ライフサイエンスコーパス: Shigella flexneri

1 , SsaG (Salmonella enterica SPI-2), or MxiH (Shigella flexneri).

2 966(T) of A. hydrophila and the vacB gene of Shigella flexneri.

3 teins complexed with lipopolysaccharide from Shigella flexneri.

4 ichia coli but not Salmonella typhimurium or Shigella flexneri.

5 iotic-resistant strain of the human pathogen Shigella flexneri.

6 y with SepA, a virulence protein secreted by Shigella flexneri.

7 t actin-based motility of Vaccinia virus and Shigella flexneri.

8 ivity in the sterile-culture supernatants of Shigella flexneri.

9 ium avium, but not Salmonella typhimurium or Shigella flexneri.

10 n other pathogenic strains of E. coli and in Shigella flexneri.

11 r realization of the pathogenic potential of Shigella flexneri.

12 i, MisL of serotype Typhimurium, and IcsA of Shigella flexneri.

13 were mapped within a pathogenicity island in Shigella flexneri.

14 nic E. coli and the global regulator virB of Shigella flexneri.

15 ial cell line, T84, isolated human PMNs, and Shigella flexneri.

16 or virulence of the human diarrheal pathogen Shigella flexneri.

17 estigated its regulation by H-NS and VirB in Shigella flexneri.

18 o required for IcsA secretion at the pole in Shigella flexneri.

19 oaggregative Escherichia coli (EAEC) 042 and Shigella flexneri 2457T.

20 The commonest serotype was Shigella flexneri 2a (89 of 292 serotypes [30.5%]).

21 coli (predominantly hexaacylated lipid A) or Shigella flexneri 2a (a mixture of hexaacylated, pentaac

22 An invasive strain of Shigella flexneri 2a (SC608) has been developed as a vec

23 Most strains of Shigella flexneri 2a and enteroaggregative Escherichia c

24 ella enterica serovar Typhi CVD 908-htrA and Shigella flexneri 2a CVD 1208 vaccines to deliver mucosa

25 nella enterica serovar Typhi CVD 908-htrA or Shigella flexneri 2a CVD 1208S live vector and were boos

26 ae were isolated and expressed in attenuated Shigella flexneri 2a guaBA strain CVD 1204.

27 e late acyltransferases, were deleted in the Shigella flexneri 2a human challenge strain 2457T to eva

28 2a-3, a DeltavirG DeltaaroD Escherichia coli-Shigella flexneri 2a hybrid vaccine strain that was prev

29 inantly plasmid-encoded virulence regulon of Shigella flexneri 2a is induced by growth at 37 degrees

30 We determine that OmpA of Shigella flexneri 2a is recognized by TLR2 and consequen

31 The Shigella flexneri 2a SC602 vaccine candidate carries del

32 The use of attenuated delta aroA delta virG Shigella flexneri 2a strain CVD 1203 as a live vector fo

33 Shigella flexneri 2a strain CVD 1204, which was construc

34 port the first community-based evaluation of Shigella flexneri 2a strain SC602, a live, oral vaccine

35 the safety and immunogenicity of attenuated Shigella flexneri 2a vaccine candidate CVD 1203, which h

36 fferent doses of CVD 1207, a live attenuated Shigella flexneri 2a vaccine candidate with specific del

37 e studied the safety and immunogenicity of a Shigella flexneri 2a vaccine comprising native S. flexne

38 of CS4 fimbriae in both E. coli DH5alpha and Shigella flexneri 2a vaccine strain CVD 1204, as detecte

39 ine of Shigella sonnei vaccine strain WRSS1, Shigella flexneri 2a vaccine strain SC602, and WRSd1 wer

40 g unit from the O-specific polysaccharide of Shigella flexneri 2a, a major cause of bacillary dysente

41 regative and uropathogenic Escherichia coli, Shigella flexneri 2a, and the hybrid enteroaggregative/S

42 In Shigella flexneri 2a, large proportions of pseudogenes a

43 hat Pic, a class 2 SPATE protein produced by Shigella flexneri 2a, uropathogenic and enteroaggregativ

44 the gene for LDC, cadA, was introduced into Shigella flexneri 2a, virulence became attenuated, and e

