ライフサイエンスコーパス: coding

1 ed on stimulus features) interact in sensory coding.

2 mpal representations and support prospective coding.

3 ls of the neural instantiation of predictive coding.

4 in, and they can powerfully influence neural coding.

5 inactivating mPFC attenuated CA1 prospective coding.

6 tences on both speech recognition and neural coding.

7 structure, which in turn improves population-coding abilities.

8 ought to be biophysical nuisances can confer coding advantages to neural systems.

9 subjects failed to identify any large-effect coding alleles of lower frequency influencing the risk o

10 In silico analysis indicated that coding amino acids encoded at these three SNP sites were

11 strate their active participation in spatial coding and contextual representation.

12 UTRs, and introns), while being depleted in coding and intergenic regions, and these findings may ha

13 The heavily mutated landscape of coding and non-coding mutations in cutaneous melanoma re

14 were G:C to A:T, their distribution between coding and non-coding regions and synonymous-to-non-syno

15 For somatic point mutations in coding and non-coding regions of the genome, we propose

16 Thus, the ASCC3 gene expresses both coding and non-coding transcript isoforms with opposite

17 We describe new mechanisms of coding and noncoding alteration and identify ten recurre

18 lts indicate that germline mutations in both coding and noncoding regions throughout the BAP1 gene ca

19 g to take shape, but it's clear that in both coding and noncoding RNAs, dynamic modifications represe

20 As suggesting that the interplay between the coding and noncoding worlds represents a fundamental pri

21 ons with predicted effects including protein coding and nonsense-mediated decay.

22 We sequenced coding and regulatory elements for 608 genes potentially

23 , which could lead to alterations in sensory coding and taste-related behaviors.

24 lective accumulation of rare variants in the coding and the UTR sequences within the genes of suicide

25 on in stress granules correlates with longer coding and UTR regions and poor translatability.

26 15% redundant indels in dbSNP, 29% in COSMIC coding, and 13% in COSMIC noncoding datasets across all

27 undant indels in dbSNP; 2,118 more in COSMIC coding, and 553 more in COSMIC noncoding indel dataset i

28 t frameworks like embodied cognition, common coding, and sensorimotor contingency that do not sequent

29 al structure for emotional learning, valence coding, and stress, can shape sensory input to the brain

30 The non-coding ASCC3 isoform counteracts the function of the pro

31 otably, this includes a shift from a protein-coding ASCC3 mRNA to a shorter ALE isoform of which the

32 infer the biological functions of those non-coding associated genes based on their co-expressed prot

33 We show that the introgression of Bcl-xL-coding Bcl2l1 transgene into NF-kappaB signalling-defici

34 by out-of-field excitation enhances temporal coding by expanding the range of theta phase precession.

35 ens concerns the acute regulation of sensory coding by the auditory cortex as demonstrated by electro

36 This may compromise information coding capacity and thereby motor processing.

37 olfactory sensory neurons increases the odor-coding capacity, providing a means of efficient sensory

38 A evidence (72%) while only 20% of them have coding capacity.

39 n with data; development of a coding scheme; coding, charting and cross comparison of data; interpret

40 ffects in the clinical interpretation of non-coding chromosomal rearrangements.

41 The coding-complete genome of the new virus, named Kanyawara

42 ribution of NMDAR hypofunction to predictive coding deficits in schizophrenia.

43 nvirus genome harbors 465 genes, with a high coding density.

44 been suggested that social prediction errors-coding discrepancies between the predicted and actual ou

45 ion study (GWAS) risk variants reside in non-coding DNA sequences.

46 Non-coding DNA variants are suspected to account for a subst

47 Here, we develop a statistically founded non-coding driver-detection method, ncdDetect, which include

48 thogonal AP firing, which may support sparse coding during hippocampal information processing.

49 n of NMDARs causes dysfunction in predictive coding during vocalization in a manner similar to the dy

50 he NMDAR antagonist, ketamine, on predictive coding during vocalization in healthy volunteers and com

51 udies, however, have shown that neural value coding dynamically adapts to the statistics of the recen

52 Thus, non-coding elements responsive to extracellular cues unique

53 ative splicing (AS) that occurs at the final coding exon (exon 47) of the Cav2.1 voltage-gated calciu

54 ce ( approximately 39%) with relatively long coding exons and few coding introns.

