ライフサイエンスコーパス: SAP

1 SAP colocalized with SLAMF6 only in association with clu

2 SAP consisted of single-shot, intravenous infusion of 1.

3 SAP domains are common among many other SUMO E3s, and ar

4 SAP expression is required for the counterselection of d

5 SAP functions are mediated, in part, by FcgammaRs, but t

6 SAP in the first 14 days was diagnosed by a criteria-bas

7 SAP mediates this function by coupling SLAM family recep

8 SAP performed significantly better than FDT in predictin

9 SAP, SLP, and OCT outcomes were compared between the con

10 Interestingly, in the presence of Ca(2+), SAP first inhibited, then significantly accelerated D76N

11 if they had a minimum of 2 NEI VFQ-25 and 5 SAP tests during follow-up.

12 they had a minimum of 2 NEI VFQ-25 and >/=5 SAP during follow-up.

13 s had a median of 3 NEI VFQ-25, 8 FDT, and 8 SAP tests during follow-up.

14 a under the curve, 0.81; 95% CI, 0.72-0.90), SAP mean sensitivity (area under the curve, 0.80; 95% CI

15 ation increased after TCR restimulation in a SAP-dependent manner, requiring both immunoreceptor tyro

16 recombinase-mediated gene deletion to ablate SAP expression after completion of iNKT cell development

17 as the development of 3 consecutive abnormal SAP test results.

18 atients had normal or nonrepeatable abnormal SAP at baseline.

19 Carriers with SH2D1A mutations abolishing SAP expression and low percentage of SAP(+) cells showed

20 d to construct expression vectors to achieve SAP overexpression, and both genetic and functional assa

21 The signaling adaptor SAP is essential for normal immune homeostasis and mutat

22 In addition, SAP's regulation of IL-17-secreting T cells was shown to

23 nosis of SAP were assessed using adjudicated SAP as the reference standard.

24 )) than physician diagnosis with adjudicated SAP.

25 reaction times even after adjusting for age, SAP mean deviation in the better eye, cognitive ability,

26 The median age, SAP mean deviation, and follow-up period were 65 years,

27 urve, 0.80; 95% CI, 0.69-0.88; P = .03), and SAP pattern standard deviation (area under the curve, 0.

28 Both EAT-2 and SAP are expressed in natural killer (NK) cells, and thei

29 130, and Q128 affect neutrophil adhesion and SAP affinity for FcgammaRIIa.

30 Levels of alloantibodies and SAP in the circulation were determined by flow cytometry

31 he sectoral measurements between the BCI and SAP.

32 numbers of apoptotic cells, stronger C4d and SAP deposition, and extensive activated caspase 3 were f

33 control T-helper function, such as CD40L and SAP.

34 present on mouse lung epithelial cells, and SAP and the aminothiazole potentiate IL-10 production fr

35 CRP and SAP dose-dependently and substoichiometrically inhibited

36 CRP and SAP interacted with fresh and aggregated Abeta(1-40) and

37 P affect human fibrocyte differentiation and SAP binding to FcgammaRI.

38 SAT performance was impaired in DL and SAP rats; however, SAT performance and falls were correl

39 lar visual fields were estimated for FDT and SAP and used to calculate rates of change.

40 d healthy controls were examined by FDT2 and SAP, both with the 24-2 test pattern, on the same day at

41 ey aspects of inflammation and fibrosis, and SAP injections improve lung function in pulmonary fibros

42 nt of eccentricity for both SAP size III and SAP size V.

43 also affects phagocytosis by macrophages and SAP affinity for FcgammaRI.

44 n of radiolabelled peptide p5+14 with p5 and SAP, in amyloid-laden mice, using dual-energy SPECT imag

45 the presence of concentrations of serum and SAP that normally completely inhibit fibrocyte different

46 ls regulate B cell survival in a SLAMF6- and SAP-dependent manner.

47 tral-domain optical coherence tomography and SAP were performed at 6-month intervals.

48 Treatment with CPHPC followed by an anti-SAP antibody safely triggered clearance of amyloid depos

49 pecifically targeted by therapeutic IgG anti-SAP antibodies.

50 fused a fully humanized monoclonal IgG1 anti-SAP antibody.

51 In response to antigen, SAP-deficient mice form extrafollicular B cell responses

52 , 10-20% of which can evolve into severe AP (SAP) causing significant morbidity and mortality.

