ライフサイエンスコーパス: centrosomal

1 nally, Aurora-A(-/-) keratinocytes displayed centrosomal abnormalities that included centrosomes loca

2 cell mitotic protein TACC3 leads to enhanced centrosomal abnormalities, activation of death programs,

3 ited by the mutant integrin by promoting the centrosomal accumulation of gamma-tubulin.

4 Here, we show that SDCCAG8 regulates centrosomal accumulation of pericentriolar material and

5 pears to be associated with decreased Rabin8 centrosomal accumulation.

6 observe that Net1 expression is required for centrosomal activation of p21-activated kinase and its d

7 Disruption of centrosomal activity or downregulation of the centriolar

8 The cancer-associated, centrosomal adaptor protein TACC3 (transforming acidic c

9 on by BMI1 exerts several effects, including centrosomal amplification and aneuploidy, antiapoptosis,

10 tumor growth in murine xenograft models, and centrosomal amplification induced by its overexpression.

11 lei, formation of anucleated daughter cells, centrosomal amplification, and aneuploidy.

12 istically significant increases (P < .05) in centrosomal amplification, micronuclei, and micronuclei

13 e, were examined for genotoxicity, including centrosomal amplification, micronuclei, and micronuclei

14 pressor p53 prevents genomic instability and centrosomal amplification.

15 ancer cells that may lead to chromosomal and centrosomal amplifications.

16 Certain phenotypes attributable to centrosomal and cell polarity functions could not be res

17 all, chromosome movements and combining the centrosomal and chromosomal pathways affect the assembly

18 sults suggest that an optimal combination of centrosomal and chromosomal pathways, spatially biased m

19 t the temporally orchestrated destruction of centrosomal and ciliary proteins is a necessary antecede

20 and mass spectrometry of interactors of the centrosomal and ciliopathy protein, CEP19, we identify C

21 suggest that Nin plays a supportive role in centrosomal and extracentrosomal microtubule organizatio

22 Both centrosomal and Golgi-emanating microtubules need gamma-

23 mediated depletion of Cyclin F in G2 induces centrosomal and mitotic abnormalities, such as multipola

24 We propose that ARH participates in centrosomal and mitotic dynamics by interacting with cen

25 Whether the centrosomal and mitotic functions of ARH are related to

26 separated from the forming spindle, and both centrosomal and noncentrosomal spindle assembly pathways

27 the function of these complexes in nuclear, centrosomal, and chromosome dynamics, and their connecti

28 n to be required in cell migration, nuclear, centrosomal, and microtubule transport, mitosis, and gro

29 ;Nedd9(-/-) cells have increased cell cycle, centrosomal, and mitotic defects, phenotypes compatible

30 A centrosomal array of microtubules subjected to dynein pu

31 CA-1 acts with gamma-tubulin to assemble non-centrosomal arrays in multiple tissues and highlight fun

32 Many cells contain non-centrosomal arrays of microtubules (MTs), but the assemb

33 In sharp contrast to radial centrosomal arrays, microtubules nucleated at the periph

34 These results underscore the importance of centrosomal assembly in neurogenesis and provide potenti

35 nt, Spc42, resulted in lethality and reduced centrosomal assembly.

36 f-function mutations predominantly affecting centrosomal-associated proteins, but the multiple roles

37 Signaling by the centrosomal asters and spindle midzone coordinately dire

38 ne width was broadened by attenuation of the centrosomal asters but was not affected by MP-GAP inhibi

39 the relative contributions of RhoA flux and centrosomal asters in controlling RhoA zone dimensions.

40 ent relative to the apicobasal axis, loss of centrosomal attachment, and apical stabilization.

41 The centrosomal Aurora-A kinase (AURKA) regulates mitotic pr

42 f motor proteins, plays an essential role in centrosomal bundling in cancer cells, but its function i

43 Accordingly, centrosomal CaMKIIbeta signaling mediates the ability of

44 Finally, disruption of the centrosomal cAMP microdomain by local displacement of PD

45 e progression relies on unique regulation of centrosomal cAMP/PKA signals.

46 r, we uncover a critical requirement for the centrosomal casein kinase I delta (CKIdelta) in centroso

47 sion from the centrosome, thereby inhibiting centrosomal Cdc20-APC activity and triggering the transi

48 The identification of a centrosomal Cdc20-APC ubiquitin signaling pathway holds

49 ination of Cdc20, stimulates the activity of centrosomal Cdc20-APC, and drives the differentiation of

50 y contribute to targeting and recognition of centrosomal Cdk substrates and is required for specific

51 Distinct mutations in the centrosomal-cilia protein CEP290 lead to diverse clinica

52 iary length in control MEFs, suggesting that centrosomal CK1delta has a role in ciliogenesis.

