ライフサイエンスコーパス: casein kinase

1 C) has recently been identified as the Golgi casein kinase.

2 clear translocation of PER2 are regulated by casein kinase.

3 ity 20C (Fam20C), is the physiological Golgi casein kinase.

4 ubiquitylation were blocked by disruption of casein kinase 1 (CK1) activity, and mass spectrometry an

5 lation was reduced by specific inhibitors of casein kinase 1 (CK1) and casein kinase 2 (CK2) (10 muM

6 such as phosphorylation of clock proteins by casein kinase 1 (CK1) and glycogen synthase kinase 3 (GS

7 ligase complex upon dual phosphorylation by casein kinase 1 (CK1) and glycogen synthase kinase 3beta

8 under physiological conditions and identify Casein Kinase 1 (CK1) as an upstream effector that bidir

9 rylation and that both were inhibited by the casein kinase 1 (CK1) delta/epsilon inhibitor IC261.

10 lated in vitro and in vivo by members of the casein kinase 1 (CK1) family and by glycogen synthase ki

11 dies to show that Ser-247 is a target of the casein kinase 1 (CK1) family of protein kinases.

12 Here, the casein kinase 1 (CK1) Hrr25 is shown to be an endocytic

13 Casein kinase 1 (CK1) is one such enzyme; it stimulates

14 Casein kinase 1 (CK1) was identified as the major kinase

15 at Ser680 promotes Ser683 phosphorylation by casein kinase 1 (CK1), and these phosphorylation events

16 Phosphorylation of the COPII coat by casein kinase 1 (CK1), Hrr25, contributes to the directi

17 nes; rephosphorylation by kinases, including casein kinase 1 (CK1), restores NFAT to its latent state

18 elsr1, Prickle1, FZD3, FZD7, Dvl2, Dvl3, and casein kinase 1 (CK1)-epsilon are upregulated in B lymph

19 er-174 and Ser-175 by the nuclear isoform of casein kinase 1 (CK1).

20 ent manner by the plasma membrane-associated casein kinase 1 (CK1).

21 Two such regulators, casein kinase 1 (CKI) and F-box and leucine-rich repeat

22 ts G2 mode by blocking Srs2 DNA helicase and Casein Kinase 1 (Hhp1).

23 We also show casein kinase 1 (Hrr25) is a key kinase that phosphoryla

24 Strikingly, loss of casein kinase 1 activity causes constitutive activation

25 Casein kinase 1 alpha (CK1 alpha) was shown to directly

26 protein stability of FOXO3A is regulated by Casein Kinase 1 alpha (CK1alpha) in an oncogenic RAS-spe

27 Here, we report that casein kinase 1 alpha (CK1alpha) phosphorylates Cdc25A o

28 We found that casein kinase 1 alpha (Csnk1a1), a serine-threonine kina

29 ung cancer (NSCLC) cell lines, we identified casein kinase 1 alpha (CSNK1A1, CK1alpha).

30 Our results describe a role for casein kinase 1 as a direct regulator of sterol homeosta

31 nstrated that Ser(568) was phosphorylated by casein kinase 1 both in vitro and in vivo.

32 Both casein kinase 1 delta (CK1delta) and epsilon (CK1epsilon

33 Casein kinase 1 delta (CK1delta) and its closest homolog

34 Inhibition of casein kinase 1 delta (CK1delta) blocks primary ciliogen

35 Casein kinase 1 epsilon (CK1epsilon) and its closest hom

36 requires both non-canonical Wnt5a ligand and casein kinase 1 epsilon (CK1varepsilon), and that this e

37 self-renewal, by inducing the expression of casein kinase 1 epsilon.

38 be our isolation and characterization of the casein kinase 1 family member Hhp2 as a novel regulator

39 We demonstrate that Casein kinase 1 family members, including isoforms of Ta

40 he Hedgehog pathway are redundant with other Casein kinase 1 family members.

41 Depletion of casein kinase 1 gamma (CSNK-1) in Caenorhabditis elegans

42 a multifaceted approach, we have found that casein kinase 1 gamma 1 (CK1gamma1) carries out this fun

43 We further evaluated whether D4476, a casein kinase 1 inhibitor, would exhibit selective antil

44 Because casein kinase 1 is associated with sites of polar growth

45 Inhibition of casein kinase 1 may also contribute to the antitumoral a

46 in 90 and glycogen synthase kinase 3 but not casein kinase 1 nor LATS in YAP-mediated TAZ loss.

