ライフサイエンスコーパス: a highly conserved

1 Both complexes contain the Tra1 subunit, a highly conserved 3744-residue protein from the Phospho

2 ) in mouse Gp78 isoform 2 that forms part of a highly conserved 41-amino acid region containing 14-3-

3 -amino group of a specific lysine present on a highly conserved acceptor protein domain, resulting in

4 Viral protein R (Vpr), a highly conserved accessory protein in primate lentivir

5 Ten patients had mutations within a highly conserved acidic loop of the PPP2R5D-encoded B5

6 sphate isomerase (TIM) barrel structure with a highly conserved active site.

7 Fear, which represents a highly conserved adaptive response to threatening envi

8 By modifying a highly conserved adenosine A2503 in 23S rRNA, methylat

9 cluding two papain-like proteases (PLPs) and a highly conserved ADP-ribose-1''-phosphatase (ADRP) mac

10 HTT has a highly conserved Akt phosphorylation site at serine 42

11 Expression of a highly conserved, alkaline-regulated, sodium ATPase wa

12 from an artemisinin ABPP equivalent confirms a highly conserved alkylation profile, with both endoper

13 The missense mutation affects a highly conserved amino acid and is predicted to severe

14 a damaging mutation, c.567 G > A, affecting a highly conserved amino acid residue (p.Gly189Arg) of t

15 The identified mutation affects a highly conserved amino acid residue in the zinc finger

16 d with the disease in the pedigree, affected a highly conserved amino acid residue, and was predicted

17 We identified 66Y (N1 numbering), a highly conserved amino acid that was critical for the

18 This missense change alters a highly conserved amino acid within CEP120 (p.Ala199Pro

19 We identify a highly conserved amino acid, Gly449, that is necessary

20 phaCPs and hnRNP E proteins), are encoded by a highly conserved and broadly expressed gene family.

21 Sleep is a highly conserved and essential behaviour in many speci

22 TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding pr

23 Arginine finger is a highly conserved and essential residue in many GTPase

24 Epithelial-mesenchymal transition (EMT) is a highly conserved and fundamental process in developmen

25 CK2 is a highly conserved and pleiotropic serine/threonine kina

26 alpha-N-terminal methylation represents a highly conserved and prevalent post-translational modi

27 Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway

28 nt of the Trm8/Trm82 holoenzyme that effects a highly conserved and specific (m(7)G46) methylation of

29 The cell cycle is a highly conserved and tightly regulated biological syst

30 NETs are believed to constitute a highly conserved antimicrobial strategy comprising dec

31 PAT family reveals PfDHHC1 to be a member of a highly conserved, apicomplexan-specific clade of PATs.

32 We found that a highly conserved asparagine (N220) in the first transm

33 binding site had been ablated by deletion of a highly conserved aspartic acid at position 385, which,

34 pproaches identified Asp93, which is part of a highly conserved AspGlu dyad found in all dual domain

35 The HK component contains a highly conserved ATP-binding site that is considered t

36 Epibatidine shares a highly conserved binding site with acetylcholine, maki

37 Sphingolipid synthesis involves a highly conserved biosynthetic pathway that produces fu

38 irth (neurogenesis) within the hypothalamus, a highly conserved brain region involved in hyperactivit

39 are present only in angiosperms and possess a highly conserved C-terminal region containing linear m

40 We identify a highly conserved C-terminal TBP-interaction domain (CT

41 the alphaB and betaB structural elements and a highly conserved carboxylate-binding loop.

42 rylating targeted protein substrates through a highly conserved catalytic core.

43 g combined with mutational analysis revealed a highly conserved catalytic dyad as well as conserved s

44 he 17b human monoclonal antibody recognizing a highly conserved CD4-induced epitope on gp120 involved

45 acterial phage shock protein (Psp) system is a highly conserved cell envelope stress response require

46 t a post-attachment step by interacting with a highly conserved central alpha helix-rich domain.

47 d panneuronal responses to visual stimuli in a highly conserved central brain region in the fruit fly

48 chromatin structure for quiescence driven by a highly conserved chromatin regulator.