53 that regulates the level of STERILE APETALA (SAP) protein in the developing petals.

54 te differentiation, and sialidases attenuate SAP function.

55 a key paracrine factor of BMSCs attenuating SAP targeting the NF-kappaB1/p50 gene and suppressing th

56 For binocular SAP mean sensitivity, each 1 dB/year change was associat

57 Each 1-dB change in binocular SAP MS per year was associated with a change of 2.9 unit

58 Each 1 decibel (dB)/year change in binocular SAP MS was associated with a change of 2.0 units in the

59 ty index, each 1 dB/year change in binocular SAP MS was associated with a change of 3.0 units in the

60 severity and the rate of change in binocular SAP sensitivity, each 1-mum-per-year loss of RNFL thickn

61 res during follow-up and change in binocular SAP sensitivity.

62 res during follow-up and change in binocular SAP sensitivity.

63 Both SAP and the specific SLAM receptor NK, T, and B cell Ag

64 ntially independent of eccentricity for both SAP size III and SAP size V.

65 ls in patients with XLP seem functional, but SAP-deficient T cells were resistant to Treg cell-mediat

66 sms of B-cell tolerance could be affected by SAP deficiency.

67 Rates of visual field loss were assessed by SAP.

68 thickness change in eyes that progressed by SAP were faster than in those that did not progress (-1.

69 In contrast to irradiation, CD45-SAP completely avoided neutropenia and anemia, spared bo

70 In SLE T cells, SAP protein is also subject to increased degradation by

71 iating the need for increasingly challenging SAP timing recommendations.

72 ter first using CPHPC to deplete circulating SAP, we infused a fully humanized monoclonal IgG1 anti-S

73 (conA), and human serum amyloid P component (SAP) at elevated temperatures prior, during, and after d

74 protein (CRP) and serum amyloid P component (SAP), two major classical pentraxins in humans, are solu

75 also involved in serum amyloid P component (SAP)-mediated clearance of apoptotic bodies.

76 l plasma protein, serum amyloid P component (SAP).

77 saminoglycans and serum amyloid P component (SAP).

78 NUSAP1 contains a conserved SAP domain (SAF-A/B, Acinus, and PIAS).

79 values below the range of healthy controls (SAP(dull)), and 1, carrying the R55L mutation, was SAP(+

80 Defective SAP induces paradoxical inhibitory function of the 2B4 c

81 carboxylic acid (CPHPC) efficiently depletes SAP from the plasma but leaves some SAP in amyloid depos

82 at is distinct from the previously described SAP-FcgammaRIIa binding site.

83 Sixty-three of 587 eyes (11%) developed SAP visual field loss during follow-up.

84 ate of FDT PSD change in eyes that developed SAP visual field loss was 0.07 dB/year versus 0.02 dB/ye

85 algorithm-defined versus physician-diagnosed SAP in 1088 patients who had dysphagic acute stroke from

86 Physicians diagnosed SAP in 176/1088 (16%) and the algorithm in 123/1088 (11.

87 CI 56% to 73%), respectively) in diagnosing SAP.

88 tic and functional assays confirmed elevated SAP activity in transformed strains.

89 tients examined for glaucoma and to evaluate SAP, OCT and RGC counts capability to discriminate the w

90 Nine cases were SAP(-), 2 expressed SAP with mean relative fluorescence intensity values bel

91 Finally, SAP inhibits the heat-induced amorphous aggregation of h

92 For SAP size III, the average difference in MD between patie

93 tem, and that FcgammaR are not necessary for SAP function.

94 levels could serve as an early predictor for SAP.

95 the Guided Progression Analysis software for SAP.

96 5% CI, 0.86-0.96), which was larger than for SAP mean deviation (area under the curve, 0.81; 95% CI,

97 antibodies isolated from single B cells from SAP-deficient patients with X-linked lymphoproliferative

98 After adjusting for the contribution from SAP, 26% (95% CI, 12%-39%) of the variability of change

99 baseline and rate of change information from SAP had stronger ability to predict change in NEI VFQ-25

100 os et al. combining light sensitivities from SAP and retinal thickness from OCT.

101 iferative disease (XLP), who lack functional SAP, were hyperresponsive to PD-1 signaling, confirming

102 ance checkpoint in the absence of functional SAP.

