ライフサイエンスコーパス: S-adenosylmethionine

1 lating agents, even physiological ones (e.g. S-adenosylmethionine).

2 he Stackebrandtia phosphonoglycan arise from S-adenosylmethionine.

3 with the donor methyl group of the cofactor, S-adenosylmethionine.

4 due to a reduced conversion of methionine to S-adenosylmethionine.

5 affected by intermolecular interactions with S-adenosylmethionine.

6 n reactions that occur via the generation of S-adenosylmethionine.

7 epsilon-amino group for methyl transfer with S-adenosylmethionine.

8 sts a mechanism for allosteric activation by S-adenosylmethionine.

9 tion of tetrahydrofolate and biosynthesis of S-adenosylmethionine.

10 almost all cellular methylation reactions is S-adenosylmethionine.

11 the position equivalent to the sulfonium of S-adenosylmethionine.

12 he extent of allosteric activation of CBS by S-adenosylmethionine.

13 pproximately 15-fold higher than the K m for S-adenosylmethionine.

14 but also by the endogenous methylating agent S-adenosylmethionine.

15 e detergent Triton X-100 and the methyldonor S-adenosylmethionine.

16 The S-adenosylmethionine-1 (SAM-I) riboswitch mediates expre

17 persisted 1 month, whereas the methyl donor S-adenosylmethionine (500 mum) had an opposite effect on

18 S-adenosylmethionine administration at these early stage

19 S-adenosylmethionine (AdoMet or SAM)-dependent methyltra

20 Bhmt resulted in a 43% reduction in hepatic S-adenosylmethionine (AdoMet) (p < 0.01) and a 3-fold in

21 itamin B9) is utilized for synthesis of both S-adenosylmethionine (AdoMet) and deoxythymidine monopho

22 ost invariably catalyzed by enzymes that use S-adenosylmethionine (AdoMet) as the methyl group donor.

23 MoaA is a radical S-adenosylmethionine (AdoMet) enzyme that catalyzes a co

24 osphate synthase; EC 4.1.99.17) is a radical S-adenosylmethionine (AdoMet) enzyme that uses a [4Fe-4S

25 S-adenosylmethionine (AdoMet) lies at an intersection of

26 Under anaerobic conditions, S-adenosylmethionine (AdoMet) radical chemistry is used.

27 insertion, LipA uses a [4Fe-4S] cluster and S-adenosylmethionine (AdoMet) radical chemistry; the rem

28 ncoded proteins, a cobalamin (Cbl)-dependent S-adenosylmethionine (AdoMet) radical enzyme, OxsB, and

29 The S-adenosylmethionine (AdoMet) radical superfamily of enz

30 e multiple methyltransferase domains for the S-adenosylmethionine (AdoMet) reactions.

31 The S-adenosylmethionine (AdoMet) salvage enzyme 5'-methylth

32 ThiC is a member of the radical S-adenosylmethionine (AdoMet) superfamily and catalyzes

33 catalyze the transfer of a methyl group from S-adenosylmethionine (AdoMet) to a peptidylarginine on a

34 ase (ACS), which catalyzes the conversion of S-adenosylmethionine (AdoMet) to ACC, the precursor of e

35 catalyzes the transfer of methyl groups from S-adenosylmethionine (AdoMet) to acceptor lysine residue

36 rase (COMT) catalyzes a methyl transfer from S-adenosylmethionine (AdoMet) to dopamine.

37 Inclusion of the PIMT co-substrate, S-adenosylmethionine (AdoMet), during panning permitted

38 cause MATbeta lowers the Ki of MATalpha2 for S-adenosylmethionine (AdoMet), this allowed steady-state

39 ble feat by using an iron-sulfur cluster and S-adenosylmethionine (AdoMet), thus placing it among the

40 an CBS (hCBS) is allosterically activated by S-adenosylmethionine (AdoMet), which binds to the regula

41 r of methyl groups for methyltransferases is S-adenosylmethionine (AdoMet), which in most cells is sy

42 S-adenosylmethionine (AdoMet)-based methylation is integ

43 Small (>1) BIEs are observed for an S-adenosylmethionine (AdoMet)-binary and abortive ternar

44 domain lysine methyltransferases (KMTs) are S-adenosylmethionine (AdoMet)-dependent enzymes that cat

45 TrmA catalyzes S-adenosylmethionine (AdoMet)-dependent methylation of U

46 investigated METTL12, a mitochondrial human S-adenosylmethionine (AdoMet)-dependent methyltransferas

47 s elegans synthesizes phosphocholine via two S-adenosylmethionine (AdoMet)-dependent phosphoethanolam

48 on PFL by the PFL-AE in a reaction requiring S-adenosylmethionine (AdoMet).

