ライフサイエンスコーパス: allodynia

1 increase in pain-like responses (mechanical allodynia).

2 of peripheral nerves to light touch (tactile allodynia).

3 (C-fibers) has limited effects on mechanical allodynia.

4 e elusive dorsal horn circuit for mechanical allodynia.

5 tely reversed oxaliplatin-induced mechanical allodynia.

6 ain without affecting the sensory mechanical allodynia.

7 genesis that are associated with neuropathic allodynia.

8 critical for expression of hyperalgesia and allodynia.

9 ritical role in the expression of mechanical allodynia.

10 l cord dorsal horn only in mice with ongoing allodynia.

11 ncreased thermal hyperalgesia and mechanical allodynia.

12 been implicated in the expression of tactile allodynia.

13 produced long-lasting generalized cutaneous allodynia.

14 , but also alleviated SNI-induced mechanical allodynia.

15 echanotransduction contributes to mechanical allodynia.

16 neuron hyperactivity and reversed mechanical allodynia.

17 selective antibody attenuated the associated allodynia.

18 butes to centrally mediated hyperalgesia and allodynia.

19 tration in rodent models of hyperalgesia and allodynia.

20 e to peripheral inflammation-induced tactile allodynia.

21 810 or HC030031 reduced spinal HXA(3)-evoked allodynia.

22 ous and long-lasting pain, hyperalgesia, and allodynia.

23 ons and in a rat behavioral model of thermal allodynia.

24 f SNC80 to inhibit PGE(2)-stimulated thermal allodynia.

25 ileuton) dose-dependently attenuated tactile allodynia.

26 resence of pain was confirmed by testing for allodynia.

27 natomical source of the influence of CGIC on allodynia.

28 ly frequency of migraine attacks, as well as allodynia.

29 nan-induced thermal hyperalgesia and tactile allodynia.

30 the expression of subsequent PGE(2)-induced allodynia.

31 g to abnormally elevated pain states such as allodynia.

32 jection after the resolution of IL-6-induced allodynia.

33 or cingulate compared to migraineurs without allodynia.

34 ve neuronal type recruited during mechanical allodynia.

35 vided an 11.2-fold attenuation of mechanical allodynia.

36 thresholds were measured to detect cutaneous allodynia.

37 heat hyperalgesia and neuropathic mechanical allodynia.

38 pinal dorsal horn of rats displaying tactile allodynia.

39 ding mechanical and thermal hyperalgesia and allodynia.

40 V1, leading to the development of mechanical allodynia.

41 s, depression, sleep disorders and cutaneous allodynia.

42 E by antibodies blocks CFA-evoked mechanical allodynia.

43 of diabetes, and protects against mechanical allodynia.

44 ented or significantly attenuated IM-induced allodynia.

45 c acid metabolites rapidly evokes mechanical allodynia.

46 ensheathed nociceptors to sustain mechanical allodynia.

47 anisms underlying cephalic and extracephalic allodynia.

48 acrophage infiltration, oxidative stress and allodynia.

49 sts attenuated cortical theta and mechanical allodynia.

50 g siRNA against C/EBPbeta reduced mechanical allodynia.

51 hannels without producing heat or mechanical allodynia.

52 emporally coincident with the alleviation of allodynia.

53 lization or PD-1 blockade induced mechanical allodynia.

54 phosphorylation leading to hyperalgesia and allodynia.

55 in severity of paclitaxel-induced mechanical allodynia.

56 xogenous IL-10 attenuated paclitaxel-induced allodynia.

57 tassium current IKD in damage-triggered cold allodynia.

58 t this contributes to neuropathic mechanical allodynia.

59 heral injury induced long-lasting (>1 month) allodynia.

60 recovery from paclitaxel-induced mechanical allodynia.

61 in WT mice attenuated neuropathic mechanical allodynia.

62 mPFC of SNI rats induced a decrease in cold allodynia.

63 eurons, which we show also convey mechanical allodynia.

64 1, which has been frequently associated with allodynia.

65 yperalgesia after SNL, but it increases cold allodynia 6h after application.