49 DEK is a highly conserved chromatin-bound protein whose upregul

50 Sirtuins are a highly conserved class of NAD(+)-dependent lysine deac

51 ng zoysiagrass, rice and sorghum genomes and a highly conserved collinearity in the gene order was ob

52 of commensal fungi are mediated by mannans, a highly conserved component of fungal cell walls, since

53 re, we provide evidence for the existence of a highly conserved, continuous, PC-specific epitope sequ

54 Hence, this study has identified a highly conserved, critical peptide in DV that is a tar

55 stal structure of the decaheme MtrC revealed a highly conserved CX8C disulfide that, when substituted

56 ovel missense mutation Cys694Arg that alters a highly conserved cysteine in the RING domain.

57 tantly, ROS also inactivate Sb9 by oxidizing a highly conserved cysteine pair (P1-P1' in rodents and

58 The p.Cys1691Ser substitution affects a highly conserved cysteine residue and is predicted by

59 tion interface by a disulfide bond formed by a highly conserved cysteine.

60 Pacman/XRN1 is a highly conserved cytoplasmic exoribonuclease which deg

61 Growth arrest specific gene two (GAS2) is a highly conserved cytoskeleton-associated protein whose

62 An allosteric sodium ion was found bound to a highly conserved D2.50 residue in inactive GPCRs, wher

63 Autophagy is a highly conserved degradation process that is involved

64 oss-of-function mutations in USP9X, encoding a highly conserved deubiquitinating enzyme.

65 tes directly to autoinhibition by precluding a highly conserved dipole-enhanced hydrogen bond between

66 We have identified a highly conserved DNA methyltransferase, which we term

67 FANCM is a highly conserved DNA remodeling enzyme that promotes t

68 A highly conserved DNA uptake system allows many bacteri

69 The TEC proteins share a highly conserved domain (DUF4123) and are genetically

70 They share a highly conserved domain (DUF583) of which the structur

71 dent methylmalonyl-CoA mutase (MCM), HCM has a highly conserved domain architecture.

72 sual case in which an equivalent mutation in a highly conserved domain of yeast and mammalian Erks ca

73 ork mapped the immunosuppressive activity to a highly conserved domain, termed the immunosuppressive

74 MDA-9/Syntenin, a highly conserved double-PDZ domain-containing scaffold

75 Lissencephaly-1 (LIS1) is a highly conserved dynein-regulatory factor that binds d

76 We further show that a highly conserved eight-base-pair segment of SL3 is not

77 Poly (ADP-ribose) polymerase-1 (PARP1) is a highly conserved enzyme focused on the self-repair of

78 (sulfide quinone oxidoreductase) protein is a highly conserved enzyme involved in H2S metabolism.

79 Pterin-4a-carbinolamine dehydratase (PCD) is a highly conserved enzyme that evolved a second, unrelat

80 Also, a highly conserved epitope (YGD/XTL) of E6 was found to

81 ds through a coordinated movement of CDRs to a highly conserved epitope encompassing a hydrophobic gr

82 g and transgenic approaches demonstrate that a highly conserved ERG-bound enhancer located upstream o

83 The bacterial cell wall is a highly conserved essential component of most bacterial

84 d from isoforms LRRC8C and LRRC8E to uncover a highly conserved extracellular region preceding the se

85 SLBP (stem-loop binding protein) is a highly conserved factor necessary for the processing,

86 clamp loader clade, RarA protein is part of a highly conserved family of DNA metabolism proteins.

87 Septins are a highly conserved family of proteins in eukaryotes that

88 We and others identified a highly conserved family of sterol transport proteins (

89 The flat Golgi cisterna is a highly conserved feature of eukaryotic cells, but how

90 A highly conserved FLV motif was identified in the C-ter

91 ther, our results demonstrate that IFT88 has a highly conserved function within the primary cilia of

92 022500) that encodes atypical amino acids at a highly conserved functional site.

93 Trace amine-associated receptor 1 (TAAR1) is a highly conserved G-protein-coupled receptor bound by e

94 Mutation of a highly conserved 'gating charge' residue in the S4 hel

95 KCNQ5 is a highly conserved gene encoding an important channel fo

96 -related oncogene; also known as DCUN1D1) is a highly conserved gene that functions as an E3 in neddy

97 Gephyrin is a highly conserved gene that is vital for the organizati

98 dy, two basic amino acids, R128 and R129, in a highly conserved GKYLQRRLQ motif were determined to be

99 We have now identified a highly conserved glutamate residue in the transmembran

100 bstitutions (p.Glu117Val and p.Glu117Gly) at a highly conserved glutamic acid residue located in the

101 llular form of the prion protein (PrP(C)) is a highly conserved glycoprotein mostly expressed in the

102 We identified murein lipoprotein (MLP), a highly conserved gram-negative outer membrane protein,

103 ant (OR 0.58; 95% CI 0.36-0.94; P = .028) in a highly conserved haplotype region surrounding the LCT

104 PEP87 corresponds to a highly conserved helical region of the HA2 subunit of

105 The mutant protein lacks a highly conserved helix consisting of the C-terminal fo

106 the conformation of the heme and changes in a highly conserved helix I motif that is associated with

107 yzed to date, serine palmitoyltransferase is a highly conserved heterodimeric enzyme complex.

