegral outer membrane beta-barrel proteins (OMPs) are assembled by the beta-barrel assembly machine

182 Outer membrane beta-barrel proteins (OMPs) are crucial for numerous cellular processes in pro

183 ntegral outer membrane beta-barrel proteins (OMPs) by a protein machine called the Bam complex.

184 gion of outer membrane beta-barrel proteins (OMPs) by combining an empirical energy function with a r

185 stress, unassembled outer-membrane proteins (OMPs) accumulate in the periplasm and their C-terminal p

186 nces in unassembled outer-membrane proteins (OMPs) activate the AlgW protease, and unassembled lipopo

187 two key components, outer membrane proteins (OMPs) and lipopolysaccharide (LPS) and by transcribing s

188 d TprI as candidate outer membrane proteins (OMPs) and subsequently demonstrated that TprC is not onl

189 beta-Barrel outer membrane proteins (OMPs) are found in the outer membranes of Gram-negative

190 Misfolded outer membrane proteins (OMPs) are typically recognized by the sigma(E) pathway,

191 in the assembly of outer membrane proteins (OMPs) because its absence resulted in the accumulation o

192 lmost all bacterial outer membrane proteins (OMPs) contain a beta barrel domain that serves as a memb

193 nteractions involve outer membrane proteins (OMPs) expressed on the bacterial surface.

194 ariety of dedicated outer membrane proteins (OMPs) facilitate this process.

195 pneumoniae, and to outer membrane proteins (OMPs) from Salmonella.

196 onema pallidum rare outer membrane proteins (OMPs) has been a longstanding objective of syphilis rese

197 onema pallidum rare outer membrane proteins (OMPs) has long eluded researchers.

198 antisera targeting outer membrane proteins (OMPs) have shown encouraging results in protecting mice

199 in the assembly of outer membrane proteins (OMPs) in Escherichia coli.

200 The biogenesis of outer-membrane proteins (OMPs) in gram-negative bacteria involves delivery by per

201 g and assembling of outer membrane proteins (OMPs) in Gram-negative bacteria.

202 esis of beta-barrel outer membrane proteins (OMPs) in Gram-negative bacteria.

203 tion of beta-barrel outer membrane proteins (OMPs) into the outer membrane of Gram-negative bacteria.

204 containing integral outer membrane proteins (OMPs) into the outer membrane.

205 of the beta-barrel outer membrane proteins (OMPs) is an essential cellular process in Gram-negative

206 Outer membrane proteins (OMPs) of Pasteurella multocida have various functions re

207 ogs predicted to be outer membrane proteins (OMPs) revealed that seven have an Msp-like bipartite str

208 (OmpA) are dominant outer membrane proteins (OMPs) that are released by gram-negative bacteria during

209 d chloroplasts have outer membrane proteins (OMPs) that perform many fundamental biological processes

210 ment of beta-barrel outer membrane proteins (OMPs) to enable adaptation to a particular habitat.

211 eract with unfolded outer membrane proteins (OMPs) to promote correct folding and membrane insertion

212 predicted to encode outer membrane proteins (OMPs), but there has been relatively little experimental

213 lymphocytes via two outer membrane proteins (OMPs), Fap2 and RadD, which share regions homologous to

214 c acids and unusual outer membrane proteins (OMPs), including those with alpha-helical structure.

215 In the case of outer-membrane proteins (OMPs), unfolded-state properties are of particular physi

216 mbly of beta-barrel outer membrane proteins (OMPs).

217 esis of beta-barrel outer membrane proteins (OMPs).

218 and metabolism and outer membrane proteins (OMPs).

219 beta-barrel-forming outer membrane proteins (OMPs): (i) surface labeling with anti-lipoidal (VDRL) an

220 During their biogenesis, OM proteins (OMPs), which function as transporters and receptors, mus

221 atively low density of integral OM proteins (OMPs).

222 accharide [LPS] and outer membrane proteins [OMPs]).

223 ta-barrel proteins (outer-membrane proteins, OMPs) assembled into an asymmetrical lipid bilayer.

224 were able to confidently predict 98 putative OMPs from the avian strain genome and 107 OMPs from the

225 lipoprotein predictors) to identify putative OMPs from two available P. multocida genomes: those of a

226 s study has increased the number of putative OMPs identified in P. multocida and allowed these OMPs t

227 ly demonstrated that TprC is not only a rare OMP but also forms trimers and has porin activity.

228 a, we conclude that TprC is a bona fide rare OMP as well as a functional ortholog of Escherichia coli

229 we generated ranked groups of candidate rare OMPs, the predicted T. pallidum outer membrane proteome

230 o generate ranked clusters of candidate rare OMPs.

231 ese mutations we demonstrate that these RcsF/OMP complexes are required for sensing OM outer leaflet

232 t those that relieve the steric clash reduce OMP activation dramatically.

233 Yet no mechanism is known for replacing OMPs in the outer membrane, an issue that is further con

234 this step accounts for much of the reported OMP biotransformation in AD.

235 n, for mycomembrane-associated and -secreted OMPs.

236 Our results showed OMP TolC could significantly enhance the transport of E.

237 stochastic methods, we are able to simulate OMP biogenesis under varying genetic conditions, each of

238 ly increasing the folding efficiency of some OMPs in vivo and in vitro.

