ライフサイエンスコーパス: bouton

1 of total and straight mitochondria per dlPFC bouton.

2 y action potential invasion of a presynaptic bouton.

3 ffect neurotransmitter release from synaptic boutons.

4 somata, proximal extensions and presynaptic boutons.

5 naptic partners in apposition to presynaptic boutons.

6 ins such as dendritic spines and presynaptic boutons.

7 osome markers in soma, neurites and synaptic boutons.

8 halt at their targets and become presynaptic boutons.

9 to the signalling in the individual synaptic boutons.

10 d dynamics along axon shafts and presynaptic boutons.

11 capture as they circulate through en passant boutons.

12 required for their localization to immature boutons.

13 a dense network of fine fibers bearing small boutons.

14 ither enhanced or suppressed the activity of boutons.

15 erived ATP in individual, living hippocampal boutons.

16 pendent and help enrich actin at presynaptic boutons.

17 ding synaptic size and presence of satellite boutons.

18 ed neurotransmitter release from presynaptic boutons.

19 ge of postsynaptic reticulums of presynaptic boutons.

20 us amplitudes observed in single mossy fiber boutons.

21 ory cilia, insect antennae, or even synaptic boutons.

22 larged intraluminal vesicles within synaptic boutons.

23 olog unc-104 disrupt the formation of mature boutons.

24 ve zone proteins moved into more presynaptic boutons.

25 induces the formation of mesofrontal axonal boutons.

26 but levels of PV protein were lower in PVBC boutons.

27 arvae have also a reduced number of synaptic boutons.

28 eration of electron-dense labeling in axonal boutons.

29 ility of release by depolarizing presynaptic boutons.

30 arization promoted synapsin movement between boutons.

31 er features, with exclusively small terminal boutons.

32 th smaller vesicular structures within these boutons.

33 within mossy fiber axons and giant synaptic boutons.

34 tivity results in a larger synapse with more boutons.

35 cluster spatially within individual synaptic boutons.

36 cant increase in the turnover of presynaptic boutons.

37 not uniformly innervated by both NA and 5-HT boutons.

38 aptic material at large maturing presynaptic boutons.

39 c overgrowth and an accumulation of immature boutons.

40 zyme responsible for GABA synthesis in these boutons.

41 es apparent in approximately 20% of observed boutons.

42 VGLUT1 terminal and their coverage of VGLUT1 boutons.

43 active spines contacting pre-existing axonal boutons.

44 odia as well as in later-stabilized synaptic boutons.

45 d that FLN90 is present surrounding synaptic boutons.

46 dramatically lowers DCV numbers in synaptic boutons.

47 hat initiate contact with presynaptic axonal boutons.

48 ely occurs after the maturation of GABAergic boutons.

49 es and presynaptic met-enkephalin-containing boutons.

50 were 14% lower in the remaining vGAT+/GAD67+ boutons.

51 Within this subpopulation of boutons, 35% of observed vesicles exhibited acceleration

52 B2 is present in cell bodies and presynaptic boutons across the spinal cord.

53 ype human PFN1 increases the number of ghost boutons, active zone density, F-actin content, and the f

54 e optics that allows accurate measurement of bouton activity deep in cortex, we found that around hal

55 cytoskeleton reveals that activity-dependent bouton addition is accompanied by the formation of new F

56 ed to construct a statistical model in which bouton addition, elimination, and size changes are descr

57 We recorded from CD and bouton afferents innervating the turtle posterior crista

58 gIA, blocked efferent-mediated inhibition in bouton afferents while leaving efferent-mediated excitat

59 ive efferent-mediated inhibition in adjacent bouton afferents.

60 ut affecting efferent-mediated inhibition in bouton afferents.

61 The varicose geometry of SC boutons alone does not impose differences in spike durat

62 ons and morphometric analyses of presynaptic boutons along 5-HT axons.

63 ramidal neurons and form rows of presynaptic boutons along them.

64 In particular, en passant bouton and filopodia connections with CA3 interneurons p

65 accumulate between membranes of the terminal bouton and the subsynaptic reticulum.

66 ich are distributed uniformly throughout the bouton and undeveloped postsynaptic specializations.

