1 tes RNA synthesis at promoter sequences that
are conserved from positions -17 to +
6 relative to the s
2 decisions within the myeloerythroid lineages
are conserved from embryo to adult.
3 ysis revealed a novel reticular lattice that
was conserved from mammals to amphibians, and was organi
4 blish that the fundamental design of the CPC
is conserved from Fungi to Animalia.
5 al morphology and molecular composition have
been conserved from plants to animals.
6 cal structure and molecular composition have
been conserved from plants to animals.
7 bunit e) is a small hydrophobic protein that
is conserved from fungi to animals.
8 at AP sites and that this AP-lyase activity
is conserved from humans to Archaea.
9 n of thylakoid membranes inside chloroplasts
is conserved from leaves to developing embryos.
10 ntain functionally important DPE motifs that
are conserved from Drosophila melanogaster to Drosophila
11 cleolar ribonucleoproteins (snoRNPs)], which
are conserved from archaea to eukaryotes.
12 These proteins
are conserved from prokaryotes to eukaryotes, but most r
13 nslation factor) class of P-loop GTPases and
is conserved from bacteria to eukaryotes.
14 as a model protein, we demonstrate that PFAR
is conserved from prokaryotes to eukaryotes.
15 s suggest that this scenario may principally
be conserved from S. pombe to filamentous fungi.
16 erefore, similar regulatory mechanisms might
be conserved from worms to flies.
17 PRC2 methylates histone H3 on lysine-27 and
is conserved from plants to flies to humans.
18 This mechanism appears to
be conserved from algae to flowering plants with a few s
19 hrome-PIF signaling module has been shown to
be conserved from Physcomitrella patens to higher plants
20 protein family in translation initiation has
been conserved from yeast through to higher eukaryotes.
21 These are members of a new gene family that
is conserved from Caenorhabditis elegans to higher verte
22 PtdIns 4-kinase activity
is conserved from yeast to higher eukaryotes.
23 Cyclin B3 (CCNB3)
is conserved from Caenorhabditis elegans to Homo sapiens
24 onserved nucleic acid binding proteins which
are conserved from bacteria to human.
25 ptotagmins (Syts) are membrane proteins that
are conserved from nematode to human.
26 Fox-1/2
are conserved from worm to human, and specifically recog
27 amily of protein O-mannosyltransferases that
are conserved from yeast (PMTs) to human (POMTs).
28 hat contains multiple tyrosine residues that
are conserved from yeast to human, a Src phosphorylation
29 Core components of cytokinesis
are conserved from yeast to human, but how these compone
30 mechanisms and machinery of premRNA splicing
are conserved from yeast to human, the details of intron
31 ins of transcription elongation factor TFIIS
are conserved from yeast to human.
32 onclude that a quality control mechanism has
been conserved from yeast to human by which binding of a
33 nscriptional control carried out by Spt3 has
been conserved from yeast to human.
34 athway is a major branch of the UPR that has
been conserved from yeast to human.
35 equence analysis reveals that the WDR19 gene
is conserved from Caenorhabditis elegans to human.
36 h the COP9 signalosome, and that interaction
is conserved from fission yeast to human.
37 ation at centromeres and form a complex that
is conserved from fission yeast to human.
38 F11) in the regulation of metabolic pathways
is conserved from flies to human.
39 CD1d activation of NKT cells
is conserved from mice to human beings, so strategies to
40 Importantly, this phenomenon
is conserved from mouse to human; however, interestingly
41 chromatids during anaphase, a function that
is conserved from prokaryotes to human.
42 hat the architecture for the vertebrate t/PK
is conserved from teleost fish to human.
43 ree amino acids of Npn-1 (S-E-A-COOH), which
is conserved from Xenopus to human, is responsible for i
44 PME-1
is conserved from yeast to human and contains a motif fo
45 It
is conserved from yeast to human and participates in cel
46 e muniscin family of endocytic adaptors that
is conserved from yeast to human beings.
47 d that this role in S-phase genome stability
is conserved from yeast to human cells.
48 egion, a central juxtamembranous domain that
is conserved from yeast to human, and five (E-Syt1) or t
49 cells during a highly regulated process that
is conserved from yeast to human, and that serves as a c
50 enes in this nutrient-sensing pathway, which
is conserved from yeast to human, extends lifespan in a
51 f ORC as a foundation to assemble the pre-RC
is conserved from yeast to human.
52 cover a protein demethylation mechanism that
is conserved from yeast to human.
53 novel WD40 repeat protein, named Bopl, which
is conserved from yeast to human.
54 The biochemical function of RNase Z(L)
is conserved from yeast to human.
