ライフサイエンスコーパス: climbing fibre

1 olive and therefore may be correlated across climbing fibres.

2 uration of electrically controlled bursts in climbing fibres.

3 s, and excitatory collaterals from mossy and climbing fibres.

4 nation of relative strengths among competing climbing fibres.

5 f conditioned eyelid responses by activating climbing fibres.

6 reover, developmental elimination of surplus climbing fibres--a model for activity-dependent synaptic

7 Climbing fibre activity elicited by an unconditioned sti

8 These results, combined with analysis of climbing fibre activity in a computer simulation of the

9 Several anatomical reports suggest that climbing fibre afferents contact Golgi cells, and electr

10 of cerebellar learning theories asserts that climbing fibre afferents from the inferior olive provide

11 ht to be a key feature of how inferior olive climbing fibre afferents make their vital contribution t

12 rtant because non-synchronous stimulation of climbing fibres and peripheral afferents failed to alter

13 ast a proportion of the fibres that activate climbing fibres are corticospinal fibres.

14 system, suggest that transient inhibition of climbing fibres below their background level is the sign

15 rkinje cells remained multiply innervated by climbing fibres beyond the normal developmental time fra

16 Golgi cell peripheral responses mediated by climbing fibres can potentially contribute to cerebellar

17 Pairing PF1 stimulation with climbing fibre (CF) activation at 1 Hz for 5 min produce

18 EPSCs from individual climbing fibre (CF) inputs were identified on the basis

19 4) to investigate changes in transmission in climbing fibre (CF) pathways during motor learning.

20 Reflex evoked climbing fibre (CF) responses (33 units) were recorded a

21 MAGL prolonged DSE at parallel fibre (PF) or climbing fibre (CF) to Purkinje cell (PC) synapses.

22 e imaged post-lesion sprouting of cerebellar climbing fibres (CFs) in mice using in vivo time-lapse m

23 hen they receive synaptic inputs solely from climbing fibres (CFs).

24 In vivo and in vitro data suggest that climbing fibre collateral excitation is weak in adult mi

25 We therefore examined climbing fibre collateral input to large premotor CbN ce

26 res in the cerebellar cortex, implicates the climbing fibre collateral pathway in early postnatal dev

27 Activating climbing fibre collaterals evoked well-timed increases i

28 The convergence of climbing fibre collaterals onto CbN cells decreases from

29 with intracellular D-aspartate prolonged the climbing fibre EPSC.

30 g fibre-Purkinje cell synaptic density, more climbing fibres extending to the outer portion of the mo

31 rts of the contralateral motor cortex evoked climbing fibre field potentials at the same cerebellar r

32 Climbing fibre field potentials evoked by low intensity

33 Normally, climbing fibres form synapses mainly on the thick, proxi

34 AG to cerebellar cortex, which terminates as climbing fibres in lateral vermal lobule VIII (pyramis).

35 ptic strength coinciding with the pruning of climbing fibres in the cerebellar cortex, implicates the

36 that attributes the persistence of multiple climbing fibre innervation to an obscured discrimination

37 eneration of proximal dendrites, the site of climbing fibre innervation, most pronounced.

38 hen painful signals are involved, and as the climbing fibre input to zone C3 is extremely responsive

39 into question the widely held view that the climbing-fibre input is an 'all-or-none' event.

40 r Purkinje cells, a single activation of the climbing-fibre input markedly potentiates mGluR-mediated

41 lex spike (CS) caused in Purkinje cells by a climbing-fibre input.

42 grating diverse afferent signals to generate climbing fibre inputs to the cerebellar cortex.

43 grating diverse afferent signals to generate climbing fibre inputs to the cerebellar cortex.

44 rning relies on movement errors signalled by climbing-fibre inputs to cause long-term depression of s

45 ggest that during learning, longer bursts in climbing fibres lead to longer-duration CS responses in

46 We reinvestigated this issue and, given that climbing fibres mediate synaptic plasticity in the cereb

47 that the conduction velocities of cerebellar climbing fibre (olivocerebellar) axons are tuned accordi

48 tive stimulation of peripheral afferents and climbing fibres on Golgi cell responses.