47 ists of two independent domains that contain casein kinase 1 phosphorylation sites.

48 depends on the ubiquitin ligase Rsp5 and the casein kinase 1 redundant pair Yck1/Yck2.

49 Deregulation of CK1 (casein kinase 1) activity can be involved in the develop

50 ing protein (IQGAP); and three NFAT kinases, casein kinase 1, glycogen synthase kinase 3, and dual sp

51 e sensitive to pharmacological inhibition of Casein kinase 1, suggesting the possibility of shared cl

52 Csnk1e, the gene encoding casein kinase 1-epsilon, has been implicated in sensitiv

53 involves SOD1-mediated stabilization of two casein kinase 1-gamma (CK1gamma) homologs, Yck1p and Yck

54 psis (Arabidopsis thaliana) CK1 member named casein kinase 1-like 6 (CKL6) associates with cortical m

55 iotic division is coordinated by a conserved casein kinase 1.

56 y for calcineurin and decreased affinity for casein kinase 1.

57 In this study, we determined the role of casein kinase-1 (CK1) in regulating NMDAR activity in th

58 Arsenite also recruited a TDP-43 kinase, casein kinase-1 (CK1), to GADD34.

59 ut not other PI3Kdelta inhibitors, inhibited casein kinase-1 epsilon (CK1epsilon).

60 CK1delta, a member of the ubiquitous casein kinase-1 family, is implicated in the progression

61 We show that casein kinase-1 inhibition increases NMDA receptor activ

62 Our data indicate that casein kinase-1 tonically regulates NMDA receptor activi

63 clock, a protein complex of frequency (FRQ), casein kinase 1a (CK1a), and the FRQ-interacting RNA Hel

64 the ability of FRQ to interact with WCC and casein kinase 1a.

65 t lenalidomide induces the ubiquitination of casein kinase 1A1 (CK1alpha) by the E3 ubiquitin ligase

66 The casein kinase 1A1 gene (CSNK1A1) is a putative tumor sup

67 Here we report that both screens identified casein kinase 1alpha (CK1alpha) as a bifunctional regula

68 report purification and characterization of casein kinase 1alpha (CK1alpha) as a bona fide major IFN

69 We identified casein kinase 1alpha (CK1alpha) as a direct target of mi

70 iRNA kinome screen, we identify and validate casein kinase 1alpha (CK1alpha) as being responsible for

71 caused by GLIPR1-mediated redistribution of casein kinase 1alpha (CK1alpha) from the Golgi apparatus

72 demonstrate that RAS-dependent elevation of casein kinase 1alpha (CK1alpha) negatively regulates aut

73 trate that the destruction complex component casein kinase 1alpha (CK1alpha) phosphorylates Jade-1 at

74 Previous studies showed that casein kinase 1alpha (CK1alpha) stably associates with M

75 and metastasis in vivo via downregulation of casein kinase 1alpha (CK1alpha), a suppressor of pro-met

76 Here we report that casein kinase 1alpha (CK1alpha), a ubiquitously expresse

77 nhibitor), adenomatous polyposis coli (APC), casein kinase 1alpha (CK1alpha), and glycogen synthase k

78 inc finger proteins 1 (IKZF1) and 3 (IKZF3), casein kinase 1alpha (CK1alpha), and the translation ter

79 IFN in the context of intestinal knockout of casein kinase 1alpha (CK1alpha), which controls the ubiq

80 Finally, we identify casein kinase 1alpha as a possible candidate for KLP10A

81 o impacted by lenalidomide, which suppressed casein kinase 1alpha expression while augmenting glycoge

82 We thus propose that Casein kinase 1alpha is essential to allow beta-Catenin

83 ion in the beta-Catenin degradation complex, Casein Kinase 1alpha mutant cells accumulate beta-Cateni

84 , we could not detect any effect of the same Casein Kinase 1alpha mutation on Hedgehog signaling.

85 mor suppressor adenomatous polyposis coli or casein kinase 1alpha uncovered new regulatory features a

86 in-related protein 2, and the protein kinase Casein kinase 1alpha.

