ライフサイエンスコーパス: ORF

1 ORF translation rate is strongly correlated with its mRN

2 aining 2,692 synonymous mutations in 9 of 11 ORFs did not lose temperature sensitivity, remained gene

3 ilisk has an unrelated genome containing 138 ORFs.

4 FH4 was 16 233 bp in length and contained 16 ORFs.

5 rent pXO1 plasmid (having 181,677 bp and 217 ORFs) is extremely stable under the same growth conditio

6 ained 217 open reading frames (ORFs) and 220 ORFs, respectively, while Basilisk has an unrelated geno

7 dependent secreted proteins among the 35,286 ORFs of the P. helianthi transcriptome.

8 e identified for the majority of the SHFV 3' ORFs, and four previously identified TRSs were found not

9 open reading frame (ORF; approximately 5,300 ORFs) to induce heritable traits.

10 R34 (medium-reiteration-frequency-family-34) ORF], with unprecedented characteristics, because it is

11 mRNAs encoding E', GP2, or ORF5a as their 5' ORF as well as sg mRNAs encoding six previously unreport

12 Segment 5, ORF 1 of the infectious salmon anemia virus (ISAV) genom

13 e exclusion of samples carrying chromosome 9 ORF 72 (C9orf72) repeat expansions.

14 908 ORFs (accounting for 2.6% of the total proteins) were id

15 ARS-CoV designated as open reading frame-9b (ORF-9b) localizes to mitochondria and causes mitochondri

16 erplay of the fluorophore photon absorption, ORF emission, RRS, and solvent Rayleigh scattering.

17 nits of secondary structure that vary across ORF boundaries such that adjacent ORFs on the same mRNA

18 ipts contain multiple translationally active ORFs, and also that most isoforms contain unique combina

19 e NFR nucleosomes without effect on adjacent ORF nucleosomes.

20 ary across ORF boundaries such that adjacent ORFs on the same mRNA molecule are structurally distinct

21 ntly higher rates than genotype 1 across all ORFs.

22 Min B (G and F), Min L (L), and Min FLC (all ORFs except M2-1 and M2-2).

23 e designed primers and probe did not amplify ORF of the E genes for some closely related and more pat

24 and translation, to produce what we call an ORF (open reading frame) graph.

25 ped hamster hypothalamus, which contained an ORF of 570 bp encoding two RFamide-related peptide (RFRP

26 is: insertion of iterated AAA codons into an ORF diminishes protein expression more than insertion of

27 as novel candidate adaptors together with an ORF factor designated as regulator of human erythroid ce

28 rt ORFs, each of which was located within an ORF ("ORF-within-ORF"), including one not previously rec

29 ORFs shorter than approximately 590 nt, and ORFs for which the total time required to complete elong

30 coprotein E (ORF68), we identified antigenic ORFs that may be useful components of subunit vaccines.

31 , we showed that the conservation of the ASP ORF in the group M could not be due to chance.

32 We found that the ASP ORF is specific to group M of HIV-1, which is responsibl

33 In total, 223 dockerin-bearing ORFs potentially involved in cellulosome assembly and a

34 t study reported that the protein encoded by ORF CT009 interacts with MreB despite low sequence simil

35 tase or hexanucleotide expansion in C9orf72 (ORF 72 on chromosome 9) the two most frequent causes of

36 tream open reading frames (uORFs), canonical ORFs shorter than approximately 590 nt, and ORFs for whi

37 panning the viral protease, RdRP, and capsid ORFs and isolated individual recombinant RNA genomes tha

38 oding exons and encode truncated or chimeric ORFs translated into products with predicted abnormal or

39 come the limitations associated with cloning ORFs from a genome that remains incompletely annotated,

40 hat represses translation of the main coding ORF under normal conditions.

41 s, they maintained translationally competent ORFs, involving elements of gag, pol, env, rev, and nef

42 The complete ORF tree diverged into two main branches from a common a

43 gain or abolish stop codons also complicates ORF-based prediction of lncRNAs.

