ライフサイエンスコーパス: bursal

1 in partial-thickness articular (48%) than in bursal (13%) tears (P<.001).

2 on of PE prolonged survival of VLR(PE)Tmu(+) bursal and peripheral B cells.

3 riant GLS or virulent IM strain caused rapid bursal atrophy or hemorrhagic lesions in the bursa, as s

4 role of BCR ligation in the later stages of bursal B cell lymphopoiesis remains elusive.

5 conclude that Ag-mediated ligation of BCR in bursal B cells acts to positively select bursal B cells

6 the chB1 molecules inhibits proliferation of bursal B cells and the DT40 cell line.

7 in bursal B cells acts to positively select bursal B cells into both short-lived and long-lived peri

8 We screened bursal B cells with a panel of Abs and lectins to identi

9 l surface molecules selectively expressed on bursal B cells.

10 disrupted the MEKK1 kinase domain in chicken bursal B-cell line DT40 by homologous recombination and

11 l myristate acetate, two known inhibitors of bursal cell apoptosis, induced Nr13 expression.

12 examined to identify the genes that regulate bursal cell apoptosis.

13 lly expressed in cultured chicken spleen and bursal cells after mitogen stimulation.

14 The abundance of bursal cells carrying these integrations increases rough

15 emarkably common, with an estimated 1 in 350 bursal cells having proviral c-myc integrations.

16 Spleen and bursal cells of IBDV-infected chickens had upregulated g

17 At 7 days p.i., 65% of bursal cells were T cells and 7% were B cells.

18 Bursal cells with proviral c-myc integrations also arise

19 Although BCR expression is sufficient for bursal colonization, the role of BCR ligation in the lat

20 attachments of the abductor muscles and the bursal complex of the greater trochanter.

21 target cell population present during early bursal development and progresses through preneoplastic

22 Infectious bursal disease (IBD) is of economic importance to the po

23 d on synthetic transcripts of the infectious bursal disease virus (IBDV) genome, was recently develop

24 Infectious bursal disease virus (IBDV) is an avian lymphotropic vir

25 Here, we analyzed the role of the infectious bursal disease virus (IBDV) VP3, a major component of IB

26 a replicating nonpathogenic avian infectious bursal disease virus (IBDV) was explored.

27 In this study, infectious bursal disease virus (IBDV) was used to investigate the

28 VP2 capsid protein (pVP2) of the infectious bursal disease virus (IBDV), a double-stranded RNA virus

29 ost proteins in the life cycle of infectious bursal disease virus (IBDV), a double-stranded RNA virus

30 endent RNA polymerase of IPNV and infectious bursal disease virus (IBDV), another birnavirus, can sup

31 Infectious bursal disease virus (IBDV), the causative agent of a hi

32 the host response to infection by infectious bursal disease virus (IBDV).

33 (chIFN-alpha) and the attenuated infectious bursal disease virus vaccine strain PBG98.

34 Infectious bursal disease viruses (IBDVs), belonging to the family

35 results in a normal pattern of posthatching bursal emigration in resistant transformed follicles, wh

36 that these cells hyperproliferate within the bursal environment.

37 tions are preferentially expanded within the bursal environment.

38 of sheep are regarded as a type of mammalian bursal equivalent where B cells diversify their repertoi

39 ated gammaglobulin and complement identified bursal-equivalent or bone marrow-derived (B) lymphocytes

40 ign, joint fluid, and subacromial-subdeltoid bursal fluid.

41 VLR(PE)Tmu expression supports bursal follicle colonization, clonal expansion, and Ig V

42 ood agreement with the number of transformed bursal follicles arising with these integrations.

43 s to an oligoclonal population of developing bursal follicles, showing a variable propensity to form

44 myc-overexpressing progenitors into ablated bursal follicles, suggesting that these angiogenic chang

45 ed early angiogenesis within myc-transformed bursal follicles, which persisted in lymphomas and metas

46 verexpressing lymphocytes within transformed bursal follicles.

47 Hence, GALT may function as a mammalian bursal homologue.

48 th the bursal medial zone (P = .002) and the bursal lateral zone (P = .003) were observed.

49 est (ROIs): bursal medial, articular medial, bursal lateral, and articular lateral.

50 Tendon attachments and bursal localization were related to the facets of the gr

51 induced, whereas Nr13 levels diminished when bursal lymphoblasts were induced to apoptosis by dispers

52 t with the expression signature of embryonic bursal lymphocytes.

53 Overexpression of Nr13 in DT40 bursal lymphoma cells protected them from low serum-indu

54 Avian leukosis virus (ALV) induces bursal lymphoma in chickens after proviral c-myc gene in

55 Avian leukosis virus (ALV) induces bursal lymphoma in tumor-susceptible chicken strains aft

56 e to avian leukosis virus (ALV) induction of bursal lymphoma, involving proviral integration within t

57 ens; these arise with a shorter latency than bursal lymphomas caused by deregulation of c-myc.

58 an, and only partially shared with, those of bursal lymphomas caused by Myc or Rel oncogenes.

59 Avian leukosis virus (ALV) infection induces bursal lymphomas in chickens after proviral integration

60 1, in a pattern similar to that observed in bursal lymphomas.

61 tween the articular medial zone and both the bursal medial zone (P = .002) and the bursal lateral zon

62 erived from four regions of interest (ROIs): bursal medial, articular medial, bursal lateral, and art

63 lls can therefore occur independently of the bursal microenvironment and is dependent on signaling do

64 interactions between B lineage cells and the bursal microenvironment, we sought to identify genes enc

65 at negative selection was independent of the bursal microenvironment.

66 s alter recognition of dormant articular and bursal monosodium urate monohydrate (MSU) crystal deposi

67 ediated overexpression of c-myc in embryonic bursal precursors induces multi-staged tumorigenesis beg

68 y indicates that c-myb mutation in embryonic bursal precursors leads to an oligoclonal population of

69 al program of differentiation and subsequent bursal retention of lymphocytes accounts for most of the

70 revent the in vivo programmed elimination of bursal stem cells after hatching, suggesting that Nr13 p

71 esting that Nr13 plays a role in maintaining bursal stem cells.

72 scopy revealed 21 full-thickness tears, five bursal surface partial-thickness tears, 10 articular sur

73 n and location of partial tear (articular or bursal surface) were recorded.

74 After virus infection, the numbers of bursal T cells expressing activation markers Ia and CD25

75 In addition, IBDV-induced bursal T cells produced elevated levels of interleukin-6

76 In IBDV-infected chickens, bursal T cells proliferated in vitro upon stimulation wi

77 c analysis of single-cell suspensions of the bursal tissue revealed that T cells were first detectabl

78 Spleen and bursal tissue were examined from control and infected bi

79 Bursal transplantation studies demonstrated that Nr13 co