1 PABA 22 alone minimally increased p21 (waf1) and acetyla
2 PABA is observed to remain on the surface at all potenti
3 PABA pools were severely depleted in engineered fruit th
4 PABA/NO is a diazeniumdiolate of structure Me(2)NN(O)=NO
5 , a further increase of the pK(a) from 4.
67 (
PABA) to 5.32 (anisidine) resulted in a 2.5-fold decreas
6 n the pK(a) range from -1.7 (H(2)O) to 4.
67 (
PABA), with a slope of beta(nuc) = 0.80 +/- 0.1.
7 The initiation of
a PABA-deficient diet after P. yoelii infection is establi
8 Protonation of p-aminobenzoic
acid (
PABA) and p-aminobenzoic acid methyl ester (PABAOMe) occ
9 e zwitterionic molecule p-aminobenzoic
acid (
PABA) at a Ag(111) electrode surface.
10 at exogenously supplied p-aminobenzoic
acid (
PABA) can antagonize the action of antifolates that inte
11 ike humans, can utilize p-aminobenzoic
acid (
PABA) for the de novo generation of folate.
12 mino acids (AroAAs) and p-aminobenzoic
acid (
PABA) was demonstrated in M. maripaludis.
13 mpetitive antagonist to p-aminobenzoic
acid (
PABA), which is a precursor of folates.
14 ve bacterial uptake: para-aminobenzoic
acid (
PABA), with uptake in all representative bacteria includ
15 which in turn cleaves a p-aminobenzoic
acid (
PABA)-peptide adduct to release free PABA and thus allow
16 lex structures with a p-aminobenzyl
alcohol (
PABA) self-eliminating spacer showed better growth inhib
17 st step in the synthesis of p-
aminobenzoate (
PABA) moiety of folate remains to be elucidated.
18 n how plants synthesize the p-
aminobenzoate (
PABA) moiety of folates.
19 size folate from pteridine, p-
aminobenzoate (
PABA), and glutamate moieties.
20 synthesized from pteridine, p-
aminobenzoate (
PABA), and glutamate precursors.
21 by mimicking the substrate p-
aminobenzoate (
PABA).
22 tep in the DKFP pathway, required AroAAs
and PABA for growth.
23 Pteridine
and PABA levels in transgenic fruit were >20-fold higher tha
24 PAHAs
and PABAs exhibit strikingly different cellular effects from
25 te 5 and cathepsin K cleavage of the Leu-
Arg-
PABA element will liberate alendronic acid.
26 inyl-para-aminophenylmeth ylalcohol (Leu-
Arg-
PABA).
27 c acid (PAS), we hypothesized that
bacterial PABA biosynthesis contributes to intrinsic antifolate re
28 to produce bioactive nitric oxide (NO),
but PABA/NO was the most reactive.
29 ined immunodeficiency were also protected
by PABA-deficient diet.
30 hese bipartite proteins are commonly
called "
PABA synthases," although it is unclear whether they pro
31 In Escherichia
coli,
PABA is made from chorismate in two steps.
32 malaria species, requires exogenous
dietary PABA for survival.
33 N,N-dimethylamino)diazen-1-ium-1,2-
diolate (
PABA/NO) were synthesized and studied.
34 N,N-dimethylamino) diazen-1-ium-1,2-
diolate (
PABA/NO) resulted in a dose-dependent increase in intrac
35 N,N-dimethylami no)diazen-1-ium-1,2-
diolate (
PABA/NO), liberates NO and elicits toxicity in vitro and
36 -N,N-dimethylamino)diazen-1-ium-1,2-
diolate (
PABA/NO), which is efficiently metabolized to potentiall
37 We sought to
explain PABA/NO's physicochemical uniqueness among these four co
38 Finally,
PABA/NO produced antitumor effects in a human ovarian ca
39 f MAC-purified PGH revealed a K(m) value
for PABA-GLU of 60 +/- 0.08 microM and a specific activity o
40 c acid (PABA)-peptide adduct to release
free PABA and thus allows the growth of an auxotrophic strain
41 for phenylalanine and arylamine derived
from PABA were observed.
42 nation of pyruvate and aromatization to
give PABA.
43 breakdown product, p-aminobenzoyl-
glutamate (
PABA-GLU).