44 Consequently, ORF 12 and 13 protein expression was abolished and Akt p

45 entifying in both genomes numerous conserved ORFs not included in the published annotation of coding

46 all three ILEs, the first 5.1 kb (containing ORFs 1-4) were structurally conserved and contained thre

47 These results indicate that SARS-CoV ORF-9b manipulates host cell mitochondria and mitochondr

48 Aberrant expression of the D4Z4 ORF called DUX4 is associated with the pathogenesis of F

49 Phylogenetic and plasmid-derived ORF analyses showed that the majority of plasmid DNAs or

50 Here we provide our streamlined double ORF expression (pDOE) BiFC system, and show that our adv

51 ons is low, then an AUG-initiated downstream ORF prevents the generation of shorter, AUG-initiated is

52 or transcript containing mccA and downstream ORFs.

53 The identified ESE at the E1^E4 ORF promotes HPV18 929^3434 splicing of both viral early

54 F) prevents HPV18 233^416 splicing in the E6 ORF through interaction with a host splicing factor, hnR

55 ultimately specifies the translation of each ORF.

56 A, was tolerated when introduced into either ORF within the intragenomic replicon, but unlike many ot

57 In SPFMV these two extra ORFs are preceded by conserved G2A6 motifs.

58 n conclusion, SCD patients with the FCGR2Cnc-ORF polymorphism have over a 3-fold lower risk for RBC a

59 on on fluorophore on-resonance fluorescence (ORF) and resonance Rayleigh scattering (RRS) is limited

60 on scattering and on-resonance fluorescence (ORF).

61 thematical model for calculating fluorophore ORF and scattering cross sections has been developed tha

62 fundamental parameters including fluorophore ORF cross sections and quantum yields have been quantifi

63 large-scale systematic study on fluorophore ORF and RRS using the conventional UV-vis extinction and

64 e experimental separation of the fluorophore ORF and photon scattering features in the fluorophore re

65 lytical methods that exploit the fluorophore ORF and photon scattering properties.

66 Another finding is that the fluorophore ORF has a depolarization close to 1, while its Rayleigh

67 six previously unreported alternative frame ORFs or 14 previously unreported C-terminal ORFs of know

68 y in containing an extra open reading frame (ORF) (named ORFX), between ORF6 and ORF7, which has no h

69 d a 2,158-bp deletion in open reading frame (ORF) 12.

70 cleocapsid (N) gene, and open reading frame (ORF) 1a.

71 targeted E-cadherin mRNA open reading frame (ORF) and suppressed E-cadherin protein expression.

72 tomegalovirus (CMV) UL11 open reading frame (ORF) encodes a putative type I transmembrane glycoprotei

73 e approximately 1,100 bp open reading frame (ORF) encoding the envelope proteins is fully nested with

74 d RRV26-95, although the open reading frame (ORF) encoding the KSHV ORFK15 homolog was disrupted in R

75 DNA encoding the open reading frame (ORF) for CFTR containing synonymous codon replacements w

76 findings that the entire open reading frame (ORF) for the large (L) envelope protein that is essentia

77 (TCV) coat protein (CP) open reading frame (ORF) has been found to promote internal expression of th

78 n initiation of the main open reading frame (ORF) in an mRNA transcript has been reported to be regul

79 a cotranscribed upstream open reading frame (ORF) in GBS strain 515 reduced bacterial adherence to VK

80 tains a primate-specific open reading frame (ORF) in the antisense orientation that we named ORF0.

81 ty of the putative BWRF1 open reading frame (ORF) is retained in over 80% of strains, and deletions t

82 The open reading frame (ORF) lengths of TmELO1 and TmELO2 were 1005 bp and 972 b

83 iridae) contains a large open reading frame (ORF) of 3,494 codons translatable as a polyprotein and t

84 of a frameshift into the open reading frame (ORF) of the target gene which truncates the coding seque

85 is encoded by the first open reading frame (ORF) of the viral genome.