49 Cerebellar climbing fibres originate in the inferior olive (IO).

50 ations for the regulation of transmission in climbing fibre pathways during voluntary movements and m

51 tory synaptic transmission from parallel and climbing fibres (PFs, CFs) to PCs in acute cerebellar sl

52 o show that blocking inhibitory input to the climbing fibres prevents extinction of the conditioned r

53 This suggests that climbing fibres projecting to different parts of the cer

54 ate significant gating of cutaneous input to climbing fibres projecting to the C1, C2 and C3 zones du

55 k-dependent modulation of cutaneous input to climbing fibres projecting to the C1, C2 and C3 zones in

56 The activation of climbing fibres projecting to the posterior lobe cerebel

57 The climbing fibre projection from the motor cortex to the c

58 The inferior olive climbing fibre projection to two somatotopically corresp

59 tive motor signals to the cerebellum via the climbing fibre projection, which sends collaterals direc

60 Climbing fibres provide one of the major excitatory inpu

61 r TrkB plays a role in the maturation of the climbing fibre-Purkinje cell (CF-PC) synapse.

62 tionship between the altered distribution of climbing fibre-Purkinje cell connections and tremor.

63 jor excitatory inputs to Purkinje cells, and climbing fibre-Purkinje cell connections are essential f

64 These findings suggest that abnormal climbing fibre-Purkinje cell connections could be of imp

65 ter type 2 immunohistochemistry, we labelled climbing fibre-Purkinje cell synapses of 12 essential tr

66 The distribution of climbing fibre-Purkinje cell synapses on Purkinje cell d

67 ter portion of the molecular layer, and more climbing fibre-Purkinje cell synapses on the thin Purkin

68 ential tremor, the increased distribution of climbing fibre-Purkinje cell synapses on the thin Purkin

69 s to examine the density and distribution of climbing fibre-Purkinje cell synapses using post-mortem

70 nge during frequency-dependent depression at climbing fibre-Purkinje cell synaptic connections.

71 ntrols, essential tremor cases had decreased climbing fibre-Purkinje cell synaptic density, more clim

72 We have re-evaluated this issue using the climbing fibre reflex.

73 ntial shape and may contribute to the unique climbing fibre response.

74 By comparison of latencies of climbing fibre responses evoked from different locations

75 the dorsal column nuclei did not affect the climbing fibre responses evoked in crus II, and produced

76 Climbing fibre responses resulting from low intensity (n

77 Large climbing fibre responses were evoked in parts of crus II

78 Corticofugal evoked climbing fibre responses were mapped across the cerebell

79 This implies that the climbing fibre responses were not exclusively mediated v

80 Climbing fibre responses with similar form and cerebella

81 nje cells were identified by the presence of climbing fibre responses.

82 brainstem stimulation that did not activate climbing fibres, responses were not depressed.

83 Additionally, however, these climbing fibres send collaterals to the cerebellar nucle

84 Here, we show that inhibition of climbing fibres serves as a teaching signal for extincti

85 precision is not an important element of the climbing fibre signal.

86 While it is well established that climbing fibre signals are important for motor coordinat

87 central role in control of olivo-cerebellar climbing fibre signals.

88 In control experiments using either the same climbing fibre stimulation alone, or peripheral afferent

89 The results confirm that climbing fibre stimulation depresses Golgi cell firing a

90 MDA receptor-mediated EPSCs can be evoked by climbing fibre stimulation, and appear to be mediated ma

91 Theories concerning the role of the climbing fibre system in motor learning, as opposed to t

92 Soma-to-dendrite translocation of climbing fibre terminals was unaffected.

93 e cells are initially innervated by multiple climbing fibres that are subsequently culled to assume t

94 iring and after conjunctive stimulation with climbing fibres these were significantly reduced.

95 cells that had axons that branched to supply climbing fibres to both regions of the zone.

96 Where overlaps occurred, cells that provided climbing fibres to one or the other region were intermin

97 stral levels of DAO, the territory providing climbing fibres to the anterior lobe was centred more la

98 r olivary neurons transmit their signals via climbing fibres, which powerfully excite Purkinje cells,

99 ts thus show that conjunctive stimulation of climbing fibres with other inputs to Golgi cells can ind