ライフサイエンスコーパス: Toll-like receptor

1 flammatory disease through the activation of toll-like receptors.

2 ell receptor (BCR), Fc receptors (FcRs), and toll-like receptors.

3 s a macrophage immunosuppressant by reducing Toll-like receptor 1/2 (TLR1/2) activation by bacterial

4 Responses to all Toll-like receptor 1/2 (TLR1/2), TLR2/6, and TLR4 agonis

5 ls of pattern recognition receptors, such as Toll-like receptors 1 and 2, dectin 1, and dendritic cel

6 s trigger pro-inflammatory responses through Toll-like receptor 2 (TLR2) activation, and this whether

7 antibodies were used to dissect the role of Toll-like receptor 2 (TLR2) and programmed death-ligand

8 ed, albeit the recognition of lipoglycans by Toll-like receptor 2 (TLR2) appears to be important for

9 We examined the inflammatory role of Toll-like receptor 2 (TLR2) in age-related macular degen

10 However, eliminating Toll-like receptor 2 (TLR2) permits bacterial replicatio

11 Toll-like receptor 2 (TLR2) plays a critical role in hos

12 es in the proinflammatory markers TNF-alpha, toll-like receptor 2 (TLR2), and TLR4.

13 l" anti-inflammatory phenotype by activating Toll-like receptor 2 (TLR2), which regulates the inducti

14 he Brucella effector protein TcpB suppresses Toll-like receptor 2 (TLR2)- and TLR4-mediated innate im

15 n of macrophages derived from MyD88-, TRIF-, Toll-like receptor 2 (TLR2)-, TLR4-, and TLR2/4-deficien

16 n induces pathogenic host inflammation via a Toll-like receptor 2 (TLR2)-dependent pathway, resulting

17 88 (MyD88), TANK binding kinase 1 (TBK1), or Toll-like receptor 2 (TLR2).

18 stimulates the innate immune system through Toll-like receptor 2 (TLR2); however, the pathogen-assoc

19 Toll-like receptor 2 agonism activated luminal endotheli

20 eneration and elevated surface expression of toll-like receptor 2 and CD11b on monocytes and neutroph

21 with broad specificity that is dependent on Toll-like receptor 2 and interleukin 1beta.

22 IFN-kappa was significantly increased after toll-like receptor 2 and UVB treatment in lupus keratino

23 Toll-like receptor 2 expression was unchanged.

24 e skin microbiome is a rich source of LTA, a Toll-like receptor 2 ligand, we mimicked the GF microbio

25 ation factor, and lipoteichoic acid (LTA), a Toll-like receptor 2 ligand.

26 bed flow and of neutrophils, hyaluronan, and Toll-like receptor 2 ligation in superficial intimal inj

27 implicate flow disturbance, neutrophils, and Toll-like receptor 2 signaling as mechanisms that contri

28 h healthy control subjects after exposure to toll-like receptor 2, 3, or 4 agonists or exposure to UV

29 r membrane of A. muciniphila, interacts with Toll-like receptor 2, is stable at temperatures used for

30 HMGB1 functions as a ligand of Toll-like receptors 2 and 4 on macrophages, leading to a

31 his article, we show that germ-free (GF) and Toll-like receptor-2 (Tlr2)-deficient mice have reduced

32 igh-iron conditions had reduced responses to Toll-like receptor-2, -3, and -4 agonists, which associa

33 olyinosine-polycytidylic acid (poly(I:C)), a Toll-like receptor 3 (TLR3) agonist used as a mimetic to

34 Defects in genes of the Toll-like receptor 3 (TLR3) pathway are associated with

35 horylation, leading to inefficient RIG-I and Toll-like receptor 3 (TLR3) responses.

36 merous interferon-regulated genes, including Toll-like receptor 3 (Tlr3), which encodes an innate imm

37 mal organization to the selective control of toll-like receptor 3 (TLR3)- and TLR4-mediated proinflam

38 These interferon responses attributed to toll-like receptor 3 (TLR3)-activated Kupffer and liver

39 Inhibition of BRD4 blocks Toll-like receptor 3 (TLR3)-dependent neutrophilia and R

40 Toll-like receptor 3 expression was analyzed in postmort

41 Toll-like receptor 3, an innate pattern recognition rece

42 We sought to evaluate an inhibitory mAb to Toll-like receptor 3, CNTO3157, on experimental HRV-16 i

43 ary and sufficient to stimulate WIHN through toll-like receptor 3.