86 nd GP130, an overlapping open reading frame (ORF) of unknown function.

87 identified ESS at the E7 open reading frame (ORF) prevents HPV18 233^416 splicing in the E6 ORF throu

88 We report here that open reading frame (ORF) R17 encodes a high-affinity chemokine binding prote

89 in the p38 coat protein open reading frame (ORF) that arose in response to a mutation in the asymmet

90 6 nucleotides of the NSs open reading frame (ORF) were needed to ensure the efficient termination of

91 NCODE lncRNAs acquire an open reading frame (ORF) when their structure is extended with CaptureSeq.

92 deleted the entire US28 open reading frame (ORF), deleted all four of the viral GPCR ORFs, or delete

93 unique variant within an Open Reading Frame (ORF).

94 lades based on the mtDNA open reading frame (ORF).

95 e large tegument protein open reading frame (ORF)64, gained the capacity to stimulate the DNA-activat

96 ability of nearly every open reading frame (ORF; approximately 5,300 ORFs) to induce heritable trait

97 eletion of the gene 9GL (open reading frame [ORF] B119L) in highly virulent ASFV Malawi-Lil-20/1 prod

98 HV-1/EP713 contains two open reading frames (ORF), each encoding an autocatalytic papain-like leader

99 in the overlapping P/C open reading frames (ORFs) (C(Delta170)) or a temperature-sensitive missense

100 nscribed with two novel open reading frames (ORFs) (termed ORF1 and ORF2 herein) conserved only in M.

101 mutations were found in open reading frames (ORFs) 1a, 2, and 6 in the RVRp22 genome based on full-le

102 t baseline included VZV open reading frames (ORFs) 68, 4, 37, and 63.

103 milar and contained 217 open reading frames (ORFs) and 220 ORFs, respectively, while Basilisk has an

104 ks that overlap dubious open reading frames (ORFs) and are likely to include previously unrecognized

105 automatically maintains open reading frames (ORFs) and does not require linkers, adaptors, sequence h

106 lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (l

107 anscription factor (TF) open reading frames (ORFs) cloned into vectors that facilitate easy expressio

108 ed the presence of five open reading frames (ORFs) corresponding to the genes for the N, P, M, G, and

109 can also predict novel open reading frames (ORFs) from regular ribosome profiling (rRibo-seq) data a

110 ) plasmid consisting of open reading frames (ORFs) GBAA_pXO1_0020 to GBAA_pXO1_0023 is not stably mai

111 alf of the 32 annotated open reading frames (ORFs) have no homologs in databases (ORFans), being puta

112 consisting of discrete open reading frames (ORFs) in a single polycistronic mRNA.

113 iliary protein-encoding open reading frames (ORFs) in HTLV-3, the latest HTLV to be discovered, is un

114 We discovered two open reading frames (ORFs) in the 3' end of the rcrQ gene that encode peptide

115 ith unusually divergent open reading frames (ORFs) in the conserved region of rpoA, the gene encoding

116 cription from all eight open reading frames (ORFs) in the terminal repeat was investigated in IgM(+)

117 The open reading frames (ORFs) involved have functions related to host-pathogen i

118 een using a kinome-wide open reading frames (ORFs) library.

119 that were localized in open reading frames (ORFs) likely associated with host cell entry and exit be

120 er, is recruited to the open reading frames (ORFs) of actively transcribed genes genome wide, suggest

121 ion, the protein coding open reading frames (ORFs) of certain individual mRNAs exhibited resistance t

122 ter translation of long open reading frames (ORFs) on cellular mRNAs, reinitiation occurs efficiently

123 Open reading frames (ORFs) orthologous to BHA007 were found on large plasmids

124 ion of products from 27 open reading frames (ORFs) previously designated "predicted," "uncharacterize

125 he formation of altered open reading frames (ORFs) that appear to be under relaxed selection.