45 n (1) the attenuation profile of Delta guaBA Shigella flexneri 2a, which harbors deletions in the gua

46 ulfisoxazole, and tetracycline, including 49 Shigella flexneri (33%) and 3 Shigella sonnei (0.3%) iso

47 the ipaH4.5 gene on the invasion plasmid of Shigella flexneri 5 indicate an unusual fusion gene, des

48 The complete sequence analysis of the 210-kb Shigella flexneri 5a virulence plasmid was determined.

49 re observed for the NleE homologue OspZ from Shigella flexneri 6 that also bound TAB3 through the (49

50 Shigella flexneri, a causative agent of bacterial dysent

51 Shigella flexneri, a gram-negative enteric pathogen, is

52 However, Shigella flexneri, a nonflagellated bacterium, and a fla

53 ected the transcriptional immune response to Shigella flexneri across different infection stages in b

54 The invasive enteropathogenic bacterium Shigella flexneri activates apoptosis in macrophages.

55 aemophilus influenzae, Escherichia coli, and Shigella flexneri, added in the concentration range of p

56 shaped pathogens, including IcsA and SepA of Shigella flexneri, AIDA-I of diffusely adherent Escheric

57 of MxiH needle protein through the needle of Shigella flexneri, an essential step during needle assem

58 Shigella flexneri, an etiological agent of bacillary dys

59 The protective efficacy was 70% against Shigella flexneri and 50% against Shigella sonnei.

60 ence mechanism in enteroinvasive E. coli and Shigella flexneri and as a factor mediating E. coli O157

61 ature-sensitive C1 repressor was examined in Shigella flexneri and Klebsiella pneumoniae.

62 Intracellular pathogens such as Shigella flexneri and Listeria monocytogenes achieve dis

63 in cytoskeleton, the intracellular pathogens Shigella flexneri and Listeria monocytogenes use molecul

64 se homologues in pathogenic bacteria such as Shigella flexneri and Pseudomonas aeruginosa.

65 retained the ability to protect mice against Shigella flexneri and S. sonnei in the lethal pulmonary

66 via the type III secretion system (TTSS) of Shigella flexneri and serves as an essential effector mo

67 e leading cause of bacterial dysentery, with Shigella flexneri and Shigella sonnei accounting for aro

68 peron homologous to the ipgDEF operon of the Shigella flexneri and Shigella sonnei virulence plasmid.

69 cted against lethal pulmonary infection with Shigella flexneri and Shigella sonnei.

70 ls in response to low iron concentrations in Shigella flexneri and that this occurs at the level of t

71 of the cytoplasmic regions of the vT3SSs of Shigella flexneri and the vT3SS and fT3SS of Salmonella

72 Salmonella enterica serovar Typhimurium and Shigella flexneri and to the formation of attaching and

73 Motility of Shigella flexneri and vaccinia virus requires both N-WAS

74 d sspH2, that encode proteins similar to the Shigella flexneri and Yersinia species TTSS substrates,

75 gene, termed slrP, with homology to ipaH of Shigella flexneri and yopM of Yersinia pestis.

76 ng Escherichia coli, Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activa

77 including enteropathogenic Escherichia coli, Shigella flexneri, and Campylobacter jejuni, but not Nei

78 teins produced by Salmonella typhimurium and Shigella flexneri, and in the conceptual translation pro

79 that includes YscJ of Yersinia spp., MxiJ of Shigella flexneri, and NolT of Rhizobim fredii.

80 nal amino acids target IpaC for secretion by Shigella flexneri, and placing additional amino acids at

81 pathogens, including Listeria monocytogenes, Shigella flexneri, and Rickettsia rickettsii, exploit th

82 Since Listeria monocytogenes, Shigella flexneri, and Vaccinia virus among other pathog

83 mutant and the psp genes of S. enterica and Shigella flexneri are highly induced during macrophage i

84 Enteropathogenic Escherichia coli (EPEC) and Shigella flexneri are human host-specific pathogens that

85 nvasion invasion plasmid antigen B (ipaB) of Shigella flexneri are not cytotoxic.

