ライフサイエンスコーパス: S. suis

1 S. suis interaction with human and pig IEC correlates wi

2 S. suis type II was recovered from their brains and join

3 Streptococcus suis serotype 2 (S. suis 2) is a highly invasive pathogen in pigs and hum

4 housekeeping gene fragments from each of 294 S. suis isolates obtained from various S. suis diseases

5 c potential, we compared whole genomes of 98 S. suis isolates from human patients and pigs with invas

6 and administered with emulsifying adjuvants, S. suis type 2 CPS is able to induce potent IgM and isot

7 hat Ssads could impair PMN's defense against S. suis 2 with decreasing of oxidative activity and degr

8 ortant roles in developing therapies against S. suis 2 infection.

9 in Streptococcus pyogenes, S. agalactiae and S. suis.

10 al role in the activation of neutrophils and S. suis clearance, which further reduced severe inflamma

11 minimizing disease associated with PRRSV and S. suis coinfection.

12 reduced mortality associated with PRRSV and S. suis coinfection.

13 oor indicator of genetic relatedness between S. suis isolates, these findings suggest that capsular g

14 infection and disease following challenge by S. suis type II.

15 njugate prototypes were prepared by coupling S. suis type 2 CPS to tetanus toxoid, and the immunologi

16 little geographical clustering of different S. suis subpopulations, and the bacterium undergoes high

17 jection for three consecutive days following S. suis challenge was the most effective regimen for min

18 multilocus sequence typing (MLST) scheme for S. suis developed in order to begin to address these iss

19 The cleavage patterns of DNA from S. suis isolated from the sows matched the cleavage patt

20 ws matched the cleavage patterns of DNA from S. suis isolated from their respective pigs.

21 undercooked pork is a risk factor for human S. suis serotype 2 (SS2) infection.

22 o understand the genetic basis of disease in S. suis, we study the genomes of 375 isolates with detai

23 robustness of the core metabolic pathways in S. suis during the infection process.

24 cose starvation induced adaptive response in S. suis makes a great contribution to understanding bett

25 A/(p)ppGpp in glucose starvation response in S. suis, the growth curves and transcriptional profiles

26 ndicate that Ssads play an important role in S. suis 2 escaping human innate immunity in the context

27 intramuscular doses of an autogenous killed S. suis vaccine (group 6) prior to S. suis challenge or

28 llenged intranasally with strain MN 87555 of S. suis type II.

29 ting isotopologue patterns in amino acids of S. suis grown under in vitro and ex vivo conditions.

30 To dissect the central metabolic activity of S. suis under different conditions of nutrient availabil

31 present, to our knowledge, the first case of S. suis arthroplasty infection and streptococcal toxic s

32 which correlated well with host clearance of S. suis.

33 cial role of PEP carboxylation for growth of S. suis in the host was supported by experiments with a

34 We compared in vitro interaction of S. suis with human and porcine intestinal epithelial cel

35 distribution of disease-causing isolates of S. suis, most isolates previously characterized as of hi

36 e the most common clinical manifestations of S. suis 2 infection.

37 However, the mechanisms of S. suis 2 surviving in human blood remains unclear, so t

38 d us to examine its effect on the outcome of S. suis infection.

39 results indicate that zoonotic potential of S. suis results from gene loss, recombination and horizo

40 The recombinant BgaC protein of S. suis was purified to homogeneity.

41 signated as Ssads (the adenosine synthase of S. suis 2).

42 sponse, and the outcome of highly pathogenic S. suis infection in a mouse model.

43 alactiae, S. equi, S. mutans, S. pneumoniae, S. suis and S. uberis, as well as representative enteroc

44 Most of the piglets in the PRRSV-S. suis dual-infection group developed suppurative menin

45 Overall, 20 out of 22 piglets in the PRRSV-S. suis dual-infection group died within 1 week after ch

46 Therefore we concluded that S. suis BgaC is an atypical surface-exposed protein with

47 immune electron microscopy demonstrated that S. suis BgaC is an atypical surface-anchored protein in

48 Here, we found that S. suis 2 can escape phagocytic clearance by adenosine s

49 classical growth experiments, we found that S. suis is auxotrophic for Arg, Gln/Glu, His, Leu, and T

50 Bioinformatics analyses revealed that S. suis BgaC shared the conserved active sites (W240, W2

51 However, little is known about the S. suis population structure, the clonal relationships b

52 ection-only group and 5 of 23 piglets in the S. suis-challenge-only group (1 of 12 in trial 1 and 4 o

53 genes may be moving horizontally through the S. suis population.

54 us killed S. suis vaccine (group 6) prior to S. suis challenge or a single 2-ml intramuscular dose of

55 ed a more severe proinflammatory response to S. suis infection and increased the mortality rate, whil

56 gulated in swine spleen cells in response to S. suis infection.

57 f 294 S. suis isolates obtained from various S. suis diseases and from asymptomatic carriage represen

58 roup died within 1 week after challenge with S. suis (10 of 11 in each of two trials).

59 ets showed clinical symptoms compatible with S. suis infection 24-48 hours after ingestion of SS2.

60 ction with human and pig IEC correlates with S. suis serotype and genotype, which can explain the zoo

61 Labeling experiments with S. suis grown ex vivo in blood or cerebrospinal fluid re

62 We identified a zoonotic S. suis clone that diverged from a non-zoonotic clone by

63 th food-borne transmission in Asia, zoonotic S. suis infections are mainly occupational hazards elsew