126 t cloning of Drosophila open-reading frames (ORFs) that are regulated by upstream activation sequence

127 ries a number of unique open reading frames (ORFs) that have not yet been investigated regarding thei

128 loss of protein-coding open reading frames (ORFs) that progress from individual missense mutations t

129 d up 22 plasmid-derived open reading frames (ORFs) that showed syntenic and copy number variation amo

130 roteins encoded by HCMV open reading frames (ORFs) UL47 and UL48 and identifying the binding domains

131 ates for the individual open reading frames (ORFs) were highest in the regions encoding the attachmen

132 ng 128 unique predicted open reading frames (ORFs), many of which were most closely related to herpes

133 of the 70 annotated VZV open reading frames (ORFs), suggesting that defective virus transcription doe

134 gth and contained eight open reading frames (ORFs), while the ILE from FH4 was 16 233 bp in length an

135 enome with 32 predicted open reading frames (ORFs), YSLV6 has a 24,837-bp genome with 29 predicted OR

136 structural protein (sP) open reading frames (ORFs).

137 r partially overlapping open reading frames (ORFs).

138 ipts with nine distinct open reading frames (ORFs).

139 Each genome encodes 21 open reading frames (ORFs).

140 pping peptides spanning open reading frames [ORFs] 1-3) was used in interferon-gamma (IFN-gamma) T-ce

141 AGI 12) composed of 137 open reading frames [ORFs].

142 ts with ORF54 gene deletions, Delta54L (full ORF deletion) and Delta54S (partial internal deletion).

143 cal ontologies, and a new collection of full ORF cDNAs.

144 sequences of these genes show no functional ORFs, but include segments of different protein coding g

145 me (ORF), deleted all four of the viral GPCR ORFs, or deleted three of the HCMV GPCRs but not the US2

146 ations of possible mutations in rt and HBsAg ORFs.

147 CD8(+) T cell responses to the HCMV ORFs were highly differentiated and predominantly CD45RA

148 N/35 transgenic mice expressing the full HCV ORF.

149 We then show how ORF graphs can be used to produce isoform predictions wi

150 xity, concentration-normalized pool of human ORFs.

151 ons inconsistencies between newly identified ORFs and pre-existing annotations of coding-regions.

152 Overall, our findings strongly implicate ORF-associated RSC in governing Pol II function and in m

153 69PUK1-like pseudogenes with stop codons in ORFs.PUK1orthologs and other pseudogenes also displayed

154 nction, ~9% of the peptides are conserved in ORFs in mouse transcripts, as are 74% of pseudogene pept

155 genomes were designed in which the indicated ORFs were recoded: Min A (NS1, NS2, N, P, M, and SH), Mi

156 Individual ORFs on the mRNA are differentially translated, with rat

157 presence of helicases in the stress-induced ORFs identified by cDNA microarray indicates that helica

158 These data suggest that intrinsic ORF mRNA structure encodes a rough blueprint for transla

159 ence (SPHINX 1.8), with an iteron before its ORF, was evaluated here for its expression in neural cel

160 on is approximately 10-fold smaller than its ORF counterparts for all the six model fluorophores, but

161 ained either wild-type (WT) K1, a deleted K1 ORF (KSHVDeltaK1), stop codons within the K1 ORF (KSHV-K

162 ORF (KSHVDeltaK1), stop codons within the K1 ORF (KSHV-K15xSTOP), or a revertant K1 virus (KSHV-K1REV

163 onymous mutations solely in the polymerase L ORF quickly lost substantial attenuation.

164 erature-sensitive missense mutation in the L ORF (L(Y942A)).

165 potentially deattenuating mutations in the L ORF as well as, surprisingly, many appearing in other OR

166 A Gat1-lacZ ORF swap experiment indicated sequence(s) responsible fo

167 sensu lato have incorporated dozens of large ORFs (putative protein-coding genes).

168 e of retroviral env genes with a full-length ORF.