103 Furthermore, SAP expression is required within iNKT cells to facilita

104 Intraseptal GAT1-SAP treatment did not alter baseline or behaviorally sti

105 e in DNMTP were impaired by intraseptal GAT1-SAP.

106 Moreover, GAT1-SAP did not alter evoked hippocampal ACh efflux related

107 lesions of the MSDB using GAT1-saporin (GAT1-SAP) and examined on spontaneous exploration (Experiment

108 alculated in 87 eyes with advanced glaucoma (SAP MD </=-12 dB).

109 However, the precise cellular basis of how SAP deficiency contributes to immune dysfunction remains

110 Collectively, our data reveal how SAP nucleates a previously unknown signaling complex inv

111 However, SAP and CRP bind the same Fcgamma receptors (FcgammaR) w

112 We found that aa Q55 and E126 in human SAP affect human fibrocyte differentiation and SAP bindi

113 (123)I-SAP proved to have high sensitivity in imaging of AA and

114 gulation of central tolerance, we identified SAP expression in a discrete subset of bone marrow immat

115 Our results identify SAP as an inhibitor of PD-1 function and SHP2 as a poten

116 In SAP patients, PAr had greater predictive strength than d

117 1.30, 1.63) and 1.31 (95% CI: 1.21, 1.41) in SAP and AMI patients, respectively.

118 fied functionally significant amino acids in SAP form a binding site that is distinct from the previo

119 receptor was a reliable predictor of ALI in SAP.

120 r subjects with the same amount of change in SAP sensitivity, those with shorter follow-up times had

121 The resulting decrease in SAP activity leads to a shortening of the cell prolifera

122 corrects the cellular and humoral defects in SAP(-/-) mice providing proof of concept for gene therap

123 r arbitrary values of intereye difference in SAP mean deviation (MD) of 0, 5, 10, and 15 dB were 0.58

124 oxyl-terminal tail of EAT-2 but not found in SAP.

125 evaluated the role of pancreatic lipases in SAP-associated visceral fat necrosis, the inflammatory r

126 of unreliable responses on the MD and PSD in SAP.

127 uced similar anti-RABV antibody responses in SAP-deficient and wild-type mice, demonstrating that BAF

128 germinal center formation, were restored in SAP-transduced mice.We demonstrate for the first time th

129 own to contain anti-CD3/TCR Abs, resulted in SAP downregulation.

130 years; however, its pathogenesis and role in SAP outcomes are poorly understood.

131 tic fat lipolysis plays an important role in SAP, we evaluated the role of pancreatic lipases in SAP-

132 LCBI and the primary endpoint was similar in SAP and ACS patients (p value for heterogeneity = 0.14).

133 mum set of items that should be addressed in SAPs for clinical trials, developed with input from stat

134 ems that should be addressed and included in SAPs for clinical trials.

135 o a complete ophthalmic evaluation including SAP and Spectral Domain OCT (SD-OCT) of RNFL and macular

136 Indeed, SAP-deficient T cells were hyperresponsive to T-cell rec

137 r-release) to be combined with intracellular SAP expression in peripheral blood NK cells.

138 was inversely correlated with intracellular SAP levels.

139 of transcription 1 (STAT1) and utilizing its SAP-domain function.

140 Furthermore, 3 d after Kiss1-SAP injection, the fish had a significantly reduced AS-e

141 The Kiss1-SAP injection significantly reduced Kiss1 immunoreactivi

142 ormed in Europe by using iodine-123-labelled SAP; however, this tracer is not available in the US.

143 y, we found that CD4 and CD8 T cells lacking SAP had a diminished capacity to differentiate into IL-1

144 the day, versus 24 h use of patient-managed SAP only, in free-living conditions.

145 odel adjusting for baseline MoCA score, mean SAP MD, age, sex, race/ethnicity, educational level, inc

146 Mechanistically, SAP opposed PD-1 function by acting as a molecular shiel

147 IGN ligand and anti-DC-SIGN antibodies mimic SAP effects in vitro.

148 isual field was estimated from the monocular SAP tests, and rates of change in mean sensitivity (MS)

149 Moreover, SAP bound principally to hepatosplenic amyloid, whereas

150 teins associated with the silicalemma, named SAPs for Silicalemma Associated Proteins.

151 They also reveal a novel SAP adaptor-independent function for a SLAM receptor.

152 he pro- and anti-amyloidogenic activities of SAP are not mutually exclusive, but reflect two sides of

153 compared early versus late administration of SAP before surgery.