86 acter rodentium, Salmonella typhimurium, and Shigella flexneri are sensed in an ill-defined manner by

87 arized epithelial Caco-2 cell monolayers and Shigella flexneri as a model enteropathogen, we found th

88 esponse against the enteroinvasive bacterium Shigella flexneri, both in vitro and in vivo.

89 The movement of the enteric pathogen Shigella flexneri, both within the cell body and from ce

90 Wild-type Shigella flexneri, but not a nonvirulent derivative, ind

91 Shigella flexneri can be phenotypically serotyped using

92 The closely related VirF regulator from Shigella flexneri cannot substitute for PerA to activate

93 Shigella flexneri causes a self-limiting gastroenteritis

94 Shigella flexneri causes a severe form of bacillary dyse

95 Shigella flexneri causes bacillary dysentery in humans b

96 Shigella flexneri causes bacillary dysentery with sympto

97 Shigella flexneri causes dysentery after invading the ep

98 Shigella flexneri causes human dysentery after invading

99 The expression of the Shigella flexneri chromosomal aerobactin genes during gr

100 Shigella flexneri contact with enterocytes induces a bur

101 The large virulence plasmid pMYSH6000 of Shigella flexneri contains a determinant that is highly

102 The large virulence plasmid pWR100 of Shigella flexneri contains a new P1par family member: pW

103 The large virulence plasmid pMYSH6000 of Shigella flexneri contains a replicon and a plasmid main

104 The tip complex of Shigella flexneri contains invasion plasmid antigen D (I

105 S. enterica serovar Typhimurium, and perhaps Shigella flexneri, contributes to bacterial colonization

106 Shigella flexneri cydC, which is deficient in cytochrome

107 A Shigella flexneri degP mutant, which was defective for p

108 t attachment and invasion by deoxycholate in Shigella flexneri, deoxycholate negatively regulates Ics

109 protective immunity to the enteric pathogen Shigella flexneri, despite the ability of Shigella to ac

110 The Mxi-Spa type III secretion system of Shigella flexneri directs the host cell contact-induced

111 entify candidate interaction partners of the Shigella flexneri effector proteins OspE1 and OspE2, whi

112 he mxi-spa locus on the virulence plasmid of Shigella flexneri encodes components of the type III sec

113 ca serovar Typhimurium, Serratia marcescens, Shigella flexneri, Enterobacter aerogenes, Klebsiella pn

114 contrast, the professional cytosol-dwelling Shigella flexneri escapes from LUBAC-mediated restrictio

115 PATEs) which also includes Pic from EAEC and Shigella flexneri, EspC from enteropathogenic E. coli, E

116 Lactoferrin protected rabbits infected with Shigella flexneri from developing inflammatory intestina

117 mote efficient transmission of the bacterium Shigella flexneri from one host cell to another.

118 d iron-deplete media, and addition of either Shigella flexneri fur or Sodalis fur to a plasmid restor

119 Eleven Shigella flexneri (group B) isolates were recovered from

120 Shigella flexneri grown to stationary phase has the abil

121 ield showing that Listeria monocytogenes and Shigella flexneri have evolved pathogen-specific mechani

122 Listeria monocytogenes, Yersinia pestis, and Shigella flexneri, have been implicated in virulence.

123 aining polar localization sequences from the Shigella flexneri IcsA protein or from the Vibrio choler

124 Yersinia pestis YapV is homologous to Shigella flexneri IcsA, and like IcsA, YapV recruits mam

125 y of guanylate-binding proteins (GBPs) coats Shigella flexneri in a hierarchical manner reliant on GB

126 agic E. coli strains, behaved like avirulent Shigella flexneri in that the macrophage monolayers were

127 o be a homolog of gadC recently sequenced in Shigella flexneri, in which it appears to encode a perme

128 vivo studies with three omp null mutants of Shigella flexneri, including classic phage plaque assays

129 ted with invasion and cell-to-cell spread by Shigella flexneri, including multiple components of the

130 Here we uncover a mechanism for Shigella flexneri-induced actin comet tail elongation th

131 cell environment, the intracellular pathogen Shigella flexneri induces the expression of numerous gen

132 By using convalescent-phase sera from 10 Shigella flexneri-infected monkeys, numerous epitopes we

133 els of enteropathogenic Escherichia coli and Shigella flexneri infection, WASp deficiency causes defe

134 N-gamma is essential to innate resistance to Shigella flexneri infection.

135 S production from the mitochondria following Shigella flexneri infections.

136 nal structure of Yersinia enterocolitica and Shigella flexneri injectisomes in situ and the first str

137 Shigella flexneri invades colonic epithelial cells by pa

138 f lipopolysaccharide (LPS) are important for Shigella flexneri invasion and virulence.