49 ng sensitivities to the allosteric effector, S-adenosylmethionine (AdoMet); whereas T257M and T257I a

50 meI in complex with its DNA substrate and an S-adenosylmethionine analog (Sinefungin).

51 MEP50 (methylosome protein 50), bound to an S-adenosylmethionine analog and a peptide substrate deri

52 ree form (2.2 A resolution) and bound to the S-adenosylmethionine analog S-adenosylhomocysteine (SAH,

53 cobalamin (coenzyme B(12)), simpler, such as S-adenosylmethionine and an iron-sulfur cluster (i.e., p

54 methylarginine formation when incubated with S-adenosylmethionine and hypomethylated ribosomes prepar

55 mitochondrial fatty-acid synthesis type II, S-adenosylmethionine and iron-sulfur clusters.

56 as the substrates for assays with [methyl-3H]S-adenosylmethionine and recombinant CpcM.

57 and ALT levels, betaine treatment increased S-adenosylmethionine and up-regulated Dnmt3b levels, and

58 otinamide adenine dinucleotide phosphate and S-adenosylmethionine) and its partner enzyme, the enoyl

59 nt on metabolites such as acetyl-coenzyme A, S-adenosylmethionine, and NAD+, among others.

60 Ursodeoxycholic acid and S-adenosylmethionine are anti-fibrotic in bile duct liga

61 he characterized pathway uses decarboxylated S-adenosylmethionine as the aminopropyl group donor to f

62 concentrations of the methionine metabolites S-adenosylmethionine, betaine, and cystathionine in MS g

63 Oscillatory production of S-adenosylmethionine, betaine, choline, phosphocholine,

64 his hydrogen bond and subsequently abolishes S-adenosylmethionine binding and its methyltransferase a

65 are dimeric with each monomer containing an S-adenosylmethionine binding domain with a core Rossmann

66 omocysteine revealed RebM to adopt a typical S-adenosylmethionine-binding fold of small molecule O-me

67 ltransferase fold, which besides the typical S-adenosylmethionine-binding site ((SAM)P) also contains

68 related to purine catabolism, methionine and S-adenosylmethionine biosynthesis and methionine salvage

69 ecific contributions made by thymidylate and S-adenosylmethionine biosynthesis to CRC risk.

70 ctivated one-carbons between thymidylate and S-adenosylmethionine biosynthesis.

71 dicate LaeA may perform novel chemistry with S-adenosylmethionine but also provide new insights into

72 Four other metabolites, S-adenosylmethionine, carbamoyl phosphate, UDP-glucose,

73 s affecting the production of decarboxylated S-adenosylmethionine (dcSAM) and polyamine synthesis.

74 otic genes encoding spermidine biosynthesis: S-adenosylmethionine decarboxylase (AdoMetDC) and spermi

75 S-adenosylmethionine decarboxylase (AdoMetDC) catalyzes

76 S-adenosylmethionine decarboxylase (AdoMetDC) is a criti

77 S-Adenosylmethionine decarboxylase (AdoMetDC) is a key e

78 Previously we showed that trypanosomatid S-adenosylmethionine decarboxylase (AdoMetDC), a key enz

79 Instead trypanosomatid S-adenosylmethionine decarboxylase (AdoMetDC), which cat

80 ne fusions of polyamine biosynthetic enzymes S-adenosylmethionine decarboxylase (AdoMetDC, speD) and

81 In the present study, S-adenosylmethionine decarboxylase (SAMDC), a key gene i

82 ng stems from mTORC1-dependent regulation of S-adenosylmethionine decarboxylase 1 (AMD1) stability.