169 conserved LepB binding motif in colicin-like ORFs from 13 additional bacterial species.

170 ae) contains species with multiple rpoA-like ORFs that show evidence of ongoing inter-paralog gene co

171 PLATO uses ribosome display (RD) to link ORF-derived mRNA molecules to the proteins they encode,

172 ct with an overlapping site early in the lrp ORF, while GcvB acts upstream at two independent sites i

173 ghly abundant transcript containing the mccA ORF and a longer minor transcript containing mccA and do

174 n is induced when ribosome binds to the mccA ORF.

175 domain, resulting from the splicing of MCMV ORFs m131 and m129 MCK-2 is essential for full MCMV infe

176 In this study, the DJ-1 superfamily member ORF 19.251/GLX3 from Candida albicans is shown to posses

177 Also, acting on mitochondria, ORF-9b targets the mitochondrial-associated adaptor mole

178 emature termination codons (PTCs) in an mRNA ORF inactivate gene function by causing production of a

179 reading frame in the FCGR2C gene (FCGR2C.nc-ORF) was strongly associated with a decreased alloimmuni

180 grown in culture as a means to validate non-ORF associated promoters discovered through BbIVET.

181 L2-dsRNA/SsMBV1 comprises two nonoverlapping ORFs (ORFA and ORFB) encoding two hypothetical proteins

182 lated pre-mRNAs, some of which contain novel ORFs, were typically intronless, <2 Kb in length, expres

183 ng amino-acid deprivation and predicts novel ORFs in 5'UTRs, long noncoding RNAs, and introns.

184 These findings suggest that these novel ORFs may play a role in recombination in these two close

185 These novel ORFs, which we name cylc-1 and -2, share sequence homolo

186 dicated that operonic mRNAs are comprised of ORF-wide units of secondary structure that vary across O

187 p29, derived from the N-terminal portion of ORF A, functions as a suppressor of RNA silencing, while

188 p48, derived from the N-terminal portion of ORF B, is required for viral RNA replication.

189 most isoforms contain unique combinations of ORFs.

190 The presence of ORFs encoding auxiliary proteins in HTLV-3 or STLV-3 gen

191 Previous studies have predicted thousands of ORFs in 5'UTRs, the vast majority of which have unknown

192 tion, we detected signatures of selection on ORF 5a and on a small subset of sites in the genome.

193 genome of Tetrahymena thermophila, the only ORF sharing similarities with FARs is fused to an acyltr

194 s, each of which was located within an ORF ("ORF-within-ORF"), including one not previously recognize

195 like many other mutations required the other ORF to express a functional NS3-5B.

196 ll as, surprisingly, many appearing in other ORFs.

197 An essential overlapping ORF, termed pipo, resides in an internal region of the m

198 hrough two (or three) completely overlapping ORFs (shifting to a new reading frame at the end of each

199 nd of the first of two partially overlapping ORFs.

200 eudogene because it contains two overlapping ORFs.

201 Although p15(INK4b) has its own ORF, p16(INK4a) and ARF share common second and third ex

202 st that the second-site mutations in the p38 ORF exert positive effects through a similar downstream

203 ortion of viral transcripts, fusing the pipo ORF in frame with the 5' third of the polyprotein ORF.

204 n an internal region of the main polyprotein ORF.

205 n frame with the 5' third of the polyprotein ORF.

206 LV7 has a 23,193-bp genome with 26 predicted ORFs.

207 LV6 has a 24,837-bp genome with 29 predicted ORFs, and YSLV7 has a 23,193-bp genome with 26 predicted

208 protein translated from a downstream primary ORF (pORF).

209 NAs from PLC/PRF/5 cells, while an L protein ORF that was truncated and fused to inverted precore seq

210 Nidovirales express their structural protein ORFs from a nested set of 3' subgenomic mRNAs (sg mRNAs)

211 RNA polymerase by -1 PRF of the 5'-proximal ORF (p33).

212 hown to contain 132,831 bp with 145 putative ORFs (open reading frames) of at least 50 amino acids.

