ライフサイエンスコーパス: S phase checkpoint

1 OP blocking most, if not all, aspects of the S phase checkpoint.

2 syndrome 1 (NBS1), and is required for intra-S phase checkpoint.

3 is not induced by IR but also affects intra-S phase checkpoint.

4 A damage checkpoint independent of the intra-S phase checkpoint.

5 to ionizing radiation (IR) to activate intra-S phase checkpoint.

6 orks, but which is compromised for the intra-S phase checkpoint.

7 DNA replication forks and a mediator of the S phase checkpoint.

8 nding domain for recruitment to IRIF and the S phase checkpoint.

9 repair, telomere maintenance, and the intra-S phase checkpoint.

10 were associated with activation of the intra-S phase checkpoint.

11 by STAT3, leading to relaxation of the intra-S phase checkpoint.

12 transcription of ASE1, which depends on the S phase checkpoint.

13 This Top1-dependent process activates the S phase checkpoint.

14 e stability distinct from its role in the G1-S phase checkpoint.

15 a readout for activation of the ATR-mediated S phase checkpoint.

16 g that death was not preventable post the G1-S phase checkpoint.

17 rigin activity and is modulated by the intra-S-phase checkpoint.

18 d stalled replication forks during the intra-S-phase checkpoint.

19 ion forks is a key step in activation of the S-phase checkpoint.

20 iency in the forks required to establish the S-phase checkpoint.

21 complex (MRN) plays an essential role in the S-phase checkpoint.

22 ivate the signaling cascades involved in the S-phase checkpoint.

23 at Ser-343, which results in a defect in the S-phase checkpoint.

24 d cell cycle progression via an ATR-mediated S-phase checkpoint.

25 ependent cell survival required a functional S-phase checkpoint.

26 stranded breaks (DSBs) and activation of the S-phase checkpoint.

27 the ionizing radiation (IR)-inducible intra-S-phase checkpoint.

28 ingly, this accumulation is not dependent on S-phase checkpoint.

29 nates stalled forks, thereby attenuating the S-phase checkpoint.

30 be an important target of the Chk1-mediated S-phase checkpoint.

31 DNA damage, replication is inhibited by the S-phase checkpoint.

32 diol epoxide (BPDE) induces a Chk1-dependent S-phase checkpoint.

33 and functions upstream of rad-5/clk-2 in the S-phase checkpoint.

34 ed for normal recovery from the BPDE-induced S-phase checkpoint.

35 c25A is a major mechanism for damage-induced S-phase checkpoint.

36 ugh maintenance of an ATR and Chk1-dependent S-phase checkpoint.

37 ases polkappa and poleta in the BPDE-induced S-phase checkpoint.

38 hat loss of CDK2 activity activates an intra-S-phase checkpoint.

39 icularly enriched for genes that support the S-phase checkpoint.

40 at leads to this slowing is called the intra-S-phase checkpoint.

41 n radiosensitivity and a defect in the intra-S-phase checkpoint.

42 stream effector of ATM activity in the intra-S-phase checkpoint.

43 al for the efficient activation of the intra-S-phase checkpoint.

44 nto how cells recover from activation of the S-phase checkpoint.

45 therapy, at least in part, by regulating the S-phase checkpoint.

46 ATRIP)-ATR complex, and this compromised the S-phase checkpoint.

47 (stalled fork) and is protected by the inter-S-phase checkpoint.

48 to introduce a G2 in embryos that lacked an S-phase checkpoint.

49 tion licensing through the activation of the S-phase checkpoint.

50 ation forks and activates the Cds1-dependent S-phase checkpoint.

51 hase lengthens, which delays mitosis via the S-phase checkpoint.

52 LL on damage to DNA, and thus compromise the S-phase checkpoint.

53 nates DNA damage-induced G2/M, G1, and intra S phase checkpoints.

54 ce show defective recovery from BPDE-induced S-phase checkpoints.