87 rvinium as a novel, potent (IC50, 10 nmol/L) casein kinase-1alpha (CK1alpha) agonist.

88 lycogen synthase kinase-3beta (GSK3beta) and casein kinase-1alpha (CK1alpha) are multifunctional kina

89 as carried out by the combined activities of casein kinase 1delta (CK1 delta) and casein kinase 1epsi

90 Casein kinase 1delta (CK1delta) and 1epsilon (CK1epsilon

91 Casein kinase 1delta (CK1delta) family members associate

92 89, while also enhancing Sid4's affinity for casein kinase 1delta (CK1delta).

93 Given the role of mammalian Hhp2 homologs, casein kinase 1delta and 1epsilon, in regulation of the

94 We and others have shown that casein kinase 1delta and epsilon (CK1delta/epsilon) are

95 ermined whether pharmacological targeting of casein kinase 1delta and epsilon (CK1delta/epsilon), key

96 n correlated with neurite outgrowth and that casein kinase 1delta, one of the enzymes that mediate Wn

97 ithin Rec8 as well as two different kinases, casein kinase 1delta/epsilon (CK1delta/epsilon) and Dbf4

98 Casein kinase 1delta/epsilon (CK1delta/epsilon) and thei

99 Earlier work has implicated casein kinase 1delta/epsilon as responsible for the Dvl

100 This activity was inhibited by a casein kinase 1delta/epsilon inhibitor, suggesting a rol

101 Casein kinases 1delta and epsilon are closely related cl

102 liver nuclei all three PERs, both CRYs, and Casein Kinase-1delta (CK1delta) are present together in

103 ties of casein kinase 1delta (CK1 delta) and casein kinase 1epsilon (CK1epsilon) and was antagonized

104 Specifically, we found that casein kinase 1epsilon (CK1epsilon) is highly expressed

105 In the present study, we found that casein kinase 1epsilon (CK1epsilon) was increased signif

106 pigment aggregation signaling also involved casein kinase 1epsilon (CK1epsilon), that both enzymes w

107 its vulnerability to degradation mediated by casein kinase 1epsilon (CSNK1E) is increased.

108 earing a short-period mutation in the enzyme casein kinase 1epsilon (tau mutation), which accelerates

109 Fat-Hippo signaling requires the Drosophila Casein kinase 1epsilon encoded by discs overgrown (Dco),

110 Here, we show that fission yeast Cki3 (a casein kinase 1gamma homolog) is a critical regulator to

111 es with thapsigargin (10 mum), inhibition of casein kinase 2 (4,5,6,7-tetrabromobenzotriazole; 10 mum

112 ific inhibitors of casein kinase 1 (CK1) and casein kinase 2 (CK2) (10 muM D4476, 100 muM CK2-inhibit

113 effects of mutant M1 spastins on FAT involve casein kinase 2 (CK2) activation.

114 rt inhibition as a consequence of endogenous casein kinase 2 (CK2) activation.

115 We focus on casein kinase 2 (CK2) and demonstrate that the regulator

116 In this study, we identified casein kinase 2 (CK2) as a critical modulator of NADPH o

117 We identify casein kinase 2 (CK2) as a key regulator of temperature

118 ave identified polo-like kinase 1 (Plk1) and casein kinase 2 (CK2) as two kinases of CLIP-170 and map

119 Casein kinase 2 (CK2) binds to the NHE3 C-terminus and c

120 Our previous results highlighted a role for casein kinase 2 (CK2) in the modulation of dopamine D1 r

121 iated stimulation, PTEN is phosphorylated by casein kinase 2 (CK2) in the Ser380-Thr382-Thr383 cluste

122 tified serine 358 as a specific site used by casein kinase 2 (CK2) in vitro and in vivo.