53 y of a prototype small molecule inhibitor of centrosomal clustering and strongly support the further

54 ve of griseofulvin, as a potent inhibitor of centrosomal clustering in malignant cells.

55 h associates with spindle poles and promotes centrosomal clustering, is essential for formation of a

56 The Pcnt gene encodes a large centrosomal coiled-coil protein that has been implicated

57 Centrosomal coiled-coil proteins paired with kinases pla

58 mutated in 3M short stature syndrome, form a centrosomal complex that regulates CUL9 and its substrat

59 The centrosomal component SAS-6 localized to basal bodies an

60 TRIM37 knockout cells formed ectopic centrosomal-component foci that suppressed mitotic defec

61 a reveal that non-visual arrestins are novel centrosomal components and regulate normal centrosome fu

62 Centrosome reduction is the decrease in centrosomal components during spermatid differentiation

63 r satellite component PCM-1 colocalized with centrosomal components in cytoplasmic granules surroundi

64 r results suggest conservation of eukaryotic centrosomal components in plant cells.

65 aused the mislocalization of p150(Glued) and centrosomal components that are critical for microtubule

66 t conclusive evidence that DVL regulates the centrosomal cycle.

67 , in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 and advances entry into mitosi

68 mogenesis by enabling CLL cells to cope with centrosomal defects acquired during malignant transforma

69 es organize the bipolar mitotic spindle, and centrosomal defects cause chromosome instability.

70 pic RGPs, as well as those in the VZ, with a centrosomal deficit exhibited prolonged mitosis, p53 upr

71 tion was significantly reduced while nuclear-centrosomal distance was extended.

72 for exocytosis and endocytosis, directed by centrosomal docking at the plasma membrane.

73 ulates a variety of cell functions including centrosomal duplication, cell cycle control, and apoptos

74 s microtubule disorganization and release of centrosomal dynactin.

75 l-associating protein mediates unanticipated centrosomal events at distinct stages of the somatic cel

76 ng concept that DNA replication is linked to centrosomal events.

77 nerated against isolated nucleolini revealed centrosomal forerunners in the oocyte cytoplasm.

78 n) expresses two major protein variants: the centrosomal form (CnnC) and a non-centrosomal form in te

79 iants: the centrosomal form (CnnC) and a non-centrosomal form in testes (CnnT).

80 is by multiple mechanisms, one involving its centrosomal function and another dependent on its intera

81 ex and that this localization regulates both centrosomal function and JAK2 kinase activity, thus cont

82 ions in CDK5RAP2 is associated with impaired centrosomal function and with changes in mitotic spindle

83 development and suggest that perturbation of centrosomal function contributes to the development of m

84 Effects of PCM1, DISC1, and BBS on centrosomal functions and corticogenesis in vivo were te

85 Our results suggest distinct apoptotic and centrosomal functions of BRCA1 in neural progenitors, wi

86 s paired with kinases play critical roles in centrosomal functions within somatic cells, however know

87 Ser-732 phosphorylation in the regulation of centrosomal functions.

88 ng to GABARAP, regulating starvation-induced centrosomal GABARAP delivery to the phagophore.

89 specifically regulate an ATG8 ortholog, the centrosomal GABARAP reservoir, and centrosome-autophagos

90 y reported, we show that loss of B1 enhanced centrosomal gamma-tubulin localization and microtubule n

91 ession results in mislocalized Plk1 and poor centrosomal gamma-tubulin recruitment, potentially contr

92 ARH interacts with centrosomal (gamma-tubulin and GPC2 and GPC3) and motor

93 e signature expression correlate with CA and centrosomal gene signature expression in breast tumors.

94 PNL was associated with higher expression of centrosomal genes and with shorter survival.

95 Defects in cilia centrosomal genes cause pleiotropic clinical phenotypes,

96 findings reveal a new function for Arpc1b in centrosomal homeostasis.

97 m a centrosomal splice form in NPCs to a non-centrosomal isoform in neurons.

98 negatively affects cell division through its centrosomal kinase activity.

99 of Aurora A (AurA) describe it as a mitotic centrosomal kinase.

