ライフサイエンスコーパス: S. dysenteriae

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1 S. dysenteriae 1 shares characteristics with other Shige

2 S. dysenteriae 1 strains obtained in locations throughou

3 Shigella dysenteriae serotype 1 (S. dysenteriae 1) is unique among the Shigella species a

4 It also offered limited protection against S. dysenteriae challenge.

5 in all strains examined, suggesting that all S. dysenteriae 1 isolates derive from a clone that resul

6 x 288 (CC288), comprising both S. boydii and S. dysenteriae strains.

7 cies: S. flexneri, S. sonnei, S. boydii, and S. dysenteriae.

8 strain induced robust serum and mucosal anti-S. dysenteriae 1 lipopolysaccharide (LPS) responses and

9 vaccine to protect against disease caused by S. dysenteriae 1 and potentially to protect against the

10 The virulence genes repressed by S. dysenteriae RyhB include those encoding the type III

11 WRSd1 was constructed from S. dysenteriae 1 strain 1617 that was originally isolate

12 of STEC are highly mobile, the stx genes in S. dysenteriae 1 have been believed to be chromosomally

13 quences flanking the haem transport locus in S. dysenteriae matched those at the 78.7 minute region o

14 ed the chromosomal region containing shuA in S. dysenteriae.

15 locus has an organization similar to that in S. dysenteriae, and it is located in the same relative p

16 ins tested were nearly identical to those in S. dysenteriae, indicating that, in these strains, the h

17 that shuA is essential for heme transport in S. dysenteriae.

18 The ability of S. dysenteriae to access iron during intracellular growt

19 We have located the toxin genes of S. dysenteriae 1 to a region homologous to minute 30 of

20 n clinical studies, we developed a series of S. dysenteriae 1 vaccine candidates containing the funda

21 lysis of the outer membrane receptor ShuA of S. dysenteriae.

22 Herein, we provide evidence that ShuS of S. dysenteriae sequesters DNA non-sequence-specifically

23 acellular growth and intercellular spread of S. dysenteriae.

24 similar to the preparation of the synthetic S. dysenteriae type 1 conjugates.

25 These observations suggest that S. dysenteriae 1 originally carried a Stx-encoding lambd

26 icant protective immune response against the S. dysenteriae 1 O antigen.

27 This region is present in all the S. dysenteriae 1 strains examined.

28 Disruption of this open reading frame on the S. dysenteriae chromosome by marker exchange yielded a s

29 ne that hybridizes at high stringency to the S. dysenteriae type 1 haem receptor gene, shuA.

30 ses and cytokine production were measured to S. dysenteriae whole-cell preparations and to purified r

31 gainst challenge with each of three virulent S. dysenteriae 1 strains.

32 (2) gene were identified by RAM assay, while S. dysenteriae and nonpathogenic E. coli isolates were u

33 um retinol was independently associated with S. dysenteriae type 1, high serum C-reactive protein con

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