83 eport X-ray structures of Trypanosoma brucei S-adenosylmethionine decarboxylase alone and in function

84 putrescine amidohydrolase in archaea, and of S-adenosylmethionine decarboxylase and ornithine decarbo

85 permidine from putrescine by the key enzymes S-adenosylmethionine decarboxylase and spermidine syntha

86 razone (MGBG), a polyamine analog and potent S-adenosylmethionine decarboxylase inhibitor, decreases

87 ethyltetrahydrofolate:Hcy methyltransferase, S-adenosylmethionine decarboxylase, DNA methyltransferas

88 ypanosomatid spermidine biosynthetic enzyme, S-adenosylmethionine decarboxylase, is regulated by hete

89 erimental frameshift frequencies measured in S-adenosylmethionine-decarboxylase and antizyme mutants,

90 all living organisms, mostly relies on SAM (S-adenosylmethionine)-dependent methyltransferases.

91 S-Adenosylmethionine-dependent DNA methyltransferases (M

92 The S-adenosylmethionine-dependent enzyme MoaA, in concert w

93 th recent evidence supporting a role for the S-adenosylmethionine-dependent enzyme NifB in the incorp

94 methylation of lysine residues, catalyzed by S-adenosylmethionine-dependent lysine methyltransferases

95 e identify a previously undescribed class of S-adenosylmethionine-dependent methylases that convert a

96 ethyltransferase (PLMT) enzymes catalyze the S-adenosylmethionine-dependent methylation of ethanolami

97 des via 2'-O-methylation, carried out by the S-adenosylmethionine-dependent methyltransferase (MTase)

98 e ATP binding region-containing proteins and S-adenosylmethionine-dependent methyltransferase protein

99 3-deazaneplanocin A (DZNep), an inhibitor of S-adenosylmethionine-dependent methyltransferase that ta

100 ethanocaldococcus jannaschii encodes a novel S-adenosylmethionine-dependent methyltransferase, now id

101 AF7, is predicted to belong to the family of S-adenosylmethionine-dependent methyltransferases charac

102 a protein with sequence similarity to other S-adenosylmethionine-dependent methyltransferases, (ii)

103 , belongs to the family of seven-beta-strand S-adenosylmethionine-dependent methyltransferases.

104 escribed the in vitro characterization of an S-adenosylmethionine-dependent O-methyltransferase (NcsB

105 Phosphatidylcholine (PC) produced via the S-adenosylmethionine-dependent phosphatidylethanolamine

106 overall architecture with a large family of S-adenosylmethionine-dependent proteins.

107 to one-carbon metabolism due to their common S-adenosylmethionine-dependent transmethylation and has

108 me and transposon derepression indicate that S-adenosylmethionine-dependent transmethylation is inhib

109 ss-linked peptide formed by MftC through two S-adenosylmethionine-dependent turnovers.

110 stronger inhibitor of BHMT-2 than BHMT, and S-adenosylmethionine does not inhibit BHMT but is a weak

111 icate that it is a new member of the radical S-adenosylmethionine enzyme superfamily.

112 Here we demonstrate that BzaF is a radical S-adenosylmethionine enzyme that catalyzes the remarkabl

113 MoaA, a radical S-adenosylmethionine enzyme, catalyzes the first step in

114 It is repaired by a radical SAM (S-adenosylmethionine) enzyme, the spore photoproduct lya

115 accessory proteins, two of which are radical S-adenosylmethionine enzymes (HydE, HydG) and one of whi

116 chemical characterization of these 8 radical S-adenosylmethionine enzymes and, in the context of huma

117 In this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesi

118 Iba57p, which aconitase and certain radical S-adenosylmethionine enzymes require for activity.

119 he current state of knowledge of the radical S-adenosylmethionine enzymes required for synthesis of t

120 HydE and HydG are radical S-adenosylmethionine enzymes that chemically modify a H-

121 O(2)-sensitive [4Fe-4S] clusters in radical S-adenosylmethionine enzymes.

122 ns, two of which (HydE and HydG) are radical S-adenosylmethionine enzymes.

123 the RhlI reaction proceeds via acylation of S-adenosylmethionine, followed by lactonization.

124 ibose and 2,6-diaminopurine produced 2-amino-S-adenosylmethionine for hydrolytic conversion to 2AMTA.

125 ionine (SAM) enzyme that reductively cleaves S-adenosylmethionine, generating 5'-deoxyadenosyl radica

126 serine-glycine-one-carbon pathway coupled to S-adenosylmethionine generation.

127 on affecting essential pathways that utilize S-adenosylmethionine in addition to methionine.

128 ver that the enzyme converting methionine to S-adenosylmethionine in mESCs, methionine adenosyltransf

129 um produces 5-methylthioadenosine (MTA) from S-adenosylmethionine in polyamine biosynthesis; however,

130 e IC(50) (6-13 micromol/L) by competing with S-adenosylmethionine in the methylation reaction.

