ライフサイエンスコーパス: commensal bacteria

1 sis and shape mucosal immunity, similarly to commensal bacteria.

2 ber of microorganisms, generally regarded as commensal bacteria.

3 ch has the unwanted side effect of depleting commensal bacteria.

4 to the HIV Env gp41 and cross-reactive with commensal bacteria.

5 pathogen colonization by suppressing related commensal bacteria.

6 technology and probed their relationship to commensal bacteria.

7 tion were largely restored in the absence of commensal bacteria.

8 thological adaptive immune cell responses to commensal bacteria.

9 ntal factors, including signals derived from commensal bacteria.

10 alterations in the composition of intestinal commensal bacteria.

11 s under conditions allowed for the growth of commensal bacteria.

12 the continuous dialogue between the host and commensal bacteria.

13 ltaneously or individually in live anaerobic commensal bacteria.

14 ide (LPS) shed from Gram-negative intestinal commensal bacteria.

15 response against luminal antigens, including commensal bacteria.

16 epletes multiple immunologically significant commensal bacteria.

17 roup, which are ubiquitous and abundant oral commensal bacteria.

18 rom uncontrolled dissemination of intestinal commensal bacteria.

19 by Enterococcus faecalis, a human intestinal commensal bacteria.

20 wth of S. Typhimurium over that of competing commensal bacteria.

21 prevented by antibiotic treatment to deplete commensal bacteria.

22 he basis of the mucus adhesion properties of commensal bacteria.

23 preferential binding sites for pathogens and commensal bacteria.

24 nted filamentous bacteria, but also by other commensal bacteria.

25 e immune system are influenced by intestinal commensal bacteria.

26 tromal factor-driven macrophage tolerance to commensal bacteria.

27 ), which prevent inflammation in response to commensal bacteria.

28 ence the composition and function of enteric commensal bacteria.

29 systemic dysbiosis of aerobic and anaerobic commensal bacteria.

30 also partially eliminate naturally existing commensal bacteria.

31 which recognizes the products of intestinal commensal bacteria.

32 t likely by enabling pathogens to outcompete commensal bacteria.

33 s disease susceptibility in mice depleted of commensal bacteria.

34 se from mouse liver, including reactivity to commensal bacteria.

35 exposed continuously to dietary antigens and commensal bacteria.

36 eyer's patches and produced IgAs reactive to commensal bacteria.

37 ith broad-spectrum antibiotics which disrupt commensal bacteria.

38 ns pallens) also impairs the survival of gut commensal bacteria.

39 onstant dialog between the immune system and commensal bacteria.

40 uired for control of CD4 T-cell responses to commensal bacteria.

41 als to the host that have been attributed to commensal bacteria.

42 Relish response to both enteropathogenic and commensal bacteria.

43 intestine is densely populated by anaerobic commensal bacteria.

44 Importantly, depletion of commensal bacteria abrogates TLR5-dependent differences

45 ucociliary clearance and overgrowth of nasal commensal bacteria accompanied by neutrophil exudation.

46 lic stress evokes significant penetration of commensal bacteria across the epithelium, which is media

47 he possible role of SIgA in the transport of commensal bacteria across the GI epithelium.

48 To preserve this niche, commensal bacteria act with the host to prevent coloniza

49 rtantly, RNA species derived from intestinal commensal bacteria activate the RIG-I-MAVS pathway to in

50 Our results clarify how commensal bacteria affect hepcidin expression and reveal

51 nt of cancer, but it remains unclear whether commensal bacteria affect inflammation in the sterile tu

52 , underpins competition among pathogenic and commensal bacteria alike.

53 t11 expression were observed in mice lacking commensal bacteria, an effect that was reversed by conve

54 ectrum, leading to indiscriminate killing of commensal bacteria and accelerated evolution of drug res

55 ion, these mechanisms preserve the niche for commensal bacteria and assist the host in preventing inf

56 Exposure to commensal bacteria and bacterial products induced NFIL3

57 that discriminates pathogenic bacteria from commensal bacteria and contributes to host defense in th

58 Interactions between potentially pathogenic commensal bacteria and cutaneous immunity are poorly und

59 l mucosa play a crucial role in tolerance to commensal bacteria and food antigens.