55 at stress-induced 26S proteasome disassembly
is conserved from yeast to human.
56 Surface residues that
are conserved from archaea to humans and are likely to i
57 Intramembrane metalloproteases (IMMPs)
are conserved from bacteria to humans and control many i
58 The RecQ helicases
are conserved from bacteria to humans and play a critica
59 nits that house the catalytic machinery (and
are conserved from bacteria to humans) and a mammalian-s
60 Although cysteine desulfurases
are conserved from bacteria to humans, Isd11p is found o
61 ns are defined by a core HPFxxGNGR motif and
are conserved from bacteria to humans.
62 of substrates across cellular membranes and
are conserved from bacteria to humans.
63 he yeast transcriptional repressor Sir2p and
are conserved from bacteria to humans.
64 Pif1 family helicases
are conserved from bacteria to humans.
65 RecQ-like DNA helicases
are conserved from bacteria to humans.
66 core components of Notch signaling pathways
are conserved from Drosophila to humans.
67 e BK channel pore-forming alpha-subunit that
are conserved from fish to humans.
68 repressive complex 1 (PRC1) class of the PcG
are conserved from flies to humans and inhibit transcrip
69 zipper (bHLH-LZ) transcription factors that
are conserved from fungi to humans and are defined by tw
70 The FKBP12 and TOR proteins
are conserved from fungi to humans, and in both organism
71 family of pattern-recognition molecules that
are conserved from insects to humans and are implicated
72 ecognition molecules of innate immunity that
are conserved from insects to humans.
73 Moreover, both cell types
are conserved from mice to humans and colocalize with IL
74 ehavior and its effect on infant development
are conserved from rodent to humans.
75 p, Sfc4p, and Sfc1p, the latter two of which
are conserved from S. cerevisiae to humans, while the fo
76 Cdc42 and other Rho GTPases
are conserved from yeast to humans and are thought to re
77 nding-protein (OSBP)-related proteins (ORPs)
are conserved from yeast to humans, and are implicated i
78 istone H3 lysine 4 (H3K4) methyltransferases
are conserved from yeast to humans, assemble in multisub
79 The key autophagic PI(3)P sensors, which
are conserved from yeast to humans, belong to the PROPPI
80 ily of chromatin-remodeling complexes, which
are conserved from yeast to humans, open the chromatin t
81 Because HMG1/2 proteins
are conserved from yeast to humans, our findings suggest
82 ugh many proteins associated with centomeres
are conserved from yeast to humans, the underlying DNA s
83 The Par-1 protein kinases
are conserved from yeast to humans, where they function
84 MAP kinases of the ERK family
are conserved from yeast to humans.
85 Both pathways
are conserved from yeast to humans.
86 II TGF-beta receptor; however, none of these
are conserved from yeast to humans.
87 NA-binding proteins is encoded by genes that
are conserved from yeast to humans.
88 53 (Cullin), and the F-box protein CDC4-that
are conserved from yeast to humans.
89 Separase and cohesin
are conserved from yeasts to humans.
90 the CED-6 signal transduction pathway, might
be conserved from C. elegans to humans and are present i
91 a new core promoter element that appears to
be conserved from Drosophila to humans.
92 ry function for the helicase domain that may
be conserved from fungi to humans.
93 ted proteins, which in some cases appears to
be conserved from microorganisms through to humans.
94 ction in a signaling pathway that appears to
be conserved from nematodes to humans.
95 pe of a rad27-null mutant, this function may
be conserved from yeast to humans.
96 taining homologous basic repeats, which have
been conserved from bacteria to humans.
97 ed and shown to contain a component that has
been conserved from bacteria to humans.
98 sisting of CENP-A, -C, -H, and Ndc80/HEC has
been conserved from yeast to humans to link centromeres
99 s of this interaction network appear to have
been conserved from yeast to humans.
100 regulator of ciliary/flagellar motility that
is conserved from algae to humans, have remained elusive
101 omosome maintenance (MCM) family of proteins
is conserved from archaea to humans and is required for
102 RIP
is conserved from bacteria to humans and governs many im
103 Enzymatic haem catabolism by haem oxygenases
is conserved from bacteria to humans and proceeds throug
104 ast part of the intricate mechanism involved
is conserved from bacteria to humans, but is also yieldi
105 The AAA+ Lon protease
is conserved from bacteria to humans, performs crucial r
106 orm of DNA double-strand break (DSB) repair,
is conserved from bacteria to humans.
107 s with an energetic signature (0.3 kBT) that
is conserved from bacteria to humans.
108 tRNA isopentenyl transferase, an enzyme that
is conserved from bacteria to humans.
