ライフサイエンスコーパス: Toll-like receptor 3

1 he expression of the innate immune receptor, Toll-like receptor 3.

2 ary and sufficient to stimulate WIHN through toll-like receptor 3.

3 nents to endosomal compartments that contain Toll-like receptor-3.

4 ch no signaling occurs via the intracellular Toll-like receptors 3, 7 and 9 (sensors for double-stran

5 RNA expression of protein kinase R (PKR) and Toll-like receptors 3, 7, and 9 was also measured from c

6 responses to RSV that correlated with lower Toll-like receptor 3/7 transcript and decreased expressi

7 Toll-like receptor 3-activated macrophages confer anti-H

8 Prestimulation of MSCs with a toll-like receptor 3 agonist further enhanced the therap

9 We show that toll-like receptor 3 agonist Poly I:C, combined with exo

10 ted, polyinosinic:polycytidylic acid (PIC, a Toll-like receptor 3 agonist) was highly effective as an

11 sion in SeV-infected cells demonstrated that Toll-like receptor 3, although essential for gene induct

12 Toll-like receptor 3, an innate pattern recognition rece

13 Toll-like receptor 3 and 4 agonists, tumor necrosis fact

14 We set to determine the role of toll-like receptor 3 and the binding of double-stranded

15 incorporating FADD is largely independent of Toll-like receptor 3 and the dsRNA-dependent kinase PKR,

16 and IPS-1 adaptor cytosolic pathway and the Toll-like receptor 3 and TIR domain-containing adaptor-i

17 Cathelicidins were induced via toll-like receptor-3 and were inhibited by IL-4/IL-13 th

18 This applies to toll-like receptors 3 and 4 (TLR3, TLR4), which sense do

19 e disease viruses or after engagement of the Toll-like receptors 3 and 4 by double-stranded RNA and l

20 ), pathogen recognition receptors RIG-I, and Toll-like receptors 3 and 7.

21 Cotransfection of human Toll-like receptors 3 and 9 (receptors for dsRNA and CpG

22 e innate pattern-recognition receptor TLR-3 (Toll-like receptor 3) and resulted in a marked inhibitio

23 terferon-beta (-/-), and wild-type mice with toll-like receptor 3 antibody neutralization.

24 re clearly defined with the observation that Toll-like receptor 3 can sense self RNA released from ne

25 We sought to evaluate an inhibitory mAb to Toll-like receptor 3, CNTO3157, on experimental HRV-16 i

26 gative lines were no longer able to induce a Toll-like receptor 3-dependent hyperinflammatory cytokin

27 Additionally, pretreatment with toll-like receptor 3/double-stranded RNA ligand inhibito

28 A toll-like receptor 3/double-stranded RNA ligand inhibito

29 double-stranded RNA from injured cells with toll-like receptor 3 drives the acute inflammatory respo

30 Toll-like receptor 3 expression was analyzed in postmort

31 Toll-like receptor 3 expression was higher in patients a

32 thimazole markedly decreased virally induced Toll-like receptor-3 expression and signaling and signif

33 otype and increased surface translocation of toll-like receptor 3 from the endosome to the surface.

34 in the toll-like receptor 2 gene (TLR2), the toll-like receptor 3 gene (TLR3), the toll-like receptor

35 In this issue, studies demonstrate that Toll-like receptor 3 has an important role in signaling

36 r the genetic dissection of inborn errors of Toll-like receptor 3 immunity.

37 ion of double-stranded RNA signaling through Toll-like receptor 3 is mediated by the viral protease N

38 Toll-like receptor-3 is critically involved in host defe

39 elanoma differentiation associated gene 5 or toll-like receptor 3, is the cytoplasmic sensor for intr

40 C57BL/6J wild-type and toll-like receptor 3 knockout mice.

41 The Toll-like receptor 3 ligand, polyinosinic-polycytidylic

42 , such as an agonistic anti-CD40 antibody or Toll-like receptor 3 ligand.