131 oxygen atom of Tyr(154) to lock the cofactor S-adenosylmethionine inside the binding cavity.

132 ethyl incorporation of radioactively labeled S-adenosylmethionine into recombinant fragments of OmpB.

133 S-Adenosylmethionine is widely used in a variety of biol

134 nity (KD of 0.14-2.2 muM) than the substrate S-adenosylmethionine (KD of 22-43 muM), which indicates

135 deficiency, as demonstrated by reductions in S-adenosylmethionine levels and in global DNA methylatio

136 Huh7 cells overexpressing MAT1A had higher S-adenosylmethionine levels but lower bromodeoxyuridine

137 protein and methylation potential [ratio of S-adenosylmethionine (major methyl donor):S-adenosylhomo

138 SAH catabolism is linked to S-adenosylmethionine metabolism, and the development of

139 without putrescine and their complexes with S-adenosylmethionine methyl ester were obtained.

140 ther choline, which can serve as a source of S-adenosylmethionine methyl groups, influences PC-DHA or

141 s sp. CX-1, and identified a gene encoding a S-adenosylmethionine methyltranserase termed BlArsM with

142 ation can be mediated by the enzyme arsenite S-adenosylmethionine methyltransferase (ArsM) or through

143 s catalyzed by the enzyme arsenite (As[III]) S-adenosylmethionine methyltransferase (ArsM).

144 sults suggest that BlArsM is a novel As(III) S-adenosylmethionine methyltransferase requiring only tw

145 cally, we demonstrate that ChuW is a radical S-adenosylmethionine methyltransferase that catalyzes a

146 We found that binding by the cofactor S-adenosylmethionine mitigates this autoinhibited struct

147 It seems that the level of S-adenosylmethionine must be regulated in response to de

148 E responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO.

149 is monomeric in the absence and presence of S-adenosylmethionine or S-adenosylhomocysteine.

150 he apo form and in complex with its cofactor S-adenosylmethionine or S-adenosylhomocysteine.

151 cofactocin biosynthesis is one example of an S-adenosylmethionine protein-dependent RiPP pathway.

152 subset of these pathways depends on radical S-adenosylmethionine proteins to modify the RiPP-produce

153 f polyamine synthesis) and hypothesized that S-adenosylmethionine reduction is driven by up-regulated

154 idoxal 5'-phosphate (PLP) for catalysis, and S-adenosylmethionine regulates the activity of human CBS

155 ated methyl cycle (AMC), which generates the S-adenosylmethionine required by methyltransferases and

156 o three putative cobalamin-dependent radical S-adenosylmethionine (RS) enzymes, ThnK, ThnL, and ThnP,

157 Radical S-adenosylmethionine (RS) enzymology has emerged as a ma

158 PqqE is a radical S-adenosylmethionine (RS) protein with a C-terminal SPAS

159 osed to be catalyzed by two putative radical S-adenosylmethionine (rSAM) enzymes, PoyB and PoyC.

160 scovery of four different classes of radical S-adenosylmethionine (rSAM) methyltransferases that meth

161 S-Adenosylmethionine, S-adenosylhomocysteine, S-ribosylh

162 ), cystathionine (P<0.01), and the decreased S-adenosylmethionine/S-adenosyl homocysteine ratio (P<0.

163 This was associated with a higher S-adenosylmethionine/S-adenosylhomocysteine ratio and lo

164 yT catalyzes the formation of 5 from 3 in a (S)-adenosylmethionine (SAM)-dependent manner.

165 ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophe

166 he levels of which are reliant upon adequate S-adenosylmethionine (SAM) and inhibited by S-adenosylho

167 carbide originates from the methyl group of S-adenosylmethionine (SAM) and that it is inserted into

168 T methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor.

169 site (rVSV-K1651A, -D1762A, and -E1833Q) or S-adenosylmethionine (SAM) binding site (rVSV-G1670A, -G

170 recombinant hMPVs carrying mutations in the S-adenosylmethionine (SAM) binding site in CR VI of L pr

171 arly days, radical enzyme reactions that use S-adenosylmethionine (SAM) coordinated to an Fe-S cluste

172 development and fertility via the methionine/S-Adenosylmethionine (SAM) cycle and breaks down the sho

173 a (Mat1a) knockout (KO) mice express hepatic S-adenosylmethionine (SAM) deficiency and increased ERK

174 The studies revealed GilMT as a typical S-adenosylmethionine (SAM) dependent O-methyltransferase

175 We found that the methyl donor S-adenosylmethionine (SAM) disrupts the SAMTOR-GATOR1 co

176 ntiviral protein that belongs to the radical S-adenosylmethionine (SAM) enzyme family.

