ライフサイエンスコーパス: TNFAIP3

1 on by targeting TNF alpha-induced protein 3 (TNFAIP3).

2 mor necrosis factor-alpha-induced protein 3 (TNFAIP3).

3 luding rs5029937, located in the intron 2 of TNFAIP3.

4 identified psoriasis variants near IL23R and TNFAIP3.

5 ed genetic association between psoriasis and TNFAIP3.

6 d NF-kappaB that enhanced expression of A20 (TNFAIP3), a potent inhibitor of NF-kappaB.

7 s by directly binding the promoter region of Tnfaip3, a deubiquitinating enzyme in TLR signaling.

8 t least partially explained by repression of TNFAIP3, a negative regulator of NF-kappaB signaling.

9 ion of anti-inflammatory TNF targets such as TNFAIP3 (A20) and NFKBIA was selectively spared or augme

10 matory molecule TNF-alpha-induced protein 3 (TNFAIP3)/A20 in memory CD4(+) T cells.

11 mor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) gene, a negative regulator of NF-kappaB, w

12 reover, it provides novel targets related to TNFAIP3/A20 activity for superior therapeutic regimens i

13 Regulation of TNFAIP3/A20 expression and cognate IL-17A production in

14 We found an inverse relationship between TNFAIP3/A20 expression levels and IL-17A production.

15 evidence for an inverse relationship between TNFAIP3/A20 expression levels and IL-17A-producing T cel

16 Inhibition of TNFAIP3/A20 promotes kinase activity of p38 mitogen-acti

17 s effect to the ability of miR-29b to target TNFAIP3/A20, a negative regulator of NF-kappaB signaling

18 onstrate that the ubiquitin-modifying enzyme TNFAIP3/A20, an upstream regulator of T cell receptor (T

19 nts, including CCL5/RANTES, CXCL1/GRO-alpha, TNFAIP3/A20, and interleukin-6.

20 This puts TNFAIP3/A20, combined with IL-17A expression, on the map

21 Anti-TNF treatment interferes in the TNFAIP3/A20-mediated anti-inflammatory feedback loop in

22 A long noncoding RNA, LincRNA-Tnfaip3, acts as a coregulator of NF-kappaB to modulate

23 tions in multiple genes, including negative (TNFAIP3, also called A20) and positive (CARD11, TRAF2, T

24 heless rapidly countered by the induction of TNFAIP3, an NF-kappaB inhibitor frequently inactivated i

25 factor alpha [TNF-alpha]-induced protein 3 [TNFAIP3]), an inhibitor of the NF-kappaB pathway and a n

26 After stratification by JIA subtype, the TNFAIP3 and C12orf30 variants were associated with oligo

27 GBS exchanges between reporters for TNFAIP3 and FKBP5, a canonical GR-induced target, reveal

28 protein 1 (TNIP1) gene, which interacts with TNFAIP3 and inhibits the TNF-alpha-induced nuclear facto

29 reover, the regulatory effects of miR-19a on TNFAIP3 and NF-kappaB signaling were confirmed using tum

30 6q23 (rs10499194, approximately 150 kb from TNFAIP3 and OLIG3) that was reproducibly associated with

31 susceptibility genes including CD40, TRAF1, TNFAIP3 and PRKCQ.

32 hism responsible for the association between TNFAIP3 and SLE.

33 as associated with downregulation of TNF and TNFAIP3 and upregulation of BAX.

34 ated genes (such as OAS1/2/3, TLR1/6/10, and TNFAIP3) and also encompass genes (including OCA2 and BN

35 G [P = 0.006], and rs2327832_G [P = 0.03] in TNFAIP3) and one with decreased risk (rs1004446_A in INS

36 The ubiquitin-editing enzyme A20 (TNFAIP3) and the deubiquitinase CYLD are central negativ

37 pha and regulate NF-kappaB signaling (TNIP1, TNFAIP3) and two genes involved in the modulation of Th2

38 on to ZIKV, dengue, and GBS infection; ATF5, TNFAIP3, and BAMB1 were common to ZIKV, dengue, and WNF;

39 d arthritis (RA) susceptibility loci, TAGAP, TNFAIP3, and CCR6, in African American patients with RA.