123 7 -: tetrabromobenzotriazole (TBB), a potent casein kinase 2 (CK2) inhibitor, as a strong suppressor

124 The protein kinase casein kinase 2 (CK2) is a pleiotropic and constitutivel

125 Casein kinase 2 (CK2) is a typical serine/threonine kina

126 Although protein kinase casein kinase 2 (CK2) is readily detected in MKs and pla

127 Previous research suggests that casein kinase 2 (CK2) may be a promising therapeutic tar

128 Previous in vitro studies indicated that casein kinase 2 (CK2) mediated the phosphorylation of NS

129 We have previously shown that casein kinase 2 (CK2) negatively regulates dopamine D1 a

130 We demonstrated that increased activity of casein kinase 2 (CK2) observed in HPC and in MDSC could

131 w that murine caspase-9 is phosphorylated by casein kinase 2 (CK2) on a serine near the site of caspa

132 at shock and antioxidants induced Hsp90, and casein kinase 2 (CK2) phosphorylated INrf2Thr55.

133 Casein kinase 2 (CK2) phosphorylates the NR2B subunit wi

134 The MRE11-PIH1D1 interaction is dependent on casein kinase 2 (CK2) phosphorylation of two acidic sequ

135 The Foxc2 amino terminus has a consensus casein kinase 2 (CK2) phosphorylation site at serine 124

136 ariant of the formin FHOD3 that introduces a casein kinase 2 (CK2) phosphorylation site.

137 the C terminus, which was predicted to be a casein kinase 2 (CK2) phosphorylation site.

138 ) of MDC1, which contains multiple consensus casein kinase 2 (CK2) phosphorylation sites.

139 and overexpression experiments, we show that casein kinase 2 (CK2) promotes stress granule dynamics.

140 that phosphorylation of recombinant TFIIF by casein kinase 2 (CK2) reduces or eliminates some of the

141 serine residues 16 and 18, which are within casein kinase 2 (CK2) sites, and serine residue 114, whi

142 ctivated through pharmacologic inhibition of casein kinase 2 (CK2) to eradicate disease in high-risk

143 sh1 is phosphorylated by the Cka2 subunit of casein kinase 2 (CK2) to promote its E3 activity for Cse

144 CD5 activates casein kinase 2 (CK2), a serine/threonine kinase that co

145 ere, we report that Brg1 is also a target of casein kinase 2 (CK2), a serine/threonine kinase, in pro

146 wn previously to require the Cka2 subunit of casein kinase 2 (CK2), a ubiquitous enzyme with multiple

147 Casein kinase 2 (CK2), a ubiquitous kinase, regulates se

148 nsists of Daz interacting protein 1 (Dzip1), casein kinase 2 (CK2), and B56 containing protein phosph

149 on was dependent on XRCC1 phosphorylation by casein kinase 2 (CK2), enhancing XRCC1's interaction wit

150 on events catalyzed first by MEK and then by casein kinase 2 (CK2), followed by interaction with impo

151 e, and this phosphorylation was catalyzed by casein kinase 2 (CK2), the levels of which were dramatic

152 a striking resemblance to that of eukaryotic casein kinase 2 (CK2), which also exhibits dual nucleoti

153 d51 phosphorylation at threonine 13 (T13) by casein kinase 2 (CK2), which in turn triggers direct bin

154 Wnt stimulation induces the casein kinase 2 (CK2)-dependent phosphorylation of LRP6

155 We have also noted that casein kinase 2 (CK2)-directed phosphorylation of Pax7 a

156 the unsuspected tyrosine kinase activity of casein kinase 2 (CK2).

157 ISA analyses and Western blotting to measure casein kinase 2 (CK2).

158 by the disease-relevant signalling protein, casein kinase 2 (CK2).

159 orylated on conserved serines 487 and 491 by casein kinase 2 (CK2).

160 t human cytomegalovirus pUL84 interacts with casein kinase 2 (CK2).

161 various kinases, including GPCR kinases and casein kinase 2 (CK2).

162 minal kinase; (ii) inhibition of calpain and casein kinase 2 activity; and (iii) induction of fibrobl

163 Casein kinase 2 alpha phosphorylates PDCD5 at Ser-119 to

164 lation sites and two putative GRIP1 kinases, casein kinase 2 and cyclin-dependent kinase 9.