100 revents NEK2-controlled dissolution of loose centrosomal linker and subsequent centrosomal separation

101 ated protein 1 (C-NAP1), two proteins of the centrosomal linker.

102 gesting that the ESCRT pathway may also have centrosomal links.

103 la Asl and human CEP152 are required for the centrosomal loading of Plk4 in Drosophila and CPAP in hu

104 wo proteins are dependent on one another for centrosomal localisation.

105 pid(3) mutant embryos, and is sufficient for centrosomal localisation.

106 Further, TBK1 is necessary for CEP170 centrosomal localization and binding to the microtubule

107 or human neurodevelopment that promotes CDK2 centrosomal localization and centriole duplication.

108 NTE and first two TPRs) are dispensable for centrosomal localization and function.

109 and C termini of BRCA1 are required for its centrosomal localization and that BRCA1 moves to the cen

110 of mitotic lymphoblasts or PBMCs bearing p53 centrosomal localization clearly discriminated among hea

111 isoforms exhibit distinct and complementary centrosomal localization during the cell cycle.

112 to the first quartet cells does not occur if centrosomal localization is bypassed.

113 riched at the centrosome in neurons, and the centrosomal localization is critical for Cdc20-dependent

114 Centrosomal localization is observed in diverse cell typ

115 ese results provide strong evidence that the centrosomal localization of CK1delta is required for Wnt

116 complex with CUL7 and regulate the level and centrosomal localization of CUL7, respectively.

117 the level of CCDC8 that is required for the centrosomal localization of CUL7.

118 , Arl2 regulates dynein function and in turn centrosomal localization of D-TACC and Msps.

119 pd2 mutants unable to bind Fzr, we show that centrosomal localization of Fzr is essential for optimal

120 The centrosomal localization of GRK5 is observed predominant

121 sition requires a functional centrosome, and centrosomal localization of numerous proteins, including

122 artic acid phosphomimetic (S490D) results in centrosomal localization of occludin and increases cell

123 ow that phosphorylation is required only for centrosomal localization of p150(Glued) and does not aff

124 variant, Leu607Phe, influenced the extent of centrosomal localization of pericentriolar material 1 (P

125 ediated by a 20 amino acid domain termed the centrosomal localization sequence (CLS), and expression

126 CK1delta catalytic activity and centrosomal localization signal (CLS) are required to re

127 Here we identify a modular centrosomal localization signal (CLS) localizing cyclin

128 Deletion analysis mapped the centrosomal localization signal (CLS) of CK1delta to its

129 microtubule stabilization causes an aberrant centrosomal localization, leading to misplaced axonal ou

130 ntriolar satellites normally restricts their centrosomal localization.

131 ated multimerization, is essential for DVL's centrosomal localization.

132 Both arrestins co-localized with the centrosomal marker gamma-tubulin during interphase and m

133 es involved in constructing neuronal and non-centrosomal microtubule arrays and in segregating chromo

134 Non-centrosomal microtubule arrays assemble in differentiate

135 NOCA-1 contributes to the assembly of non-centrosomal microtubule arrays in multiple tissues.

136 , we investigate the organization of the non-centrosomal microtubule arrays present in the epidermis

137 separation but, surprisingly, did not rescue centrosomal microtubule assembly and microtubule dynamic

138 pendent Aurora B pathway activation promotes centrosomal microtubule assembly and produces aberrant a

139 Second, ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent

140 Our data indicate that, through increased centrosomal microtubule nucleation, centrosome amplifica

141 size, and we recently found evidence for non-centrosomal microtubule nucleation.

142 oadly, illuminates mechanisms regulating non-centrosomal microtubule nucleation.

143 microtubule cytoskeleton that grows from non-centrosomal microtubule organising centres (ncMTOCs) alo

144 Non-centrosomal microtubule organizing centers (MTOCs) direc

145 solely by repetitive "search and capture" of centrosomal microtubule plus ends.

146 lizes with Hice1, a previously characterized centrosomal microtubule-binding protein, at the spindle

147 -Tog is required to produce or maintain long centrosomal microtubules after nuclear-envelope breakdow

148 When kinetochore capture of centrosomal microtubules is not used, the polar ends of

149 Hence, we propose that non-centrosomal microtubules organized by epidermal junction

150 The finding of inequality in the centrosomal microtubules revealed by these small molecul

151 iated by the plus-end kinesin KIF16B and non-centrosomal microtubules, and its delivery to the apical

152 Our interpretation is that capture of centrosomal microtubules-when deployed-is limited to ear

153 ation signal, the factors that regulate Mps1 centrosomal Mps1 are unknown.