43 To test this idea, we encapsulated the Toll-like receptor-3 ligand poly(inosinic:cytidylic acid

44 showed reduced stimulation of T cells after Toll-like receptor 3 ligation.

45 on caused by poly(I:C)-induced activation of toll-like receptor 3 localized in intracellular vesicles

46 se (IKK)-epsilon) are critically involved in Toll-like receptor-3-mediated IFN-beta production throug

47 Alveolar macrophages from toll-like receptor 3 (-/-) mice had a lower early apopto

48 oceeded normally in macrophages deficient in Toll-like receptor 3 or 7.

49 Neither NK cells nor signaling via Toll-like receptor 3 or MyD88 were essential for viral c

50 ation of type I IFN responses through either Toll-like receptor 3 or retinoic acid-inducible gene I/m

51 s caused by defects in the activation of the Toll-like receptor 3 pathway, overall contributed to the

52 We observed that IHH possesses a functional Toll-like receptor 3 pathway.

53 TLR3 (Toll-like receptor 3) recognizes dsRNA, a potent indicat

54 on, or the binding of double-stranded RNA to Toll-like receptor 3, results in the coordinate activati

55 Compared with wild-type septic mice, toll-like receptor 3 septic mice had attenuated abdomina

56 lication of the HGC, in which we generated a Toll-like receptor 3-specific connectome useful for the

57 ion, and macrophage apoptosis was reduced in toll-like receptor 3 (-/-), TIR-domain-containing adapte

58 Unilateral lung contusion was induced in toll-like receptor 3 (-/-), TIR-domain-containing adapte

59 In the presence of 4-1BB ligation and Toll-like receptor 3 (TLR)3 and/or TLR4 triggering, CD8

60 model of brain inflammation by injecting the Toll-like receptor 3 (TLR-3) agonist polyinosinic:polycy

61 Mice deficient in Toll-like receptor 3 (TLR-3) also developed this same sy

62 molecule that is critically involved in the Toll-like receptor 3 (TLR-3) and TLR-4 signaling pathway

63 an cell line competent for signaling through Toll-like receptor 3 (TLR-3) and TLR-5.

64 Experiments with astrocytes from Toll-like receptor 3 (TLR-3) knockout mice indicated tha

65 The dsRNA signaling moieties Toll-like receptor 3 (TLR-3), retinoic acid-inducible ge

66 (ISG15) E3 ligase, HERC5, in the context of Toll-like receptor 3 (TLR3) activation and IFN induction

67 nhances double-stranded RNA (dsRNA)-mediated Toll-like receptor 3 (TLR3) activation.

68 -1 but did inhibit responses to poly(I.C), a Toll-like receptor 3 (TLR3) activator that does not sign

69 olyinosine-polycytidylic acid (poly(I:C)), a Toll-like receptor 3 (TLR3) agonist used as a mimetic to

70 rough in vivo administration of poly(I:C), a Toll-like receptor 3 (TLR3) agonist.

71 are emerging; in particular, dsRNA receptors Toll-like receptor 3 (TLR3) and cytosolic helicases expr

72 of the mRNA to evade activation of endosomal Toll-like receptor 3 (TLR3) and downstream innate immune

73 ich is released from damaged skin, activates Toll-Like Receptor 3 (TLR3) and its downstream effectors

74 Poly(I:C) acts through two dsRNA sensors, Toll-like receptor 3 (TLR3) and melanoma differentiation

75 This induction is mediated through toll-like receptor 3 (TLR3) and protein kinase R (PKR),

76 Viral double-stranded RNA, a ligand for Toll-like Receptor 3 (TLR3) and the cytoplasmic RNA rece

77 physical and functional relationship between Toll-like receptor 3 (TLR3) and the pattern recognition

78 naling of the pathogen recognition receptors Toll-like receptor 3 (TLR3) and TLR4.

79 ucing signals from intracellularly signaling Toll-like receptor 3 (TLR3) and TLR4.