165 molecular events of this modulation involved casein kinase 2 and the synaptic vesicle rapid endocytos

166 posttranslationally regulated by TNF-induced casein kinase 2 catalytic subunit (CK2alpha') phosphoryl

167 These data support a role for casein kinase 2 in regulation of protein synthesis by do

168 We report here that casein kinase 2 phosphorylates a conserved threonine res

169 Upon hypertrophic stimuli, casein kinase 2 phosphorylates DPF3a at serine 348.

170 We also show that casein kinase 2 phosphorylates G3BP1 at serine 149 in vi

171 a physical interaction between S6KII and the casein kinase 2 regulatory subunit (CK2beta), suggesting

172 We now show that TFIIF phosphorylated by casein kinase 2 remains competent to support PIC assembl

173 Casein kinase 2 stimulates the biogenesis of Tom22 and T

174 an interacting protein, protein kinase C and casein kinase 2 substrate in neurons 1 (PACSIN1).

175 The PACSIN (protein kinase C and casein kinase 2 substrate in neurons) adapter proteins c

176 This activity, and the ability of casein kinase 2 to use GTP as a phosphate donor, may be

177 ine 424 by protein kinase CK2 (also known as casein kinase 2) activated the HDAC3 in vitro.

178 ylation of calmodulin by protein kinase CK2 (casein kinase 2) rapidly and reversibly modulated KCNQ2

179 overed that murine Arl13b is a substrate for casein kinase 2, a contaminant in our preparation from h

180 Protein kinase CK2 (CK2) (formerly casein kinase 2, a protein Ser/Thr kinase signal that is

181 ation of ErbB2 or loss of the betasubunit of casein kinase 2, shifted the whole population toward a f

182 uired Rab11-dependent trafficking and FAM20C/casein kinase 2-dependent C-terminal phosphorylation of

183 required for insulin induction of Sort1 in a casein kinase 2-dependent manner and that inhibition of

184 Casein kinase 2-mediated phosphorylation at VHL N-termin

185 ERK promotes casein kinase 2-mediated phosphorylation of alpha-cateni

186 t we identified as substrates for Erk1/2 and casein kinase 2.

187 I, whereas Ca(V)1.1-T1579 is a substrate for casein kinase 2.

188 c but not the cardiac CCRK with cyclin H and casein kinase 2.

189 nts indicate that phosphorylation of TLE1 by casein kinase-2 (CK2) at Ser-239 and Ser-253 is necessar

190 Casein kinase-2 (CK2) promotes cell survival and is upre

191 Conversely, casein kinase-2 (CK2)-inhibitor increases Ikaros functio

192 s NMDA receptor activity by interacting with casein kinase-2 and protein phosphatases in the hypothal

193 r localization of Atx3 was not affected by a casein kinase-2 inhibitor or by mutating a predicted nuc

194 he protein phosphatase 1/2A, calcineurin, or casein kinase-2 inhibitor.

195 Some interesting cross reactivity with casein kinase-2 was also identified, and structural feat

196 M1-type muscarinic receptors and occur in a casein kinase-2-dependent manner.

197 In this study, we explored whether casein kinase 2alpha (CK2alpha), the human homolog of Ck

198 ated protein 1 (MRP1), is regulated by yeast casein kinase 2alpha (Cka1p) via phosphorylation at Ser2

199 se kinase-3beta and an increase in levels of casein kinase 2alpha, and led to increased cyclin-D1, an

200 orylation status of the downstream molecules casein kinase-2alpha and histone deacetylase 2 were sign

201 x1 regulates normal cardiac function via p27/casein kinase-2alpha/histone deacetylase 2 and indicate

202 e U.S. Food and Drug Administration-approved casein kinase activator, pyrvinium) in C57Bl/6J mice res

203 NUCKS1 (nuclear casein kinase and cyclin-dependent kinase substrate 1) i

204 kDa enamelin that is phosphorylated by Golgi casein kinase and is thought to mediate calcium binding.

205 " with Axin, glycogen synthase kinase 3, and casein kinase, APC targets sscatenin (sscat) for phospho

206 e interacting proteins were found to contain casein kinase (CK) 2, phosphokinase (PK)C phosphorylatio

207 acidic amino acids, is regulated in vivo by casein kinase (CK) Idelta and/or CKIepsilon, but not by

208 R2 is phosphorylated on Ser-662 and flanking casein kinase (CK) sites in vivo.

209 g peptide, we established a pivotal role for casein kinase (CK)-2-mediated circadian BMAL1-Ser90 phos

210 HDAC inhibitors transcriptionally activated casein kinase (CK)2alpha expression through increased as

211 Increased levels of casein kinase (CK1 and CK2), which are associated with T

212 Casein kinase CK2 is an essential enzyme in higher organ

213 s of ataxia-telangiectasia-mutated (ATM) and casein kinases (CKs) 1 and 2.