40 cruitment domain-containing protein 11), A20/TNFAIP3, and CD79A/B.

41 of nonsynonymous coding polymorphisms within TNFAIP3, and found that the A125V coding-change variant

42 ariants, along with tagging polymorphisms in TNFAIP3, and identified a novel African-derived risk hap

43 c loci-HLA-C, IL12B, IL23R, IL23A, IL4/IL13, TNFAIP3, and TNIP1-and ongoing studies are revealing add

44 Functionally, lincRNA- Tnfaip3 appears to mediate both the activation and repre

45 latory regions of TAGAP and an intronic SNP (TNFAIP3) are potential susceptibility loci in African Am

46 These results implicate TNFAIP3 as a functionally important endogenous suppresso

47 Our results offer strong evidence for TNFAIP3 as a key regulator of the cytoplasmic signaling

48 o two outcome groups (P = .037) and revealed TNFAIP3 as part of an optimized four-gene predictor asso

49 mor necrosis factor alpha-induced protein 3 (TNFAIP3) as a key endogenous suppressor of ASK1 activati

50 und evidence of two independent signals near TNFAIP3 associated with SLE, including one previously as

51 und evidence of two independent signals near TNFAIP3 associated with SLE, including one previously as

52 acts through chromatin looping not only with TNFAIP3, but also with IL20RA, located 680 kb upstream.

53 ced Tnfaip3 gene expression in DCs in either Tnfaip3(CD11c) or Tnfaip3(LysM) mice dose-dependently co

54 Both extrinsic death receptor (TNFAIP3, CFLAR, SOD2) and intrinsic mitochondrial (BCL2A

55 CXCL10), immune suppression (PD-L1, NFKB1B, TNFAIP3, CGB), apoptosis (CASP9, FAS, IL-24), and cell g

56 This resultant NF-kappaB/Hmgb1/lincRNA-Tnfaip3 complex can modulate Hmgb1-associated histone mo

57 Hmgb1), assembling a NF-kappaB/Hmgb1/lincRNA-Tnfaip3 complex in macrophages after LPS stimulation.

58 These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.

59 These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.

60 TNFAIP3-deficient DCs induced HDM-specific TH17 cell dif

61 ressor of ASK1 activation, and we found that TNFAIP3 directly interacts with and deubiquitinates ASK1

62 TNFAIP3 encodes A20, a tumor necrosis factor (TNF)-alpha

63 TNFAIP3, encoding the ubiquitin-modifying enzyme A20, is

64 Hepatocyte-specific ablation of Tnfaip3 exacerbated nonalcoholic fatty liver disease- an

65 expression pattern of a regulator molecule, TNFAIP3, exhibited prominent variability between individ

66 Importantly, miR-125a/mir-125b effects on TNFAIP3 expression and NF-kappaB activity were confirmed

67 These data show that the extent of TNFAIP3 expression in DCs controls TH2/TH17 cell differe

68 isms in the deubiquitinating (DUB) domain of TNFAIP3: F127C, which is in high-linkage disequilibrium

69 self-regulatory loop whereby termination of TNFAIP3 function by miR-125 could strengthen and prolong

70 R/NF-kappaB cooperation, suggesting that the TNFAIP3 GBS acts primarily as a docking site in this con

71 ese findings point to variability in the A20/TNFAIP3 gene as a modulator of CAD risk in type 2 diabet

72 ransgenic or adeno-associated virus-mediated TNFAIP3 gene delivery in the liver in both mouse and non

73 We demonstrated that reduced Tnfaip3 gene expression in DCs in either Tnfaip3(CD11c)

74 xposed mice with conditional deletion of the Tnfaip3 gene in either myeloid cells (by using the lysoz

75 Inactivation of the TNFAIP3 gene, encoding the A20 protein, is associated wi

76 cations in autoimmunity; A20, encoded by the TNFAIP3 gene, Lyp encoded by the PTPN22 gene, and the BC

77 mor necrosis factor-alpha-induced protein 3 (TNFAIP3) gene has been associated with psoriasis, rheuma