44 Toll-like receptor-3 (TLR3), a member of the pathogen re

45 NA levels were assessed by real-time PCR and Toll like receptor 4 (TLR-4) protein expression by Weste

46 Additionally, the activation of toll like receptor 4 (TLR4) induced by LPS showed no alt

47 This activation is through the toll like receptor 4 (TLR4)/myeloid differentiation prim

48 increase in TJ permeability was mediated by toll-like receptor 4 (TLR-4)/MyD88 signal-transduction p

49 Toll-like receptor 4 (TLR4) activation by bacterial infe

50 e microbiota, hematopoietic cell deletion of Toll-like receptor 4 (TLR4) and inactivation of the IL-1

51 with a decrease in the expression of mucosal toll-like receptor 4 (TLR4) and its adaptor myeloid diff

52 Here we identify endothelial Toll-like receptor 4 (TLR4) and the gut microbiome as cr

53 the combination of synthetic small-molecule Toll-like receptor 4 (TLR4) and TLR7 ligands is a potent

54 ntigens adjuvanted with ligands specific for Toll-like receptor 4 (TLR4) and TLR7/8 encapsulated in p

55 The results point to modified signaling via Toll-like receptor 4 (TLR4) as a possible mechanism for

56 further implicate the innate immune receptor toll-like receptor 4 (TLR4) as an underlying mechanism m

57 Stimulation of Toll-like receptor 4 (TLR4) by bacterial lipopolysacchar

58 Similarly, Toll-like receptor 4 (TLR4) has been implicated in breas

59 Ps) induced NF-kappaB activation mediated by Toll-like receptor 4 (TLR4) in a glycoprotein (GP)-depen

60 LPS-mediated activation of Toll-like receptor 4 (TLR4) in macrophages results in th

61 Toll-like receptor 4 (TLR4) is a critical component of i

62 SIGNIFICANCE STATEMENT: Toll-like receptor 4 (TLR4) is a key mediator of innate

63 Toll-like receptor 4 (TLR4) is a pattern recognition mol

64 Innate immune system activation via Toll-like receptor 4 (TLR4) leads to inflammation and ox

65 morphine binds to the innate immune receptor toll-like receptor 4 (TLR4) localized primarily on micro

66 Here, we show that Toll-like receptor 4 (TLR4) mediates cancer-induced musc

67 To test the hypothesis that toll-like receptor 4 (TLR4) mediates proinflammatory pol

68 rs of innate immunity, via activation of the toll-like receptor 4 (TLR4) on myeloid cells.

69 rs of innate immunity, via activation of the toll-like receptor 4 (TLR4) on myeloid cells.

70 ow that GOS is recognized by and upregulates Toll-like receptor 4 (TLR4) on RAW264.7 macrophages, fol

71 entiation revealed that binding of S100A9 to Toll-like receptor 4 (TLR4) promotes activation of p38 m

72 emonstrate that hRetn binds the LPS receptor Toll-like receptor 4 (TLR4) through its N terminal and m

73 ent of Gram-negative bacteria that activates Toll-like receptor 4 (TLR4) to trigger proinflammatory r

74 300b, and its adaptor DAP12, associated with Toll-like receptor 4 (TLR4) upon LPS binding, thereby en

75 Binding of MfP to Toll-like receptor 4 (TLR4) was determined by co-immunop

76 WD-fed Toll-like receptor 4 (TLR4)(-/-) mice did not exhibit my

77 -NS5A in liver up-regulate the expression of Toll-like receptor 4 (TLR4), and develop liver tumors co

78 o found to bind TRAM, an adaptor protein for Toll-like receptor 4 (TLR4), and thereby impact both vir

79 In the ALHS, we tested for a gene [Toll-like Receptor 4 (TLR4), encoding the endotoxin rece

80 ytoplasm and downregulated the expression of toll-like receptor 4 (TLR4), receptor for advanced glyca