66 VZ+434 protected against mechanical allodynia 8 weeks after STZ injection.

67 nerve injury, effectively reduced mechanical allodynia, a cardinal feature of late-phase neuropathic

68 horn, has been implicated in injury-induced allodynia, a condition wherein pain is produced by innoc

69 nsitized response to a painful stimulus, and allodynia, a pain-like response to an innocuous stimulus

70 onse to noxious thermal stimuli, and thermal allodynia, a responsiveness to subthreshold thermal stim

71 After the resolution of IL-6-induced allodynia, a subsequent intraplantar injection of prosta

72 d allodynia to dissect the framework of cold allodynia-activated central pain pathways.

73 hdrawal-like behavioral signs and mechanical allodynia, activates NR1 and NR2 receptors, and downregu

74 Allodynia affects millions of people and remains highly

75 -314) dose-dependently suppresses mechanical allodynia after chemotherapy, nerve injury, and diabetic

76 by which CNS TRPV1 mediates hyperalgesia and allodynia after injury.

77 contribute to the development of mechanical allodynia after L5 spinal nerve ligation.

78 Disruption of this inhibition results in allodynia, allowing low-threshold drive onto pain and te

79 sed both thermal hyperalgesia and mechanical allodynia although each individual dose alone did not re

80 ave previously been implicated in mechanical allodynia, an A-fiber-selective pharmacological blocker

81 of headache and the development of cutaneous allodynia and central sensitization.

82 targeted O2(.-)scavenger) reduced mechanical allodynia and decreased pCREB and pC/EBPbeta.

83 ceiving verum treatment developed mechanical allodynia and distinct gait alterations.

84 ver several days prevented the expression of allodynia and enhanced sensitivity to stress observed fo

85 s time, BAMBI-KO mice were protected against allodynia and exhibited increased expression and functio

86 tly attenuated paclitaxel-induced mechanical allodynia and heat hyperalgesia.

87 nt receptor potential (TRP) channels mediate allodynia and hyperalgesia downstream of these pathways.

88 (Hh) signaling is required for both thermal allodynia and hyperalgesia following ultraviolet irradia

89 n and potentially related conditions such as allodynia and hyperalgesia in a comparative setting that

90 All hybrids alleviated allodynia and hyperalgesia in neuropathic pain models.

91 in the RVM, before or after SNI, attenuates allodynia and hyperalgesia in rats.

92 zation in the pain neuraxis, associated with allodynia and hyperalgesia observed in patients with chr

93 Spinal application of TNFalpha induces both allodynia and hyperalgesia, and at least part of the pro

94 ate-phase neuropathic pain symptoms, such as allodynia and hyperalgesia, for several weeks in murine

95 ld relieve the paclitaxel-induced mechanical allodynia and hyperalgesia, which was assessed 30 min af

96 b did not affect centrally mediated referred allodynia and hyperalgesia.

97 l three antagonists blocked EA inhibition of allodynia and hyperalgesia.

98 responses and tissue or nerve injury-induced allodynia and hyperalgesia.

99 d virus into the dorsal horn also suppressed allodynia and hyperalgesia.

100 that is manifested by mechanical or thermal allodynia and hyperalgesia.

101 eline levels, rats showed enhanced cutaneous allodynia and increased CGRP in the blood following chal

102 IM1alpha expression reversed the SNL-induced allodynia and increased spontaneous EPSC (sEPSC) frequen

103 of inflammatory hyperalgesia and neuropathic allodynia and is devoid of ancillary cardiovascular or C

104 RPV1) plays a major role in hyperalgesia and allodynia and is expressed both in the peripheral and ce

105 ificantly increased and sustained mechanical allodynia and loss of motor function.

106 xynucleotide against CREB reduced mechanical allodynia and lowered pC/EBPbeta.

107 is critical for the expression of cutaneous allodynia and may mask the expression of diffuse noxious

108 ta fibers, giving rise to dynamic mechanical allodynia and mechanical hyperalgesia.

109 RPA1 silencing in Schwann cells reduced both allodynia and neuroinflammation.

110 id, prevents nerve injury-induced mechanical allodynia and ongoing pain in mice.

111 e-specific trkB.T1 KO mice; using mechanical allodynia and pain-related measurements on the CatWalk,

112 SCP1, an acetaminophen analog, suppressed allodynia and promoted agrin upregulation.

113 litating disease characterized by mechanical allodynia and spontaneous pain.