154 y of centrioles by controlling the levels of centrosomal Mps1 through the Cdk2-regulated Mps1 degrada

155 sent the first theoretical model for the non-centrosomal MT cytoskeleton in Drosophila oocytes, in wh

156 MT organizing center, the regulation of non-centrosomal MT polarity is poorly understood.

157 Here, we use the robust loss of centrosomal MTOC activity in the epidermis to identify t

158 regulation of these complexes drives loss of centrosomal MTOC activity.

159 is for this mitochondrial MTOC and other non-centrosomal MTOCs has not been discerned.

160 ation of MT assembly and organization of non-centrosomal MTOCs.

161 Although centrosomal MTs are organized with plus-ends away from t

162 ule, reveal that the anchoring of apical non-centrosomal MTs at apical junctions is polarized, observ

163 Our data indicate that centrosomal MTs complement Golgi self-organization for p

164 question of whether Golgi assembly requires centrosomal MTs or can be self-organized, relying on its

165 Increased DVL levels, in contrast, sequester centrosomal NEK2 and mimic monopolar spindle defects ind

166 subunit-associated protein 2 (CDK5RAP2) and centrosomal Nek2-associated protein 1 (C-NAP1), two prot

167 yndromes with mutations in genes that encode centrosomal or intraflagella transport proteins.

168 clude that cell confinement controls nuclear-centrosomal orientation and lumen initiation during 3D e

169 s recruitment is dependent on hSAS-6 but not centrosomal P4.1-associated protein (CPAP) and CP110.

170 ssembles in prometaphase by a combination of centrosomal pathway, in which dynamically unstable micro

171 Centrosomal PCM1 immunoreactive area was smaller in Cys7

172 We quantified centrosomal PCM1 immunoreactivity in STG glia of 81 cont

173 in vivo that DISC1 coding variants modulate centrosomal PCM1 localization, highlight a role for DISC

174 sonance energy transfer reporters shows that centrosomal PDE4D3 modulated a dynamic microdomain withi

175 The centrosomal pericentrin-related proteins play pivotal ro

176 IMCD3 cells induced multi-ciliated and multi-centrosomal phenotypes.

177 We previously identified the centrosomal phosphoprotein NDE1 as a negative regulator

178 AKAP9-anchored, centrosomal PKA showed a reduced activation threshold as

179 Upon mitotic entry, centrosomal Plk1 becomes more dynamic, a process that is

180 ay in interphase cells, and depletion of its centrosomal pool entails microtubule disorganization.

181 ft140-deleted collecting ducts showed normal centrosomal positioning and no misorientation of the mit

182 In the absence of either golgin, peri-centrosomal positioning of the Golgi apparatus was disru

183 Peri-centrosomal positioning of the mammalian Golgi apparatus

184 l a critical role for SDCCAG8 in controlling centrosomal properties and function, and provide insight

185 d to depletion of multiple subunits from the centrosomal proteasome.

186 ing a recently identified ciliopathy protein centrosomal protein 164 (CEP164).

187 ature centrioles (basal bodies) and requires centrosomal protein 164kDa (Cep164), a component of dist

188 unction by recruiting an additional protein, Centrosomal Protein 190 (CP190).

189 s) and recruitment of the insulator proteins Centrosomal Protein 190 kD (CP190) and Modifier of mdg4

190 The gene coding for centrosomal protein 290 (CEP290), a large multidomain pr

191 Mutations in the gene centrosomal protein 290 kDa (CEP290) cause an array of d

192 Mutations of the centrosomal protein 290 kDa (CEP290) lead to distinct cl

193 The normal cellular level of centrosomal protein 4.1-associated protein (CPAP), achie

194 Centrosomal protein 4.1-associated protein (CPAP), centr

195 CPAP (centrosomal protein 4.1-associated protein) was previous

196 Centrosomal protein 55 (Cep55), which is localized to th

197 n, the membrane glycoprotein dysadherin, the centrosomal protein 68 (Cep68), and the cytoskeletal ada

198 hts the article by Shi et al that identified centrosomal protein 70 as a key mediator of breast cance

199 -1G>A and c.534delT) in CEP78, which encodes centrosomal protein 78, in six individuals of Jewish anc

200 CEP57 is a centrosomal protein and is involved in nucleating and st

201 We show that cofactor D is also a centrosomal protein and that overexpression of either th

202 es and basal bodies via interaction with the centrosomal protein CAP350 and demonstrate that CYLD mus

203 ntrioles in Drosophila embryos that lack the centrosomal protein Centrosomin (Cnn) can recruit PCM co

204 We further show that downregulation of the centrosomal protein Cep120 impairs microtubule organizat

205 The centrosomal protein Cep135 localizes to this cartwheel,

206 TBK1 binds to the centrosomal protein CEP170 and to the mitotic apparatus

207 sensor through proline hydroxylation of the centrosomal protein Cep192.