81 gle study revealed a new complex composed of Toll-like receptor 4 (TLR4), TLR6, and CD36 induced by f

82 del of PHH, we demonstrate that IVH causes a Toll-like receptor 4 (TLR4)- and NF-kappaB-dependent inf

83 Disease was linked to a Toll-like receptor 4 (TLR4)-dependent mechanism of IAP d

84 EL induced PTX3 expression by activating the Toll-like receptor 4 (TLR4)-dependent pathway via nuclea

85 ct ligations or sham surgeries on C57BL/6 or toll-like receptor 4 (TLR4)-knockout mice to induce live

86 ages involves multiple mechanisms, including Toll-like receptor 4 (TLR4)-mediated NADPH oxidase (NOX)

87 f opioids, and we recently demonstrated that Toll-like receptor 4 (TLR4)-mediated neuroinflammation i

88 Toll-like receptor 4 (TLR4)-mediated signaling was asses

89 ue damage and expressed by tumors, activates toll-like receptor 4 (TLR4)-mediated sterile inflammatio

90 ated predominantly via the membrane receptor Toll-like receptor 4 (TLR4).

91 s in cultured myenteric neurons that express Toll-like receptor 4 (TLR4).

92 ts demonstrate that the use of the synthetic Toll-like receptor 4 agonist glucopyranosyl lipid A in s

93 reduced lipopolysaccharide activation of the toll-like receptor 4 and increased survival times compar

94 evated hepatic stellate cell-derived TnC and Toll-like receptor 4 expression was observed in the diet

95 n end products (RAGE) messenger RNA, but not toll-like receptor 4 in hippocampal microglia.

96 amplified platelet response to the agonists; Toll-like receptor 4 inhibitor blunted this effect.

97 primes the cell for an enhanced response to toll-like receptor 4 ligands.

98 gen species production and activation of the Toll-like receptor 4 signaling pathway.

99 resistant to Fas-mediated apoptosis ex vivo, Toll-like receptor 4(TLR4)-ligation restored Fas-sensiti

100 In the brain, levels of RAGE and Toll-like receptor 4, glial fibrillary acidic protein an

101 also attenuated proinflammatory signaling by Toll-like receptor 4, which has a central role in Ad pat

102 nd SseK3 suppress TNF-alpha-induced, but not Toll-like receptor 4- or interleukin-induced, NF-kappaB

103 failed to induce depressive-like behavior in Toll-like receptor 4-deficient mice and in mice harborin

104 rass pollen or mite allergens to enhance the Toll-like receptor 4-mediated proallergic properties of

105 s, an event triggered by the innate receptor Toll-like receptor 4.

106 lowing binding of growth factor receptors or Toll-like receptor 4.

107 eta1 integrin and the innate immune receptor toll-like receptor 4.

108 ury triggering the macrophage activation via Toll-like receptor 4.

109 s blunted by incubation with an inhibitor of Toll-like receptor 4.

110 Additionally, we found a significant toll-like receptor 4/alpha4beta1-dependent enrichment in

111 livery system, and simultaneously, activated Toll-Like Receptor-4 (TLR-4) on APCs to release chemokin

112 In this work, human Toll-Like Receptor-4 (TLR-4), a protein responsible for

113 innate immune signaling components including Toll-like receptor-4 and type I IFNs.

114 The NMDA-R and Toll-like receptor-4 were not required for proinflammato

115 so improved the level of HA receptors (CD44, Toll-like receptor-4, and receptor for HA-mediated motil

116 Toll-like receptor 5 (TLR5) is considered an attractive

117 Toll-like receptor 5 (TLR5) recognition of flagellin ins

118 ellin:allergen fusion protein containing the Toll-like receptor 5 ligand flagellin A from Listeria mo

119 Fusion proteins incorporating the Toll-like receptor 5 ligand flagellin are currently unde

120 n of bacterial flagellins that interact with Toll-like receptor 5.

121 Toll-like receptor 7 (TLR7) mediates autoantigen and vir

122 Toll-like receptor 7 (TLR7) stimulation in the airways m

123 The induction of toll-like receptor 7 (TLR7)-dependent type I interferons

124 cognition of intracellular Y. pestis by host Toll-like receptor 7 (TLR7).