108 l domain are facilitated by the Bam complex, a highly conserved heteroligomer that plays a general ro

109 or the periplasm of bacteria is mediated by a highly conserved heterotrimeric membrane protein compl

110 Replication protein A (RPA) is a highly conserved heterotrimeric single-stranded DNA-bi

111 cytochrome b561), and abolished by mutating a highly conserved His residue (H292L) predicted to coor

112 al, and mass spectrometry analyses show that a highly conserved His, immediately N-terminal to His(nu

113 enesis and biophysical studies revealed that a highly conserved histidine (His(113)) functions as a p

114 nally, all types of neurons are specified in a highly conserved histogenic order, although its signif

115 Nucleoplasmin (Npm) is a highly conserved histone chaperone responsible for the

116 Histone H3.3 is a highly conserved histone H3 replacement variant in met

117 H2A.Z is a highly conserved histone variant involved in several k

118 H2A.Z is a highly conserved histone variant of the canonical hist

119 esidues adjacent to Asn-110 and Asn-137 form a highly conserved hydrophobic cleft interacting with th

120 Our data reveal that splicing has a highly conserved impact on the availability of sodium

121 vel neutralizing monoclonal antibody targets a highly conserved internal fusion loop in the glycoprot

122 The Lon AAA+ protease is a highly conserved intracellular protease that is consid

123 the discovery of target of rapamycin (TOR), a highly conserved kinase and central controller of cell

124 may be functionally redundant, as they share a highly conserved kinase domain.

125 s of mechanistic target of rapamycin (mTOR), a highly conserved kinase within a nutrient-sensing path

126 Specifically, three-toed sloths possess a highly conserved, low-diversity foregut community with

127 haploinsufficiency for LOX or are located at a highly conserved LOX catalytic domain, which is relati

128 L4-ROC1 E3 ubiquitin ligase (CRL4(VprBP)) on a highly conserved lysine residue.

129 nonstructural protein 3 (nsP3) that contains a highly conserved MacroD-type macrodomain at the N term

130 Its crystal structure revealed a highly conserved macrodomain fold.

131 on is a core cellular process carried out by a highly conserved macromolecular machine, the ribosome.

132 ne the metabolic responses to dietary AAs in a highly conserved manner.

133 AMPK is a highly conserved master regulator of metabolism, which

134 Catabolite control protein A (CcpA) is a highly conserved, master regulator of carbon source ut

135 Tenascin-C (TNC) is a highly conserved matricellular protein with a distinct

136 factor (SRF)-mediated gene transcription is a highly conserved mechanism that connects dynamic reorg

137 romote epigenetic transcriptional poising by a highly conserved mechanism.

138 ct with and activate Galpha proteins through a highly conserved mechanism.

139 UNC-45A is a highly conserved member of the UNC-45/CRO1/She4p famil

140 respectively) envelope glycoproteins contain a highly conserved, membrane-proximal endocytosis motif

141 ults demonstrate the selective inhibition of a highly conserved metabolic enzyme that contains identi

142 swip-10 encodes a protein containing a highly conserved metallo-beta-lactamase domain, within

143 on that encodes a substitution of valine for a highly conserved methionine (p.Met184Val) in both affe

144 we show that a homozygous mutation affecting a highly conserved MFSD2A residue (p.Ser339Leu) is assoc

145 nuclear receptor and major drug target, has a highly conserved minor splice variant, GRgamma, which

146 entameric ligand-gated ion channels, sharing a highly conserved modular 3D structure.

147 In this study, we found that HSP90, a highly conserved molecular chaperone, is overexpressed

148 the R128A or R129A mutation introduced into a highly conserved motif ((123)GKYLQRRLQ(131)) reduced t

149 s physically interact with tankyrase through a highly conserved motif at their N terminus, and mutati

150 tic analysis revealed that the PRR contained a highly conserved motif of 18 amino acids.