55 that Cks overexpression abrogates the intra-S-phase checkpoint, a major barrier to oncogene-mediated

56 rikingly, phosphorylation of Mrc1 during the S phase checkpoint abolishes Pol2N binding, but not Pol2

57 The S-phase checkpoint activated at replication forks coordi

58 we report that Chk1p has a role in the intra-S-phase checkpoint activated when yeast cells replicate

59 Arrest was accompanied by DNA damage and S phase checkpoint activation and required ATR or ATM ki

60 Therefore, Trp53 is required for the S phase checkpoint activation observed in Fancd2 mutant

61 R-induced foci (IRIF) formation of R/M/N and S phase checkpoint activation, but only the BRCT domain

62 nd intermediate levels of UV sensitivity and S phase checkpoint activation, but similar levels of Mre

63 d breaks repair and DNA damage-induced intra-S phase checkpoint activation.

64 Intriguingly, an ATM inhibitor suppressed S-phase checkpoint activation after exposure to replicat

65 involved in replication fork stabilization, S-phase checkpoint activation and establishment of siste

66 processing is not necessary for ATR-mediated S-phase checkpoint activation and that the lesion recogn

67 oduces replication-dependent DNA lesions and S-phase checkpoint activation following DPC formation.

68 BS cells are radiosensitive and defective in S-phase checkpoint activation following irradiation.

69 DR), promotes cellular survival and prevents S-phase checkpoint activation in budding yeast undergoin

70 Each of these agents also triggered S-phase checkpoint activation in parental ES cells, as i

71 Following ionizing radiation-induced S-phase checkpoint activation, Tax-expressing cells prog

72 duced p21(Waf1/Cip1) and MDM2, demonstrating S-phase checkpoint activation.

73 k1 phosphorylation, and abolished UV-induced S-phase checkpoint activation.

74 sphorylation of Chk2 and Smc1, necessary for S-phase checkpoint activation.

75 cell cycle re-entry after DNA damage-induced S-phase checkpoint activation.

76 This intra-S-phase checkpoint actively regulates DNA synthesis by i

77 ia RPA and directly control the amplitude of S phase checkpoint activity and the subsequent deactivat

78 Ino80, function to attenuate and deactivate S phase checkpoint activity.

79 langiectasia and Rad3 related (ATR)-mediated S phase checkpoint acts as a surveillance mechanism to p

80 akage syndrome protein, known to mediate the S phase checkpoint after DNA damage.

81 cells from interphase arrest and loss of the S-phase checkpoint after DNA damage, accompanied by high

82 Furthermore, the S-phase checkpoint after UV irradiation was defective in

83 rosine phosphorylation mediated by the intra-S-phase checkpoint, allowing cells to continue replicati

84 UV exposure, a defective UV responsive intra-S phase checkpoint and a specific pattern of genomic ins

85 and SMC3 acetylation are required for intra-S phase checkpoint and cellular survival after IR.

86 nase is necessary for both activation of the S phase checkpoint and for efficient DNA damage repair r

87 Tipin complex plays an important role in the S phase checkpoint and replication fork stability in met

88 Both S phase checkpoint and SCC defects are phenocopied by H3

89 prevent mitotic catastrophe, function in the S-phase checkpoint and also cooperate with atm-1 in the

90 re equally important for triggering of intra-S-phase checkpoint and ATM signaling promoted recovery o

91 n important role for the p21-dependent intra-S-phase checkpoint and extensive rereplication, whereas

92 log of the human ATR/ATM genes, controls the S-phase checkpoint and prevents replication fork collaps

93 sion of MDC1 expression results in defective S-phase checkpoint and reduced apoptosis in response to

94 /Tim1 complex plays an important role in the S-phase checkpoint and replication fork stability.