154 Early administration of SAP did not significantly reduce the risk of SSI compare

155 were highly predictive of the development of SAP visual field loss in glaucoma suspects.

156 Mean deviation of SAP was -0.47 +/- 0.9 dB and -1.43 +/- 2.3 dB in the con

157 OR of algorithmic and physician diagnosis of SAP were assessed using adjudicated SAP as the reference

158 Together, these effects of SAP reduce key aspects of inflammation and fibrosis, and

159 Forced expression of SAP in SLE T cells normalized IL-2 production, calcium (

160 The expressions of SAP and SLAM family members were assessed in human bone

161 necrosis volume of 112.5 ml was a marker of SAP and 433.0 ml cut-off value could be used to predict

162 473.4 pg/ml) were reliable early markers of SAP.

163 n hepatic amyloid load, as shown by means of SAP scintigraphy and measurement of extracellular volume

164 eal thickness, and follow-up measurements of SAP PSD).

165 CA) testing was performed within 6 months of SAP testing.

166 us SAP use during the day versus 2 months of SAP use only under free-living conditions.

167 ty, educational level, income, and number of SAP tests, each 5-point decline in MoCA score was associ

168 lishing SAP expression and low percentage of SAP(+) cells showed neutral 2B4 function at the polyclon

169 ordinary least squares linear regressions of SAP mean deviation (MD) values over time.

170 We also found that removal of SAP expression during progression of CIA attenuated dise

171 ncrease of 0.23 dB in the SD of residuals of SAP MD (95% CI, 0.11-0.35; P < .001).

172 ncrease of 0.18 dB in the SD of residuals of SAP MD (R2 = 4.3%; 95% CI, 0.06-0.30; P = .003).

173 Restoration of SAP levels in SLE T cells corrects the overexcitable lup

174 The risk of SAP increased in a dose-response manner with delays in S

175 SALT) were associated with patients' risk of SAP.

176 r stroke, are associated with higher risk of SAP.

177 OR 2.01, 1.76 to 2.30) had a higher risk of SAP.

178 , with a lower dose of collagen, the role of SAP was more dependent on Fyn binding, suggesting that a

179 Silencing of SAP augmented and overexpression blocked PD-1 function.

180 Study of SAP expression is specific but may have insufficient sen

181 d cellular mechanisms distinct from those of SAP.

182 the longitudinal measurement variability of SAP mean deviation (MD) using linear regressions.

183 gest that the physiological contributions of SAPs to vaginal immunopathology require hypha formation,

184 Accurate detection of SAPs is an important issue in proteomic analysis at the

185 uencing (NGS) data and the identification of SAPs through database searching, post-processing and gen

186 time of the earliest visual field defect on SAP.

187 between GCC loss, NFL loss, and deficits on SAP.

188 dict the development of visual field loss on SAP, adjusting for confounding variables (baseline age,

189 Forty-six eyes (8.4%) showed progression on SAP during follow-up.

190 nts) was conducted to establish consensus on SAPs.

191 rombin may be an initial trigger to override SAP inhibition of fibrocyte differentiation to initiate

192 lated human serum proteins, serum amyloid P (SAP) and C-reactive protein (CRP), strongly affect fibro

193 lylated glycoprotein called serum amyloid P (SAP) inhibits fibrocyte differentiation, and sialidases

194 The plasma protein serum amyloid P (SAP) reduces neutrophil adhesion, inhibits the different

195 bited by the plasma protein serum amyloid P (SAP), and healthy tissues contain very few fibrocytes.

196 ith the fibrocyte inhibitor serum amyloid P (SAP; pentraxin-2) significantly prolonged survival and s

197 n associated with severe acute pancreatitis (SAP) for over 100 years; however, its pathogenesis and r

198 ial management of severe acute pancreatitis (SAP) is conservative.

199 m tuberculosis sulfate-assimilation pathway (SAP) represent major immunogenic targets of the bacillus

200 linked lymphoproliferative disease patients, SAP deficiency reduces CD74 expression, resulting in the

201 graphy for suspected stable angina pectoris (SAP) (n = 4131) and an independent cohort of patients wh

202 r angiography due to stable angina pectoris (SAP) or acute coronary syndrome (ACS).

203 6N beta2-m fibril was coated with pentameric SAP.