109 ember of the Pif1 DNA helicase family, which
is conserved from bacteria to humans.
110 a homologous recombination (HR) protein that
is conserved from bacteriophage to humans.
111 Although kinetochore function
is conserved from budding yeast to humans, it was though
112 A family of proteins related to TRP
is conserved from Caenorhabditis elegans to humans, and
113 fucosyltransferase 1, O-fucosyltransferase 2
is conserved from Caenorhabditis elegans to humans.
114 The Toll receptor family, which
is conserved from Drosophila species to humans, mediates
115 The hedgehog (Hh) pathway
is conserved from Drosophila to humans and plays a key r
116 odal signalling in left-right axis formation
is conserved from fish to humans.
117 ; this complex is absent from Drosophila but
is conserved from fish to humans.
118 rms a homotetramer, showing tetrameric Mis18
is conserved from fission yeast to humans.
119 tion signals, suggesting that the RIC family
is conserved from flies to humans.
120 that this unusual self-association mechanism
is conserved from flies to humans.
121 e structural class of nuclear receptors that
is conserved from fly to humans.
122 hat scavenger receptor bacterial recognition
is conserved from insects to humans and may represent on
123 s a principal aspect of innate immunity that
is conserved from insects to humans.
124 FMR family of KH domain RNA-binding proteins
is conserved from invertebrates to humans.
125 rophage-specific transcription factor, PU.1,
is conserved from lizards to humans.
126 n occurs at a single amino acid residue that
is conserved from mice to humans and is located adjacent
127 Breakpoint (JTB) is an orphan receptor that
is conserved from nematodes to humans and whose gene exp
128 Hd protein sequence
is conserved from plants to humans, and published microa
129 The aly gene family
is conserved from plants to humans.
130 h an appended C-terminal domain (C-Ala) that
is conserved from prokaryotes to humans but with a wide
131 It belongs to the copine gene family, which
is conserved from protozoa to humans.
132 he form of cytoplasmic triglyceride droplets
is conserved from Saccharomyces cerevisiae to humans.
133 The lin-12/Notch signaling pathway
is conserved from worms to humans and is a master regula
134 This ancient metformin response pathway
is conserved from worms to humans.
135 uction, from biology to molecular mechanism,
is conserved from worms to humans.
136 AMPK is a heterotrimeric enzyme that
is conserved from yeast to humans and functions as a 'fu
137 RDM4 encodes a novel protein that
is conserved from yeast to humans and interacts with Pol
138 The Nedd8 conjugation pathway
is conserved from yeast to humans and is essential in ma
139 This specificity
is conserved from yeast to humans and is independent of
140 ndicate that the Tel1p/ATM signaling pathway
is conserved from yeast to humans and suggest that the X
141 served Cog5-Cog7 interface, indicate that it
is conserved from yeast to humans, and demonstrate that
142 red for transport-I (ESCRT-I) complex, which
is conserved from yeast to humans, directs the lysosomal
143 Sgt2
is conserved from yeast to humans, has previously been i
144 chanism of G protein activation by receptors
is conserved from yeast to humans, mammalian receptors m
145 Although ORC
is conserved from yeast to humans, the DNA sequence elem
146 Although ino80
is conserved from yeast to humans, this study represents
147 unanticipated amyloid-depolymerase activity
is conserved from yeast to humans, which lack Hsp104 ort
148 d substitutions within a region of Rtf1 that
is conserved from yeast to humans, which we termed the h
149 y, we demonstrate that facilitated recycling
is conserved from yeast to humans.
150 a PP2A-specific methylesterase PME-1, which
is conserved from yeast to humans.
151 opBP1, and the Mec1/ATR activation mechanism
is conserved from yeast to humans.
152 stone deacetylase (HDAC) corepressor complex
is conserved from yeast to humans.
153 ation and multivesicular body biogenesis and
is conserved from yeast to humans.
154 in mitochondria is an essential process and
is conserved from yeast to humans.
155 ed with the mitochondrial inner membrane and
is conserved from yeast to humans.
156 The Pif1p family of DNA helicases
is conserved from yeast to humans.
157 growth, cell cycle and nutrient uptake that
is conserved from yeast to humans.
158 ucture (C2H2 motif) at its N terminus, which
is conserved from yeast to humans.
159 The Pif1 family of DNA helicases
is conserved from yeast to humans.
160 rb9, showing the entire Srb8/9/10/11 complex
is conserved from yeast to humans.
161 RNA polymerase (pol) III transcription that
is conserved from yeast to humans.
162 ific H3K36me3 function of this enzyme, which
is conserved from yeast to humans.