78 mor necrosis factor alpha-induced protein 3 (Tnfaip3) gene, is an early-primary response gene control

79 Somatic mutations of TNFAIP3 have been observed in the mucosa-associated lymp

80 tudied germline and somatic abnormalities of TNFAIP3 in 574 patients with pSS, including 25 with lymp

81 rheumatoid arthritis susceptibility gene A20/Tnfaip3 in mice (A20(myel-KO) mice) triggers a spontaneo

82 is study we investigated the precise role of TNFAIP3 in myeloid cells for the development of TH2- and

83 3) and increased TNFalpha-induced protein 3 (TNFAIP3) in Vldlr(-/-) photoreceptors.

84 back inhibitor mRNAs, such as Ier3, Dusp1 or Tnfaip3, in the absence of MK2-dependent TTP neutralizat

85 tiple single nucleotide polymorphisms in the TNFAIP3 interacting protein 1 (TNIP1) gene, which intera

86 TNF receptor-associated factor (TRAF) 1, and TNFAIP3-interacting protein (TNIP) 3.

87 s2233290) at position 151 (Pro-->Ala) in the TNFAIP3-interacting protein 1, TNIP1, confers even stron

88 overed that the negative NF-kappaB regulator TNFAIP3 is a direct target of miR-125a and miR-125b, whi

89 paB and extrinsic apoptosis, confirming that TNFAIP3 is a functionally relevant target of miR-29b.

90 Specifically, induction of lincRNA-Tnfaip3 is required for the transactivation of NF-kappaB

91 A20 (TNFAIP3) is a critical negative regulator of NF-kappaB.

92 mor necrosis factor (TNF)-induced protein 3 (TNFAIP3) is a negative regulator of nuclear factor-kappa

93 The TNF alpha-induced protein 3 (TNFAIP3) is an ubiquitin-modifying enzyme and an essenti

94 We report here that the lincRNA gene lincRNA-Tnfaip3, located at mouse chromosome 10 proximal to the

95 variants in the PTPN22, TRAF1/C5, STAT4, and TNFAIP3 loci.

96 xpression, GR and NF-kappaB occupancy at the TNFAIP3 locus and GR-repressed targets was similar.

97 wide association studies have implicated the TNFAIP3 locus in susceptibility to autoimmune disorders

98 ci including rs10499194 and rs6920220 in the TNFAIP3 locus, rs6679677 in the RSBN1 locus, rs17696736

99 xpression in DCs in either Tnfaip3(CD11c) or Tnfaip3(LysM) mice dose-dependently controlled developme

100 to depict how the A125V amino acid change in TNFAIP3 may affect the three-dimensional structure of th

101 pe carrying this variant resulted in reduced TNFAIP3 mRNA and A20 protein expression.

102 as rescue assays and genetic modulation of a TNFAIP3-null model defined the essential role of the TNF

103 Ablation of TNF-alpha-induced protein 3 (TNFAIP3), one of the crucial negative regulators of nucl

104 tase, DUSP1, the ubiquitin-modifying enzyme, TNFAIP3, or the mRNA-destabilizing protein, ZFP36.

105 Both Tnfaip3(OTU) and Tnfaip3(ZF4) mice exhibited increased r

106 ting either A20's deubiquitinating activity (Tnfaip3(OTU) mice) or A20's ZF4 (Tnfaip3(ZF4) mice).

107 kappaB signaling normally in compound mutant Tnfaip3(OTU/ZF4) cells.

108 4149 near IL23R, p = 0.00018; rs9321623 near TNFAIP3, p = 0.00022).

109 LincRNA-Tnfaip3 physically interacts with the high-mobility grou

110 on (ARID1A and MEF2B), NF-kappaB (CARD11 and TNFAIP3), PI3 kinase (PIK3CD, PIK3R1, and MTOR), B-cell

111 s the first report of an association between TNFAIP3 polymorphisms and autoimmunity in African-Americ

112 d methylation of cytosine nucleotides in the TNFAIP3 promoter was found to be correlated with this va

113 with variants in 29 other regions, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and

114 We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are

115 We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are

116 A co-occupied intronic TNFAIP3 regulatory element mediated cooperative enhancem

117 /NF-kappaB cooperative induction of a mutant TNFAIP3 reporter harboring the FKBP5 GBS.