114 Despite severe allodynia and structural knee joint damage equal to wild

115 r necrosis factor (TNF) signaling to mediate allodynia and that distinct transient receptor potential

116 ter SNI, wild-type mice developed mechanical allodynia and the functionality of mu-opioid receptors w

117 inished in cKO mice, but both the mechanical allodynia and the microgliosis generated by nerve injury

118 significantly blocked CFA-induced mechanical allodynia and thermal hyperalgesia 1 day post-CFA inject

119 duced a long-duration reversal of mechanical allodynia and thermal hyperalgesia for at least 4 weeks.

120 ute pain perception, and reversed mechanical allodynia and thermal hyperalgesia in a model of neuropa

121 , cis-(+)-37 was effective at reversing both allodynia and thermal hyperalgesia in a standard Chung (

122 ical scores of EAE and attenuated mechanical allodynia and thermal hyperalgesia in EAE.

123 Correlating with the development of tactile allodynia and thermal hyperalgesia, spinal CaMKIIalpha a

124 t tibial fracture with pinning triggers cold allodynia and up-regulates nerve injury and inflammatory

125 st DHPG (dihydroxyphenylglycol) precipitated allodynia and/or nocifensive responses.

126 pain threshold, mechanical pain sensitivity, allodynia and/or windup), yielded four phenotypes of fib

127 be accompanied by abnormal skin sensitivity (allodynia) and muscle tenderness.

128 ession of cranial and extracranial cutaneous allodynia, and are consistent with a brainstem generator

129 ynucleotide against TNFRI reduced mechanical allodynia, and decreased mtO2(.-), pCREB and pC/EBPbeta.

130 elta attenuated spontaneous pain, mechanical allodynia, and heat hyperalgesia in TOW mice.

131 d decreases in mechanical hyperalgesia, cold allodynia, and sciatic nerve conduction velocity.

132 s sufficient to induce persistent mechanical allodynia, and this allodynia was suppressed by CXCL1 ne

133 al neuropathic pain that includes mechanical allodynia are limited.

134 Therefore, NGF-evoked thermal and mechanical allodynia are mediated by spatially distinct mechanisms.

135 Having established facial and hind-paw allodynia as a useful animal surrogate of headache-assoc

136 rsed oxaliplatin-induced cold and mechanical allodynia as well as social interaction impairment.

137 Facial and hind-paw allodynia associated with dural stimulation is a useful

138 are consistent with a brainstem generator of allodynia associated with headache disorders.

139 Melatonin alone failed to reverse allodynia at all three tested doses (30, 60 and 120 mg/k

140 This sensitization manifests as allodynia (aversive withdrawal to previously nonnoxious

141 on of ATL313 in rats with neuropathy-induced allodynia but had no effect on allodynia in the absence

142 r HXB(3) evoked profound, persistent tactile allodynia, but 12(S)-HpETE and HXA(3) produced relativel

143 ice that lack Ccr2 also developed mechanical allodynia, but this started to resolve from 8 wk onwards

144 ation of 18.1 +/- 3.4 d delayed the onset of allodynia by 1 mo.

145 of block 6.9 +/- 1.2 d) delayed the onset of allodynia by 2 d.

146 n suggested that they play a crucial role in allodynia by modulating voltage-gated calcium channel cu

147 contribute more to the maintenance phase of allodynia by redirecting tactile information to the cort

148 basal mechanical sensitivity and mechanical allodynia by regulating auxiliary voltage-gated calcium

149 sts that evoke the development of mechanical allodynia by this receptor.

150 Spontaneous tonic pain and evoked allodynia can be experimentally dissociated.

151 reduced thermal hyperalgesia and mechanical allodynia caused by inflammation, nerve injury, and pron

152 rmalized mechanical hyperalgesia and tactile allodynia caused by SNL but had no significant effect on

153 sociated with the pathogenesis of mechanical allodynia, changes in cortical circuits also accompany p

154 Paclitaxel-induced mechanical and cold allodynia developed to an equivalent degree in CB1KO, CB

155 Moreover, tactile allodynia did not develop as an unwanted side effect in

156 has a role in the development of mechanical allodynia during neuropathic pain.

157 nerve ligation (SNL), in addition to causing allodynia, enhances the Rab3-interactive molecule-1alpha

158 s in the PNS were associated with mechanical allodynia, even in the absence of nerve injury.

159 Finally, migraineurs with a history of allodynia exhibit significantly reduced connectivity bet

160 lateralized and in proportion to the tactile allodynia exhibited by SNI animals.