204 ity indices in standard automated perimetry (SAP) affect the global indices of visual field (VF) resu

205 monitored with standard automated perimetry (SAP) and had longitudinal assessment of cognitive abilit

206 l subjects had standard automated perimetry (SAP) and optical coherence tomography was used to measur

207 re tested with standard automated perimetry (SAP) at 6-month intervals, and evaluation of rates of vi

208 d annually and standard automated perimetry (SAP) at 6-month intervals.

209 d annually and standard automated perimetry (SAP) at 6-month intervals.

210 eld defects on standard automated perimetry (SAP) at baseline.

211 table abnormal standard automated perimetry (SAP) or progressive glaucomatous changes on stereophotog

212 t one reliable standard automated perimetry (SAP) test, while RNFL measurements were obtained using t

213 eld loss using standard automated perimetry (SAP) when considering different frequencies of testing u

214 BCI device and standard automated perimetry (SAP) within 3 months.

215 be observed by Standard Automated Perimetry (SAP), the second by Optic Coherence Tomography (OCT) tha

216 asurements and standard automated perimetry (SAP).

217 -25), FDT, and standard automated perimetry (SAP).

218 try to current standard automated perimetry (SAP).

219 atio (C/N ratio), soil available phosphorus (SAP), soil NH4(+)-N, soil NO3(-)N, aboveground biomass (

220 uired content of statistical analysis plans (SAPs) to support transparency and reproducibility.

221 nths of AP use from dinner to waking up plus SAP use during the day versus 2 months of SAP use only u

222 Diagnosing stroke-associated pneumonia (SAP) is challenging and may result in inappropriate anti

223 ces the risk of stroke-associated pneumonia (SAP), or of how quickly it should be done after admissio

224 tion method based on superabsorbent polymer (SAP) beads.

225 ncluding 510 single amino acid polymorphism (SAP) peptides, 2 INDEL peptides, 49 splice junction pept

226 n result in single amino acid polymorphisms (SAPs), leading to alteration of the corresponding amino

227 Stretch-attend posture (SAP) occurs during risk assessment and is prevalent in c

228 act of three different set anode potentials (SAPs; -0.25, 0, and 0.25 V vs. standard hydrogen electro

229 em, and the symptom association probability (SAP) test might distinguish extraesophageal manifestatio

230 We describe a spike adjustment procedure (SAP) that, unlike commonly used normalization methods in

231 ation of surgical antimicrobial prophylaxis (SAP) for the prevention of surgical site infection (SSI)

232 isplay reduced levels of the adaptor protein SAP, probably as a result of continuous T cell activatio

233 ytic activation molecule-associated protein (SAP) adaptor are important in the development of several

234 cyte activation molecule-associated protein (SAP) adaptors.

235 n the gene encoding SLAM-associated protein (SAP) and leads to abnormalities of NKT-cell development,

236 ytic activation molecule-associated protein (SAP) are highly susceptible to one specific viral pathog

237 tivation molecule (SLAM)-associated protein (SAP) can mediate the function of SLAM molecules, which h

238 disease, which lack SLAM-associated protein (SAP) expression.

239 es, mediated by the SLAM-associated protein (SAP) family of adaptors.

240 cyte activation molecule-associated protein (SAP) for their development.

241 ytic activation molecule-associated protein (SAP) was functionally and mechanistically analyzed for i

242 cyte activation molecule-associated protein (SAP), may present with HLH.

243 tivation molecule (SLAM)-associated protein (SAP), the X-linked lymphoproliferative gene product.

244 tivation molecule (SLAM)-associated protein (SAP)-deficient mouse model.

245 -95, PSD-93, and synapse-associated protein (SAP)102 and combining electrophysiology and transmission

246 The T. pseudonana SAPs (TpSAPs) are characterized by their motif organizat

247 (UEV) domain with a pocket that can bind PT/SAP motifs and another pocket that can bind Ub.

248 0 patients were randomly assigned to receive SAP early (2798 patients) or late (2782 patients).

249 ter-generated list in a 1:1 ratio to receive SAP early in the anaesthesia room or late in the operati

250 ells (BMSCs) have the potential of repairing SAP, but the detailed mechanism remains unknown.