95 st cancer cells is preceded by activation of S-phase checkpoint and selective induction of E2F1, a re

96 e to degrade cyclin D1 compromises the intra-S-phase checkpoint and suggest that cyclin D1 degradatio

97 requires the coordinated action of the intra-S-phase checkpoint and the Fanconi anaemia pathway, whic

98 ication fork arrest, activation of the intra-S phase checkpoint, and global defects in chromatin stru

99 eplication stress and activation of an intra-S phase checkpoint, and suppressed the growth of VHL-/-

100 ologous recombination, telomere maintenance, S-phase checkpoint, and genome stability during replicat

101 Neither the DNA damage nor the intra-S phase checkpoints are activated in the first cell cycl

102 ment, as well as DNA damage-induced G2/M and S phase checkpoint arrest and radiation survival are dep

103 lution triggers anaphase, is dispensable for S phase checkpoint arrest.

104 esulfonate, inducers of DNA damage and intra-S-phase checkpoint arrest in all examined eukaryotes.

105 S-phase checkpoint arrest was incomplete, however, allow

106 f Chk1 was associated with inefficient inter-S phase checkpoint, as Hsp72 depleted cells failed to ha

107 be explained by co-dependence on a single G1/S-phase checkpoint, as S phase and zygotic polarization

108 on--with zygotes having to pass through a G1/S-phase checkpoint before the polarization axis can be f

109 We propose that S phase arrest activates the S phase checkpoint blocking mitosis onset and inhibiting

110 d independently of the replication-dependent S phase checkpoint but by similar conditions involving t

111 Esc4p is not required for the intra-S-phase checkpoint but is essential for resumption of ch

112 the ataxia telangiectasia mutated-dependent S-phase checkpoint, but rather closely resembled a previ

113 of NBN is required for the activation of the S-phase checkpoint, but the mechanism whereby these phos

114 ally induce and activate p53 and activate an S phase checkpoint by modifying the Nijmegen breakage sy

115 tive phosphorylation by CK2 may affect intra-S phase checkpoint by modulating SMC3 phosphorylation by

116 Bypass of the intra-S-phase checkpoint by caffeine activates many new origin

117 Induction of the intra-S-phase checkpoint by hydroxyurea (HU) inhibits Rad52 fo

118 phase and that activating the Rad3 dependent S-phase checkpoint by inhibiting DNA replication had lit

119 g a high threshold for the ATR-Chk1-mediated S-phase checkpoint by promptly repairing DNA breaks that

120 by which E2F1 regulates transit through the S phase checkpoint, by acting on a specific DNA sequence

121 eveal a novel pathway, defended by the intra-S-phase checkpoint, by which MDM2 induces unscheduled or

122 in response to cytarabine (ara-C) induced an S-phase checkpoint characterized by the inhibition of Cd

123 lizing or restarting replication forks under S phase checkpoint conditions.

124 n the absence and presence of DNA damage and S-phase checkpoint conditions.

125 The intra-S-phase checkpoint contributed to the high-level of fork

126 as a missing link between p53 activation and S phase checkpoint control designed to eliminate replica

127 lication machinery plays additional roles in S phase checkpoint control, although the identities of t

128 We propose that Ddk modulates the S-phase checkpoint control by attenuating checkpoint sig

129 ion of Nbs1-S343A mutant disrupted the intra-S-phase checkpoint, decreased homologous recombinational

130 proteins after IR, they exhibit a defective S-phase checkpoint, decreased survival, and increased ch

131 phosphorylation of Ser-1067 as well as intra-S phase checkpoint defect.

132 int competent, but set1Delta displays a mild S phase checkpoint defect.

133 53BP1(-/-) cells show a slight S-phase checkpoint defect and prolonged G(2)/M arrest af

134 horylation of ATM on Ser 1981, and caused an S-phase checkpoint defect in DNA-damaged cells.

135 anch, and provides a molecular basis for the S-phase checkpoint defect in NBS cells.

136 e ATM kinase inhibitor KU 55933 results in a S-phase checkpoint defect similar to that observed in WR

137 pts checkpoint signaling and causes an intra-S-phase checkpoint defect.