60 crobiome driven by low relative abundance of commensal bacteria and high relative abundance of potent

61 ar mechanisms that mediate symbiosis between commensal bacteria and humans may redefine how we view t

62 s reciprocal interactions between intestinal commensal bacteria and ILCs in the context of health and

63 enerically responsive to the presence of any commensal bacteria and innate in nature, as for IL-22-re

64 a pathogen and yet maintain tolerance toward commensal bacteria and innocuous dietary antigens.

65 ship that exists between the mammalian host, commensal bacteria and invasive pathogens can provide in

66 mmalian intestine is colonized by beneficial commensal bacteria and is a site of infection by pathoge

67 t contains a large and diverse population of commensal bacteria and is also one of the primary sites

68 lated adaptive immune cell responses against commensal bacteria and low-grade systemic inflammation.

69 plored role of MAVS in monitoring intestinal commensal bacteria and maintaining tissue homeostasis.

70 ely shape the symbiotic relationship between commensal bacteria and mammalian hosts.

71 These IgAs react with commensal bacteria and oral antigens.

72 ent of the microbiome, and interactions with commensal bacteria and other microbial agents influence

73 e may promote ecological competition between commensal bacteria and pathogenic species.

74 malian cells, as well as mechanisms by which commensal bacteria and pathogens maintain immune privile

75 , Muc2(-/-) mice showed increased killing of commensal bacteria and prevented intestinal bacterial ov

76 ognized role for T cells in controlling skin commensal bacteria and provide a mechanism to account fo

77 ILCs resulted in peripheral dissemination of commensal bacteria and systemic inflammation, which was

78 tic signalling molecules may be common among commensal bacteria and that manipulation of microbiota g

79 that, after conditioning therapy, intestinal commensal bacteria and the damage-associated molecular p

80 Regular interactions between commensal bacteria and the enteric mucosal immune enviro

81 se driven by dysbiosis, an imbalance between commensal bacteria and the host organism.

82 In contrast, other commensal bacteria and their antigenic products, when pr

83 An imbalance of commensal bacteria and their gene products underlies muc

84 s that govern the interactions between these commensal bacteria and their host remain poorly understo

85 Together, these data demonstrate that commensal bacteria and their products activate ROS signa

86 Commensal bacteria and their products provide beneficial

87 tem constitutively senses vast quantities of commensal bacteria and their products through pattern re

88 deficiency, demonstrating the importance of commensal bacteria and TNF in the IEC Ripk1 knockout phe

89 Commensal bacteria and/or their products engender benefi

90 Intestinal epithelial contact with commensal bacteria and/or their products has been shown

91 viral infection, a toxic insult to the gut, commensal bacteria, and a Crohn's disease susceptibility

92 ass Ib molecule MHC-related protein 1 (MR1), commensal bacteria, and a thymus.

93 inhibit colonization by specific subsets of commensal bacteria, and cooperatively maintain intestina

94 atory protein responses are dependent on the commensal bacteria, and more specifically, lipopolysacch

95 leum anti-gp41 antibodies cross-reacted with commensal bacteria, and of those, 43% showed non-HIV-1 a

96 with these VH4-34-encoded IgG clones binding commensal bacteria antigens.

97 ther than promote, inflammatory responses to commensal bacteria appears to be a central component of

98 Whether mutation and selection among commensal bacteria are associated with infection is unkn

99 Commensal bacteria are believed to have important roles

100 Thus, although commensal bacteria are capable of driving chronic inflam

101 nt roles in digestion and harvesting energy, commensal bacteria are crucial for the proper functionin

102 Although commensal bacteria are crucial in maintaining immune hom

103 hat control proper anatomical containment of commensal bacteria are essential to maintain tissue home

104 While the majority of commensal bacteria are found in the intestinal lumen, ma

105 glycolipid antigens derived from intestinal commensal bacteria are important hepatic NKT cell agonis

106 Commensal bacteria are known to have a significant role

107 Commensal bacteria are known to provide colonization res

108 the numerous gut microbial species, certain commensal bacteria are known to provide health benefits

109 Commensal bacteria are largely seen as harmless and can

110 een gastrointestinal parasitic helminths and commensal bacteria are likely to play a pivotal role in

111 Commensal bacteria are necessary for the development and

112 However it has recently become obvious that commensal bacteria are not simply beneficial bystanders,

113 investigate whether targeted pathogenic and commensal bacteria are related to risk of preterm birth

114 llin-hPepT1 transgenic mice, indicating that commensal bacteria are required to aggravate intestinal

115 A major metabolic product of commensal bacteria are short-chain fatty acids (SCFAs) t

116 interest, such as lipid structures found in commensal bacteria, are emphasized.