139 The guinea pig model for Shigella flexneri invasion of the colonic mucosa was use

140 The behavior of Shigella flexneri ipaH mutants was studied in human mono

141 Shigella flexneri is a bacterial pathogen that invades c

142 Shigella flexneri is a facultative intracellular organis

143 Shigella flexneri is a facultative intracellular pathoge

144 Shigella flexneri is a facultative intracellular pathoge

145 Shigella flexneri is a facultative intracellular pathoge

146 Shigella flexneri is a gram-negative bacterium that caus

147 Shigella flexneri is a gram-negative bacterium that caus

148 Shigella flexneri is a Gram-negative enteric pathogen th

149 Shigella flexneri is a Gram-negative intracellular patho

150 Shigella flexneri is a Gram-negative pathogen that invad

151 Shigella flexneri is a gram-negative, facultative intrac

152 The LPS of the enteropathogen Shigella flexneri is a hexa-acylated isoform possessing

153 ing the putative NF-T3SS C-ring component in Shigella flexneri is alternatively translated to produce

154 Shigella flexneri is an enteropathogen responsible for s

155 Shigella flexneri is an intracellular pathogen that diss

156 Shigella flexneri is an intracellular pathogen that is a

157 Pathogenesis of Shigella flexneri is dependent on the ability of the bac

158 e of the type-III secretion system needle of Shigella flexneri is determined to a precision of 0.4 A.

159 sol, the facultative intracellular bacterium Shigella flexneri is exposed to an environment that may

160 aintenance of the large virulence plasmid of Shigella flexneri is highly dependent on one of its PSK

161 Invasion of epithelial cells by Shigella flexneri is mediated by a set of translocated b

162 polar localization of IcsA on the surface of Shigella flexneri is required for efficient formation of

163 IcsA of Shigella flexneri is required for intercellular spread a

164 The Gram-negative enteroinvasive bacterium Shigella flexneri is responsible for the endemic form of

165 Shigella flexneri is the causative agent of dysentery, a

166 Shigella flexneri is used to illustrate how pathogens us

167 h-quality reference genome of the historical Shigella flexneri isolate NCTC1 and to examine the isola

168 of Bartonella henselae, Bartonella quintana, Shigella flexneri, Klebsiella oxytoca, and Cryptococcus

169 Thus, Shigella flexneri M90T, incubated at 37 or 40 degrees C

170 PMN) against an invasive wild-type strain of Shigella flexneri (M90T) and a plasmid-cured noninvasive

171 e show that the type III effector IpgB1 from Shigella flexneri may bind to acidic phospholipids and r

172 h a mobility equivalent to a circular 230-kb Shigella flexneri megaplasmid marker.

173 herichia coli and also conferred growth on a Shigella flexneri mutant that has a severe defect in iro

174 d growth in both rich and minimal media of a Shigella flexneri mutant that produces no siderophores.

175 in the closely related Salmonella SPI-1 and Shigella flexneri Mxi-Spa-Ipa TTSSs.

176 ns of this family, the crystal structures of Shigella flexneri MxiC we present here confirm the conse

177 have determined the crystal structure of the Shigella flexneri MxiH needle.

178 ei (BsaK), Escherichia coli (EprJ and EscI), Shigella flexneri (MxiI), and Pseudomonas aeruginosa (Ps

179 It has previously been shown that the Shigella flexneri needle has a helical symmetry of appro

180 We showed previously that the monomer of the Shigella flexneri needle, MxiH, assembles into a helical

181 The antigenic recognition of Shigella flexneri O-polysaccharide, which consists of a

182 E. coli isolates that were misidentified as Shigella flexneri or S. boydii by the kmer ID, and 8 wer

183 Here we exploit two effector proteins, the Shigella flexneri OspF protein and Yersinia pestis YopH

184 d H2 (NleH2), display sequence similarity to Shigella flexneri OspG, which inhibits activation of the

185 autotransporter family that is required for Shigella flexneri pathogenesis.