161 ects of this drug were studied on mechanical allodynia following unilateral spinal nerve ligation (SN

162 3CR1 exhibited a delay in the development of allodynia following VCR administration.

163 dependent attenuation of hind paw mechanical allodynia for up to 1h after administration, with no not

164 by six weeks after STZ injection, mechanical allodynia had developed (mechanical withdrawal threshold

165 iately after IL-6, but not after the initial allodynia had resolved.

166 For this reason, cutaneous allodynia has been measured in animal models as a surrog

167 nisms for the development and maintenance of allodynia have been investigated in the spinal cord, bra

168 ctivity; these changes probably underlie the allodynia, hyperalgesia, and spontaneous pain seen in pa

169 which may cause several symptoms, including allodynia, hyperalgesia, anxiety, and depression.

170 ndicate that EA at 10 Hz inhibits mechanical allodynia/hyperalgesia more potently than does EA at 100

171 EA significantly inhibits paclitaxel-induced allodynia/hyperalgesia through spinal opioid receptors,

172 ared nerve injury (SNI) developed mechanical allodynia in 1 wk; nerve blockade with a single dose of

173 of the TAT-4BB reversed M3G-induced tactile allodynia in a dose-dependent manner but did not affect

174 IL10 combination therapy and also inhibited allodynia in a mouse model of neuropathic pain.

175 olecule 20 (AM-1488), which reversed tactile allodynia in a mouse spared-nerve injury (SNI) model.

176 2-mediated suppression of paclitaxel-induced allodynia in CB1KO mice; these antiallodynic effects wer

177 a lesser extent, also diminishes mechanical allodynia in CCI in female mice.

178 ompletely blocked the development of tactile allodynia in diabetic rats, whereas relatively minor eff

179 PD-L1 or PD-1 elicited spontaneous pain and allodynia in melanoma-bearing mice.

180 We observed persistent mechanical allodynia in mice lacking MKP-3 (postoperative day 21),

181 CL13-activated astrocytes induced mechanical allodynia in naive mice.

182 with hyperbaric oxygen alleviated mechanical allodynia in nerve-injured animals.

183 enhanced thermal hyperalgesia and mechanical allodynia in Pap(-/-) mice.

184 genated fatty acids (EpFAs), greatly reduces allodynia in rats caused by streptozocin-induced type I

185 ed naloxone-sensitive reversal of mechanical allodynia in rats following chronic constriction injury

186 rved marked increases in mechanical and cold allodynia in rats of both sexes that were maintained on

187 ertain whether HBO2 treatment might suppress allodynia in rats with neuropathic pain and whether this

188 inal ganglia and in development of cutaneous allodynia in response to migraine triggers, even weeks a

189 associated with the development of cutaneous allodynia in some patients.

190 pathy-induced allodynia but had no effect on allodynia in the absence of the A(2A)R agonist.

191 eversible enzyme inhibition, 3 reversed cold allodynia in the chronic constriction injury model of ne

192 Rats develop hyperalgesia and allodynia in the hind paw after L5 spinal nerve ligation

193 pared-nerve injury showed the development of allodynia in the operated limb (P < 0.001).

194 tribute directly to the pathogenesis of cold allodynia in the rat SNL model, but it is a potential me

195 in-induced flinching, and attenuated tactile allodynia in the spinal nerve ligation model of neuropat

196 the inferior alveolar nerve (IANx) produces allodynia in the whisker pad (V2 division) of rats.

197 Importantly, P7C3-A20 blocked PTX-induced allodynia in tumored mice without reducing antitumoral e

198 respectively) and carrageenan-evoked tactile allodynia in vivo.

199 n vitro as well as PGE(2)-stimulated thermal allodynia in vivo.

200 hecal injection of 5,6-EET caused mechanical allodynia in wild-type but not TRPA1-null mice.

201 daily, i.p. ) suppressed paclitaxel-induced allodynia in WT and CB2KO mice, but not CB1KO mice.

202 of AM1710 also attenuated paclitaxel-induced allodynia in WT mice, but not CB2KO mice, implicating a

203 HC suppressed established paclitaxel-induced allodynia in WT mice.

204 delivery of SerpinA3N attenuated mechanical allodynia in WT mice.