125 On treatment with the toll-like receptor 7 agonist imquimod (IMQ), Trim32 knoc

126 e isolated from whole blood, stimulated with Toll-like receptor 7 agonist, and analyzed by means of e

127 rge amounts of type 1 interferon (IFN) after Toll-like receptor 7 and 9 engagements.

128 it, colony stimulating factor 3 receptor and toll-like receptor 7 mRNA expression increases in the th

129 application of Aldara cream, containing the Toll-like receptor 7/8 agonist Imiquimod, is a widely us

130 ammatory conditions, exposure of APCs to the Toll-like receptor 7/8 agonist R848 increases nanocluste

131 Activation of Toll-like receptor 7/8 by means of topical application o

132 We show that activation of pDCs through Toll-like receptor 7/8 suppresses ILC2-mediated AHR and

133 highly conserved cysteine residue (Cys98) on Toll-like receptor-7.

134 on by the pattern-recognition receptor (PRR) Toll-like receptor 8 (TLR8).

135 rich in unmethylated CG motifs (CpGs) engage Toll-Like Receptor 9 (TLR-9) in endosomes and are well d

136 re cultured with CD40 ligand (CD40L) and the Toll-like receptor 9 (TLR9) agonist cytidine-phosphate-g

137 thesized that a single drug molecule-a novel Toll-like receptor 9 (TLR9) agonist, MGN1703-could funct

138 ly, we identify parasite DNA-sensing through Toll-like receptor 9 (TLR9) along with inflammatory cyto

139 Toll-like receptor 9 (TLR9) enhances proinflammatory res

140 a key role in recognition, as highlighted by Toll-like receptor 9 (TLR9) in the endosomal compartment

141 Toll-like receptor 9 (TLR9) is an endosome bound, innate

142 We investigated the ability of the Toll-like receptor 9 (TLR9) ligand CpG to modulate estab

143 responsiveness of paired lung fibroblasts to Toll-like receptor 9 (TLR9) stimulation by CpG-oligodeox

144 Toll-like receptor 9 (TLR9)-deficient (TLR9(-/-)) mice a

145 FcvarepsilonRI receptor for IgE, followed by Toll-like receptor 9 (TLR9)-mediated sensing of DNA in p

146 In this study, we report that the Toll-like receptor 9 (TLR9)-MyD88 pattern-recognition re

147 a defective response to ligation of BCR and Toll-like receptor 9 (TLR9).

148 wed that stimulation of innate immunity with Toll-like receptor 9 agonist, class B CpG (cytosine-phos

149 hout co-administration or encapsulation of a Toll-Like Receptor 9 agonist.

150 Breg cells obtained by Toll-like receptor 9 and CD40 activation of B cells prev

151 Healthy neutrophil Toll-like receptor 9 expression increased upon stimulati

152 stem and microglia/macrophage activation via Toll-like receptor 9 using CpG (cytosine-phosphate-guani

153 Intracellular Toll-like receptor 9 was induced by costimulation with i

154 -kappaB-->ZEB1 signaling represses the TLR9 (toll-like receptor 9), IFNG, MCP-1 (monocyte chemoattrac

155 CD40 ligand- and Toll-like receptor 9-mediated signaling were less strong

156 or prostate cancer cells stably adorned with Toll-like receptor-9 ligand-loaded particles using strep

157 Toll-like receptor agonists are potent enhancers of inna

158 Western diet or by applying topical TLR7/8 (Toll-like receptor) agonists.

159 hypersensitivity accompanied by increases in Toll-like receptor and cytokine gene expression in the s

160 mmune response, leading to activation of the Toll-like receptor and NF-kappaB pathways.

161 her, it is critical for activating endosomal toll-like receptors and antiviral humoral immunity.

162 Expression of Toll-like receptors and cellular adhesion molecules were

163 (MyD88) is an adaptor protein that mediates Toll-like receptors and interleukin-1 receptor signaling

164 tivated kinase 1 (TAK1) is a key mediator of toll-like receptors and pro-inflammatory cytokine signal

165 associated with its antagonistic effects on Toll-like receptors and suppression of RhoA GTPase signa

166 These pathways include Toll-like receptors and the recently described cGAS-STIN

167 eceptors, including CD40, BAFF receptor, and Toll-like receptors, and also plays a critical role inhi

168 the innate immune system, via inhibition of Toll-like receptor- and complement receptor-mediated act

169 d by the induction of chemokines, cytokines, Toll-like receptors, antimicrobial peptides, monocytoid

170 thway activation in SS through activation of Toll-like receptor-dependent and -independent pathways.