186 ructure of IroE to the structure of Fes from Shigella flexneri (PDB entry 2B20).

187 m extracts of both Escherichia coli 1090 and Shigella flexneri PHS-1059.

188 structed Escherichia coli strains expressing Shigella flexneri plasmid and chromosomal virulence fact

189 Shigella flexneri possesses at least two putative high-a

190 Shigella flexneri possesses multiple iron acquisition sy

191 Shigella flexneri proliferate in infected human epitheli

192 rotease autotransporter secreted by EAEC and Shigella flexneri, promote colonization of the mouse.

193 mbda and HK97, S. enterica phage ST64T, or a Shigella flexneri prophage.

194 Recently, the Shigella flexneri protease IpaJ was found to cleave myri

195 EspG is homologous with Shigella flexneri protein VirA, and the cloned espG (ror

196 ri, Vibrio cholerae, Salmonella typhimurium, Shigella flexneri, Pseudomonas aeruginosa, Bordetella pe

197 The synthesis of Shigella flexneri RecA (protein sequence identical to th

198 The pathogenesis of Shigella flexneri requires a functional type III secreti

199 Shigella flexneri requires iron for survival, and the ge

200 Invasion of enterocytes by Shigella flexneri requires the properly timed release of

201 e-derived macrophages in vitro with virulent Shigella flexneri resulted in cell death which involved

202 Mutations in vps or vacJ in Shigella flexneri resulted in increased sensitivity to l

203 Infection by the gram-negative bacterium Shigella flexneri results in dysentery, an acute inflamm

204 olysaccharide of the Gram-negative bacterium Shigella flexneri (S. flexneri) as a first step of bacte

205 Upon exposure to UV radiation, Shigella flexneri SA100 displayed survival and mutation

206 stationary phase, the ppk gene of pathogenic Shigella flexneri, Salmonella enterica serovar Dublin, a

207 dered restriction maps, sequenced strains of Shigella flexneri serotype 2a (2457T and 301), Yersinia

208 mic analysis, we sequenced the oldest extant Shigella flexneri serotype 2a isolate using single-molec

209 e determined the complete genome sequence of Shigella flexneri serotype 2a strain 2457T (4,599,354 bp

210 whole-genome sequenced clinical isolates of Shigella flexneri serotype 3a from high-risk and low-ris

211 Lactoferrin impairs ability of Shigella flexneri serotype 5 strain M90T to invade HeLa

212 al display PCR (DDPCR), a cDNA fragment from Shigella flexneri serotype 5 that showed enhanced expres

213 tants, dsbA::kan, dsbC-kan, and dsbD-kan, of Shigella flexneri serotype 5 were constructed and charac

214 rategy for broad cross-protection against 14 Shigella flexneri serotypes was designed.

215 (Vp-MtlR) and its homolog YggD protein from Shigella flexneri (Sf-YggD).

216 hologues in E.coli EDL933, E.coli CFT073 and Shigella flexneri Sf301.

217 genic E. coli strain CFT073, homologs of the Shigella flexneri SHI-2 pathogenicity island gene shiA,

218 Studies with Shigella flexneri show that hfq transcription is regulat

219 The Shigella flexneri sit genes can be lost as a result of d

220 at 1.6 and 2.8 A and a wild-type PCP-1 from Shigella flexneri solved at 2.8 A.

221 Shigella flexneri Spa15 is a chaperone of the type 3 sec

222 tion by the opportunistic bacterial pathogen Shigella flexneri stimulates tyrosine phosphorylation of

223 Importantly, an unsequenced Shigella flexneri strain (serotype Y strain AMC[328Y]) w

224 s research highlighting induced virulence in Shigella flexneri strain 2457T following exposure to bil

225 Global proteomic analysis was performed with Shigella flexneri strain 2457T in association with three

226 ) to visualize intact machines in a virulent Shigella flexneri strain genetically modified to produce

227 es is essential for virulence in a prototype Shigella flexneri strain.

