ライフサイエンスコーパス: S-nitrosocysteine

1 ication of protein cysteine residues to form S-nitrosocysteine.

2 5-HT whereas the BJR responses elicited by L-S-nitrosocysteine (10 micromol/kg, i.v.) were similar be

3 In this setting, S-nitrosocysteine (10 muM) effectively blocked the Trx-m

4 responses elicited by the S-nitrosothiol, L-S-nitrosocysteine (5 micromol/kg, i.v.), were not attenu

5 cular smooth muscle cells, both the NO donor S-nitrosocysteine and atrial natriuretic peptide induced

6 We observed that both S-nitrosocysteine and cytokine-activated NOS2 inhibited

7 aortic smooth muscle cells upon exposure to S-nitrosocysteine and propylamine propylamine NONOate.

8 peared to be due to both competition between S-nitrosocysteine and Prx1 for the Trx system and direct

9 e system and in cells, NO/SNO donors such as S-nitrosocysteine and S-nitrosoglutathione readily induc

10 cond order rate constants of 76,900 M-1 s-1 (S-nitrosocysteine) and 12,800 M-1 s-1 (S-nitrosoglutathi

11 f nitrosothiols (i.e., S-nitrosoglutathione, S-nitrosocysteine, and S-nitrosoalbumin) and amperometri

12 with other cellular thiols, the formation of S-nitrosocysteine at Cys-145 was found to lead to the ra

13 es similar to those seen with injection of L-S-nitrosocysteine, blockade of excitatory amino acid rec

14 of cystine and nitric oxide, two products of S-nitrosocysteine breakdown, produced no significant res

15 ar weight RSNOs (i.e., S-nitrosoglutathione, S-nitrosocysteine) by tuning the irradiation exposure.

16 This strategy identified 20 unique S-nitrosocysteine-containing peptides belonging to 18 pr

17 Sequence analysis of the S-nitrosocysteine-containing peptides revealed the prese

18 ted in primary aortic smooth muscle cells by S-nitrosocysteine (CSNO), an S-nitrosylating agent, in h

19 r effects of S-nitrosothiols is specific for S-nitrosocysteine (CSNO), is stereoselective, and requir

20 In the present study, we show that S-nitrosocysteine (CSNO), S-nitrosoglutathione (GSNO), a

21 ls and human erythroid progenitor cells with S-nitrosocysteine (CysNO), an NO donor, and found simila

22 y the reaction of cysteine with GSNO to form S-nitrosocysteine (CysNO), mixed disulfides, and nitrosy

23 an be poly-S-nitrosylated by the NO carrier, S-nitrosocysteine (CysNO).

24 O from the biologically occurring substrate, S-nitrosocysteine (CysNO).

25 henanthroline were related to suppression of S-nitrosocysteine decay by cysteine-mediated reduction o

26 Comparison of the rates of S-nitrosocysteine decay in different subcellular fractio

27 used a concentration-dependent inhibition of S-nitrosocysteine decay, whereas deferoxamine (100 micro

28 In the presence of o-phenanthroline, S-nitrosocysteine decomposition followed saturable kinet

29 The rate of S-nitrosocysteine degradation by aortic homogenates in t

30 try as well as nitrosation experiments using S-nitrosocysteine demonstrate that GSNO binding does not

31 molecular mass cell-permeable S-nitrosothiol S-nitrosocysteine ethyl ester (SNCEE).

32 In HepG2 cells, we observed that S-nitrosocysteine ethyl ester impedes the activity of ca

33 res that underlie the specificity of protein S-nitrosocysteine formation in these cells remain unknow

34 The free S-nitrosocysteine generated in the reaction with GSNO br

35 eterolytic decomposition of the S-NO bond of S-nitrosocysteine in a process involving redox cycling o

36 We recently reported that degradation of S-nitrosocysteine in homogenates of porcine aorta increa

37 ular effects elicited by microinjection of L-S-nitrosocysteine in the nucleus tractus solitarii (NTS)

38 , we established that Trx1 protects GC1 from S-nitrosocysteine-induced desensitization.

39 The study demonstrates that S-nitrosocysteine is biologically active in the NTS.

40 ion of cysteine residues in proteins to form S-nitrosocysteine, is a major emerging mechanism by whic

41 ication of protein cysteine residues to form S-nitrosocysteine, is one of the molecular mechanisms by

42 he reaction at low initial concentrations of S-nitrosocysteine (< or = 15 microM) and inhibited the r

43 within the ER molecule by immunodetection of S-nitrosocysteine moieties in ER.

44 for the Trx system and direct modulation by S-nitrosocysteine of Trx reductase activity.

45 With regard to S-nitrosocysteine or cysteine oxide formation, no eviden

46 eact with cysteine sulfhydryl groups to form S-nitrosocysteine or cysteine oxides such as cysteinesul

47 Incubation of S-nitrosocysteine or S-nitrosoglutathione (5-100 M) in t

48 when exposed to S-nitrosoglutathione (GSNO), S-nitrosocysteine, or S-nitrosoacteylpenicillamine, resu

49 L-S-nitrosocysteine produced dose-related decreases of art

50 ing chemiluminescence revealed that L- and D-S-nitrosocysteine released identical amounts of nitric o

51 lity plot indicated that the distribution of S-nitrosocysteine residues was skewed toward larger surf

52 In contrast, D-S-nitrosocysteine, S-nitrosoglutathione, glyceryl trinit

53 S-nitrosocysteine (SNC) and, to a more modest extent, S-

54 s of the endothelium-derived relaxing factor S-nitrosocysteine (SNC) may not be simply due to its dec

55 in clusters and are indirectly activated by S-nitrosocysteine (SNC), an NO donor.

56 SNAP, 5 to 10 nmol/L or 100 to 800 mumol/L), S-nitrosocysteine (SNC, 100 mumol/L or 1 mmol/L), and S-

57 S-Nitrosocysteine (SNC, an NO donor) and 8-bromo-cGMP (8

58 esponse directed against proteins containing S-nitrosocysteine (SNO-cysteine) and showed that anti-NO

59 ctal neuron processes bathed in the NO donor S-nitrosocysteine (SNOC) and in RGC growth cones to whic

60 Among the NO-donors used, only S-nitrosocysteine (SNOC) was found to be capable of mode

61 prevents formation from either *NO donor or S-nitrosocysteine, the latter treatment resulting in 100

62 At non-limiting concentrations of S-nitrosocysteine, the rate of degradation in the cytoso

63 This reaction converts unstable S-nitrosocysteines to dehydroalanine derivatives under v

64 A reductive elimination of S-nitrosocysteines using phosphine substrates has been d

65 Responses to L-S-nitrosocysteine were not affected by local injection o