138 eletion mutants (dot1Delta) are G1 and intra-S phase checkpoint defective after ionizing radiation bu

139 Nbs1(DeltaC/DeltaC) cells exhibit intra-S-phase checkpoint defects, but are otherwise indistingu

140 not S516A or DeltaSET mutant MLL rescues the S-phase checkpoint defects.

141 ent causes a persistent Mec1-dependent intra-S-phase checkpoint delay characterized by slow DNA repai

142 -R696W, we discovered that pol3-R696W causes S-phase checkpoint-dependent elevation of dNTP pools.

143 xia causes replication arrest independent of S-phase checkpoint, DNA damage response, or transformati

144 Multiple pathways, such as S-phase checkpoints, DNA replication, recombination, chr

145 at BID plays an unexpected role in the intra-S phase checkpoint downstream of DNA damage distinct fro

146 id-type genomic abnormalities, indicative of S-phase checkpoint dysfunction.

147 (MRN) complex is required for mediating the S-phase checkpoint following UV treatment, but the under

148 n of RPA2, a critical event in mediating the S-phase checkpoint following UV treatment.

149 We find that the S-phase checkpoint function of Sgs1p is dispensable for

150 of mismatch repair function restored normal S-phase checkpoint function.

151 These data indicate that the intra-S-phase checkpoint functions to block late origin firing

152 F1 has also been implicated in regulating an S phase checkpoint, however its role in this checkpoint

153 w MRN affects DNA replication to control the S-phase checkpoint, however, remains unclear.

154 at Snm1B-deficient cells exhibit a defective S phase checkpoint in response to MMC, but not to IR, an

155 wo mechanisms are involved in regulating the S-phase checkpoint in an MRN-dependent manner following

156 involved in ATM pathway activation and in a S-phase checkpoint in cells exposed to DNA interstrand c

157 netic studies indicate the role of an intact S-phase checkpoint in maintaining genome integrity.

158 owed that DDK is an important target for the S-phase checkpoint in mammalian cells to suppress replic

159 an important mechanism underlying the intra-S-phase checkpoint in mammalian cells.

160 ubstrate of ATM and ATR to mediate the intra-S-phase checkpoint in mammalian cells.

161 Although the basic framework of the S-phase checkpoint in multicellular organisms has been o

162 as to how MDC1 regulates NBS1 and the intra-S-phase checkpoint in response to DNA damage.

163 ation, G2-M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation.

164 air system is required for activation of the S-phase checkpoint in response to ionizing radiation.

165 r, DDK-null cells fail to activate the intra-S-phase checkpoint in the presence of hydroxyurea-induce

166 overexpress Cks1 or Cks2 override the intra-S-phase checkpoint in the presence of replication stress

167 ilon (Pol epsilon) was shown to activate the S-phase checkpoint in yeast in response to replicative s

168 failed to recover from the UV light-induced S-phase checkpoint), in sharp contrast to Polk(-/-) MEFs

169 Recovery from the S-phase checkpoint includes inactivation of checkpoint s

170 s(checkpoint kinase 1) (Grp(Chk1))-dependent S-phase checkpoint, increased levels of CycB drives cyto

171 se pathway and show that deregulation of the S-phase checkpoint incurred by MLL translocations probab

172 ever, dun1Delta cells are proficient for the S-phase-checkpoint-induced anaphase block.

173 e Dun1p, yeast Chk1p is not required for the S-phase-checkpoint-induced anaphase block.