44 Within 4
h,
PABA/NO activated the UPR and led to translational atten
45 far, the only known plant enzyme involved
in PABA synthesis is ADC synthase, which has fused domains
46 onsistent with the presence of
intracellular PABA/NO or metabolites, because cells overexpressing MRP
47 Analysis of the pH-k(cat)/
K(
PABA) profile revealed a pK(a) of 5.52 +/- 0.14 and a so
48 e effect (SKIE) of 2.01 +/- 0.04 on k(cat)/
K(
PABA).
49 Mice fed
low-
PABA diets do not die from lethal doses of P. yoelii.
50 g fruit contained an average of 19-fold
more PABA than controls.
51 Moreover,
PABA was shown to be derived from an early intermediate
52 studies showed that in the absence of
MRP1,
PABA/NO activated the extracellular-regulated and stress
53 was added, indicating that it forms ADC,
not PABA.
54 Exogenous application
of PABA or compounds downstream in the folate biosynthesis
55 ons of a new pathway for the biosynthesis
of PABA in methanococci.
56 k inhibited by physiologic concentrations
of PABA, its glucose ester, or folates.
57 inhibited by physiological concentrations
of PABA, its glucose ester, or folates.
58 Cytotoxicity
of PABA/NO was also examined in a mouse skin fibroblast (NI
59 Disruption
of PABA biosynthesis is also demonstrated to lead to loss o
60 Herein, we demonstrate that disruption
of PABA biosynthesis potentiates the anti-tubercular action
61 a single pharmacologically relevant dose
of PABA/NO, S-glutathionylation occurs rapidly (<5 min) and
62 38 were critical to the cytotoxic effects
of PABA/NO.
63 ally, we demonstrate selective inhibition
of PABA biosynthesis in M. tuberculosis using the small mol
64 nfirmed that a GSTpi-activated metabolite
of PABA/NO was effluxed by MRP1 in a GSH-dependent manner.
65 tential on the adsorption and orientation
of PABA.
66 ay be linked with the cytotoxic potential
of PABA/NO.
67 synthase, which catalyzes the first step
of PABA synthesis.
68 Plasmodial enzymes for the synthesis
of PABA via the shikimate pathway are being investigated as
69 the DKFP pathway, did not require AroAAs
or PABA for growth.
70 xamic acids (PAHAs) and
polyaminobenzamides (
PABAs) were synthesized and evaluated as isoform-selecti
71 ombinant Arabidopsis protein did not
produce PABA unless the E. coli PabC enzyme was added, indicatin
72 although it is unclear whether they
produce PABA or ADC.
73 tutes a revision of the previously
published PABA/NO structure.
74 mycetes, and Plasmodium spp. also
synthesize PABA but have proteins comprising fused domains homologo
75 ence of biosynthetic machinery to
synthesize PABA, Plasmodium yoelii, a rodent malaria species, requi
76 This is consistent with the fact
that PABA/NO induces S-glutathionylation and inactivation of
77 Changes in the SFG signal indicate
that PABA changes orientation in response to the charge on th
78 peared only in chloroplasts, indicating
that PABA synthesis is plastidial.
79 Studies revealed
that PABA/NO's N-methyl-p-aminobenzoic acid substituent is bo
80 We now show
that PABA/NO induces nitrosative stress, resulting in undetec
81 content in food plants and that boosting
the PABA supply can produce further gains.
82 Our studies suggest that
the PABA content in the diet will affect the host clearance
83 purified recombinant proteins convert ADC
to PABA.
84 ion product of the PabA and PabB enzymes--
to PABA and pyruvate.
85 GSTpi results in a decreased sensitivity
to PABA/NO.
86 ing advanced, but there was no fall in
total PABA content, which stayed between 0.7 and 2.3 nmol.g(-1
87 When
transgenic PABA- and pteridine-overproduction traits were combined
88 This study reveals that the M.
tuberculosis PABA biosynthetic pathway is responsible for intrinsic r
89 AHAs inhibited HDAC >50% (1 microM), and
two PABAs inhibited HDAC >50% (5 microM).
90 that whereas nitrosylation was
undetectable,
PABA/NO treatment caused S-glutathionylation of PDI.
91 ate levels 2-fold, but engineered fruit
were PABA-depleted.
92 tion of cellular proteins in comparison
with PABA/NO.
93 Consistent
with PABA/NO's potent suppression of A2780 human ovarian canc
94 igh in folate, and supplying such fruit
with PABA by means of the fruit stalk increased their folate
95 E. coli pabA pabB double mutant and a
yeast PABA-synthase deletant.