ライフサイエンスコーパス: SLC6A4

1 folding of the serotonin transporter (SERT; SLC6A4).

2 ymorphism in the serotonin transporter gene (SLC6A4).

3 GS2, two in HTR2A, one in SLC6A2, and one in SLC6A4).

4 y to ASD are PTEN and Serotonin transporter (SLC6A4).

5 terial artificial chromosome drivers Pet1 or Slc6a4.

6 variants of two functional polymorphisms of SLC6A4 (5-HTTLPR, intron 2 variable number tandem repeat

7 variants of the serotonin transporter gene (SLC6A4), a long-standing OCD candidate, have so far been

8 anxiety typically associated with the short SLC6A4 allele.

9 er region of the serotonin transporter gene (SLC6A4; also known as 5-HTT) and its contribution to str

10 ted with altered transcriptional activity of SLC6A4; an earlier study reported an association of the

11 Analyzing four markers in SLC6A4 and four markers in ITGB3 in 117 white family tri

12 Recent major findings from studies of SLC6A4 and its corresponding protein, the serotonin (5-H

13 Messenger RNA (mRNA) expression of SLC6A4 and p11 was measured in sigmoid and rectal mucosa

14 nteraction between two markers--rs1042173 in SLC6A4 and rs3809865 in ITGB3.

15 nges in mice and rats), it seems likely that SLC6A4 and SERT will remain areas of high interest in ou

16 llustrate significant variation worldwide at SLC6A4 and that the functionally implicated alleles at t

17 Restraint stress was applied to pregnant Slc6a4 (+/+) and Slc6a4 (+/-) mice and post-stress embry

18 nsiently express the 5-HT transporter (SERT; Slc6a4) and accumulate 5-HT, suggesting that the SERT ac

19 ions between the serotonin transporter gene (SLC6A4) and alcohol, heroin, cocaine, or methamphetamine

20 er region of the serotonin transporter gene (SLC6A4) and exposure to childhood trauma.

21 er protein (SERT or soluble carrier protein, SLC6A4) and p11 (S-100A10, or calpactin I light chain).

22 variants at the serotonin transporter gene (SLC6A4) and serotonin 2A receptor gene (HTR2A) predict c

23 of interest--the serotonin transporter gene (SLC6A4) and the integrin beta 3 gene (ITGB3) on chromoso

24 en Nrxn1alpha, En2 and Fmr1; Nlgn3, BTBR and Slc6A4; and also between X monosomy and Mecp2.

25 Polymorphisms in SLC6A4 are associated with differences in emotional, end

26 am region of the serotonin transporter gene (SLC6A4) are associated with individual differences in st

27 llection of multiple, often rare, alleles at SLC6A4 as imposing risk of autism.

28 there was no consistent association between SLC6A4*C and any Tridimensional Personality Questionnair

29 analysis revealed a positive linkage between SLC6A4*C and the 2 anxiety-related subdimensions of Harm

30 We have attempted to confirm the role of SLC6A4*C in anxiety-related personality traits by sibpai

31 association, raising the question of whether SLC6A4*C locus is itself affecting anxiety or is linked

32 sent study we replicated the relationship of SLC6A4*C to anxiety by sibpair linkage analysis but foun

33 ter of the human serotonin transporter gene (SLC6A4*C) was identified and found to be linked to an an

34 Association studies at SLC6A4 cannot a priori extrapolate across populations an

35 membrane serotonin (5-HT) transporter (SERT, SLC6A4) clears 5-HT after release at nerve termini and i

36 escribed in the promoter region of the gene (SLC6A4) coding for the serotonin transporter protein (SE

37 hism, 5HTTLPR, in the serotonin transporter, SLC6A4, coupled with prenatal stress is reported to incr

38 of p38alpha MAPK in serotonergic neurons (by Slc6a4-Cre or ePet1-Cre) or astrocytes (by Gfap-CreERT2)

39 thy human volunteers (ADORA2A, SLC6A3, BDNF, SLC6A4, CSNK1E, SLC6A2, DRD2, FAAH, COMT, OPRM1).