67 ayers exhibited sharper tuning than thalamic boutons and a greater diversity of preferred orientation

68 properties of approximately 28,000 thalamic boutons and approximately 4,000 cortical neurons in laye

69 centrated in the region surrounding synaptic boutons and consequently enlarges the membrane folds of

70 scopy to characterize the dynamics of axonal boutons and dendritic spines in APP/Presenilin 1 (APP(sw

71 metric analysis of presynaptic glutamatergic boutons and dendritic spines was performed on SPNs 1 hou

72 ses the number of parallel fiber presynaptic boutons and functional parallel fiber/Purkinje cell syna

73 zed spatial profile of calcium elevations in boutons and helps to expand the dynamic range of mossy f

74 f C-boutons that altered the morphology of C-boutons and impaired the spontaneous rhythmic discharges

75 er of healthy straight mitochondria in dlPFC boutons and inversely correlated with the number of path

76 effects, suggesting that the loss of axonal boutons and presynaptic vesicles was dependent on N-meth

77 ptured DCVs are available to populate distal boutons and replenish neuropeptide stores following rele

78 tassium channels, with clustered hotspots at boutons and restricted expression at adjoining shafts.

79 TC cells by releasing GABA from their axonal boutons and specialized dendritic spines.

80 Finally, the spatial organization of boutons and whisker map organization revealed the subdiv

81 l, Schwann cells that ensheathe the terminal bouton, and a highly specialized postsynaptic membrane.

82 tory fields, forming small- and medium-sized boutons, and also hitherto unknown giant terminals.

83 r (vGAT+), which is present in all cartridge boutons, and the subset of cartridges that contain calbi

84 ses, and inhibits Ca(2+) entry into synaptic boutons, and we can reverse this by controlled intracell

85 kephalin (mENK) and dynorphin-immunoreactive boutons appeared to contact ARC TH neurons.

86 shaped) of mitochondria in dlPFC presynaptic boutons are altered with aging and menopause in rhesus m

87 riable expression density of Kv3 channels at boutons are key determinants underlying compartmentalize

88 nets and perisomatic rings of glutamatergic boutons are present in many subcortical areas and often

89 ey V1 do not differ, the size of presynaptic boutons are significantly larger in monkey V1.

90 We found that budding of new boutons at Syn(-) NMJs was significantly diminished, and

91 rapidly induce the outgrowth of new synaptic boutons at the larval neuromuscular junction (NMJ), prov

92 anterograde or retrograde DCV transport into boutons, bouton location, and time of arrival in the ter

93 dynamic process and demonstrated that rapid bouton budding requires retrograde bone morphogenic prot

94 ogical disruption of actin turnover inhibits bouton budding, indicating that local changes in the act

95 on of Limk, which inhibits Cofilin, inhibits bouton budding.

96 otein LIM domain kinase 1 (Limk) to regulate bouton budding.

97 shaft, MPS is disrupted in most presynaptic boutons but is present in an appreciable fraction of den

98 th CA3 pyramidal cells via large mossy-fibre boutons, but rather to all synapses formed by dentate gr

99 B or photobleaching DCVs entering a synaptic bouton by retrograde transport.

100 We identified thalamic boutons by their immunoreactivity for the vesicular glut

101 In presynaptic boutons, calcium (Ca(2+)) triggers both neurotransmitter

102 We reconstructed and quantified the bouton clouds originating from adjacent L5B columns in t

103 protrusions primarily arise independently of bouton contact sites, and that a dramatic increase in pr

104 Labeled boutons contain dense-core vesicles, and they resemble a

105 less than 50% of hippocampal CA1 presynaptic boutons contain mitochondria, raising the question of wh

106 y found that in schizophrenia, ChC cartridge boutons contain normal levels of the 67 kDa isoform of g

107 ed as a marker of local activity, and axonal boutons containing clathrin-coated pits showed a more pr

108 y correlated inversely with the frequency of boutons containing donut-shaped mitochondria, which exhi

109 and vesicle decrement was greatest in adult boutons containing mitochondria.

110 r that a significant fraction of glycinergic boutons corelease GABA in the ICC.