171 nt work showing that a combinatorial code of Toll-like receptors downstream of pair-rule genes contri

172 ally upregulated by ligands of IL-1 receptor/Toll-like receptor family members via the activation of

173 Indeed, Toll-like receptors, G-protein-coupled receptors, integr

174 tivation of innate immune components such as Toll-like receptors, IL-1 receptor-associated kinase/tum

175 adhesion and signaling, including integrins, Toll-like receptors, immunoglobulins, and mutant myocili

176 Toll-like receptors in alveolar macrophages (AMPhi) reco

177 Although C-type lectin receptor- and Toll-like receptor-induced signaling pathways are key ac

178 osis factor secretion after stimulation with Toll-like receptor ligands and M. tuberculosis whole-cel

179 25 plus IL-33 (IL-25/IL-33), or a mixture of Toll-like receptor ligands to evaluate their ability to

180 s whereas exposure to innate stimuli such as Toll-like receptor ligands was not sufficient.

181 Activation of this reporter, using Toll-like receptor ligands, resulted in GFP expression,

182 cells migrate to lymph nodes and respond to toll-like receptor ligation; however, they differ marked

183 at wild-type pigs display both a basal and a Toll-like receptor-mediated ASL secretory response to th

184 atum orchestrates a molecular network of the Toll-like receptor, microRNAs, and autophagy to clinical

185 tection of circulating microbial products by Toll-like receptors on T cells, and this regulation is c

186 tor of interferon genes (STING), but not the Toll-like receptor or the mitochondrial antiviral-signal

187 ICs co-localized with these toll-like receptor pathway proteins.

188 Toll-like receptors play a central role in the initiatio

189 R2-/- and TLR4-/- mice that are defective in toll like receptor signaling.

190 Moreover, the toll-like receptor signaling adaptor protein TRIF (TIR-d

191 Impaired toll-like receptor signaling by the HBV surface antigen

192 In contrast, stimulating Toll-like receptor signaling in medaka enhanced immune c

193 ve low-dose naltrexone influencing opioid or toll-like receptor signaling to improve calcium mobiliza

194 ession is not driven by adaptive immunity or toll-like receptor signaling, and that BabA may have oth

195 ways induced by the LPS stimulation included toll-like receptor signaling, IL-6 signaling, and Nrf2-m

196 regulates innate immune responses, including Toll-like receptor signaling, which initiate adaptive im

197 ccompanied by elevated activation of TCR and Toll-like receptor signaling-related proteins.

198 ation of the tumor-associated microbiota and toll-like receptor signaling.

199 RNAs are estrogen responsive and target TLR (toll-like receptor) signaling pathways.

200 o-inflammatory priming with phorbol ester or Toll-like receptor stimulation.

201 aling pathways initiated by IL-1, IL-18, and toll-like receptors, the precise contribution of MyD88 t

202 Toll-like receptor (Tlr) 13(-/-) BMDCs showed a weak res

203 In the present study, the roles of toll-like receptor (TLR) 2, TLR4 and MyD88, in exacerbat

204 Therefore, the role of Toll-like receptor (TLR) 2, TLR4, myeloid differentiatio

205 ate molecules reportedly engage and activate Toll-like receptor (TLR) 4 and other TLRs, yet the inter

206 eversed the upregulation of calprotectin and Toll-like receptor (TLR) 4 in inflamed skin.

207 hma was induced in C57BL/6 J wild-type mice, Toll-like receptor (TLR) 4 knockout (Tlr4(-/-)) mice, an

208 sponse that was independent of both upstream Toll-like receptor (TLR) 4 signaling and downstream type

209 g distinct lung APC subsets or cell-specific Toll-like receptor (TLR) 4 signaling.