213 Among these unique ORFs are two putative ORFs, ORF011 and ORF012, which are found at the extreme

214 Downstream of these resided ORFs of the 'variable side' with structural and sequence

215 gion that harbors a short proline codon-rich ORF--termed mgtP--the translation of which is predicted

216 mgtA mRNA contains a 17-codon, proline-rich ORF, mgtL, whose translation regulates the transcription

217 ned to the genes displaying the greatest RSC ORF enrichment.

218 linically relevant mutations in HBsAg and rt ORFs, successfully treated with a combination of nucleot

219 t prevent translation of the downstream RTC4 ORF.

220 trast, we detected selection focused on SHFV ORFs 5a and 5, which encode putative membrane proteins.

221 which the time taken to translate the short ORF, impacted by distance, sequence, and structure, not

222 e also detected the expression of four short ORFs, each of which was located within an ORF ("ORF-with

223 le as a polyprotein and two embedded shorter ORFs in the -1 frame: PISPO, of 230 codons, and PIPO, of

224 AlignWise produces a single ORF per transcript and identifies and corrects frame-shi

225 olytic microbes; yet the function of a small ORF, kdgF, which cooccurs with the genes for these enzym

226 Translation of hundreds of small ORFs (smORFs) of less than 100 amino acids has recently

227 Computational prediction of small ORFs from codon conservation patterns corroborates and e

228 The prediction of translated small ORFs (sORFs) by quantitation of translation termination

229 identifies several hundred translated small ORFs in zebrafish and human.

230 al translation events but also uncover small ORFs in annotated noncoding RNAs and pseudogenes.

231 h for quantification of the fluorophore SSF, ORF, and scattering depolarization and anisotropy using

232 e relative to the start site of the terminal ORF.

233 utation of the start codon of two C-terminal ORFs in an infectious clone reduced virus yield.

234 ORFs or 14 previously unreported C-terminal ORFs of known proteins were also identified.

235 gested translation of some of the C-terminal ORFs.

236 The recent discovery that ORF 72 on chromosome 9 (C9orf72), the gene most commonly

237 The ORF encodes 453 amino acids with a RXXR proteolytic site

238 The ORF excluding transit peptides encoded a 64.9 kDa protei

239 omiscuous glycosyltransferase encoded by the ORF atu2297, with UDP-glucose or UDP-glucuronic acid as

240 By disrupting the ORF MXAN7041 in two different sublines, we demonstrated

241 Surprisingly, the release of p48 from the ORF B-encoded polyprotein was not prevented by mutation

242 epitope tags (or regulatory regions) in the ORF library strains, which further extends the potential

243 A premature termination codon (PTC) in the ORF of an mRNA generally leads to production of a trunca

244 The discovery of the ORF 12 deletion, revealed through targeted genome sequen

245 ap completely prevents the expression of the ORF and avoids expression of C-terminal truncated protei

246 ubiquitin-specific protease activity of the ORF UL48 protein was functional in the complex, cleaving

247 tion, and in some cases, a total loss of the ORF.

248 r AIP4 expression substantially reversed the ORF-9b-mediated reduction of MAVS and the suppression of

249 Specifically, the ORF of the IRES-driven mRNA is established by the placem

250 Additionally, RSC recruitment to the ORF requires the activities of the SAGA and NuA4 HAT com

251 (2017) report that ribosomes translating the ORF that encodes the copper pump frequently frameshift a

252 envelope proteins is fully nested within the ORF of the viral replicase P.