174 During replication stress, the S-phase checkpoint inhibits the DDK- and CDK-dependent a

175 bromodeoxyuridine incorporation to evaluate S phase checkpoint integrity, monoubiquitination of Fanc

176 Furthermore, the intra-S-phase checkpoint is activated in Orc2-S188A-expressing

177 uce early mitotic entry, but reversal of the S-phase checkpoint is compromised by pairwise cyclin kno

178 Interestingly, the intra-S-phase checkpoint is crucial for the cellular response

179 ether, our study demonstrates that the intra-S-phase checkpoint is exerted by Chk1 not only upon repl

180 ssion yeast, the signal activating the intra-S-phase checkpoint is generated only when replication fo

181 ec1, a key regulatory ATR-like kinase in the S-phase checkpoint, is required for both normal chromati

182 mitant phosphorylation and activation of the S phase checkpoint kinase, Rad53.

183 The S-phase checkpoint kinase and telomere maintenance facto

184 The intra-S-phase checkpoint kinase Chk1 phosphorylates Cdc25A to

185 phorylation of S331 is mediated by CHK1, the S-phase checkpoint kinase implicated in the Fanconi anem

186 ilon depend on damage uninducible (Dun)1, an S-phase checkpoint kinase that maintains dNTP levels dur

187 evidenced by autophosphorylation of ATR, the S-phase checkpoint kinase, and by recruitment of ATR and

188 The S-phase checkpoint kinases Mec1 and Rad53 in the budding

189 signals from active replication forks to the S-phase checkpoint machinery in human cells.

190 to be an essential target inactivated by the S-phase checkpoint machinery that inhibits DNA replicati

191 o present evidence suggesting that the intra-S-phase checkpoint makes a relatively minor contribution

192 ons argue that Drf1 is regulated by an intra-S-phase checkpoint mechanism that down-regulates the loa

193 se progression to G2 by modulating the intra-S phase checkpoint mediated by Chk1.

194 the loading onto chromatin of various intra-S-phase checkpoint mediators and found that NONO favours

195 mined the expression and activation of known S-phase checkpoint mediators in FdUrd-treated SW620 and

196 The DNA replication or S-phase checkpoint monitors the integrity of DNA synthes

197 S-phase checkpoint mutants fail to stabilize Dia2 in res

198 In contrast, most S-phase checkpoint mutants were synthetically lethal in

199 to better understand replication dynamics in S-phase checkpoint mutants, we developed a replication o

200 ign MLL as a novel effector in the mammalian S-phase checkpoint network and identify checkpoint dysfu

201 Finally, neither the S-phase checkpoint nor the G(2) checkpoints appear to af

202 treatment with SN-38 and UCN-01 resulted in S-phase checkpoint override, an amplified DNA damage res

203 cdk2 have only been implicated in the intra-S phase checkpoint pathway after DNA damage.

204 The S phase checkpoint pathway preserves genome stability by

205 lecular mechanisms by which the ATR-mediated S phase checkpoint pathway prevents DNA rereplication an

206 urthermore, cells lacking H2A.Z required the S-phase checkpoint pathway for survival.

207 iated proteolysis and that activation of the S-phase checkpoint pathway inhibits Dia2 protein degrada

208 During DNA replication, the S-phase checkpoint pathway responds to replication stres

209 h many chemotherapy drugs activate the intra-S-phase checkpoint pathway to block S-phase progression,

210 signaling through the conserved Mec1/Rad53, S-phase checkpoint pathway to induce the expression and

211 rity of the Pol binding module and block the S-phase checkpoint pathway, downstream of the Mec1 kinas

212 quire NBS1, a component of the IR-responsive S-phase checkpoint pathway.

213 ons as an effector in the ATM/NBS1-dependent S-phase checkpoint pathway.