111 developmental trajectories of PVChC and PVBC boutons could represent cell type-specific differences i

112 inje cells with functional adherent synaptic boutons, demonstrating the presynaptic locus of modulati

113 ecific increases in the formation of LA axon boutons, dendritic spines of ACx layer 5 pyramidal cells

114 ynapse formation is restricted to biological bouton densities and numbers of synapses per connection,

115 Baseline bouton density and gains during training correlate with

116 These inverse developmental changes in bouton density could explain why an electron microscopy

117 vGAT+ bouton density did not differ between subject groups, co

118 cluding those on cholinergic interneurons; C bouton density increased correspondingly.

119 ouse cortical cultures, knowing if GABAergic bouton density is altered in schizophrenia would provide

120 Although presynaptic bouton density or size was not significantly different a

121 control of AP repolarization at presynaptic boutons depends on Kv3 channels keeping APs brief, thus

122 has low fractions of false positive/negative bouton detections (2/0 out of 18), and that 2PLSM-based

123 to probe the effects of Wnd and Ttk69 on R7 bouton development and conclude that Ttk69 coordinates m

124 ce or absence of mitochondria at presynaptic boutons dictates neurotransmitter release properties thr

125 in adult animals, whereas PV levels in PVChC boutons did not differ between age groups.

126 served in the remaining approximately 80% of boutons did not exhibit apparent dynamical changes in re

127 GSI treatment did neither affect spines and boutons distant from plaques in amyloid precursor protei

128 rons, exhibited a gradual increase in axonal boutons during training.

129 a striking and unexpected increase in axonal bouton dynamics in the aged cortex.

130 are contacted by several individual afferent boutons, each facing a single ribbon.

131 activate integrin signaling, induce synaptic bouton enlargement, and increase postsynaptic glutamate

132 nd that the density of spines and en passant boutons (EPBs) in pyramidal cells increases throughout a

133 Optical stimulation of Type II boutons evokes exocytosis of octopamine, which is detect

134 Occupancy in boutons exceeds that at nearby extrasynaptic axonal site

135 % of CG neurons was associated with terminal boutons expressing GAD-immunoreactivity in addition.

136 to the transient enlargement of the synaptic boutons, followed by a sustained increase in conduction

137 that the types of synaptic connections these boutons form are altered with aging and menopause in rhe

138 We found that the Ipc terminal boutons form glomerulus-like structures in the superfici

139 at increased Cofilin activity promotes rapid bouton formation in response to elevated synaptic activi

140 s circuit-specific increased rates of axonal bouton formation, elimination, and destabilization.

141 During new synaptic bouton formation, synapsin redistributed upon stimulatio

142 process of basket cell axonal branching and bouton formation.

143 oad tracks specifically wrap around immature boutons formed during development and in response to ele

144 ron microscopic observations revealed septal boutons forming axosomatic or axodendritic type II synap

145 thalamic axons are myelinated and make large boutons, forming multiple asymmetric, adherent, and perf

146 n a disproportionate stripping of inhibitory boutons from high-density GABApre-sensory synapses, sugg

147 nificant loss of contralateral corticospinal boutons from M2 compared with controls.

148 oprioceptive IA afferent synapses (VGLUT1-IR boutons) from motoneurons, the reduction of IA EPSPs in

149 with anterogradely labeled Ipc axon-terminal boutons, further supporting a glutamatergic function for

150 ealed that larger numbers of presynaptic AAC boutons giving rise to larger postsynaptic responses pro

151 Instead, presynaptic boutons grow in size and cluster during this process.

152 The small size of synaptic boutons has hampered efforts to define the dynamical sta

153 measurement of structural changes in axonal boutons imaged with time-lapse two-photon laser scanning

154 itatory neurons, showed a decrease in axonal boutons immediately after the training began, whereas pa

155 in were approximately twofold higher in PVBC boutons in adult animals, whereas PV levels in PVChC bou

156 found that visual preferences of presynaptic boutons in each area were distinct and matched the avera

157 Using two-photon Ca(2+) imaging of axonal boutons in hippocampal CA1 of behaving mice, we found th

158 o quantify significant structural changes in boutons in long-term imaging experiments.

159 Axonal boutons in LPFC were also larger in volume and contained

160 Furthermore, thalamic boutons in M1 targeted spiny dendrites exclusively, wher

161 VGluT2(+) boutons in M1 were smaller and formed fewer synapses per

162 sms of maturation of PV-containing GABAergic boutons in monkey PFC.