118 pression of an miR-29b-refractory isoform of TNFAIP3 restored NF-kappaB and extrinsic apoptosis, conf

119 erse populations, we fully characterized the TNFAIP3 risk haplotype and identified a TT>A polymorphic

120 Childhood-onset RA was associated with TNFAIP3 rs10499194 (OR 0.60 [95% confidence interval 0.4

121 an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR

122 an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR

123 27 SNPs (CCR6 rs3093023, TAGAP rs394581, and TNFAIP3 rs6920220) demonstrated ORs in the opposite dire

124 s were significantly associated with RA: the TNFAIP3 rs719149 A allele (OR 1.22 [95% confidence inter

125 0 patients with paired germline and lymphoma TNFAIP3 sequence data had functional abnormalities of A2

126 sponse of psoriasis to TNF blockers with two TNFAIP3 single-nucleotide polymorphisms (rs2230926 in ex

127 ently mutated tumor suppressor genes such as TNFAIP3, SOCS3 and TNFRSF14.

128 associations between JIA and variants in the TNFAIP3, STAT4, and C12orf30 regions that have previousl

129 ude and direction of the association between TNFAIP3, STAT4, and PTPN22 variants and childhood-onset

130 tor A (VEGFA) pathway directly, and elevated TNFAIP3 suppressed SOCS3 (suppressor of cytokine signali

131 null model defined the essential role of the TNFAIP3 targeting on miR-125a/miR-125b-mediated lymphoma

132 n CD loci (ICOSLG and TNFSF15) and T1D loci (TNFAIP3) that confer UC risk, known UC loci (HERC2 and I

133 wn, the association is generally assigned to TNFAIP3, the closest gene.

134 A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-kappaB inhibitor A20,

135 Along with other associations near TRAF1 and TNFAIP3, this implies a central role for the CD40 signal

136 In light of recently discovered A20/TNFAIP3 (TNFalpha-induced protein 3) single nucleotide p

137 1B, CDK5, CDC42SE2, MDM4, NME7, RAB8B, TFE3, TNFAIP3, TNK1, TOP1, VAMP2, and YY1.

138 regulatory role of NF-kappaB-induced lincRNA-Tnfaip3 to act as a coactivator of NF-kappaB for the tra

139 ve generated mice bearing a floxed allele of Tnfaip3 to interrogate A20's roles in regulating B cell

140 Notably, the sub-networks regulated by TNFAIP3, TRAFD1 and PML are involved in innate immune re

141 fully identified several MRs including SOX3, TNFAIP3, TRAFD1, POU3F3, STAT2, and PML that govern the

142 n A20 closely mirrored the expression of the TNFAIP3 transcript, and was inversely related to NF-kapp

143 uced inflammatory responses through inducing Tnfaip3 transcription and controlling the metabolic repr

144 ptor (TLR)-induced inflammation by promoting Tnfaip3 transcription and fine-tuning of metabolic repro

145 The TNFAIP3 (tumor necrosis factor alpha-induced protein 3)

146 The TNFAIP3 (tumor necrosis factor alpha-induced protein 3)

147 ith JIA risk or protection were observed for TNFAIP3 variants rs10499194 (OR 0.74 [95% CI 0.61-0.91],

148 mor necrosis factor-alpha-induced protein 3 (TNFAIP3) was identified as a new regulatory component of

149 regulators of NF-kappaB signaling (MYD88 and TNFAIP3) were gained at transformation.

150 Polymorphisms of TNFAIP3, which encodes the A20 protein that plays a key

151 enetrance heterozygous germline mutations in TNFAIP3, which encodes the NF-kappaB regulatory protein

152 Given recent data linking A20 (TNFAIP3) with human B cell lymphomas and systemic lupus

153 Both Tnfaip3(OTU) and Tnfaip3(ZF4) mice exhibited increased responses to TNF a

154 g activity (Tnfaip3(OTU) mice) or A20's ZF4 (Tnfaip3(ZF4) mice).