117 xample of pathogen T6SS-dependent killing of commensal bacteria as a mechanism to successfully coloni

118 utes to both host-mediated recolonization by commensal bacteria as well as to defense against bacteri

119 key molecule for innate immune responses to commensal bacteria, as a target of miR-10a.

120 In this review, we propose that commensal bacteria associated with the mammalian GI trac

121 ial products (lipoteichoic acid) produced by commensal bacteria at the epithelial surface.

122 We have assembled a consortium of commensal bacteria belonging to the Clostridiales order,

123 Here we investigate how two commensal bacteria, Bifidobacterium longum and Bacteroid

124 However, the commensal bacteria bound by IgA are poorly characterized

125 mmalian gut are not always relatively benign commensal bacteria but may also include larger and more

126 , maintaining homeostasis in the presence of commensal bacteria, but activating immune defenses in re

127 demonstrate exquisite targeting of distinct commensal bacteria by multiple layers of humoral immunit

128 ised and specific effector responses against commensal bacteria can develop.

129 conclude that serine proteases derived from commensal bacteria can directly impact the excitability

130 Signals from commensal bacteria can influence immune cell development

131 Therefore, bacteriocin expression by commensal bacteria can influence niche competition in th

132 Conversely, dysregulated localization of commensal bacteria can lead to inappropriate activation

133 rom host and environmental factors, and many commensal bacteria can produce multiple capsule types.

134 However, selective species of commensal bacteria can reside within intestinal lymphoid

135 w B. thetaiotaomicron, and other major human commensal bacteria, can metabolize and potentially tailo

136 tyrate, which is secreted in high amounts by commensal bacteria, can modulate the function of intesti

137 Commensal bacteria co-exist on the mucosal surfaces of a

138 ting that, as is widely found in amphibians, commensal bacteria confer protection against this pathog

139 trate that a precisely defined consortium of commensal bacteria containing the Clostridium cluster XI

140 These findings indicate that commensal bacteria contribute to acute stress-induced in

141 Commensal bacteria contribute to immune homeostasis in t

142 y secretion systems, the mechanisms by which commensal bacteria deliver molecules to the host remain

143 ytokines interleukin-22 and lymphotoxin in a commensal bacteria-dependent and -independent manner, re

144 e RORgammat(+) ILCs resulted in dysregulated commensal bacteria-dependent CD4(+) T-cell responses tha

145 interactions and highlight the influence of commensal bacteria-derived H(2)O(2) on host physiology.

146 rients and metabolites and discuss how these commensal bacteria-derived products may regulate the dev

147 ular and molecular mechanisms that recognize commensal bacteria-derived signals and regulate mammalia

148 In the context of infection, commensal bacteria-derived signals can influence the hos

149 t HDAC3 is a critical factor that integrates commensal-bacteria-derived signals to calibrate epitheli

150 Collectively, our data reveal a unique host-commensal-bacteria dialog whereby selective subsets of c

151 tabolites, presumably from pathogenic and/or commensal bacteria, distinguishes MAIT cells from peptid

152 Commensal bacteria downregulated dendritic cell miR-10a

153 We report that TLR5-dependent commensal bacteria drive malignant progression at extram

154 creen led to the identification of 26 unique commensal bacteria effector genes (Cbegs) that are predi

155 for the systematic identification of diverse commensal bacteria effectors that impact host cellular f

156 tigated whether oral administration of human commensal bacteria engineered to secrete GLP-1(1-37) cou

157 iza et al. (2016) uncover a new link between commensal bacteria, enteric glial cells, and ILC3s that

158 Recently, enteric commensal bacteria Enterobacter cloacae has been recogni

159 d influenza A virus infection occurring upon commensal bacteria eradication is efficiently overturned

160 Commensal bacteria, especially segmented filamentous bac

161 to target these enzymes without killing the commensal bacteria essential for human health.