163 tons results in a lower density of GABAergic boutons in mouse cortical cultures, knowing if GABAergic

164 tivity, we investigated the formation of new boutons in NMJs lacking synapsin [Syn(-)], a synaptic pr

165 djacent to fluorescently labeled presynaptic boutons in physiological levels of extracellular Mg(2+).

166 rmal turnover of dendritic spines and axonal boutons in presymptomatic EAE mice.

167 cally form a single synapse, thalamocortical boutons in S1 usually formed multiple synapses, which me

168 hoton imaging of dendritic spines and axonal boutons in somatosensory cortex for up to 1 year in thy1

169 s was significantly diminished, and that new boutons in Syn(-) preparations were smaller and had redu

170 lted in enhanced numbers of terminal labeled boutons in the iCSP from cM1 compared with controls.

171 in cortex, we found that around half of the boutons in the main thalamorecipient L4 carried orientat

172 roduction is markedly reduced in a subset of boutons in the PFC of schizophrenia subjects and that th

173 hat GABA(A) receptors located on cholinergic boutons in the PnO are responsible for the REM sleep ind

174 wever, the spatial organization of L5B giant boutons in the POm and other subcortical targets is not

175 re, the balance of inhibitory and excitatory boutons in the spinal cord and the level of an ion co-tr

176 labeled somata in the cerebellar nuclei and boutons in the ventrolateral thalamus.

177 turnover and destabilization rates of large boutons indicate that learning and memory deficits in th

178 Blockade of Kv channels at individual boutons indicates that currents immediately local to a r

179 ng anterograde transport vesicles entering a bouton inhibits neuropeptide replenishment after activit

180 translates to GAD67 protein levels in axonal boutons is important for understanding the impact it mig

181 irming that the number of cortical GABAergic boutons is not lower in schizophrenia.

182 The existence of synapses between PNMT-ir boutons labeled with diaminobenzidine and orexinergic ne

183 in lamina VIII, at the expense of lamina VII bouton labeling.

184 aintaining near normal levels of ATP even in boutons lacking mitochondria.

185 ere we report that the destruction of SVs in boutons lacking Piccolo and Bassoon was associated with

186 m Bassoon inhibited presynaptic autophagy in boutons lacking Piccolo and Bassoon, providing insights

187 s mice showed deficiency of GABA perisomatic bouton-like puncta and processes in the KF nucleus; (ii)

188 ctions, we find that MF axons initially form bouton-like specializations directly onto dendritic shaf

189 sive axonal arborizations and accumulated in bouton-like structures.

190 de or retrograde DCV transport into boutons, bouton location, and time of arrival in the terminal.

191 ning correlate with rule exploitation, while bouton loss correlates with exploration and scales with

192 16 but absent by P19, with most postsynaptic boutons lost before P16.

193 tion produced also a higher loss of synaptic boutons, mainly at the dendritic level.

194 Boutons making axosomatic symmetric synapses in the gran

195 allows presynaptic AMPARs to depolarize the bouton membrane sufficiently to modulate both phasic and

196 synaptic, single-synaptic, and multisynaptic boutons (MSBs) in the dlPFC.

197 Multisynaptic boutons (MSBs) were of particular interest, because they

198 Unlike mature boutons, new varicosities have synaptic vesicles which a

199 er vGAT, CB, or GAD67 protein levels per ChC bouton nor the number of boutons per cartridge differed

200 ssion of Shank result in defects in synaptic bouton number and maturation.

201 development, including controlling synaptic bouton number and the ability to bud new varicosities in

202 parietal injury blocked this response; total bouton number was similar to controls, demonstrating tha

203 However, compared with controls, elevated bouton numbers occurred in lamina VIII, at the expense o

204 ospinal tract or serotonergic axons, limited bouton numbers suggested that these supraspinal inputs m

205 l innervation is target specific in terms of bouton numbers, density, and projection volume.

206 ions in the size and stability of spines and boutons observed in this brain area.

207 amate with low probability, whereas the next bouton of the same axon has high release probability whe

208 o the mitochondrial matrix or to presynaptic boutons of cortical pyramidal neurons, we demonstrate th

209 n a reduction of pY816 in axons and synaptic boutons of hippocampal mossy fibers, thereby implicating

210 vity was increased in axons but not synaptic boutons of mossy fibers in ZnT3 knockout mice that lack

211 sicle exocytosis and endocytosis in synaptic boutons of rat cerebellar granule cells.