163 o a family of stress-inducible proteins that
is conserved from yeast to humans.
164 is a general mRNA nuclear export factor that
is conserved from yeast to humans.
165 This means of rebalancing proteostasis
is conserved from yeast to humans.
166 the regulatory subunit of calcineurin (CNB)
is conserved from yeast to humans.
167 1's function in maintaining H2BK123ub levels
is conserved from yeast to humans.
168 cterize a novel Pol II transport factor that
is conserved from yeast to humans.
169 Cmc2 function
is conserved from yeast to humans.
170 d diffusion mechanism and that this activity
is conserved from yeast to humans.
171 CPEB, which
is conserved from mammals to invertebrates, is composed
172 Several amino acid residues
are conserved from bacterial sphingomyelinase to mammali
173 id residues from this domain, D163 and K168,
are conserved from bacterial to mammalian sphingomyelina
174 n protease is a multi-functional enzyme that
is conserved from archae to mammalian mitochondria, whic
175 t the biosynthetic pathway for D-amino acids
is conserved from bacteria to mammalian brain.
176 STIM1, a ubiquitously expressed protein that
is conserved from Drosophila to mammalian cells, plays a
177 The COP9/signalosome complex
is conserved from plant to mammalian cells.
178 by Aurora B/Ipl1 kinase and this regulation
is conserved from yeast to mammalian cells.
179 Sirtuins
are conserved from archaea to mammals and regulate trans
180 They
are conserved from bacteria to mammals, with different n
181 evelopment, and many aspects of this network
are conserved from Drosophila to mammals.
182 n of CR3 within the complex and its sequence
are conserved from fish to mammals, suggesting it has a
183 dance mechanisms for dorsoventral migrations
are conserved from nematodes to mammals, mechanisms for
184 Heterotrimeric G protein complexes
are conserved from plants to mammals, but the complexity
185 These signaling pathways
are conserved from simple invertebrates to mammals.
186 e that the mechanisms governing pluripotency
are conserved from urodele amphibians to mammals.
187 f a newly discovered family of proteins that
are conserved from yeast to mammals and to which natural
188 Proteins involved in DNA replication
are conserved from yeast to mammals, suggesting that the
189 The SIN3 and RPD3 genes
are conserved from yeasts to mammals, and recent work su
190 This cell death pathway appears to
be conserved from flies to mammals.
191 engulfment during programmed cell death may
be conserved from nematodes to mammals.
192 the structure of chromatin, Spt4p appears to
be conserved from S. cerevisiae to mammals.
193 f putative cis-regulatory elements that have
been conserved from fish to mammals, an evolutionary dis
194 Interestingly, whereas this interaction has
been conserved from yeast to mammals, the subcomplex mod
195 n in vivo, indicating that this activity has
been conserved from yeast to mammals.
196 human cells via a TIKI homology domain that
is conserved from bacteria to mammals and acts likely as
197 the function of retinaldehyde as chromophore
is conserved from bacteria to mammals, RA-mediated trans
198 The E2F family
is conserved from Caenorhabditis elegans to mammals, wit
199 eded for flagellar and ciliary morphogenesis
is conserved from Chlamydomonas to mammals and support t
200 y within the plane of epithelial tissues and
is conserved from Drosophila to mammals.
201 hat the role of these proteins in myogenesis
is conserved from Drosophila to mammals.
202 lyl isomerase (PPIase) cyclophilin A (Cpr1p)
is conserved from eubacteria to mammals, yet its biologi
203 emonstrate that the PU.1-ZBTB11-TP53 pathway
is conserved from fish to mammals.
204 g that the regulatory machinery for flk1/kdr
is conserved from fish to mammals.
205 Because the SUN domain
is conserved from fission yeast to mammals, we suggest t
206 nal silencing of pericentric heterochromatin
is conserved from fission yeast to mammals.
207 th inhibition, and this regulatory mechanism
is conserved from flies to mammals.
208 plays essential roles in clock functions and
is conserved from fungi to mammals.
209 a recently discovered protein family, which
is conserved from insect to mammals and is implicated in
210 The frizzled gene family
is conserved from insects to mammals and codes for putat
211 ositions with high precision, a feature that
is conserved from insects to mammals.
212 on by PGRP-S, but not its effector function,
is conserved from insects to mammals.
213 Peptidoglycan recognition protein (PGRP)
is conserved from insects to mammals.
214 t with PDZ-domain proteins at cell junctions
is conserved from invertebrates to mammals.
215 domain-leucine rich repeat (NLR) gene family
is conserved from plants to mammals, and several members
216 mechanism that protects from Abeta toxicity
is conserved from worms to mammals and point to the modu
217 data suggest that regulation of the UPR(mt)
is conserved from worms to mammals.