151 n inhibits cell wall synthesis by binding to a highly conserved motif of lipid II (precursor of pepti

152 The major homology region (MHR) is a highly conserved motif that is found within the Gag pr

153 Rs) from diverse animal phyla and identified a highly conserved motif, which we termed the "hydrophob

154 ilable structural information, we identified a highly conserved motif.

155 is domain, these four amino acids constitute a highly conserved motif.

156 The target of rapamycin complex 1 (TORC1) is a highly conserved multiprotein complex that functions i

157 d by removal of the GPI-modification signal, a highly conserved N-glycan or the deletion of predicted

158 elated voltage-gated potassium channels have a highly conserved N-linked glycosylation site in the fi

159 The proteostasis network is a highly conserved network of cellular stress responses

160 PAR proteins constitute a highly conserved network of scaffolding proteins, adap

161 mediated by the hypothalamic-pituitary axis, a highly conserved neurohormonal cascade that culminates

162 an ortholog of the mammalian neuropeptide Y, a highly conserved neuromodulator that stimulates food-s

163 rates thyrotropin-releasing hormone (TRH) is a highly conserved neuropeptide that exerts the hormonal

164 Interestingly, this regulation required a highly conserved NF-kappaB-binding site but not a pred

165 Heterochromatin protein 1 (HP1), a highly conserved non-histone chromosomal protein in eu

166 MHC-E is a highly conserved nonclassical MHC class Ib molecule th

167 The m.7551A > G mutation is localized at a highly conserved nucleotide(A37), adjacent (3') to the

168 The primary cilium is a highly conserved organelle housing specialized molecul

169 Mammalian Ecdysoneless (ECD) is a highly conserved ortholog of the DrosophilaEcd gene pr

170 eport the identity of swip-13, which encodes a highly conserved ortholog of the human atypical MAP ki

171 tion of the hedgehog (Hh) signaling pathway, a highly conserved pathway best understood for its role

172 Wnt/beta-catenin signaling is a highly conserved pathway essential for embryogenesis a

173 Nucleotide excision repair (NER) is a highly conserved pathway that removes helix-distorting

174 This uORF encodes a highly conserved peptide (CPuORF) that is present in v

175 acterized by low cell-surface expression and a highly conserved peptide-binding cleft.

176 DNA binding was dependent upon a highly conserved Phe residue (F65) that in human POT1

177 neurotoxicity in HIV-infected macrophages is a highly conserved phenotype of macrophage-tropic HIV st

178 in Drosophila demonstrated the importance of a highly conserved phenylalanine for Pur-alpha's unwindi

179 Intriguingly, a highly conserved phosphomimetic RxEP motif in NS3 was

180 Phosducin (Pdc), a highly conserved phosphoprotein involved in the regula

181 ed by cAMP-dependent protein kinase (PKA) at a highly conserved phosphorylation site and by cyclin-de

182 roliferating cell nuclear antigen (PCNA) via a highly conserved PIP box motif within the kinase domai

183 tural and functional domains; in particular, a highly conserved pore-loop sequence that determines th

184 plants is an additional function of NIa-Pro, a highly conserved potyvirus protein.

185 Each of these proteins has a highly conserved primary activity; however, numerous a

186 Melanogenesis is a highly conserved process of cytophotoprotection from U

187 b development has otherwise been shown to be a highly conserved process.

188 COP9, which is a highly conserved protein complex composed of eight CSN

189 cinate dehydrogenase complex (complex II) is a highly conserved protein complex composed of the SDH1

190 SMC5/6 is a highly conserved protein complex related to cohesin an

191 s an ABCB1 auxin transporter and Dw1 encodes a highly conserved protein involved in the regulation of

192 Rad52 is a highly conserved protein involved in the repair of DNA

193 The vaccinia virus B1R gene encodes a highly conserved protein kinase that is essential for

194 Proliferating cell nuclear antigen (PCNA) is a highly conserved protein necessary for proper componen

195 XPhi uses an infection strategy that targets a highly conserved protein of Gram-negative bacteria ess

196 Bax inhibitor 1 (BI-1) is a highly conserved protein originally identified as a su

197 Scribble is a highly conserved protein regulator of cell polarity th

198 NS1 is a highly conserved protein secreted at high concentratio

199 TPM1 encodes a highly conserved protein that regulates muscle contrac

200 id of secretome phage display, we identified a highly conserved protein that specifically binds and i