212 onotopic arrangement was observed across the boutons of the corticocollicular axons, which form a den

213 1 were smaller and formed fewer synapses per bouton on average (1.3 vs 2.1) than those in S1, but VGl

214 fractions of labeled proteins in presynaptic boutons on a time scale of seconds permit the detection

215 cycling of synaptic vesicles in a subset of boutons on cerebellar granule cells, an effect that was

216 ugh synapse formation rates were unaffected, boutons on injured axons were either rapidly and persist

217 eurons in the medial intermediate zone and C boutons on motoneurons.

218 es and numbers of OC inhibitory dopaminergic boutons on neonatal SGN fibers.

219 s the high-density accumulation of GABAergic boutons on sensory terminals.

220 tributions of contacts formed by NA and 5-HT boutons on the reconstructed dendritic trees of these mo

221 annel clusters associated with cholinergic C-boutons on the soma and proximal dendrites of alpha-MNs.

222 The efferent boutons on vestibular cells in alpha9, alpha10, and alph

223 erent synapses and presynaptic inhibition (P-boutons) on retrogradely labeled motoneurons.

224 treated rats are not attributable to smaller boutons or fewer docked vesicles.

225 tein levels per ChC bouton nor the number of boutons per cartridge differed between subject groups.

226 l segments, with an average of three to five boutons per cartridge.

227 The mean number of PVChC boutons per pyramidal neuron AIS was, significantly, 32%

228 nth-old monkeys, whereas the density of PVBC boutons per pyramidal neuron did not differ between age

229 sed to quantify the number of PVChC and PVBC boutons per pyramidal neuron in the PFC of 3-month-old a

230 ignificant decrease in the number of GAD65 P-boutons per VGLUT1 terminal and their coverage of VGLUT1

231 not experience of reward alone, enhances OFC bouton plasticity.

232 c points along the axon, such as presynaptic boutons, play critical roles in axon morphogenesis [4, 5

233 ant activity-evoked change across the entire bouton population.

234 es in the actin cytoskeleton at pre-existing boutons precede new budding events.

235 ished in the dissociated Purkinje cell-nerve bouton preparation.

236 o occurred when stimulating over presynaptic boutons, rather than axons, at CA3-->CA1 synapses, but n

237 Therefore, dynamic bouton redistribution along a broad axon backbone repres

238 aptic clusters, whereas neuronal presynaptic boutons remain unaltered.

239 However, any given bouton responded with stereotypic polarity across multip

240 , but not after, the maturation of GABAergic boutons results in a lower density of GABAergic boutons

241 the young adult brain, large (i.e., strong) boutons show 10-fold higher rates of destabilization and

242 , tracking of individual DCVs moving through boutons shows that activity selectively increases captur

243 how that AP width varies between presynaptic bouton sites, even within the same axon branch.

244 ir unique features, including their terminal bouton size and anatomy, are related to their suggested

245 1) Bouton size increases with proportionally rising number

246 tochondrial volume was a strong predictor of bouton size independent of pathology.

247 pses, probability of release correlates with bouton size, active zone area, and number of docked vesi

248 ptic transmission is attributable to smaller boutons, smaller synapses, and abnormally low numbers of

249 cular glutamate transporter 3-immunoreactive bouton, specific to C-LTMRs, on PKCgamma-immunoreactive

250 rol neurotransmitter release properties in a bouton-specific way through presynaptic Ca2+ clearance.

251 contractions, loss of neuromuscular junction bouton structures, impaired olfactory perception, and se

252 We recorded instead from small boutons supplied by intact axons identified with scannin

253 n-positive interneurons (INs) than in low Pr boutons synapsing onto mGluR1alpha-positive INs.

254 higher Ca(2+) inflow per AZ area in high Pr boutons synapsing onto parvalbumin-positive interneurons

255 nt of pyramidal neurons, forming an array of boutons termed a cartridge.

256 t a large number of dynorphin-immunoreactive boutons terminate on or near anorexigenic proopiomelanoc

257 associated with greater numbers of terminal boutons than smaller frontal lobe lesions.