218 irected migration of the target cells - that
is conserved from worms to mammals.
219 l giant larvae (Lgl) tumor suppressor family
is conserved from yeast to mammals and plays a critical
220 This serine-threonine kinase that
is conserved from yeast to mammals seems to play a role
221 The underlying molecular mechanism of -1 PRF
is conserved from yeast to mammals, enabling yeast to be
222 r membrane biogenesis, and that this cascade
is conserved from yeast to mammals.
223 of translation reinitiation involving uORFs
is conserved from yeast to mammals.
224 tion between guanylyltransferase and the CTD
is conserved from yeast to mammals.
225 various intra- or extracellular stimuli that
is conserved from yeast to mammals.
226 egulation in transcriptional elongation that
is conserved from yeast to mammals.
227 plays an essential role in AE assembly that
is conserved from yeast to mammals.
228 filaments in vivo and that this organization
is conserved from yeast to mammals.
229 romoter/enhancer revealed five motifs, which
were conserved from zebrafish to mammals, and each of wh
230 ility depends upon the RecQ helicases, which
are conserved from bacteria to man, but little is known
231 rm multiple protein-protein interactions and
are conserved from mouse to man.
232 CHD proteins
are conserved from yeast to man and many are subunits of
233 gen-activated protein kinase (MAPK) pathways
are conserved from yeast to man and regulate a variety o
234 ctor 3 (eIF3) consists of core subunits that
are conserved from yeast to man as well as less conserve
235 The toxic properties of alpha-synuclein
are conserved from yeast to man, but the precise underpi
236 cell proliferation and mRNA translation and
are conserved from yeast to man.
237 cesses of membrane fission and fusion, which
are conserved from yeast to man.
238 males, suggesting that the control point may
be conserved from flies to man.
239 Hence, in a mechanism that appears to
be conserved from phage to man, the DNA-binding activity
240 s suggest that the Vps15p.Vps34p complex has
been conserved from yeast to man and in both species is
241 d core of the TATA-binding protein (TBPcore)
is conserved from Archae bacteria to man.
242 at the mechanism of homologous recombination
is conserved from bacteria to man.
243 mponent of the cytochrome bc1 complex, which
is conserved from bacteria to man.
244 lial cells, including epithelial stem cells,
is conserved from Drosophila to man.
245 : pGlu-His-Ser-His-Gly-Trp-Tyr-Pro-Gly-NH2),
is conserved from fish to man and is widely distributed
246 This complex
is conserved from nematodes to man and contains histone
247 e conclude that Crm1p structure and function
is conserved from S.cerevisiae to man.
248 The Arp2/3 protein complex
is conserved from yeast to man, and in yeast the complex
249 this unique modification in tRNA(Ala), which
is conserved from yeast to man.
250 ding Parkinson's disease, whose pathobiology
is conserved from yeast to man.
251 -GCB cells, and show epigenetic changes that
are conserved from HSPCs to mature B-cells.
252 le for neuronal subclass diversification may
be conserved from nematodes to mice.
253 spect of the Wnt-1/engrailed interaction has
been conserved from flies to mice.
254 In both respects, Disp function
is conserved from Drosophila to mice.
255 ORC1 activity in the early meiotic cycle has
been conserved from single cell to multicellular organis
256 vel components of the secretory pathway that
are conserved from humans to plants.
257 Finally, these interactions have
been conserved from yeast to plants, indicating that hom
258 ng results indicate that the KIRREL2 protein
is conserved from rodents to primates, and it is highly
259 ting that TRPV1 function in thermoregulation
is conserved from rodents to primates.
260 Though this identity element
is conserved from bacteria to the cytoplasm of eukaryote
261 his basic mechanism of Golgi inheritance may
be conserved from yeast to vertebrate cells.
262 for synaptogyrin localization are likely to
be conserved from C. elegans to vertebrates.
263 mode of action of many of these factors has
been conserved from invertebrates to vertebrates through
264 ese data indicate that the function of xCdc7
is conserved from fungi to vertebrates.
265 Sleep
is conserved from invertebrates to vertebrates, and is t
266 The clustered organization of Hox genes
is conserved from nematodes to vertebrates.
267 trograde tRNA nuclear import, a process that
is conserved from yeast to vertebrates.
268 ing, and SR protein-specific kinases (SRPKs)
are conserved from humans to yeast.
269 ated 60S subunit export, by a mechanism that
is conserved from vertebrates to yeast.
270 he population; amino acids Glu344 and Arg356
are conserved from humans to zebrafish; and substitution