214 the absence of Rtt/genome caretakers trigger S-phase checkpoint pathways to stimulate Ty1 reverse tra

215 Here, we show that either or both of two S-phase checkpoint pathways, the replication stress path

216 The S-phase checkpoint phenotype was independent of Nbs1 sta

217 ombination), mec1Delta tel1Delta (DNA damage/S-phase checkpoints), pif1Delta (maintenance of mitochon

218 hases of replication and triggers the "intra-S phase checkpoint." Previous work with budding yeast ha

219 iency in HCT116 is associated with defective S-phase checkpoint, prolonged G2 arrest, and hypersensit

220 Such compromised intra-S phase checkpoints promoted gene amplification independ

221 The S phase checkpoint protects the genome from spontaneous

222 The intra-S phase checkpoint protein complex Tof1/Csm3 of Saccharo

223 evel of global control mediated by the intra-S-phase checkpoint protein complex of Tof1p and Csm3p th

224 e function of DNA polymerase epsilon and the S-phase checkpoint protein Mec1.

225 droxyurea (HU) treatment activates the intra-S phase checkpoint proteins Cds1 and Mrc1 to prevent rep

226 Third, deletions of the intra-S phase checkpoint proteins Tof1 and Csm3 abolished fork

227 F-box protein Dia2 as a novel player in the S-phase checkpoint recovery pathway.

228 ring DNA replication reinitiation during the S-phase checkpoint recovery.

229 Dia2 contributes to Mrc1 degradation during S-phase checkpoint recovery.

230 ased recruitment of Mre11 to IRIF, abrogated S phase checkpoint, reduced activation of ATM, Chk1, and

231 much is known about how and where the intra-S-phase checkpoint regulates origins of replication in h

232 1 (whose products regulate G(2) and G(1) or S phase checkpoints, respectively) after the cells have

233 The budding yeast S phase checkpoint responds to hydroxyurea-induced nucle

234 ndent pathway plays an important role in the S phase checkpoint response following ionizing irradiati

235 The S phase checkpoint response slows down replication in th

236 may be an additional step in regulating the S phase checkpoint response to DNA damage on the leading

237 n stabilizing stalled replication forks, the S phase checkpoint response, and suppressing genetic cro

238 s essential for the DNA damage-induced intra-S phase checkpoint response.

239 ATR-dependent phosphorylation of Chk2 or the S-phase checkpoint response after ionising radiation.

240 DM2 transgenic mice enter S phase and induce S-phase checkpoint response earlier than lung cells from

241 not inhibited during the DNA-damage-induced S-phase checkpoint response in Xenopus egg extracts and

242 u80(-/-) cells show a stronger ATM-dependent S-phase checkpoint response than Ku80(+/+) cells after i

243 Wild-type Tetrahymena elicits an intra-S-phase checkpoint response that is induced by hydroxyur

244 V fibroblasts lacking poleta showed a normal S-phase checkpoint response to BPDE (but failed to recov

245 nduces replication stress eliciting an early S-phase checkpoint response to inhibit further firing of

246 s is required for establishment of the intra-S-phase checkpoint response.

247 on, PP5 is required to elicit an appropriate S-phase checkpoint response.

248 uring S phase activate the S-phase and intra-S-phase checkpoint responses, respectively, regulated by

249 ion (IR), Hus1-deficient cells showed intact S-phase checkpoint responses.

250 he nucleus and not the cytoplasm to modulate S-phase checkpoint responses: alpha-syn up-regulates his

251 Thus, the MRN S-phase checkpoint role is separate from its Ctp1- and r

252 ctedly, induction of the p21-dependent intra-S-phase checkpoint seemed to be independent of both Cdt1

253 replication, whereas the ATR-dependent intra-S-phase checkpoint seemed to play a less dominant role.

254 The Chk1 kinase is a major effector of S phase checkpoint signaling during the cellular respons

255 cks on the same RPA70N surface that recruits S phase checkpoint signaling proteins to chromatin.

256 Inhibition of RPA/ATR/Chk1-mediated S-phase checkpoint signaling partially inhibited BPDE-in

257 rk at a replication fork pause site restores S-phase checkpoint signaling to chk1Delta dun1Delta cell

258 unctions as an upstream regulator to monitor S-phase checkpoint signaling.

259 that Ddk plays an active role in regulating S-phase checkpoint signaling.