251 binding of these antibodies to the residual SAP in amyloid deposits activates complement and trigger

252 Cells are permeabilized using saponin (SAP), digitonin (DIG) or recombinant perfringolysin O (r

253 ingle dose of the immunotoxin, CD45-saporin (SAP), enabled efficient (>90%) engraftment of donor cell

254 ish Kiss1 peptide was conjugated to saporin (SAP) to selectively inactivate Kiss-R1-expressing neuron

255 eyes were compared with global and sectoral SAP parameters.

256 Since SAP is one of the main causes of mortality after acute s

257 ollectively, these results suggest that SLAM-SAP signaling drives the differentiation and function of

258 ognizing self-antigens, suggesting that SLAM/SAP regulate B-cell receptor-mediated central tolerance.

259 We sought to determine whether the SLAM/SAP pathway regulates the establishment of human B-cell

260 depletes SAP from the plasma but leaves some SAP in amyloid deposits that can be specifically targete

261 Algorithm-based approaches can standardise SAP diagnosis for clinical practice and research.

262 described the discovery of sulfonylpyridine (SAP), benzothiazole (BZT), indazole (IND), and tetrahydr

263 binding domain of p65 through its C-terminal SAP-like domain in the nuclei under the condition of inf

264 degradation of propionate in all the tested SAPs was facilitated by syntrophic interactions between

265 r relative abundance varied among the tested SAPs.

266 ergic lesions (DL) fell more frequently than SAP or 6-OHDA rats.

267 f iNKT cell development, we demonstrate that SAP is essential for T-cell receptor (TCR)-induced iNKT

268 We present evidence that SAP protein levels are decreased in T cells and in their

269 Here, we report that SAP but not CRP binds the receptor DC-SIGN (SIGN-R1) to

270 Our data suggest that SAP activates DC-SIGN to regulate the innate immune syst

271 Together, these results suggest that SAP binds to FcgammaRI on monocytes to inhibit fibrocyte

272 These data suggest that SAP first exhibits anti-amyloidogenic activity possibly

273 to bridging of the MEF2C-bound sites by the SAP domain-containing co-activator protein myocardin, an

274 In contrast, the SAP of -0.25 V had the lowest electron flux to current (

275 hat exhibited MSMPs that occurred during the SAP (which were treated during surgery) show SS greater

276 We demonstrate that antibody blocking of the SAP-dependent 2B4 receptor is sufficient to induce XLP-l

277 ed to wild-type levels in mice receiving the SAP vector in comparison to control mice.

278 cgammaRI with an IgG-blocking Ab reduces the SAP effect on fibrocyte differentiation, and ligating Fc

279 by piloting of the guidance document in the SAPs of 5 trials.

280 tient-managed sensor-augmented pump therapy (SAP) during the day, versus 24 h use of patient-managed

281 nt genera detected on the anode of all three SAPs based on 16S rRNA gene sequencing were Geobacter, S

282 Among the three SAPs tested, 0 V showed the highest electron flux to ele

283 fat by pancreatic lipases convert mild AP to SAP independent of pancreatic necrosis and the inflammat

284 noted obesity to convert mild cerulein AP to SAP with greater cytokines, unsaturated fatty acids (UFA

285 and in Phase 1 and Phase 2 clinical trials, SAP affects several aspects of the innate immune system

286 New York, from 23 patients who had undergone SAP with a total of 40 treated sinuses.

287 Unlike SAP, EAT-2 does not enhance conjugate formation.

288 Clinicians now use SAP for the diagnosis and management of glaucoma through

289 ll)), and 1, carrying the R55L mutation, was SAP(+).

290 Nine cases were SAP(-), 2 expressed SAP with mean relative fluorescence

291 When SAP beads swell with water, small molecules can be sorbe

292 (FcgammaR) with similar affinities, and why SAP and CRP have opposing effects is unknown.

293 n of the visual sensitivity as assessed with SAP size III and size V.

294 nd inhibiting fibrocyte differentiation with SAP may interfere with this process.

295 these values were 3% with FDT2 and none with SAP.

296 patients with FDT2, in 17% of patients with SAP, and in 3% of patients with both techniques; in cont

297 ) patients were adjudicated as patients with SAP.

298 he target range was higher with AP than with SAP use: 66.7% versus 58.1% (paired difference 8.6% [95%

299 e disease or normal T cells transfected with SAP-specific small interfering RNA, consistent with RICD

300 Although worse SAP sensitivity was associated with worse ability to div