177 The radical S-adenosylmethionine (SAM) enzyme HydG lyses free l-tyro

178 rikoshii Dph2 (PhDph2) is an unusual radical S-adenosylmethionine (SAM) enzyme involved in the first

179 estigation of the incredibly diverse radical S-adenosylmethionine (SAM) enzyme superfamily, PPP aided

180 DesII is a radical S-adenosylmethionine (SAM) enzyme that catalyzes the C4-

181 Viperin is an IFN-inducible radical S-adenosylmethionine (SAM) enzyme that inhibits viral re

182 Biotin synthase is a radical S-adenosylmethionine (SAM) enzyme that reductively cleav

183 TsrM, an annotated radical S-adenosylmethionine (SAM) enzyme, catalyzes the methyla

184 AprD4 is shown to be a radical S-adenosylmethionine (SAM) enzyme, catalyzing homolysis

185 ross-link, which is installed by the radical S-adenosylmethionine (SAM) enzyme, StrB.

186 SPL is a radical S-adenosylmethionine (SAM) enzyme, utilizing the 5'-deox

187 Radical S-adenosylmethionine (SAM) enzymes account for nearly 2%

188 Radical S-adenosylmethionine (SAM) enzymes are emerging as a maj

189 one and is a member of a subclass of radical S-adenosylmethionine (SAM) enzymes called radical SAM (R

190 Radical S-adenosylmethionine (SAM) enzymes catalyze an astonishi

191 Radical S-adenosylmethionine (SAM) enzymes exist in organisms fr

192 RimO and MiaB are radical S-adenosylmethionine (SAM) enzymes that catalyze the att

193 Radical S-adenosylmethionine (SAM) enzymes use a [4Fe-4S] cluste

194 Radical S-adenosylmethionine (SAM) enzymes use a [4Fe-4S] cluste

195 Radical S-adenosylmethionine (SAM) enzymes use the oxidizing pow

196 We determined two radical S-adenosylmethionine (SAM) enzymes, one each from an SNP

197 ssembly scaffolds by the activity of radical S-adenosylmethionine (SAM) enzymes.

198 has been shown to be a member of the radical S-adenosylmethionine (SAM) family of enzymes, [4Fe-4S] c

199 ry structures that is typical of the radical S-adenosylmethionine (SAM) family of proteins.

200 ansferase (MAT2A) catalyzes the formation of S-adenosylmethionine (SAM) from ATP and methionine.

201 S-Adenosylmethionine (SAM) is both the methyl donor and

202 tenance of proper levels of the methyl donor S-adenosylmethionine (SAM) is critical for a wide variet

203 The methyl donor S-adenosylmethionine (SAM) is produced in most cells thr

204 S-adenosylmethionine (SAM) is the methyl donor for biolo

205 sion, Hcy, S-adenosylhomocysteine (SAH), and S-adenosylmethionine (SAM) levels, and SAM/SAH ratios in

206 family of proteins that perform both radical-S-adenosylmethionine (SAM) mediated sulfur insertion and

207 We found that threonine and S-adenosylmethionine (SAM) metabolism are coupled in plu

208 rmational changes upon Mg(2+) compaction and S-adenosylmethionine (SAM) metabolite binding.

209 show that NosN, a predicted class C radical S-adenosylmethionine (SAM) methylase, catalyzes both the

210 ession of the arsM gene encoding the As(III) S-adenosylmethionine (SAM) methyltransfase from Rhodopse

211 ed using CysS, a cobalamin-dependent radical S-adenosylmethionine (SAM) methyltransferase.

212 ny of the arsM gene that encodes the As(III) S-adenosylmethionine (SAM) methyltransferase.