214 y mechanistic target of rapamycin (mTOR) and casein kinase (CSNK)-2.

215 The casein kinase family of serine/threonine kinases regulat

216 r axonemes has implicated the protein kinase casein kinase I (CK1) in regulation of dynein.

217 To assess the role of casein kinase I (CK1) in the regulation of dopamine sign

218 Although members of the casein kinase I (CKI) family phosphorylate alphaSyn at S

219 to growth signals, and in collaboration with casein kinase I (CKI), generates a phosphodegron that bi

220 biquitination and destruction of VEGFR2 in a casein kinase I (CKI)-dependent manner.

221 -induced phosphorylation of its prodomain by casein kinase I (Yck1/2).

222 dation requires phosphorylation of PHLPP1 by casein kinase I and glycogen synthase kinase 3beta (GSK-

223 r a critical requirement for the centrosomal casein kinase I delta (CKIdelta) in centrosome transloca

224 Activating beta-catenin through Casein Kinase I inhibition or Wnt3A addition increased b

225 es, we show that Hrr25p, an isoform of yeast casein kinase I, phosphorylates Tif6p both in vitro and

226 ucleation pathway were identified as well as casein kinase I, which had a similar morphological RNAi

227 res downstream assistance from an inhibitory casein kinase I, Yck3.

228 When HOPS is phosphorylated by the vacuolar casein kinase I, Yck3p, tethering only takes place when

229 Casein kinase I-alpha (CKI-alpha) was identified as an N

230 Set8 for ubiquitination and degradation in a casein kinase I-dependent manner, which is activated by

231 We identify the PI-4,5-P(2)-sensitive casein kinase Ialpha (CKIalpha) as a protein kinase resp

232 Casein kinase Ialpha (CKIalpha) directly phosphorylated

233 Following these changes, loss of Casein kinase Ialpha and induction of chronic DNA damage

234 (PER) proteins, which is highly dependent on casein kinase Idelta/epsilon (CKIdelta/epsilon; termed D

235 Casein kinases Idelta and Iepsilon (CKIdelta/epsilon) ca

236 ks, including three compounds that inhibited casein kinase Iepsilon in vitro and a unique benzodiazep

237 f Drosophila Doubletime (DBT) and vertebrate casein kinase Iepsilon/delta (CKIepsilon/delta) produce

238 f the gilgamesh (gish) gene, which encodes a casein kinase Igamma homolog that is preferentially expr

239 t sites by at minimum two different kinases, casein kinase II (CK II) and tousled-like kinase (tlk).

240 for phosphorylation by protein kinase C and casein kinase II (CK-II).

241 ar substrates of human protein kinases (e.g. casein kinase II (CK2) and Akt), that implicated several

242 s presented here identify the protein kinase casein kinase II (CK2) as a BMP receptor type Ia (BRIa)

243 Casein kinase II (CK2) has been shown to act as a positi

244 Here we uncover a novel role for casein kinase II (CK2) in the cellular response to hyper

245 calmodulin-dependent kinase II (CaMKII) and casein kinase II (CK2) inhibition.

246 -dione derivatives were synthesized as human casein kinase II (CK2) inhibitors.

247 that the conserved serine/threonine kinase, casein kinase II (CK2), promotes miRISC function in Caen

248 y, Brd4 association with p53 is modulated by casein kinase II (CK2)-mediated phosphorylation of a con

249 The N-terminal phosphorylation by cellular casein kinase II (CKII) at S21, T32, and S43, and other

250 roaches, we have identified a novel role for casein kinase II (CKII) in the modification of the polym

251 We have demonstrated that casein kinase II (CKII) is involved in the phosphorylati

252 n intact pocket protein binding domain and a casein kinase II (CKII) phosphorylation motif.

253 ed the phosphorylation of Dgk1 DAG kinase by casein kinase II (CKII).