210 LPS binds Toll-like receptor (TLR) 4, which leads to the release o

211 Toll-like receptor (TLR) 5 binding was assessed with HEK

212 expression of two closely related receptors, Toll-like receptor (TLR) 7 and TLR9, is balanced to allo

213 Small-molecule imidazoquinoline Toll-like receptor (TLR) 8 agonists robustly activate ne

214 Toll-like receptor (TLR) activation contributes to prema

215 Toll-like receptor (TLR) activation stimulates antiviral

216 The TIR domain is able to interact with the Toll-like receptor (TLR) adaptors TIRAP and MyD88, as we

217 zation and activation of the inflammasome by Toll-like receptor (TLR) agonism with bacterial lipopoly

218 Toll-like receptor (TLR) agonist adjuvant formulations h

219 nitric oxide synthase (iNOS) mRNA following Toll-like receptor (TLR) agonist treatment.

220 acrophages submitted to oxidative stress and toll-like receptor (TLR) agonist.

221 reased inflammatory cytokines in response to Toll-like receptor (TLR) agonists and lipopolysaccharide

222 ons in combination with several Th1-inducing Toll-like receptor (TLR) agonists in vivo In mice, the T

223 atal innate immune response, for example, to Toll-like receptor (TLR) agonists, can reduce the effica

224 cells, IL-10 can be produced in response to Toll-like receptor (TLR) agonists.

225 other types of dangers through their role in Toll-like receptor (TLR) and interleukin 1 receptor (IL-

226 Most members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-

227 onse gene 88 (MyD88), the common adaptor for toll-like receptor (TLR) and Interleukin-1 receptor sign

228 o insulin resistance and type 2 diabetes via Toll-like Receptor (TLR) and TNF-family cytokine recepto

229 s, acting as a negative regulator of ILR and Toll-like receptor (TLR) downstream signalling pathways

230 This study investigates whether Toll-like receptor (TLR) expression and signaling during

231 r immune cell composition by flow cytometry, Toll-like receptor (TLR) expression by quantitative PCR,

232 ith the latter reflected in changes in local Toll-like receptor (TLR) expression.

233 ctivate several members of the transmembrane Toll-like receptor (TLR) family.

234 TOLL-like receptor (TLR) ligands activate both innate an

235 blast response to self-antigens that contain Toll-like receptor (TLR) ligands is prominent in murine

236 cally relevant immune-agonists, specifically Toll-like receptor (TLR) ligands, using biodegradable, p

237 1-derived macrophages activated by different toll-like receptor (TLR) ligands.

238 Cross-regulation of Toll-like receptor (TLR) responses by cytokines is essen

239 Accumulating evidence indicates that Toll-like receptor (TLR) signaling adapter protein inter

240 ed kinase 1 (TAK1) is critical for mediating Toll-like receptor (TLR) signaling and subsequent activa

241 The role of Toll-like receptor (TLR) signaling in processing of SLE

242 We determined the function of Toll-like receptor (TLR) signaling on the progression of

243 be a role for alphav integrins in regulating Toll-like receptor (TLR) signalling by modulating intrac

244 ptor protein TRAF6 has a central function in Toll-like receptor (TLR) signalling, yet the molecular m

245 ues are phosphorylated both before and after Toll-like receptor (TLR) stimulation.

246 ns involved in signaling pathways, including Toll-like receptor (TLR), mitogen-activated protein kina

247 HCC because it has critical roles in virus-, Toll-like receptor (TLR)-, and IFN-induced signaling pat

248 Dysregulated Toll-like receptor (TLR)-4 activation is involved in acu

249 Escherichia coli lipopolysaccharide (LPS), a Toll-like receptor (TLR)-4 agonist.

250 Extracted monocytes were stimulated with the toll-like receptor (TLR)-4 ligand, lipopolysaccharide (L

251 ne chest wall mammary cancers with a topical toll-like receptor (TLR)-7 agonist, imiquimod.

252 ses to T-cell-independent antigens through a Toll-like receptor (TLR)-amplified pathway involving tra

253 Toll-like receptor (TLR)-dependent pathways induce IFN-I

254 Toll-like receptor (TLR)-mediated sensing of the microbi

255 ctivation, a host response also critical for Toll-like receptor (TLR)-mediated signaling.