55 a majority of miR-122 binding on 3' UTRs and coding exons followed by extensive binding to other geni

56 Due to titin's large size (363 coding exons), current web applications are unable to ma

57 ults and highlight the importance of neurons coding feature values for parallel learning of values fo

58 terpenes express, at very high levels, genes coding for a unique pair of ferredoxin and ferredoxin-NA

59 the supply of full-length, functional mRNAs coding for a variety of proteins essential to cell growt

60 capsids, while also containing capacity for coding for a viral protein.

61 it is not surprising that mutations in genes coding for components of the ubiquitin system cause immu

62 ce the expression of CAP-D2 and CAP-D3 genes coding for corresponding condensin I and II subunits, re

63 inants, the strain over-expressing zwf gene (coding for glucose-6-phosphate dehydrogenase), WX-zwf, p

64 However, the gene coding for hexokinase-2, which catalyzes the first step

65 The gene coding for middle T antigen (MT) is the murine polyomavi

66 hat under favourable growth conditions mRNAs coding for proteins involved in the translation machiner

67 missense de novo mutation in GRIN2B(p.P553T) coding for the GluN2B subunit of NMDAR.

68 hat these gram-negative bacteria carry genes coding for thiol-disulfide oxidoreductases in their geno

69 recently emerging features that distinguish coding from noncoding transcription and discuss how thes

70 Rare missense coding FYCO1 variants were present in 11.3% of sIBM pati

71 We also report a novel protein-coding gene evolution-D6Ertd527e-in which an MT LTR prov

72 he lncRNA, its binding protein MYH9, and the coding gene FOXE1 underlies the predisposition to PTC tr

73 the neighboring transcription of the protein-coding gene SLC3A2 in cis by binding the Mediator comple

74 encompassing the 3' end of the delta protein-coding gene.

75 The four mt genomes contain 12 protein-coding genes (viz.

76 long inverted repeat with one or two protein-coding genes and conserved non-coding regions putatively

77 on of extracellular matrix remodeling-enzyme coding genes and increased levels of some of their inhib

78 lymerase II (pol II) transcribes all protein-coding genes and many noncoding RNAs.

79 bio-annotations of both high-quality protein coding genes and ncRNAs, we considered the associations

80 nduced widespread hypomethylation of protein-coding genes and transposable elements (TEs), preferenti

81 functional interrogation of not only protein-coding genes but also noncoding DNA.

82 is increased the number of annotated protein-coding genes by 14% (from 3612 to 4113), compared to usi

83 historical focus on transcription of protein-coding genes has left the roles of Pol III in organismal

84 structed 48 359 transcript models of protein-coding genes in eleven tissues.

85 cterization that has been applied to protein-coding genes in large part because there has not been a

86 Transcriptional regulation of protein-coding genes is a major mechanism of controlling cellula

87 s adaptability, as many mutations in protein-coding genes occurred during the outbreak.

88 and provide lists for each strain of protein-coding genes that acquired sequence variations that caus

89 ts shifts the steady-state output of protein-coding genes toward circular RNAs.

90 ximately one-quarter of A. baumannii protein coding genes were differentially expressed in vivo compa

91 mRNAs, which consisted of 17 unique protein-coding genes yielding a 17-gene signature.

92 this study, we highlight that together with coding genes, (antisense) long non-coding RNAs are dereg

93 Each mitogenome contained 13 protein coding genes, 2 ribosomal RNA and 22 transfer RNA genes,

94 expressed, annotated genes, 78 novel protein-coding genes, and 567 putative long intergenic noncoding

95 al information for almost 80 million protein-coding genes, including a comprehensive set of general a

96 l proportion of the reads mapping to protein-coding genes, long ncRNAs, and antisense RNAs were due t

97 ly through eliminating non-essential protein coding genes, rDNA and LTRs.

98 ms of number of datasets and overall protein coding genes, while its analysis tools have been extende

99 8) in 1,354 significantly identified protein-coding genes, with skipped exon and alternative first ex

100 e observed for all but 265 annotated protein-coding genes.