253 The ORFs display high homology between the strains, but they

254 nt with such a role, Pol II occupancy in the ORFs of weakly transcribed genes is drastically reduced

255 eletion of, or start codon mutations in, the ORFs for the peptides in the DeltarcrR-NP background res

256 CPD of the ORFs for the G and F surface glycoproteins provided the

257 promoter strength driving expression of the ORFs was largely unchanged and the mRNA half-lives were

258 tes could produce transcripts bringing these ORFs in frame with the upstream polyprotein, thus leadin

259 omic mRNAs (sg mRNAs), and for most of these ORFs, a single genomic transcription regulatory sequence

260 ically localized, which indicates that these ORFs came from the nucleus or (less likely) a cryptic en

261 The gene product of this ORF localizes to promyelocytic leukemia-adjacent nuclear

262 Of HEV's three ORFs, the function of ORF3 has remained elusive.

263 early stage after establishment of the tmRNA ORF as the surrogate mRNA template.

264 After vaccination, responses to ORFs 40, 67, 9, 59, 12, 62, and 18 were also prevalent.

265 important for NuA4 occupancy in transcribed ORFs.

266 Finally, transient ORF-9b expression led to a strong induction of autophagy

267 ce and secondary structure of the translated ORF.

268 nt on the mRNA to define actively translated ORFs by ribosome footprinting.

269 s could be used to identify novel translated ORFs.

270 UAS sites); the resulting GAL4-inducible UAS-ORF plasmid library is then used to generate Drosophila

271 These transgenic UAS-ORF strains are a useful resource to complement and vali

272 We found that the UL11 ORF gives rise to several proteins due to both posttrans

273 ersions or carry a stop mutation in the UL11 ORF.

274 ntified a viral protein encoded by the UL148 ORF (UL148) that influences the ratio of gH/gL/gO to gH/

275 A substantial number of these unannotated ORFs are evolutionarily conserved, and some produce stab

276 Here, we applied an unbiased, ORF-based screen to identify genetic modifiers of EGFR d

277 Among these unique ORFs are two putative ORFs, ORF011 and ORF012, which are

278 oteins in other rhabdoviruses and an unknown ORF of 111 amino acids located between the G- and L-prot

279 sidues caused an accumulation of unprocessed ORF A product p69.

280 ranslated region (UTR) generates an upstream ORF (uORF) that affects both the background expression o

281 ng ribosome bypass of an inhibitory upstream ORF (uORF) situated in the 5'-leader of the CHOP mRNA.

282 egulated mRNAs, 30% had one or more upstream ORF (uORF) that influenced the number of ribosomes on th

283 ences lie close to start codons and upstream ORFs.

284 ycin (TOR) promotes reinitiation at upstream ORFs (uORFs) in genes that play important roles in stem

285 by a mechanism mediated in part by upstream ORFs situated in the 5'-leader of CDKN1A mRNA.

286 also changes the inclusion of long upstream ORFs (uORFs).

287 to the evidence that the removal of upstream ORFs by RNA processing is not typically required for the

288 so exposed the inhibitory effect of upstream ORFs on the translation of downstream protein-coding reg

289 cription factor ATF4 through paired upstream ORFs (uORFs) plays an important role in eukaryotic gene

290 t produce protein due to regulatory upstream ORFs in its extended 5' leader.

291 Short, upstream ORFs (uORFs) located in the 5'-leader of the mRNA can be

292 ders of GADD34 and CReP contain two upstream ORFs (uORFs).

293 ne the regulatory features by which upstream ORFs (uORFs) direct downstream translation control and e

294 y as infection with viruses lacking the US28 ORF alone or in combination with the remaining HCMV-enco

295 Specifically, viral ORFs were recoded by rearranging existing synonymous cod

296 Therefore, we suggest that these two viral ORFs are involved in the same mechanism or pathway that

297 system, we demonstrate the role of two viral ORFs, ORF18 and ORF30, in regulating viral gene expressi

298 ted deletion of a significant portion of VZV ORF 12 following propagation in cultured human fibroblas

299 e variants of poliovirus type 1 (PV1), whose ORF (6,189 nucleotides) carried up to 1,297 "Max" mutati

300 which was located within an ORF ("ORF-within-ORF"), including one not previously recognized or known