201 TD-60 (also known as RCC2) is a highly conserved protein that structurally resembles t

202 A highly conserved protein, ACTA1 is implicated in multi

203 RadA (also known as 'Sms') is a highly conserved protein, found in almost all eubacter

204 nts, indicating that CdiA-CT(EC536) exploits a highly conserved protein-protein interaction to promot

205 pocampus.Finally, we confirm that Lhx2 binds a highly conserved putative enhancer of Dmrt5, suggestin

206 of Haemophilus influenzae LpoA (HiLpoA) has a highly conserved, putative substrate-binding cleft bet

207 lyzed by O-acetylserine sulfydrylase (OASS), a highly conserved pyridoxal 5'-phosphate (PLP)-dependen

208 in organization, and both subclasses contain a highly conserved Rab-binding domain at their C termini

209 CRM1 is a highly conserved, RanGTPase-driven exportin that carri

210 Autophagy is a highly conserved recycling process that involves degra

211 associated (CA) HIV-1 DNA and RNA, targeting a highly conserved region in HIV-1pol, with sensitivitie

212 ucleotide polymorphisms, one of which was in a highly conserved region of a gene encoding a sensor ki

213 inkage at multiple sites near the D1 domain, a highly conserved region of bacterial flagellins that i

214 We also discovered a highly conserved region of She3p upstream of its hook

215 sed the recently solved crystal structure of a highly conserved region of the Drosophila orthologue o

216 phorylation of a single tyrosine (p*Y504) in a highly conserved region of the fibronectin type III (F

217 This variant is in exon 2, a highly conserved region of the gene.

218 A RNA interference construct, designed to a highly conserved region of these genes, was used to tr

219 TLR13 has recently been identified to sense a highly conserved region within bacterial 23S rRNA.

220 gene in human Chanarin-Dorfman syndrome, is a highly conserved regulator of adipose triglyceride lip

221 ome remodeling deacetylase (NuRD) complex is a highly conserved regulator of chromatin structure and

222 Gle1 is a highly conserved regulator of RNA-dependent DEAD-box A

223 The JAK/STAT pathway is a highly conserved regulatory module, activated by many

224 These pathways share a highly conserved regulatory molecule, beta-catenin, wh

225 ontrolled by the orientation of arginine 66, a highly conserved residue in Anthozoan PCFPs.

226 ed missense mutation c.591C>A p.Glu197Asp in a highly conserved residue in exon 4 of ACTA1.

227 ar, the p.Thr270Ala missense variant affects a highly conserved residue in the DBL homology domain, w

228 C479 is a highly conserved residue in the extracellular domain o

229 Moreover, W69, a highly conserved residue located at the interface betw

230 persistent PKD1 phosphorylation at Ser(203), a highly conserved residue located within the PKD1 N-ter

231 These results indicate that a highly conserved residue of an ABC transporter plays a

232 dentified a single novel missense variant in a highly conserved residue of FLNC (filamin C; p.V2297M)

233 mouse model with an RNase H2 AGS mutation in a highly conserved residue of the catalytic subunit, Rna

234 Previous studies identified a highly conserved residue of the inner domain, W69, as

235 causes a missense mutation (p.Arg2024Gln) in a highly conserved residue that is essential for carbamo

236 The mutation is at a highly conserved residue within the DNA binding domain

237 This study investigates the role of a highly conserved residue, tryptophan residue 420, of t

238 tion responsible encodes the substitution of a highly conserved residue, which lies outside the benza

239 criptomes were broadly similar and exhibited a highly conserved response to LPS.

240 iggering nonsense-mediated mRNA decay (NMD), a highly conserved RNA degradation pathway.