40 Embryos of stressed Slc6a4 (+/+) dams exhibited significantly altered methyl

41 ontrast, the response of embryos of stressed Slc6a4 (+/-) dams was found to be attenuated, shown by s

42 idate genes for neuropsychiatric phenotypes: SLC6A4, encoding the serotonin transporter; and SLC18A2,

43 ults contribute to a better understanding of SLC6A4 expression genetics and provide a functional hapl

44 hydroxytryptamine, 5-HT) transporter (hSERT, SLC6A4) figures prominently in the etiology and treatmen

45 nalysis supports that the association of the SLC6A4 gene with substance use disorder varies depending

46 T) transporter SERT (which is encoded by the SLC6A4 gene) to platelet 5-HT stores suggests an importa

47 point to a more complex relationship between SLC6A4 genotype and protein availability.

48 There was no effect of SLC6A4 genotype upon serotonin transporter binding.

49 The serotonin transporter (SERT/SLC6A4) has a rich pharmacology including inhibitors, re

50 ion of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of n

51 The serotonin transporter (SLC6A4) has been associated with several stress-related

52 The 5-HT transporter (SERT) gene (SLC6A4) has been associated with whole blood 5-HT levels

53 er region of the serotonin transporter gene (SLC6A4) has been found to moderate several categories of

54 promoter of the serotonin transporter gene (SLC6A4) has been proposed as a pharmacogenetic marker fo

55 Variation at the serotonin transporter gene, SLC6A4, has been associated with a variety of neuropsych

56 rotonin (5-HT) transporter (SERT, encoded by SLC6A4) have been identified in ASD.

57 e found normal colonic mucosal expression of SLC6A4 in diarrhea (IBS-D)- or constipation-predominant

58 Colonic mucosal expression of SLC6A4 in IBS is normal.

59 ssion and activity of 5-HT Transporter (SERT/Slc6a4) in 5-HT neurons leading to an increase of 5-HT u

60 he serotonin (5-HT) transporter gene (5-HTT, SLC6A4) in modulating amygdala and prefrontal activation

61 The serotonin transporter (SERT, SLC6A4) in the platelet plasma membrane represents a wel

62 amine (5-HT)] transporters (hSERT, 5HTT, and SLC6A4) inactivate 5-HT after release and are prominent

63 lymorphism of the serotonin transporter gene SLC6A4, influences cerebral cortical structure volumes i

64 The serotonin transporter gene (SLC6A4) is a strong autism candidate gene because of its

65 , including the human serotonin transporter (SLC6A4), is critical for efficient synaptic transmission

66 er region of the serotonin transporter gene (SLC6A4), is implicated in speech encoding in the human s

67 Similarly, maternal Slc6a4 knock-out and prenatal stress in rodents results

68 Combining these HTR3A/HTR3B and SLC6A4-LL/TT genotypes increased the target cohort from

69 B in the same sample that they genotyped for SLC6A4-LL/TT in the previous randomized, double-blind, 1

70 rted that the 5'-HTTLPR-LL and rs1042173-TT (SLC6A4-LL/TT) genotypes in the serotonin transporter gen

71 nvestigate the role of additional functional SLC6A4 loci in OCD.

72 The SLC6A4 locus encodes the serotonin transporter, which in

73 pothesis that the S allele of 5HTTLPR at the SLC6A4 locus is associated with a poor outcome after tre

74 umber of genes including SLC6A3, DRD5, DRD4, SLC6A4, LPHN3, SNAP-25, HTR1B, NOS1 and GIT1.

75 ess was applied to pregnant Slc6a4 (+/+) and Slc6a4 (+/-) mice and post-stress embryonic brains were

76 this phenotype is exacerbated in Pten(+/-); Slc6a4(+/-) mice.

77 ype that is exacerbated in female Pten(+/-); Slc6a4(+/-) mice.