101 litates transcription termination at protein-coding genes.

102 ed genes based on their co-expressed protein-coding genes.

103 s), preferentially those adjacent to protein-coding genes.

104 and even supporting evolution of new protein-coding genes.

105 RNAs" to conventional mRNAs coded by protein-coding genes.

106 exons is found to be extensive among protein coding genes: 23.5%-59.3% (95% confidence interval) of h

107 and the mechanisms by which variation in non-coding genetic sequences contributes to disease.

108 urons helps functional interpretation of non-coding genetic variants associated with these diseases.

109 improve the functional interpretation of non-coding genetic variants in the molecular genetic dissect

110 predict pathogenicity of synonymous and non-coding genetic variants, and provide a web server of pre

111 and extends potential involvement of the non-coding genome in its pathogenesis.

112 entified sequence variants, localized to non-coding genomic regions, associated with kidney function.

113 Such adaptive coding has been linked to midbrain dopamine neurons in n

114 However, as evidence for labeled-line coding has mounted, studies promoting alternative itch-c

115 activity on spatial learning and hippocampal coding in a plus maze task that requires both structures

116 ontal cortex are involved in vibrotactile WM coding in humans.

117 correlations can limit efficient information coding in neuronal populations.

118 igh-dimensional rsc structure on information coding in the neuronal ensembles.

119 Our results support the argument that odor coding in the olfactory bulb depends on the recent histo

120 model serves as an example of non-monotonic coding in the spinal cord and better explains observatio

121 an provide powerful insights into population coding in touch.

122 nonsense and three missense changes) and two coding indels, one of them found in two unrelated patien

123 %) with relatively long coding exons and few coding introns.

124 The two primary theories of peripheral pitch coding involve stimulus-driven spike timing, or phase lo

125 We show that the spike burst coding is size and speed-tuned and is selectively modula

126 form counteracts the function of the protein-coding isoform, indicating crosstalk between them.

127 approach identified two long intergenic non-coding(linc)RNAs, lincRNA-Cox2 and lincRNA-AK170409, tha

128 This fundamental sensory coding mechanism facilitates spatial discrimination and

129 des a comprehensive picture of the olfactory coding mechanisms of bed bugs that will ultimately contr

130 As but have also recently been identified in coding (messenger) RNAs as well.

131 sory representation, but also its underlying coding metric.

132 peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root ganglia (D

133 onse patterns hypothesized by the predictive coding model, whereas posterior insula encoded stimulus

134 may be closely related to mixture of sparse coding models.

135 Over 4 million coding mutations are described in v78 (September 2016),

136 The extent to which non-coding mutations contribute to Mendelian disease is a ma

137 heavily mutated landscape of coding and non-coding mutations in cutaneous melanoma resolved novel si

138 tification of causal variants has discovered coding mutations in some AD-associated genes, a lot of r

139 individuals with inherited loss-of-function coding mutations in TERT or poly(A)-specific ribonucleas

140 In summary, WES identified sixty-five coding mutations including forty-three mutations not rep

141 responsible for inhibiting expression of the coding NDC80 mRNA isoform.

142 pair of the genome that may be transcribed: coding, noncoding, and intergenic regions, as well as re

143 t, we characterized the unique expression of coding, noncoding, and intergenic RNAs in the mature mou

144 of different transcript types (i.e., protein coding, noncoding, and pseudogenes) was associated with

145 ciation was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293,

146 educes the peripheral temporal resolution in coding odor stimuli and allows for robust olfactory beha

147 rtical responses, adult patterns in cortical coding of binaural timing cues were measured.

148 tional separation reveals action-independent coding of declarative memory-based familiarity and confi

149 uning of neural activity and impaired sparse coding of information, and deficits in the temporal tuni

150 Coding of itch versus pain has been heatedly debated for

151 Fine-grained coding of location is thought to depend on the hippocamp

152 re, we demonstrate sexually dimorphic neural coding of odorants by olfactory sensory neurons (OSNs),

153 e RF, a property thought to underlie optimal coding of sensory information and important perceptual f

154 In contrast, coding of the value of the second offer is entirely deci

155 few studies have addressed the issue of odor coding on top of continuous odorous backgrounds.