80 UVB-damaged keratinocytes were dependent on Toll-like receptor 3 (TLR3) and Toll-like receptor adapt

81 anded RNA (dsRNA) induces phosphorylation of Toll-like receptor 3 (TLR3) at tyrosine 759 and subseque

82 ter activation in response to stimulation of Toll-like receptor 3 (TLR3) by extracellular double-stra

83 The innate immune receptor Toll-like receptor 3 (TLR3) can be present on the surfac

84 Toll-like receptor 3 (TLR3) can signal the production of

85 The structure of the human Toll-like receptor 3 (TLR3) ectodomain (ECD) was recentl

86 us 1 (HSV-1), children with inborn errors of toll-like receptor 3 (TLR3) immunity are prone to HSV-1

87 Here, we report a role for toll-like receptor 3 (TLR3) in cone-rod dystrophy (CORD)

88 idylic acid sodium salt (poly I:C) to target Toll-like receptor 3 (TLR3) in endosomes.

89 N) leads to a reduction in the expression of Toll-like receptor 3 (TLR3) in macrophages from young do

90 Toll-like receptor 3 (TLR3) is a key effector of the inn

91 Toll-like receptor 3 (TLR3) is an innate immune system r

92 Finally, we found that Toll-like receptor 3 (TLR3) is not required for either p

93 We previously showed that Toll-like receptor 3 (TLR3) is the critical pattern reco

94 86, and CD40) expression and did not inhibit Toll-like receptor 3 (TLR3) ligand [poly(I:C)]-induced m

95 of innate immunity by viral infection or the toll-like receptor 3 (TLR3) ligand on liver regeneration

96 Here we show that the Toll-like receptor 3 (TLR3) ligand poly(I:C) (PIC) induc

97 Toll-like receptor 3 (TLR3) mediates antiviral response

98 ants impaired IFN-beta production induced by Toll-like receptor 3 (TLR3) or TLR4 agonists but failed

99 Defects in genes of the Toll-like receptor 3 (TLR3) pathway are associated with

100 ral dsRNA through two distinct pathways; the Toll-like receptor 3 (TLR3) pathway detects dsRNA phagoc

101 d loss-of-function studies, we find that the toll-like receptor 3 (TLR3) pathway enables efficient in

102 iation-associated protein 5 (RIG-I/MDA5) and Toll-like receptor 3 (TLR3) pathways.

103 Toll-like receptor 3 (TLR3) recognizes double-stranded R

104 Toll-like receptor 3 (TLR3) recognizes dsRNA and initiat

105 a (TNF-alpha) and has been implicated in the Toll-like receptor 3 (TLR3) response to double-stranded

106 horylation, leading to inefficient RIG-I and Toll-like receptor 3 (TLR3) responses.

107 tic properties, acts as a novel regulator of Toll-like receptor 3 (TLR3) signaling to interferon (IFN

108 We investigated whether Toll-like receptor 3 (TLR3) stimulation would protect th

109 Recognition of viral RNA by Toll-like receptor 3 (TLR3) triggers activation of the t

110 Recognition of double-stranded RNA by Toll-like receptor 3 (TLR3) will increase the production

111 y of RNA interference by directly activating Toll-like receptor 3 (TLR3), a double-stranded RNA immun

112 lock type I interferon signaling mediated by Toll-like receptor 3 (TLR3), a receptor we have previous

113 e 561 mRNA by exogenous dsRNA is mediated by Toll-like receptor 3 (TLR3), and it requires no new prot

114 tremendously when HEK293 cells overexpressed Toll-like receptor 3 (TLR3), and the increased secretion

115 sm through both its membrane-bound receptor, Toll-like receptor 3 (TLR3), as well as cytoplasmic rece

116 agonist that recognizes the cellular sensor Toll-like receptor 3 (TLR3), in regulating Valpha14iNKT