258 ncta, and PVBC inputs were defined as a PVBC bouton that overlapped a GABA(A) receptor alpha1 subunit

259 VAPB protein onto the postsynaptic site of C-boutons that altered the morphology of C-boutons and imp

260 vesicles were decreased only in presynaptic boutons that contained mitochondria at P15, and vesicle

261 found that only a small fraction of dopamine boutons that exhibited Ca(2+) influx engaged in exocytos

262 s, where MSBs comprised approximately 40% of boutons, the vast majority of dlPFC boutons were single-

263 the perisomatic chemical GABAergic synaptic boutons to the distal AIS, lacks both sodium channels an

264 Unlike M1, where thalamocortical boutons typically form a single synapse, thalamocortical

265 ectron microscopy analysis revealed that new boutons typically form near the edge of postsynaptic ret

266 der after high-frequency AP firing: synaptic boutons undergo a rapid enlargement, which is mostly tra

267 ies of the hippocampal mossy fiber axons and boutons using an antibody selective for pY816 of TrkB, a

268 naptic growth and facilitates budding of new boutons via a cAMP/PKA-dependent pathway.

269 s, active zone area and docked vesicles, and bouton volume and reserve pool vesicles.

270 n the two subtypes (active zone area by 86%; bouton volume by 105%) rather than to postsynaptic densi

271 s with detectable GAD67 levels (vGAT+/GAD67+ boutons) was 16% lower and mean GAD67 levels were 14% lo

272 ics and heterogeneity of individual dopamine boutons, we developed fluorescent false neurotransmitter

273 ctions (2/0 out of 18), and that 2PLSM-based bouton weights are correlated with their volumes measure

274 t populations of septo-hippocampal GABAergic boutons were activated during locomotion and salient sen

275 Lamina IX boutons were also elevated in two frontoparietal lesion

276 PVBC axonal boutons were defined as PV/GAD65 dual-labeled puncta, an

277 o restore normal pH and PCO2Tac1-Pet1 axonal boutons were found localized to brainstem areas implicat

278 Immunoreactive cholinergic boutons were found to be colocalized with GABA(A) recept

279 ined cortical regions, many septal GABAergic boutons were in close apposition to somata or dendrites

280 inous synapses, as well as multiple synaptic boutons were increased in the perilesion cortex by NPT.

281 At the synaptic level, axonal boutons were larger, and dendritic spines were predomina

282 dial sectors of lamina VII and fewer labeled boutons were located in other ipsilateral laminae.

283 >GC boutons were predicted to be smaller in volume, have few

284 CGRP(+) SP(-) boutons were prevalent in lateral lamina I and in lamina

285 y 40% of boutons, the vast majority of dlPFC boutons were single-synaptic, whereas MSBs constituted a

286 Responses of feedback boutons were sparse, odor specific, and often outlasted

287 s, acoustically responsive corticocollicular boutons were sparse, produced unreliable responses, and

288 0 axonal vesicles occurring between synaptic boutons, were stable at 30 minutes but markedly reduced

289 channel density in high release probability boutons, whereas freeze-fracture immunolocalization demo

290 motoneuron terminals to have fewer synaptic boutons, whereas increased neuronal activity results in

291 ton Ca(2+) imaging in cerebellar mossy fiber boutons, which fire at exceptionally high rates.

292 mber of gamma-aminobutyric acid (GABA)-ergic boutons, which may result from impaired localization and

293 The frequency of axonal boutons with a single postsynaptic partner was decreased

294 tic complexity follows the association of MF boutons with CA3 dendritic protrusions.

295 izophrenia subjects, the proportion of vGAT+ boutons with detectable GAD67 levels (vGAT+/GAD67+ bouto

296 itation Ca(2+) imaging in presynaptic axonal boutons with optical quantal analysis in postsynaptic de

297 epileptic pilocarpine-treated rats displayed boutons with over twice the average volume, active zone

298 ll PNs reduce synaptic branching and enlarge boutons, with ultrastructural and synaptic reconstitutio

299 y for synaptic vesicle cycling is similar in boutons without mitochondria as in those with mitochondr

300 However, as R7 growth cones become boutons, Wnd levels are further repressed by a temporall