156 ome sequencing did not reveal any pathogenic coding or canonical splicing mutations within the linkag

157 ating the relative rate parameter of the non-coding partition in a heterochronous dataset, MCMC integ

158 Here, the authors show that a non-coding polymorphic regulatory element at 7p14.3 may pred

159 ICANCE STATEMENT The integrin beta3 Leu33Pro coding polymorphism has been associated with autism spec

160 The ITGB3 coding polymorphism Leu33Pro (rs5918, Pl(A2)) produces h

161 ntrachromosomal rearrangements fusing the 3' coding portion of the EGFR gene to the 5'-UTR of the SEC

162 pected large proportion of NATs with protein coding potential, as estimated by ribosome release score

163 Thus, we hypothesize that the coding principle of facial features in the middle patch

164 Theories like predictive coding propose that lower-order brain areas compare thei

165 t extends 13 nucleotides into the N-terminal coding region and, when a mRNA structure overlaps or par

166 LARP4 mRNA contains a translation-dependent, coding region determinant (CRD) of instability that limi

167 Inserting the ER-targeting sequence coding region of NA into different 5' UTRs confirmed tha

168 ition gene, while the analysis of the entire coding region of the FANCM gene in familial index cases

169 ion of any intergenic or deeply intronic non-coding region, indicating that proximal regulatory seque

170 in RNA (shRNA) targeted against the reporter coding region, we have characterized the dynamics of the

171 le small open reading frames upstream of the coding region.

172 and a shorter construct containing only the coding region.

173 RNAs with 3' ends within protein-coding regions and introns were less stable than mRNAs t

174 und evidence that this mechanism of using 5' coding regions and particular RBPs to achieve gene-speci

175 T, their distribution between coding and non-coding regions and synonymous-to-non-synonymous mutation

176 ed a greater contribution of SNPs in protein-coding regions and within 3'-UTR regions of genes.

177 However, because protein-coding regions are under high selective constraints, the

178 The sizes of non-coding regions in the Longidoridae nematodes were very s

179 odel specifically studies the effects of non-coding regions of DNA (in this case, CpG sites) on mappi

180 or somatic point mutations in coding and non-coding regions of the genome, we propose CScape, an inte

181 ect, pathogenic or neutral, of indels in non-coding regions of the human genome.

182 potential pathogenic impact of indels in non-coding regions of the human genome.

183 r two protein-coding genes and conserved non-coding regions putatively involved in replication and/or

184 e show that editing levels in non-repetitive coding regions vary more between tissues than editing le

185 outside of functionally well-defined protein coding regions.

186 tely predict all or even most of the protein-coding regions.

187 mutations occur at similar frequencies as in coding regions.

188 introduced premature termination codons into coding regions.

189 terious genomic variation, especially in non-coding regulatory regions of human genome.

190 whole-exome sequencing, and variants in non-coding regulatory regions.

191 ngs show the importance of investigating non-coding regulatory variants when determining risk factors

192 In striking contrast, spatial and object coding remained intact.

193 We identified a rodent-specific long non-coding RNA (lncRNA) linc1281, hereafter Ephemeron (Eprn)

194 with the expression of an antisense long non-coding RNA (lncRNA) that has previously been shown to pr

195 ZNF750 promoted the expression of a long non-coding RNA (TINCR), which mediated both cancer-inhibitio

196 Furthermore, a long non-coding RNA antisense to FOXM1 (FOXM1-AS) promotes the in

197 ps among RNAs for mutation detection and non-coding RNA classification.

198 tional profiling, we found that the long non-coding RNA MIR100HG and two embedded microRNAs, miR-100

199 calized the Bcl11b enhancer identified a non-coding RNA named ThymoD (thymocyte differentiation facto

200 tumor suppressor gene PTEN and the long non-coding RNA NEAT1.

201 the complex, underscoring its role as a non-coding RNA processing/degradation unit.