239 Few membrane-spanning OMPs of B. burgdorferi have been definitively identified

240 least for the assembly of a small 8-stranded OMP in vitro.

241 C-catalyzed reactions of the whole substrate OMP and the substrate pieces (1-beta-D-erythrofuranosyl)

242 the barrel lumen, which indicates substrate OMPs may not be threaded through the barrel during bioge

243 lex then catalyzes the assembly of substrate OMPs and BamA.

244 e N-terminal domains of protease-susceptible OMPs are exported through an autotransporter pathway.

245 Most of the protease-susceptible OMPs contain a large protease-susceptible extracellular

246 facilitate integration of newly synthesized OMPs into the outer membrane.

247 A synthetic OMP-1X peptide was shown to react with A. platys-positiv

248 ) VSNs have a functional vomeronasal system, OMP is not critical for stimulus detection.

249 We conclude that OMP plays a key regulatory role in ORN physiology by con

250 Here, we show that OMP peptides initiate a steric clash between the PDZ dom

251 Our results suggest that OMP assembly machineries are required in vivo to enable

252 We observe that OMPs have a prolonged lifetime in the periplasm where an

253 The OMP group had lower BVF and BMD levels compared to the o

254 essential components of this complex are the OMP BamA [which contains a carboxyl-terminal beta-barrel

255 dies are required to refine conclusions, the OMP's chemical structure was a determinant for AK action

256 iated by a protein complex that contains the OMP BamA and four associated lipoproteins (BamBCDE).

257 regulate the conformation of BamA during the OMP assembly reaction.

258 was cotranscribed with the gene encoding the OMP BB0405.

259 ession of both cytokines was observed in the OMP group at day 1 (P <0.05).

260 beta and TNF-alpha by IHC was highest in the OMP group at day 1, with progressive reduction thereafte

261 The BAM complex consists of the OMP component BamA along with several outer membrane ass

262 us, our findings suggest that opening of the OMP via interaction with the MFP is energy-independent,

263 n of signaling proteins underlie some of the OMP(-/-) phenotypes.

264 Skp and SurA, on the folding kinetics of the OMP, PagP.

265 exes without inactivating either RcsF or the OMP.

266 In the comparative sample, the OMP (+) VSNs appear to be far more numerous in the spide

267 The OMPs bound by live vaccine-induced antibody overlapped w

268 The OMPs in Gram-negative bacteria are inserted and folded i

269 was significantly greater divergence in the OMPs and greater divergence in both OMP sequences and th

270 obial polypeptides were determined for these OMP gene deletion mutants.

271 The ability of these OMP gene deletion mutants to induce immune responses was

272 identified in P. multocida and allowed these OMPs to be identified with a higher degree of confidence

273 Here, we characterize the roles of these OMPs in pathogenesis during bacteremia caused by Klebsie

274 BB0406 and found that the gene encoding this OMP was cotranscribed with the gene encoding the OMP BB0

275 orin and integrin-binding activities of this OMP as they relate to B. burgdorferi physiology and Lyme

276 erol head groups impose a kinetic barrier to OMP folding.

277 of the deduced amino acid sequences of Tr1, OMP-1X, and P44/Msp2 proteins from A. platys with those

278 Translated OMP P6 gene sequences are not conserved among all isolat

279 all predicted lipoproteins and transmembrane OMPs.

280 ies established that inactivation of the two OMPs led to significantly reduced ability to trigger cel

281 all RNAs to down-regulate excess unassembled OMPs.

282 nly when activated by binding to unassembled OMPs.

283 Here we uncover the process underpinning OMP turnover in E. coli and show it to be passive and bi

284 lifetime in the periplasm where an unfolded OMP makes, on average, hundreds of short-lived interacti

285 minal consensus sequence or binding unfolded OMP intermediates.

286 for entropically favored binding of unfolded OMPs to chaperones and, by facilitating conformational s

287 It has been shown to interact with unfolded OMPs, and the simultaneous loss of Skp and the main peri

288 are disfavored not only because unintegrated OMPs are subjected to degradation, but also because OMPs

289 sp(2) geometry of the transition states upon OMP binding.

290 ed on the NA gene signatures, we used Visual-OMP to design primers with optimal hybridization affinit

291 To better understand the mechanisms by which OMP precursors were sorted in C. glutamicum, we first in

292 mmon structural features may determine which OMPs require Skp for their assembly.

293 ype pups prefer the biological mother, while OMP knock-out pups fail to show preference.

294 studies on OMP biogenesis, it is unclear why OMPs require assembly machineries to fold into their nat

295 d the conformational changes associated with OMP folding and insertion.

296 ly that BamA and BamD interact directly with OMP substrates.

297 Finally, we targeted the Wnt pathway with OMP-18R5, a therapeutic antibody that interacts with mul

298 ients for the wild-type E. coli strain (with OMP TolC) was usually >50% lower than those of the tolC-

299 s using a wild-type E. coli K12 strain (with OMP TolC), as well as the corresponding transposon mutan

300 ive vaccine-induced antibody overlapped with OMPs that were immunogenic in animals vaccinated with in