254 s work, we show that Pah1 is a substrate for casein kinase II (CKII); its phosphorylation was time- a

255 Casein kinase II (formerly known as CK2), a ubiquitous S

256 damage in a manner dependent on TCOF1 and on casein kinase II and ATM, which are known to modify TCOF

257 In vitro studies support roles for casein kinase II and PKC in this modification, consisten

258 this repression by directly interacting with Casein Kinase II and preventing it from activating HDAC3

259 phorylated by two EVI1 interactome proteins, casein kinase II and protein phosphatase-1alpha.

260 Thr1704-sites of phosphorylation by PKA and casein kinase II at the interface between the proximal a

261 RNA designed to knock down expression of the casein kinase II beta-subunit gene family lengthens peri

262 t with previous reports of a short period in casein kinase II beta-subunit overexpressors.

263 phosphatase calcineurin (TAX-6), and of the casein kinase II homologue KIN-10.

264 preincubation of RBCs with DMAT, a specific casein kinase II inhibitor.

265 dition, our data indicate that inhibition of casein kinase II or GSK3beta significantly reduced hnRNP

266 uniquely possess lysine residues following a casein kinase II phosphorylation motif which is critical

267 he nuclei of infected cells, indicating that casein kinase II phosphorylation of S186 occurs in the n

268 Mutations of the casein kinase II phosphorylation site caused a complex p

269 region identified IE63 S186 as a target for casein kinase II phosphorylation.

270 serine 72 and pharmacological inhibition of casein kinase II reduced GTPCH-1 phosphorylation and blu

271 ll three members of the protein kinase C and casein kinase II substrate in neurons (PACSIN) family an

272 ously reported that the protein kinase C and casein kinase II substrate in neurons (PACSIN) forms a c

273 his report we identify CK2 (formerly termed "casein kinase II") as the kinase responsible for phospho

274 ned the role of protein kinase CK2 (formerly casein kinase II) in increased N-methyl-d-aspartate rece

275 ng 1 (YY1) in vitro and in vivo by CK2alpha (casein kinase II), a multifunctional serine/threonine pr

276 se A/calcium calmodulin-dependent kinase II, casein kinase II, and proline-directed kinase, indicatin

277 Ser184 of Geminin could be phosphorylated by Casein kinase II, resulting in the enhanced binding to H

278 trated that Ser(10) can be phosphorylated by casein kinase II, Ser(21) can be phosphorylated by prote

279 on of myosin light chain kinase (P<0.05) and casein kinase II-alpha (P=0.06).

280 EGF enhanced secretion of AMF through its casein kinase II-mediated phosphorylation.

281 , which in turn increases enzyme activity of casein kinase II.

282 ivity) is inactivated via phosphorylation by casein kinase II.

283 P<0.0001) through a mechanism that includes casein kinase II.

284 ain binding to Asf1-T(270) phosphorylated by casein kinase II.

285 Dual mutation of Ser1700 and a nearby casein-kinase II site (Thr1704) caused accelerated hyper

286 and signaling pathways, including CaMK, PKA, Casein kinase-II, and the Raf-MEK-ERK and PI-3K-Akt path

287 RNA synthesis through the phosphorylation of casein kinase IIalpha (CK2alpha) on a threonine residue

288 Casein kinase Ivarepsilon phosphorylates the S102 in thi

289 Casein kinase levels were not altered after treatment wi

290 e WC complex in the nucleus by promoting the casein kinases-mediated WC phosphorylation.

291 n HapMap cell lines was protein kinase C and casein kinase substrate in neurons 2 (PACSIN2).

292 or by coexpression with protein kinase C and casein kinase substrate in neurons 3 (PACSIN3), a regula

293 eletions of YCK3, encoding a vacuolar type I casein kinase; SVP26, encoding an endoplasmic reticulum

294 Fam20C is the Golgi casein kinase that phosphorylates secretory pathway prot

295 Fam20C appears to be the Golgi casein kinase that phosphorylates secretory pathway prot

296 Fam20C is the physiological Golgi casein kinase, which phosphorylates many secreted protei

297 We also show that the type-I casein kinases Yck1 and Yck2 phosphorylate Ubr1 on Ser(3

298 We report here that the redundant casein kinases Yck1p and Yck2p phosphorylate sites withi

299 e requires its phosphorylation by the type 1 casein kinase Yck3.

300 The yeast casein kinases (Ycks) are key players in this pathway.