205 and this is causally related to the onset of allodynia, in which a non-noxious stimulus becomes painf

206 We found that cold allodynia induced by chronic constriction injury (CCI) o

207 b.i.d. for 3 d, intraperitoneal) suppressed allodynia induced by chronic constriction injury of the

208 there was a significant decrease in thermal allodynia induced by CIP, but no effect on edema formati

209 GAT211 suppressed allodynia induced by complete Freund's adjuvant and the

210 Here, we show that cold allodynia induced by inflammation, nerve injury, and che

211 de significantly attenuated hyperalgesia and allodynia induced by paclitaxel.

212 Mechanical allodynia, induced by normally innocuous low-threshold m

213 ensitivity is controlled in nociceptors, and allodynia involves TrkB(+) light-touch mechanoreceptors.

214 Cold allodynia is a common symptom of neuropathic and inflamm

215 Furthermore, established cold allodynia is blocked in animals treated with neutralizin

216 Allodynia is dependent upon a tumor necrosis factor (TNF

217 Together, our results suggest that cold allodynia is largely due to a functional downregulation

218 Our results suggest that cold allodynia is linked to a reduction of IKD in both high-t

219 izing other modalities after an insult, cold allodynia is mediated exclusively by a single molecular

220 g neuropathic pain, and nerve damage-induced allodynia is reduced in Epac1-/- mice.

221 pain disorders in which hyperalgesia and not allodynia is the primary symptom.

222 ute to the intense sensation associated with allodynia is unclear.

223 Nonetheless, cold pain (allodynia) is prevalent in many inflammatory and neuropa

224 n (10 mug, 10 mul; i.t.) reduced SNL-induced allodynia, kalirin and pNR2B expression, as well as kali

225 etreatment with l-THP reduced the mechanical allodynia (MA) induced by direct activation of sigma-1 r

226 nt of SNL animals, at a dose that alleviated allodynia, markedly reduced the elevation of alpha(2)del

227 iabetes-induced thermal hypoalgesia, tactile allodynia, motor and sensory nerve conduction velocity d

228 Cutaneous allodynia observed during the period of triptan administ

229 acological inhibition reduced the persistent allodynia observed in these mice.

230 Cold allodynia occurs as a major symptom of neuropathic pain

231 y pain, thermal hyperalgesia, and mechanical allodynia, of which the latter is completely dependent o

232 (15, 30 or 60 mg/kg), it reduced mechanical allodynia only at high doses (30 or 60 mg/kg).

233 f icilin (0.1nM to 1microM) affected tactile allodynia or thermal hyperalgesia after SNL, but it incr

234 required during the initiation of mechanical allodynia or thermal hyperalgesia, these cells may not b

235 We describe the defining feature of the cold allodynia pain percept in the human brain and illustrate

236 indings, real rTMS significantly reduced hot allodynia pain ratings.

237 Behavioral testing for tactile allodynia, performed one week prior to STZ injection and

238 Tactile allodynia produced by placing a plastic cuff around the

239 Surprisingly, Merkel cells also mediate allodynia, providing a new cellular target for chronic p

240 , and cold hyperalgesia but tactile and cold allodynia remain following peripheral nerve injury.

241 and whether it has a causal relationship to allodynia remain unsolved.

242 tent thermal hypersensitivity and mechanical allodynia require de novo protein translation and are me

243 t CQ-evoked mechanical hyperalgesia and cold allodynia require TRPA1 in vivo.

244 day 12, while both MAPK phosphorylation and allodynia resolved on postoperative day 7 in wild-type m

245 DG uptake in the nerves correlated well with allodynia (rho = -0.59; P < 0.024).

246 the loss of tactile sensitivity and tactile allodynia seen in patients who have diabetes, inflammato

247 These effects were reminiscent of cutaneous allodynia seen in patients with migraine or other primar

248 eral manifestations of the neuropathic state-allodynia, sensory loss, shooting pains, etc, that can m

249 In addition, because disinhibition-induced allodynia shares some features with the immature dorsal

250 ventromedial medulla (RVM) also reversed the allodynia, showing this brain area to be an important si

251 cer-related thermal hyperalgesia, mechanical allodynia, spontaneous and movement-evoked pain behavior

252 Such cutaneous allodynia suggests a state of 'central sensitization' of

253 Allodynia suppression was a consequence of serine residu

254 with either AAV-Ag50 vector or SCP1, blocked allodynia suppression, agrin upregulation, and NR1 phosp

255 pinA3N developed more neuropathic mechanical allodynia than wild-type (WT) mice, and exogenous delive

256 pe mice, oxaliplatin treatment produced cold allodynia that could be prevented by RgIA4.