208 microcephaly- and primordial dwarfism-linked centrosomal protein CEP215 has been implicated in this p

209 the result of mutations in the gene encoding centrosomal protein CEP290.

210 In humans, loss-of-function of the cilia-centrosomal protein CEP290/NPHP6 is associated with Joub

211 The centrosomal protein CP110 is known to suppress ciliogene

212 Asl was previously reported to be a centrosomal protein essential for centrosome function.

213 Cep55 is a relatively novel member of the centrosomal protein family.

214 ALMS1 encodes a centrosomal protein implicated in the assembly and maint

215 motifs of TRMs are found in CAP350, a human centrosomal protein interacting with FOP, and the C-term

216 er region of the CEP72 gene, which encodes a centrosomal protein involved in microtubule formation, h

217 entrosomin (cnn), an essential gene encoding centrosomal protein isoforms required during syncytial d

218 .226C>T (p.Arg76( *)), in KIZ, which encodes centrosomal protein kizuna.

219 somal protein 4.1-associated protein (CPAP), centrosomal protein of 152 kDa (CEP152), and centrobin a

220 oteins, Modifier of (mdg4)67.2 (Mod67.2) and Centrosomal Protein of 190kDa (CP190).

221 e/threonine kinase, Aurora A (AurA), and the centrosomal protein of 192 kDa (Cep192)/spindle defectiv

222 in rat brain-11A, Ras-like in rat brain-8A, centrosomal protein of 290 kDa, pericentriolar material

223 ts in human pericentrin (PCNT), encoding the centrosomal protein pericentrin, cause a form of osteody

224 Here, we identify Cep120, a centrosomal protein preferentially expressed in neural p

225 Pericentrin is a critical centrosomal protein required for organizing pericentriol

226 has a mutation in KIAA0586, which encodes a centrosomal protein required for the formation of primar

227 yeast two-hybrid screening, we identify the centrosomal protein RSA-2 as a SYS-1 binding partner and

228 identified mutations in a gene encoding the centrosomal protein SDCCAG8 as causing NPHP type 10 in h

229 CEP63 is a centrosomal protein that facilitates centriole duplicati

230 by the protein PCM1, that are implicated in centrosomal protein trafficking.

231 Ninein (Nin) is a centrosomal protein whose gene is mutated in Seckel synd

232 ding the first evidence linking a structural centrosomal protein with DNA damage signaling.

233 hat mutations in CSPP1, which encodes a core centrosomal protein, are disease causing on the basis of

234 ns, which share similarity with FOP, a human centrosomal protein, are essential for microtubule organ

235 Mutations in CDK5RAP2, which encodes a centrosomal protein, cause autosomal recessive primary m

236 The centrosomal protein, CDK5RAP2, is mutated in primary mic

237 e mutations in CEP41, which encodes a 41-kDa centrosomal protein.

238 tial functional link between apoptosis and a centrosomal protein.

239 influence of DISC1 genotype extends to other centrosomal proteins and DISC1 binding partners remains

240 ) in muscle cells due to the accumulation of centrosomal proteins and microtubule (MT) nucleation act

241 We used centrosomal proteins as molecular markers in cultured mo

242 Mutations in several genes encoding centrosomal proteins dramatically decrease the size of t

243 Our results expand the list of centrosomal proteins implicated in human ciliopathies.

244 Our data further support for the role of centrosomal proteins in cortical development and suggest

245 tubule organization and unexpected roles for centrosomal proteins in epidermal function.

246 melanogaster spermiogenesis, the quantity of centrosomal proteins is dramatically reduced; for exampl

247 from the other events and to determine that centrosomal proteins lead the reorganization hierarchy.