78 ions of the DR, there were no differences in slc6a4 mRNA expression between MS15 and AFR rats.

79 ubsequent exposure to adult social defeat on slc6a4 mRNA expression in the dorsal raphe nucleus (DR)

80 sed to social defeat as adults had increased slc6a4 mRNA expression throughout the DR compared to bot

81 to a novel cage control condition, increased slc6a4 mRNA expression was observed in the dorsal part o

82 Social defeat increased slc6a4 mRNA expression, but only in MS180 rats and only

83 ience during adulthood interact to determine slc6a4 mRNA expression.

84 ween these factors on serotonin transporter (slc6a4) mRNA expression, we investigated in rats the eff

85 human primates indicate that combinations of SLC6A4 non-coding 5', 3' UTRs and intronic regions plus

86 ne promotor polymorphism (5-HTTLPR) locus of SLC6A4 now exist.

87 R and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine.

88 In Necdin-KO pups, the genetic deletion of Slc6a4 or treatment with Fluoxetine, a 5-HT reuptake inh

89 on serotonin (5-HT) transporter (5-HTT/SERT, SLC6A4) polymorphism is believed to confer lower 5-HTT e

90 gical mechanisms underlying the link between SLC6A4 polymorphisms and the emotionally vulnerable phen

91 SLC6A4 polymorphisms STin2, 5-HTTLPR, and rs25531 were g

92 influenced ability to detect association of SLC6A4 polymorphisms with personality measures; populati

93 We first sequenced the marmoset SLC6A4 promoter and identified a double nucleotide polym

94 rry a specific stress responsiveness-related SLC6A4 promoter genotype.

95 The SLC6A4 promoter polymorphism 5-HTTLPR influences cerebra

96 The authors assessed genotypes at the SLC6A4 promoter polymorphism in 96 healthy European Amer

97 They assessed genotype at the SLC6A4 promoter polymorphism, and an additional polymorp

98 , serotonin], member 4) gene, as well as the SLC6A4 promoter region polymorphism, 5-HTTLPR.

99 ociation between the serotonin protein gene (SLC6A4) promoter variant (5-HTTLPR) and risk of current

100 ansmitter transporter, serotonin), member 4 (SLC6A4), promoter, affects transcription and may be invo

101 sm and serotonin transporter genotype at the SLC6A4 promotor VNTR polymorphism in 30 healthy subjects

102 PR) in the human serotonin transporter gene (SLC6A4), resulting in altered transcription and transpor

103 synaptosomal-associated protein, 25 kDa) and SLC6A4 (serotonin transporter).

104 ter (SLC6A2, NET) and serotonin transporter (SLC6A4, SERT) genes and remission in depressed older adu

105 sopressin receptor 1a) gene and STin2 in the SLC6A4 (solute carrier family 6 [neurotransmitter transp

106 17q11.2 region that harbors the SERT locus (SLC6A4) supports a genetic effect at or near this gene.

107 ed copy of the 5-HT transporter (i.e., SERT, slc6a4) that bears a single amino acid substitution, I17

108 cleotide polymorphisms (SNPs) for AVPR1A and SLC6A4 to determine whether other variants in these gene

109 location of the serotonin transporter (SERT, SLC6A4) to the synaptic terminals of serotonergic neuron

110 P1, GABRB2, GRIN2B, HP, IL1B, MTHFR, PLXNA2, SLC6A4, TP53 and TPH1) showed nominally significant effe

111 Because the L(A) allele confers increased SLC6A4 transcription, increased serotonin transporter le

112 sm in the serotonin transporter gene (locus, SLC6A4; variant, serotonin 5-HTTLPR) moderates risk of p

113 In vivo, SLC6A4 variants in humans and other species lead to mark

114 32 and all other known non-coding functional SLC6A4 variants revealed a highly significant omnibus as

115 Genotype of the promoter for SLC6A4 was also assessed in all participants.

116 To determine the extent of variation at SLC6A4, we genotyped 23 markers on approximately 2500 in