213 Members of every kingdom have ArsM As(III) S-adenosylmethionine (SAM) methyltransferases that methy

214 sis of a methyl group partially derived from S-adenosylmethionine (SAM) onto electrophilic sp(2)-hybr

215 se domains in apo form as well as with bound S-adenosylmethionine (SAM) or S-adenosylhomocysteine (SA

216 The radical S-adenosylmethionine (SAM) protein PqqE is predicted to

217 LipA is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes and us

218 TsrM is a member of the radical S-adenosylmethionine (SAM) superfamily of enzymes, but i

219 RimO is a member of the growing radical S-adenosylmethionine (SAM) superfamily of enzymes, which

220 reductase (MTHFR) provides methyl donors for S-adenosylmethionine (SAM) synthesis and methylation rea

221 n of the liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/II

222 ecial [4Fe-4S] cluster to reductively cleave S-adenosylmethionine (SAM) to generate a reactive 5'-dA

223 atalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to glycine generating S-adeno

224 talyze the transfer of the methyl group from S-adenosylmethionine (SAM) to lysine residues in histone

225 en fundamental bacterial metabolic pathways: S-adenosylmethionine (SAM) utilization, polyamine biosyn

226 Inspiration from Nature's methylating agent, S-adenosylmethionine (SAM), allowed for the design and d

227 l PBMC DNA methylation, plasma folate, blood S-adenosylmethionine (SAM), and concentrations of As in

228 , betaine, S-adenosylhomocysteine (SAH), and S-adenosylmethionine (SAM), and higher percentages of me

229 cellular concentrations of the methyl donor, S-adenosylmethionine (SAM), and increasing the demethyla

230 : phosphocholine cytidylyltransferase (PCT), S-adenosylmethionine (SAM), and S-adenosylhomocysteine (

231 Here we review the roles of acetyl-CoA and S-adenosylmethionine (SAM), donor substrates for acetyla

232 lic steatohepatitis, with reduction in liver S-adenosylmethionine (SAM), elevation in liver S-adenosy

233 ese nutrients, S-adenosylhomocysteine (SAH), S-adenosylmethionine (SAM), homocysteine, cysteine, and

234 iboswitch, one of several classes that binds S-adenosylmethionine (SAM), represses translation upon b

235 Met is the obligate precursor of S-adenosylmethionine (SAM), the methyl donor utilized by

236 hieno-pyrimidones that were competitive with S-adenosylmethionine (SAM), the physiological methyl don

237 pi1p represses genes that maintain levels of S-adenosylmethionine (SAM), the substrate for most methy

238 d expression of SIN3 leads to an increase in S-adenosylmethionine (SAM), which is the major cellular

239 acid methionine is a metabolic precursor for S-adenosylmethionine (SAM), which serves as a coenzyme f

240 depends on the integrity of the helicase and S-adenosylmethionine (SAM)-dependent methyltransferase-l

241 S-Adenosylmethionine (SAM)-dependent methyltransferases

242 SAH is a potent feedback inhibitor of S-adenosylmethionine (SAM)-dependent methyltransferases

243 ic programming and is most often achieved by S-adenosylmethionine (SAM)-dependent methyltransferases.

244 and oxygenation through the action of eight S-adenosylmethionine (SAM)-dependent mycolic acid methyl

245 Several members of a distinct family of S-adenosylmethionine (SAM)-dependent N-methyltransferase

246 The S-adenosylmethionine (SAM)-I riboswitch is a noncoding R

247 molecular dynamics simulation studies of the S-adenosylmethionine (SAM)-II riboswitch that is involve

248 cusing almost exclusively upon Mg(2+) and/or S-adenosylmethionine (SAM)-induced folding of full-lengt

249 hich recycles adenine and methionine through S-adenosylmethionine (SAM)-mediated methylation reaction

250 The S(MK) (SAM-III) box is an S-adenosylmethionine (SAM)-responsive riboswitch found i

251 ich represents one of three known classes of S-adenosylmethionine (SAM)-responsive riboswitches, regu

252 he purified enzyme contains internally-bound S-adenosylmethionine (SAM).

253 ionine boosts synthesis of the methyl donor, S-adenosylmethionine (SAM).

254 facilitate the unusual acyl conjugation with S-adenosylmethionine (SAM).

255 ed the MCD diet-induced depletion of hepatic S-adenosylmethionine (SAM).

256 a lesser degree, of its metabolic precursor S-adenosylmethionine (SAM).

257 d in bacterial mRNAs that specifically binds S-adenosylmethionine (SAM).