260 In the absence of a functional S-phase checkpoint, stalled replication forks collapse a

261 is enhanced in cells lacking the IR-induced S-phase checkpoint, such as those lacking Nbs1 or Brca1

262 The intra-S-phase checkpoint suppresses origin firing after the lo

263 x6-dependent Chk1 degradation contributes to S phase checkpoint termination and that a defect in this

264 angiectasia and Rad3-related (ATR)-dependent S phase checkpoint that inhibits replication fork progre

265 e during DNA-replication arrest requires the S phase checkpoint that inhibits the S phase CDK.

266 DNA replication elongation trigger the intra-S phase checkpoint that leads to the activation of the C

267 yeast, DNA replication stress activates the S phase checkpoint that stabilizes replication forks and

268 essoria on the rice leaf surface requires an S-phase checkpoint that acts through the DNA damage resp

269 r cell types, leads to override of the intra-S-phase checkpoint that blocks DNA replication in respon

270 intaining the integrity of the genome is the S-phase checkpoint that functions to prevent DNA replica

271 n and suppresses the ATM/ATR-dependent intra-S-phase checkpoint that inhibits origin firing.

272 ent with MMC is part of a caffeine-sensitive S-phase checkpoint that is controlled by xATR.

273 ely resistant to FdUrd, have an intact early S-phase checkpoint that protects against FdUrd-induced D

274 e for aberrant Gli1 in the regulation of the S-phase checkpoint that suppresses replication stress an

275 completion of both double-stranded break and S-phase checkpoints that should arrest all replication w

276 vent is required for activation of the intra S phase checkpoint (the RDS checkpoint).

277 cy, consequently causes abnormalities in the S-phase checkpoint, the G(2)/M checkpoint, the spindle c

278 Based on synthetic phenotypes, the intra-S-phase checkpoint, the SRS2 inhibitor of recombination,

279 es by their sensitivity to activation by the S-phase checkpoint, thereby, providing an effective mech

280 uced DNA damage signaling and controls intra-S-phase checkpoint through CHK2 activation.

281 horylation of Dbf4 is critical for the intra-S-phase checkpoint to inhibit DNA replication.

282 vely slow down the DNA replication through a S-phase checkpoint to provide time for repair.

283 wever, most dying neurons do not pass the G1/S-phase checkpoint to resume DNA synthesis.

284 Rad17 are required for the activation of the S-phase checkpoint to suppress DNA synthesis in response

285 larization involves a novel, DDR-independent S-phase checkpoint, triggered by appressorium turgor gen

286 ent of replication forks in coordinating the S-phase checkpoint using dun1Delta cells that have a def

287 ting for DNA synthesis when the BPDE-induced S-phase checkpoint was active.

288 4) The G(1) to S-phase checkpoint was intact in primary and spontaneous

289 y, the ability of cytarabine to activate the S-phase checkpoint was severely compromised in Rad9(-/-)

290 ation initiation and elongation to the intra-S-phase checkpoint, we examined cells treated with the s

291 o investigate other potential targets of the S-phase checkpoint, we tested the effects of BPDE on the

292 stream and downstream of ATR to regulate the S-phase checkpoint when replication forks are stalled.

293 in Pol1 renders yeast cells dependent on the S phase checkpoint, whereas truncation of Pol1 at amino

294 HU treatment triggers the S-phase checkpoint, which arrests cells at S-phase, inhi

295 damage and may also play a role in the intra-S-phase checkpoint, which delays the replication of dama

296 V-induced DNA damage by activating the intra-S-phase checkpoint, which prevents replication fork coll

297 otes activate a signaling pathway called the S-phase checkpoint, which produces a multifaceted respon

298 The eukaryotic intra-S-phase checkpoint, which slows DNA synthesis in respons

299 re not caused by defects in the ATM-mediated S-phase checkpoint, which was intact in primary Fancd2 m

300 atively involving the activation of an intra-S-phase checkpoint, would also inhibit tumor proliferati