248 How centrosome removal or perturbations of centrosomal proteins leads to G1 arrest in untransformed

249 Down-regulation of the centrosomal proteins Ninein and adenomatous polyposis co

250 on-induced autophagosome biogenesis, but how centrosomal proteins regulate GABARAP localization is un

251 Thus, Talpid3 is one of a growing number of centrosomal proteins that affect both ciliogenesis and H

252 this paper, we identify a specific subset of centrosomal proteins that are recruited to the cell cort

253 specifically interacts with CP110 and Cep97, centrosomal proteins that play a role in regulating cent

254 These include Lis1 and Ndel1, which are centrosomal proteins that regulate microtubule organizat

255 gesting that Mps1 phosphorylates a subset of centrosomal proteins to drive the assembly of new centri

256 by the asymmetric inheritance of peripheral centrosomal proteins when centrioles separate and migrat

257 Redistribution of centrosomal proteins, conditional on differentiation, wa

258 eractions of INPP5E with several ciliary and centrosomal proteins, including a recently identified ci

259 on (BioID) method [13, 14], we found several centrosomal proteins, including Akap450, Pcm1, and Peric

260 The relocalization of centrosomal proteins, including Pericentrin, Pcm1, and g

261 y of kinesin and that Akap450, but not other centrosomal proteins, is required for MT nucleation from

262 We show that, similar to many centrosomal proteins, MeCP2 deficiency causes aberrant s

263 ic mutations in genes coding for a subset of centrosomal proteins.

264 entriolar satellites, which are comprised of centrosomal proteins.

265 mal and mitotic dynamics by interacting with centrosomal proteins.

266 KIAA0586 was identified in the human centrosomal proteome and, using an antibody against chic

267 f centrosomes from cells' ends, we show that centrosomal proximity is predictive of the placement of

268 es Evi5 to centriolar appendages to turn off centrosomal Rab11 activity.

269 Moreover, centriolin depletion displaces the centrosomal Rab11 GAP, Evi5, and increases mother-centri

270 ated Rab11; depletion of Evi5 also increases centrosomal Rab11.

271 stream vesicular transport events leading to centrosomal Rab8 activation and ciliary membrane formati

272 show that TRAPP II subunits colocalize with centrosomal Rabin8 and are required for Rabin8 preciliar

273 in RNAs or a loss-of-function allele impairs centrosomal recruitment of gamma-tubulin and pericentrin

274 n1, but again not hODF2, also contributed to centrosomal recruitment of ninein and primary cilia form

275 fication in parallel to previously described centrosomal reduction [7].

276 th Rab5a and PKC dynamically interact at the centrosomal region of migrating cells, and PKC-mediated

277 d to MT-associated protein 1B (MAP1B) in the centrosomal region, where it maintained MT acetylation.

278 limb mediates proteolytic degradation of the centrosomal regulatory kinase Plk4.

279 under all circumstances, and conditional on centrosomal reorganization.

280 We previously reported that centrosomal reorientation and microtubule polarization d

281 ng and phosphorylation of BRCA1 enhanced its centrosomal retention and regulation of centrosome ampli

282 with Aurora A kinase inhibitor, suggesting a centrosomal role for the Aurora A-dependent complex of c

283 l of linker proteins, an event necessary for centrosomal separation and proper formation of the mitot

284 n of loose centrosomal linker and subsequent centrosomal separation.

285 reorganize and move from centrosomal to non-centrosomal sites at the RB-sperm boundary whereas actin

286 MTOC and MTOC function is reassigned to non-centrosomal sites such as the apical membrane in epithel

287 both centrosomal (spindle pole body) and non-centrosomal sites.

288 o recruits the gamma-tubulin complex to both centrosomal (spindle pole body) and non-centrosomal site

289 l differentiation by switching Ninein from a centrosomal splice form in NPCs to a non-centrosomal iso

290 newly synthesized ILK protein colocalized to centrosomal structures and was required for correct cent

291 ial for optimal APC/C activation towards its centrosomal substrate Aurora A.

292 on cycle 20-anaphase promoting complex) as a centrosomal substrate of CaMKIIbeta.

293 wn and unique substrates, including multiple centrosomal substrates for Syk, were identified, support

294 Based on our observations of centrosomal SYS-1 dynamics, we discuss the possibility t

295 We conclude that centrosomal targeting of SYS-1 promotes its degradation

296 The centrosomal targeting sequence of RHAMM was required for

297 p115 and gamma-tubulin and functioned in its centrosomal targeting.

298 necessary and sufficient to mediate HsSAS-6 centrosomal targeting.

299 this process was significantly delayed upon centrosomal tethering of Plk1.

300 intact microtubules reorganize and move from centrosomal to non-centrosomal sites at the RB-sperm bou