202 a chromatin environment that influences non-coding RNA production, DNA methylation, and transcriptio

203 MicroRNAs (miRNAs) are small non-coding RNA species that have been shown to have roles in

204 racterization of a novel long intergenic non-coding RNA with MyoD-regulated and skeletal muscle-restr

205 genomic output is transcribed as non-protein coding RNA, <2% of the protein data bank structures comp

206 xpresses seven small nuclear uracil-rich non-coding RNAs (called HSURs) in latently infected cells.

207 To date, Y chromosome-linked long non-coding RNAs (lncRNAs) are poorly characterized and the p

208 To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered thro

209 transcription of a wide variety of long non-coding RNAs (lncRNAs) in the genomes of several organism

210 New evidence indicates that long non-coding RNAs (lncRNAs) play crucial roles in epigenetic a

211 Although long non-coding RNAs (lncRNAs) regulate various cellular events,

212 have vastly expanded the catalog of long non-coding RNAs (lncRNAs) with varying evolutionary conserva

213 small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs), undergo trans-splicing and polyad

214 isproportionately present in human long, non-coding RNAs (lncRNAs).

215 r, we identify multiple neurite-targeted non-coding RNAs and RNA-binding proteins with potential regu

216 ther with coding genes, (antisense) long non-coding RNAs are deregulated in skin tissue of systemic s

217 might be attributed to the hypothetical non-coding RNAs embedded within the gene.

218 PIWI-interacting RNAs (piRNAs) are small non-coding RNAs essential for animal germ cell development.

219 Various families of non-coding RNAs have been identified as substrates of the co

220 raconserved regions (T-UCRs) encode long non-coding RNAs implicated in human carcinogenesis.

221 Our results suggest that non-coding RNAs play important roles in the regulatory netwo

222 utant are correlated with changes in the non-coding RNAs produced by Pol IV and Pol V.

223 In trypanosomes, all mRNAs, and non-coding RNAs such as small nucleolar RNAs (snoRNAs) and l

224 6-30-nucleotide germ line-specific small non-coding RNAs that have evolutionarily conserved function

225 MicroRNAs (miRNAs) are small, non-coding RNAs that play critical roles in the post-transcr

226 Recently, site-specific small non-coding RNAs, also termed DNA damage response RNAs (DDRNA

227 Small non-coding RNAs, in particular microRNAs (miRNAs), regulate

228 The NtcA regulon also included eight non-coding RNAs, of which Ncr1071, Syr6 and NsiR7 were exper

229 bias transcription toward coding versus non-coding RNAs.

230 for the quality control of mitochondrial non-coding RNAs.

231 f: (i) new leads for gene function, (ii) non-coding RNAs; (iii) genes, pathways and ncRNAs that are i

232 ction measures and a manualised consultation-coding scheme were used.

233 familiarisation with data; development of a coding scheme; coding, charting and cross comparison of

234 ximately 6%), and a high fraction of protein-coding sequence ( approximately 39%) with relatively lon

235 (ORF) of the target gene which truncates the coding sequence (CDS) and targets the corresponding tran

236 evolutionarily plastic both at the level of coding sequence and expression across A. thaliana access

237 However, the role of coding sequence evolution remains unresolved.

238 al start codon while the bulk of the protein-coding sequence evolved through a CAG repeat expansion.

239 portion of RNA1 5' UTR but extends into the coding sequence for nine nucleotides, thus was missed in

240 analyzed the genetic variation in the FOXP2 coding sequence in 63 chimpanzees, 11 bonobos, 48 gorill

241 Each gene has a coding sequence insertion/deletion mutation within the S

242 l II into transcriptional elongation) to the coding sequence of an active gene, ADH1, independently o

243 nce to missense variation within the protein-coding sequence of genes.

244 ion because overexpression of a noncleavable coding sequence of MYB83 significantly increased plant s

245 Two coding sequence variants in the APOL1 gene (G1 and G2) e

246 ion of an mRNA, despite carrying a canonical coding sequence, can directly cause gene repression.

247 est that in addition to allelic variation of coding sequence, the heterogenous nature of the tetraplo

248 Cryptic polyadenylation within coding sequences (CDS) triggers ribosome-associated qual

249 ity and/or translation, while changes in the coding sequences lead to mRNAs encoding distinct protein

250 nor the implications of DTU on their protein coding sequences or functions, are currently well unders

251 r have largely focused on genes, whereas non-coding sequences remain relatively unexplored.