256 n activate CREBH in mouse liver tissues in a toll-like receptor (TLR)/MyD88-dependent manner.

257 of inflammation-associated genes, including toll-like receptor (TLR)2, the receptor for advanced gly

258 Expression of Toll-like receptor (TLR)2, TLR4, and nuclear factor (NF)

259 ot suppressed by inhibitors of intracellular toll-like receptor (TLR)9.

260 Toll-like receptors (TLR) are conserved immune sensors m

261 nterpart, has been achieved using hybridized toll-like receptors (TLR) combining TLR1 and TLR2 onto a

262 Inflammatory mediators binding to Toll-Like receptors (TLR) induce an influx of superoxide

263 survival defect after engagement of CD40 or Toll-like receptors (TLR), despite paradoxically enhance

264 A unifying feature for the two components is Toll-like receptors (TLR), which are key regulators of t

265 -induced cytokine expression is abolished in Toll-like receptor (TLR2)(-/-) bone marrow-derived macro

266 Given the fundamental role of Toll-like receptors (TLRs) and complement in inflammatio

267 le of rescuing gp96 client proteins, such as Toll-like receptors (TLRs) and integrins, in a gp96-defi

268 Recent work has identified Toll-like receptors (TLRs) and type I interferon (IFN) s

269 vital to rapidly responding to pathogens and Toll-like receptors (TLRs) are a critical component of t

270 Toll-like receptors (TLRs) are innate immune receptors f

271 Toll-like receptors (TLRs) are major players of the inna

272 In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detector

273 RAK4 or MYD88, which mediate the function of Toll-like receptors (TLRs) except TLR3, contained VH4-34

274 Endosomal Toll-like receptors (TLRs) have been shown to be crucial

275 te innate immune activation through specific toll-like receptors (TLRs) in epidermal keratinocytes, a

276 The retention of intracellular Toll-like receptors (TLRs) in the endoplasmic reticulum

277 Therapies based on activation of multiple Toll-like receptors (TLRs) may offer superior therapeuti

278 Toll-like receptors (TLRs) play a role in innate immunit

279 Toll-like receptors (TLRs) play an important role in B c

280 Toll-like receptors (TLRs) play an important role in imm

281 Ligand binding to Toll-like receptors (TLRs) results in dimerization of th

282 als are sensed and acted upon acutely by the Toll-like receptors (TLRs) to halt proliferation and act

283 critical role in innate immune signaling by Toll-like receptors (TLRs), and loss of IRAK4 activity i

284 tain nucleic acids that can be recognized by Toll-like receptors (TLRs), engulfment of ACs does not i

285 t al. (2016) report that TRIF, an adaptor of Toll-like receptors (TLRs), is essential for STING-media

286 e immunity, involved in signaling by several Toll-like receptors (TLRs), key pattern recognition rece

287 When activated through toll-like receptors (TLRs), macrophages generate IL-33,

288 n recognition receptors (PRRs), specifically toll-like receptors (TLRs), sense and respond to pathoge

289 Pathogen-activated Toll-like receptors (TLRs), such as TLR2 and TLR4, dimer

290 Several microglia-related molecules, such as Toll-like receptors (TLRs), the complement system, cytok

291 uction of the expression of Il12 and Il23 by Toll-like receptors (TLRs), which impaired the different

292 One such family is the Toll-like receptors (TLRs).

293 oxidase pathway modulators and inhibitors of Toll-like receptors (TLRs).

294 production of membrane-associated mucins and Toll-like receptors (TLRs).

295 e 1/2 MAP kinase signaling pathway following Toll-like receptor, TNFR1, and IL-1R stimulation.

296 ficient mice, by which microbiota signal via Toll-like receptors to elicit IgD CSR.

297 ) mice) and mice defective in trafficking of Toll-like receptors to the endosome (Unc93b1(-/-) mice).

298 (myeloid differentiation factor 88) or TLRs (Toll-like receptors), we demonstrate that TLR2 and TLR6

299 es for proinflammatory cytokines and various toll-like receptors were overexpressed in SAH neutrophil

300 mma on stimulation of dectin-1, mannose, and Toll-like receptors with Candida albicans and Staphyloco