241 eIF4A is a highly conserved RNA-stimulated ATPase and helicase in

242 cribe the identification of translin (trsn), a highly conserved RNA/DNA binding protein, as essential

243 One of these subclades plays a highly conserved role in cell division, while the dist

244 coded protein associates with rRNA and plays a highly conserved role in the maturation of the 60S rib

245 tion in zebrafish cloche mutants, indicating a highly conserved role in vertebrate vasculogenesis and

246 tural accessions of this species, indicating a highly conserved role of this protein in controlling o

247 Instead, our analysis reveals a highly conserved salt-bridge network, which likely has

248 This is achieved in part by Notum, a highly conserved secreted feedback antagonist.

249 o the complex by engaging the latter through a highly conserved segment adjacent to the helical HID s

250 A highly conserved self-antigen, nonmuscle myosin heavy

251 Autophagy is a highly conserved self-degradative process that has a k

252 Autophagy is a highly conserved self-digestion process, which is esse

253 at a single amino acid change (Arg135Gly) in a highly conserved sensor kinase (LiaS) of a poorly defi

254 sp/Glu-rich hypervariable region followed by a highly conserved sequence comprising two potential HXH

255 A cross-species analysis identifies a highly conserved sequence element in LINC-PINT that is

256 A highly conserved sequence motif on helix I contributes

257 Phosphorylation of a highly conserved serine cluster in the intracellular d

258 A highly conserved serine located at position 375 in gro

259 ng identified a germline mutation (S631G) at a highly conserved serine residue in the uncharacterized

260 PP2A(Cdc55) is a highly conserved serine-threonine protein phosphatase

261 A highly conserved set of approximately 1,000 proteins i

262 Granzyme B cleaves a highly conserved set of proteins in all three bacteria

263 The Hedgehog (Hh) pathway is a highly conserved signaling cascade crucial for cell fa

264 tivates the unfolded protein response (UPR), a highly conserved signaling cascade that functions to a

265 f intragenic suppressors, all located within a highly conserved six amino acid tether region of ISP-1

266 ious GAS M-Prts have shown that they contain a highly conserved sortase A-dependent cell wall-anchore

267 A highly conserved Sox2/Pax6 bound site near the Sprouty

268 Maresin 1 (MaR1) is a highly conserved specialized proresolving mediator (SP

269 Exogenous administration of MaR1, a highly conserved SPM, propagated inflammatory resoluti

270 ractions networks (PPINs) are known to share a highly conserved structure across all organisms.

271 This is a highly conserved structure and the target of numerous

272 Our data show that, despite a highly conserved structure, elements of substrate spec

273 e fine specificity is strongly influenced by a highly conserved substitution that regulates receptor

274 The RSV F protein is a highly conserved surface glycoprotein and is the main

275 n PHF5A demonstrating that Y36 is located on a highly conserved surface.

276 r the stability of the fold, forming part of a highly conserved symmetrically repeating hydrogen-bond

277 Fever is a highly conserved systemic response to infection dating

278 Repressor/activator protein 1 (RAP1) is a highly conserved telomere-interacting protein.

279 KstR is a highly conserved TetR family transcriptional repressor

280 A highly conserved threonine near the C terminus of gp12

281 AZ-bound transcription factors, and contains a highly conserved TIF[F/Y]XG motif that defines the lar

282 RIZ homology domain containing 8 (PRDM8) as a highly conserved transcription factor that is abundant

283 this resilience is linked to the activity of a highly conserved transcription factor, nuclear factor

284 Eyes absent (Eya) is a highly conserved transcriptional coactivator and prote

285 Mediator is a highly conserved transcriptional coactivator organized

286 function of elongation factor 4 (EF-4/LepA), a highly conserved translational GTPase, has remained el

287 ce lacking the p75(NTR) death domain (DD) or a highly conserved transmembrane (TM) cysteine residue (

288 RNase Z(L) is a highly conserved tRNA 3'-end processing endoribonuclea

289 h results from cis/trans isomerization about a highly conserved Trp-Pro imide bond in a region of the

290 Here, we show that a highly conserved tryptophan at position 69 of the gp12

291 The Hippo (Hpo) pathway is a highly conserved tumor suppressor network that restric

292 we identify Abl-mediated phosphorylation of a highly conserved Tyr residue in the P + 1 loop of prot

293 toggle switch for sensing agonists involves a highly conserved tyrosine residue in helix VI.

294 methyl group of dTMP apparently clashes with a highly conserved tyrosine residue, preventing the form

295 Rather, we discovered a highly conserved tyrosine-based motif in the third int

296 ajor histocompatibility complex E (MHC-E) is a highly conserved, ubiquitously expressed, nonclassical

297 WDR92 is a highly conserved WD-repeat protein that has been propo

298 matin assembled from the IGFBP1 promoter via a highly conserved winged helix motif.

299 cysteine residues to form disulfide bonds at a highly conserved zinc site.

300 y of the Vpx- or Vpr-CRL4 E3 ligase requires a highly conserved zinc-binding motif.