228 quired for growth stimulation of E. coli and Shigella flexneri strains in low-iron medium.

229 of 20 recent clinical isolates, including 4 Shigella flexneri strains, 1 Shigella boydii strain, and

230 htrB, in GMMA-producing Shigella sonnei and Shigella flexneri strains.

231 The human pathogen Shigella flexneri subverts host function and defenses by

232 ropel itself in infected cells, the pathogen Shigella flexneri subverts the Cdc42-controlled machiner

233 n together, our studies showed that virulent Shigella flexneri targets the host cell mitochondria for

234 Shigella flexneri temperate bacteriophage Sf6 is of inte

235 (TTS) is an essential virulence function for Shigella flexneri that delivers effector proteins that a

236 ype III secretion system (T3SS) effectors of Shigella flexneri that downregulate the host innate immu

237 ETEC and other enteric pathogens, including Shigella flexneri, that express similar proteins.

238 is also secreted in response to infection by Shigella flexneri, that it is produced by a pathway invo

239 We show here that the selC locus of Shigella flexneri, the aetiological agent of bacterial d

240 Shigella flexneri, the causative agent of bacillary dyse

241 Here, we show that infection by Shigella flexneri, the causative agent of human bacillar

242 Shigella flexneri, the causative agent of shigellosis, i

243 In Sf6, a P22-like phage that infects Shigella flexneri, the tail needle presents a C-terminal

244 The ability of Shigella flexneri to multiply within colonic epithelial

245 A Shigella flexneri translocated effector, IpaH9.8, which

246 Shigella flexneri two-component regulatory systems (TCRS

247 rulent strains of Listeria monocytogenes and Shigella flexneri, two other facultative intracellular b

248 Pseudomonas aeruginosa covalently linked to Shigella flexneri type 2a O-antigen (Sf2E) produced by e

249 ace polysaccharides of pneumococcus type 14, Shigella flexneri type 2a, and Escherichia coli K1.

250 a protein CRM9 or rEPA, bound to the O-SP of Shigella flexneri type 2a.

251 tigen J (IpaJ), a previously uncharacterized Shigella flexneri type III effector protein with cystein

252 report the identification of two homologous Shigella flexneri type III secretion system effector E3

253 a pig model increased bacterial clearance of Shigella flexneri upon colonic infection, strongly sugge

254 tro, plasma-derived IgA and SIgA neutralized Shigella flexneri used as a model pathogen, resulting in

255 The pathogenic bacterium Shigella flexneri uses a type III secretion system to in

256 The gram negative rod Shigella flexneri uses it surface protein IcsA to induce

257 Shigella flexneri uses its T3SS to invade human intestin

258 Shigella flexneri uses its type III secretion apparatus

259 Shigella flexneri uses its type III secretion system (T3

260 The expression of a subset of Shigella flexneri virulence genes is dependent upon a cy

261 A degP mutant of Shigella flexneri was identified in a screen for inserti

262 Using bacteriophage Sf6 and its host, Shigella flexneri, we investigated how Sf6 utilizes oute

263 ron transporting sequence of the sit gene of Shigella flexneri were detected without PCR amplificatio

264 Here we show that Shigella flexneri, which causes dysentery, encounters va

265 Shigella flexneri, which replicates in the cytoplasm of

266 terohemorragic E. coli, and SepA and VirG of Shigella flexneri, which seem to involve a host endopept

267 lla typhimurium, Listeria monocytogenes, and Shigella flexneri with M cells by using a murine ligated

268 ace O-antigen polysaccharide of the pathogen Shigella flexneri Y and an octapeptide (Met-Asp-Trp-Asn-

269 Salmonella typhimurium, Mycobacterium bovis, Shigella flexneri, Yersinia enterocolitica and reoviruse

270 ampylobacter coli and Campylobacter jejuni), Shigella flexneri, Yersinia enterocolitica, adenovirus,

271 upstream of polysaccharide gene clusters of Shigella flexneri, Yersinia enterocolitica, Vibrio chole