ライフサイエンスコーパス: SAHF

1 SAHF contain known heterochromatin-forming proteins, suc

2 SAHF formation coincides with the recruitment of heteroc

3 SAHF is enriched in a transcription-silencing histone H2

4 SAHF represses expression of proliferation-promoting gen

5 Notably, both SAHF formation and the silencing of E2F target genes dep

6 ration-promoting genes that are repressed by SAHF and associates with histone methyltransferase activ

7 ASF1a drive formation of macroH2A-containing SAHF and senescence-associated cell cycle exit, via a pa

8 Conversely, BRG1 overexpression drives SAHF formation and senescence in a DNA damage-independen

9 senescence-associated heterochromatic foci (SAHF) formation in human fibroblasts.

10 senescence-associated heterochromatic foci (SAHF), and beta-gal staining.

11 senescence-associated heterochromatic foci (SAHF), containing heterochromatin proteins such as HP1,

12 senescence-associated heterochromatic foci (SAHF).

13 senescence-associated heterochromatin foci (SAHF) and cell cycle exit.

14 senescence-associated heterochromatin foci (SAHF), are thought to contribute to the irreversible cel

15 senescence-associated heterochromatin foci (SAHF), as well as specific families of non-genic and gen

16 Senescence-Associated Heterochromatin Foci (SAHF), which are thought to repress expression of prolif

17 senescence-associated heterochromatin foci (SAHF), which repress expression of proliferation-promoti

18 senescence-associated heterochromatin foci (SAHF), which repress expression of proliferation-promoti

19 senescence-associated heterochromatin foci (SAHF).

20 senescence-associated heterochromatin foci (SAHF).

21 senescence-associated heterochromatic foci (SAHFs), which may provide a chromatin buffer that preven

22 senescence-associated heterochromatic foci (SAHFs).

23 s genomic profile and their implications for SAHF formation and gene regulation during senescence.

24 Here we show that BRG1 is required for SAHF formation and senescence induced by oncogenic RAS o

25 How SASP genes are excluded from SAHF-mediated global gene silencing remains unclear.

26 ins are not required for the accumulation in SAHF of histone H3 methylated on lysine 9, the recruitme

27 of histone H3, a site that is methylated in SAHF.

28 Furthermore, BRG1 knockdown inhibits SAHF formation and senescence induced by BRCA1 knockdown

29 tectably affect chromosome condensation into SAHF.

30 for efficient incorporation of HP1gamma into SAHF.

31 es with incorporation of SASP gene loci into SAHF.

32 prior to incorporation of HP1 proteins into SAHF.

33 pathway cooperates with pRB and p53 to make SAHF, with the HIRA/ASF1a and pRB pathways acting in par

34 ated the composition and mode of assembly of SAHF and its contribution to cell cycle exit.

35 The possible contribution of SAHF to tumor suppression and tissue aging is also criti

36 ence, and ASF1a is required for formation of SAHF and efficient senescence-associated cell cycle exit

37 or, ASF1a, is rate limiting for formation of SAHF and onset of senescence, and ASF1a is required for

38 lization of HIRA to PML bodies, formation of SAHF and senescence, likely through GSK3beta-mediated ph

39 BRG1 knockdown suppresses the formation of SAHF and senescence, while it has no effect on BRCA1 chr

40 Formation of SAHF in human cells is driven by a complex of histone ch

41 Formation of SAHF is driven by a complex of histone chaperones, HIRA

42 alization to PML bodies prevent formation of SAHF, as does a PML-RARalpha fusion protein which disrup

43 UBN1 is indispensable for formation of SAHF.

44 A to PML bodies is required for formation of SAHF.

45 istone chaperone, ASF1a, drives formation of SAHF.

46 ASF1a), plays a key role in the formation of SAHF.

47 ropose a stepwise model for the formation of SAHF.

48 Furthermore, modulation of SAHF structure does not affect the occupancy of these re

49 s and are essential structural components of SAHFs.

50 ith both the subsequent layered structure of SAHFs and the global landscape of the repressive marks,

51 h the p16(INK4a) tumor suppressor to promote SAHF formation and proliferative arrest and stabilize se

52 ich BRG1 acts downstream of BRCA1 to promote SAHF formation and senescence.

53 me3-positive heterochromatin, thus promoting SAHF formation, which could be inhibited by ectopic LMNB

54 molecular mechanism by which BRCA1 regulates SAHF formation and senescence is unclear.

55 that each chromosome condenses into a single SAHF focus.

56 P1), and p16(INK4a), but not p53, suppressed SAHF formation induced by BRG1.

57 However, how the SAHF assembly pathway is activated in senescent cells is

58 essential to identify all components of the SAHF assembly pathway.

59 he structure, assembly and function of these SAHF at a cellular level.

60 cted the series of events that contribute to SAHF formation.

61 hese repressive marks remains unchanged upon SAHF formation, suggesting that in somatic cells, hetero