257 (EA) on paclitaxel-induced hyperalgesia and allodynia that has not been studied in an animal model.

258 In vivo, 8-pCPT induces long-lasting allodynia that is prevented by the knockdown of Epac1 an

259 e developed early-onset secondary mechanical allodynia that was maintained for 16 wk.

260 e-dependent and reversible cutaneous tactile allodynia that was maintained throughout and transiently

261 Mechanical allodynia, the perception of innocuous tactile stimulati

262 ignificantly reduced the nerve crush-induced allodynia; this anti-allodynic effect of HBO2 was revers

263 rsistent thermal hyperalgesia and mechanical allodynia to determine the role of transient receptor po

264 We used CTXs as a surrogate model of cold allodynia to dissect the framework of cold allodynia-act

265 hibition completely abolished both prolonged allodynia to hindpaw PGE(2) and enhanced nocifensive beh

266 ch as respiratory suppression, constipation, allodynia, tolerance, and dependence, as well as abuse p

267 In a murine model of chemotherapy-induced allodynia, VCR treatment induced upregulation of endothe

268 al and spinal sites of action and mechanical allodynia via only a spinal site of action.

269 ns of heat on capsaicin-sensitized skin, hot allodynia was assessed during 3 Tesla functional magneti

270 ce, chemotherapy-induced development of cold allodynia was attenuated and the milder, temporary cold

271 Reversible cold allodynia was induced in healthy male volunteers by shal

272 of diabetes-induced retinopathy and tactile allodynia was investigated.

273 Spinal RIM1alpha-associated allodynia was mediated by Fbxo3, which abates Fbxl2-depe

274 as attenuated and the milder, temporary cold allodynia was not relieved by RgIA4.

275 Paclitaxel-induced mechanical allodynia was prolonged in T-cell-deficient (Rag1(-/-))

276 Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by

277 The SNE-induced mechanical allodynia was reversibly suppressed, partially or comple

278 ce persistent mechanical allodynia, and this allodynia was suppressed by CXCL1 neutralization, CXCL1

279 ar cortex lesion, even though the mechanical allodynia was suppressed.

280 Consistent with clinical observations, the allodynia was unaffected by a neurokinin-1 antagonist.

281 eful animal surrogate of headache-associated allodynia, we next showed that blocking pain-facilitatin

282 Brain areas that responded during cold allodynia were almost always located bilaterally and app

283 ionally, thermal hyperalgesia and mechanical allodynia were enduringly enhanced when PIP(2) levels we

284 and superoxide production in the retina and allodynia were inhibited in diabetic animals in which iN

285 istic of the early stages of retinopathy and allodynia were measured in chimeric mice lacking inducib

286 Impaired RDD and allodynia were present in type 1 and type 2 diabetic rat

287 haviors (thermal hyperalgesia and mechanical allodynia) were established at one week after CCI.

288 were effective in preventing PGE(2)-induced allodynia when given immediately after IL-6, but not aft

289 ons may result in the development of tactile allodynia, where non-painful stimuli gain the capacity t

290 ly-phase analgesia and late-phase mechanical allodynia which requires NMDAR; both phases are prolonge

291 persensitivity to cold or mechanical-induced allodynia, which are established tests to assess acute o

292 n sensory perception, such as photophobia or allodynia, which have in common an uncomfortable amplifi

293 of NMDA induces GluN2B-dependent mechanical allodynia, which is prolonged in Arrb2-KO mice and condi

294 IM elicited robust facial and hind-paw allodynia, which peaked within 3 hours.

295 e Sprague Dawley rats resulted in behavioral allodynia, which was associated with phosphorylated SGK1

296 luR5-signaling pathway suppressed mechanical allodynia, while activating this pathway in the absence

297 injury prevented exacerbation of mechanical allodynia with a concurrent improvement of depression-li

298 2 agonists for managing chemotherapy-induced allodynia with a favorable therapeutic ratio marked by s

299 ement in potency in vivo, evoking mechanical allodynia with an EC(5)(0) of 14.4 pmol.

300 lencing in nociceptors attenuated mechanical allodynia, without affecting macrophage infiltration and