252 Further analysis of the AraEXLB8 coding sequences showed high conservation across the Ara

253 fected by recurrent mutations disrupting non-coding sequences was similar to that affected by recurre

254 including density of ribosomal footprints on coding sequences, 5' leader ribosomal densities, distrib

255 l densities, distribution of ribosomes along coding sequences, and ribosome codon occupancies.

256 ty patterns and coverage similarities across coding sequences, and showed that they yield comparable

257 ally, Rho promotes termination at the end of coding sequences, but it can also terminate transcriptio

258 y activating transcription, altering protein-coding sequences, producing noncoding RNAs, and even sup

259 To remove rRNA and enrich coding sequences, subtractive hybridization procedures h

260 r to that affected by recurrent mutations to coding sequences.

261 create in-frame and frameshift insertions in coding sequences.

262 l tool for the genome-wide detection of AARS coding sequences.

263 rent 3' untranslated regions (3'UTRs) and/or coding sequences.

264 her, these results indicate a functional non-coding SNP in EPHA2 promoter affects PAX2 binding and re

265 te loss-of-function effects of multiple rare coding SNVs found in SCZ subjects in the GIT1 (G protein

266 This cshRNA expression system reduces the coding space required for shRNA expression by >2-fold as

267 adruplex-forming sequences (PQS) in promoter-coding strands, initiating base excision repair (BER) by

268 mounted, studies promoting alternative itch-coding strategies have emerged, complicating our underst

269 Predictive coding suggests that the brain infers the causes of its

270 approach is also suggestive in many cases of coding techniques that can approach fundamental limits i

271 s are accounted for by a model of numerosity coding that has been used to explain neural responses in

272 ntity in propagated calls relies on a neural coding that is robust to intensity changes, signals' qua

273 o the raw data were masked to study group by coding the groups until after the analyses were complete

274 the ASCC3 gene expresses both coding and non-coding transcript isoforms with opposite effects on tran

275 ental progression and tumor suppression, non-coding transcription orchestrates chromatin folding and

276 also monitored the behaviors of X-linked non-coding transcripts before and after XCI.

277 LncRNAs as well as coding transcripts share similar structural features in

278 satellite array produces a unique set of non-coding transcripts, and RNAs present at active centromer

279 d species; yet, lncRNAs slightly differ from coding transcripts.

280 of MFC reward signaling have inferred value coding upon temporally sustained activity during the per

281 ently, a novel partial loss-of-function AKT2 coding variant (p.Pro50Thr) was identified that is nearl

282 nclusion, we describe a low-frequency CYP2R1 coding variant that exerts the largest effect upon 25OHD

283 d fine-mapping analyses identified a protein-coding variant, rs4788863 in SLC16A5, that was associate

284 n the Hutterites suggest that these rare non-coding variants are likely to mediate their effects on l

285 We identified rare coding variants associated with Alzheimer's disease in a

286 wo different contexts: the prediction of non-coding variants associated with Mendelian and with compl

287 ther functional classification of HNF1A rare coding variants can inform models of diabetes risk predi

288 Here we report a compilation of coding variants from 1,055 healthy Korean individuals (K

289 mulants inhibit DA reuptake and multiple DAT coding variants have been reported in patients with neur

290 We identified 14 coding variants in 13 genes, of which 8 variants were in

291 Coding variants in the APOL1 gene are associated with ki

292 lated genetic risk factors for AD, including coding variants in the gene TREM2 (triggering receptor e

293 with human pigmentation characteristics two coding variants of TPC2, rs35264875 (encoding M484L) and

294 Among these non-coding variants, somatic insertions are among the least

295 nts were grouped by gene, as were functional coding variants.

296 analyzed and replicated genome-wide protein coding variation in a total of 8,227 individuals with T2

297 ensive assessment of the consequences of non-coding variation.

298 tivity between this region and general value coding ventromedial prefrontal cortex (vmPFC) predicted

299 ed by evolution to bias transcription toward coding versus non-coding RNAs.

300 formed based on title and then abstract, and coding was performed by 2 coders.