258 S-Adenosylmethionine (SAM, also known as AdoMet) radical

259 ment with ursodeoxycholic acid (UDCA) and/or S-adenosylmethionine (SAMe) affects the expression of th

260 S-Adenosylmethionine (SAMe) and its metabolite 5'-methyl

261 which have chronically low levels of hepatic S-adenosylmethionine (SAMe) and spontaneously develop st

262 iver disease often leads to impaired hepatic S-adenosylmethionine (SAMe) biosynthesis, and mice with

263 Ursodeoxycholic acid (UDCA) or S-adenosylmethionine (SAMe) prevented the LCA-induced de

264 T) are the primary genes involved in hepatic S-adenosylmethionine (SAMe) synthesis and degradation, r

265 The principal methyl donor of the cell, S-adenosylmethionine (SAMe), is produced by the highly c

266 ts were found for replicated studies testing S-adenosylmethionine (SAMe), methylfolate, omega-3 (prim

267 ycine N-methyltransferase (GNMT) catabolizes S-adenosylmethionine (SAMe), the main methyl donor of th

268 ole in peripheral nerve myelination and that S-adenosylmethionine (SAMe), the principal methyl donor

269 S-Adenosylmethionine (SAMe), the principal methyl donor

270 ltransferase (MAT) catalyzes biosynthesis of S-adenosylmethionine (SAMe), the principle methyl donor.

271 their liver tissues have abnormal levels of S-adenosylmethionine (SAMe).

272 arbon cycle, which produces the methyl donor S-adenosylmethionine (SAMe).

273 in alpha5, beta3, and alpha6, increasing the S-adenosylmethionine site solvent exposure.

274 idue and becomes much more dramatic when the S-adenosylmethionine substrate is present in the enzyme

275 tant uncovered a nitrogen-, methionine-, and S-adenosylmethionine-sufficiency response, resulting in

276 s/methylsynthases that belong to the radical S-adenosylmethionine superfamily of enzymes.

277 has been shown to be a member of the radical S-adenosylmethionine superfamily of proteins, suggesting

278 ion of worm methionine synthase (metr-1) and S-adenosylmethionine synthase (sams-1) imply metformin-i

279 teins have diverse cellular roles, including S-adenosylmethionine synthesis, respiration, and host tr

280 AdoMet formation is catalyzed by S-adenosylmethionine synthetase (ATP: L-methionine S-ade

281 enzymes central to all cellular methylation, S-adenosylmethionine synthetase and S-adenosylhomocystei

282 psis (Arabidopsis thaliana), one of the four S-adenosylmethionine synthetase genes, METHIONINE ADENOS

283 lso identified highly induced levels of four S-adenosylmethionine synthetase genes, the EARLY-RESPONS

284 The S-adenosylmethionine synthetase type 1 (MAT1A) gene enco

285 hich contains serine metabolic enzymes, SAM (S-adenosylmethionine) synthetases, and an acetyl-CoA syn

286 late, which is required for the synthesis of S-adenosylmethionine, the methyl donor for cellular meth

287 novo synthesis of purines, thymidylate, and S-adenosylmethionine, the primary cellular methyl donor.

288 transferase (MAT) catalyzes the synthesis of S-adenosylmethionine, the principal methyl donor, and is

289 ne (3-MeA) is formed in DNA by reaction with S-adenosylmethionine, the reactive methyl donor, and by

290 e been found to catalyze alkyl transfer from S-adenosylmethionine to halide ions.

291 The enzyme utilizes S-adenosylmethionine to methylate a variety of phosphona

292 d by a typical Sn2-type methyl transfer from S-adenosylmethionine to pEA.

293 mes, and utilizes an iron-sulfur cluster and S-adenosylmethionine to repair SP by a direct reversal m

294 of GSH to oxidized forms of glutathione and S-adenosylmethionine to S-adenosylhomocysteine levels, r

295 fer of donor methyl groups from the cofactor S-adenosylmethionine to specific acceptor lysine residue

296 Transfer of a methyl group from S-adenosylmethionine to the target RNA is performed by f

297 extracellular concentration of methionine or S-adenosylmethionine was increased.

298 ylated sulfonium ions that were analogues of S-adenosylmethionine were investigated by computational

299 deuterated 5'-deoxyadenosine and deuterated S-adenosylmethionine when the reaction is carried out in

300 Incubation of geranyl diphosphate and S-adenosylmethionine with a mixture of both SCO7700 and