117 Differentiation-associated gene 5 (MDA5) and Toll-Like Receptor 3 (TLR3), induces the TANK-Binding Ki

118 d the modulatory effects of Th2 cytokines on Toll-like receptor 3 (TLR3), interferon-responsive facto

119 egfr1) siRNA suppressed CNV via cell-surface toll-like receptor 3 (TLR3), its adaptor TRIF, and induc

120 erleukin-1 (IL-1)/Toll receptor superfamily, Toll-like receptor 3 (TLR3), recognizes double-stranded

121 his family of pattern recognition receptors, toll-like receptor 3 (TLR3), recognizes viral double-str

122 se HCV dsRNAs also induced the expression of Toll-like receptor 3 (TLR3), retinoic acid-inducible gen

123 wnstream of several viral sensors, including Toll-like receptor 3 (TLR3), RIG-I, and MDA5.

124 ors, respectively, and with the exception of Toll-like receptor 3 (TLR3), signal via the adaptor mole

125 CL22, CD274, and CD273 and downregulation of Toll-like receptor 3 (TLR3), TLR5, and TLR7.

126 eltaE3L is unaffected by genetic ablation of Toll-like receptor 3 (TLR3), TRIF, TLR9, and MyD88.

127 Influenza stimulates toll-like receptor 3 (TLR3), which can increase RhoA act

128 merous interferon-regulated genes, including Toll-like receptor 3 (Tlr3), which encodes an innate imm

129 mal organization to the selective control of toll-like receptor 3 (TLR3)- and TLR4-mediated proinflam

130 rmore, preexposure of LC to L3 did not alter Toll-like receptor 3 (TLR3)- or TLR4-mediated expression

131 These interferon responses attributed to toll-like receptor 3 (TLR3)-activated Kupffer and liver

132 Inhibition of BRD4 blocks Toll-like receptor 3 (TLR3)-dependent neutrophilia and R

133 Inborn errors in Toll-like receptor 3 (TLR3)-IFN type I and III pathways

134 hat West Nile virus (WNV) is able to inhibit Toll-like receptor 3 (TLR3)-mediated activation of inter

135 Here we report that EV68 inhibits Toll-like receptor 3 (TLR3)-mediated innate immune respo

136 nse to viral infection is often triggered by Toll-like receptor 3 (TLR3)-mediated signaling by double

137 Huh7 hepatoma cells by ectopic expression of Toll-like receptor 3 (TLR3).

138 ed by signalling through the dsRNA receptor, toll-like receptor 3 (TLR3).

139 ) from necrotic keratinocytes that activates Toll-like receptor 3 (TLR3).

140 f the endosomal pattern recognition receptor Toll-like receptor 3 (TLR3).

141 een identified as an endogenous activator of Toll-like receptor 3 (TLR3).

142 ed (ds) RNA-induced innate responses through Toll-like receptor 3 (TLR3).

143 g the caspase-11 pathway in vivo with LPS or Toll-like receptor-3 (TLR3) agonist resulted in high mor

144 Toll-like receptor-3 (TLR3) is crucial for the innate im

145 Toll-like receptor-3 (TLR3) senses double-stranded RNA,

146 We found that Toll-like receptor-3 (TLR3) senses HCV infection in cult

147 Toll-like receptor-3 (TLR3), a member of the pathogen re

148 The innate immune receptor Toll-like-Receptor 3 (TLR3) was upregulated after ZIKV i

149 s well as following exposure to poly(I.C) (a Toll-like receptor 3 [TLR3] stimulus) and 5' poly(U) HCV

150 lectively on keratinocytes triggered through Toll-like receptor 3(TLR3).

151 pothesized that small-molecule activators of toll-like receptor 3, together with external microenviro

152 kinase, 2'5'-oligoadenylate synthetase, and Toll-like receptor 3, transcripts that encode dsRNA-resp

153 is sensed by the human epithelial cells via Toll-like receptor 3, triggering Interferon Regulating F

154 eover, a direct interaction between PAR2 and Toll-like receptor 3 was observed.