162 Our results indicate that coinfecting commensal bacteria exacerbate C. albicans infection thro

163 . albicans and nonfermentative gram-negative commensal bacteria exhibited increased fungal burden and

164 Therefore, commensal bacteria exploit the TLR pathway to actively s

165 Commensal bacteria express factors that support coloniza

166 dole, which is produced from l-tryptophan by commensal bacteria expressing tryptophanase, not only is

167 S and increased survival of oxygen-sensitive commensal bacteria (Faecalibacterium prausnitzii and Ros

168 for identifying potential mechanisms used by commensal bacteria for host interactions and outlines a

169 Commensal bacteria-free animals have thymocyte maturatio

170 Commensal bacteria from the skin and mucosal surfaces ar

171 The ubiquitous commensal bacteria harbour genes of antimicrobial resist

172 Although obligate anaerobic commensal bacteria have been associated with colonizatio

173 these nutrients and metabolites derived from commensal bacteria have been implicated in the developme

174 colonic immune homeostasis and tolerance to commensal bacteria have been intensively researched, the

175 Commensal bacteria have begun to receive much attention

176 It is known that commensal bacteria have evolved a number of mechanisms t

177 Overall, TNFR2 blockade appears to disrupt commensal bacteria-host immune symbiosis to reveal autoi

178 These data support the role of H(2)O(2) in commensal bacteria-host interactions and highlight the i

179 Commensal bacteria impact host health and immunity throu

180 The mechanisms of how commensal bacteria impact systemic immunity are unclear.

181 Reintroduction of commensal bacteria in a murine model of enterococcal col

182 terial activity and that S Typhimurium kills commensal bacteria in a T6SS-dependent manner.

183 22 tipped the balance between pathogenic and commensal bacteria in favor of a pathogen.

184 Enterococcus faecalis strains are commensal bacteria in humans and other animals, and they

185 ibution of eosinophils to a response against commensal bacteria in IBD.

186 ne homeostasis of the intestine, the role of commensal bacteria in immune responses at other mucosal

187 The importance of gut commensal bacteria in maintaining immune homeostasis is

188 tly labeled bacteria, we found that entry of commensal bacteria in Peyer's patches (PP) via the M cel

189 uggest a critical role for Cxcr2, Cxcl5, and commensal bacteria in regulation of the IL-17/G-CSF axis

190 e prenatal environment and early exposure to commensal bacteria in shaping the host immune system and

191 The selectivity of the commensal bacteria in stress-evoked IL-1beta and IL-18 r

192 erji et al. now report a surprising role for commensal bacteria in the circadian regulation of glucoc

193 +/Sigirr-/- mice depended on the presence of commensal bacteria in the gastrointestinal tract.

194 ow HIV infection might change the balance of commensal bacteria in the gut.

195 lso affects the composition and diversity of commensal bacteria in the gut.

196 virus can replace the beneficial function of commensal bacteria in the intestine.

197 cquisition, composition, and localization of commensal bacteria in the intestine.

198 elative to the fast-paced research examining commensal bacteria in the intestine.

199 tary nitrate, serially reduced to nitrite by commensal bacteria in the oral cavity and subsequently t

200 The high load of commensal bacteria in the small intestine may contribute

201 ensor appears to be conserved among numerous commensal bacteria, in contrast with numerous Gram-posit

202 Commensal bacteria, in particular, are key participants

203 ivo model to reveal protective mechanisms of commensal bacteria, including those relevant to mammalia

204 Commensal bacteria induce epithelial fucosylation, and e

205 Intestinal commensal bacteria induce protective and regulatory resp

206 All tested strains of commensal bacteria induced ERK phosphorylation without s

207 with inhibitors of ROS generation attenuated commensal bacteria-induced ERK signaling, indicating tha

208 The majority of commensal bacteria inhabit the gastrointestinal tract an

209 y, we expand on these findings and show that commensal bacteria initiate ERK signaling through rapid

210 bacteria dialog whereby selective subsets of commensal bacteria interact with dendritic cells to faci

211 We propose that binding of free SC to commensal bacteria is a key and conserved mechanism for

212 ommunication between pathogenic bacteria and commensal bacteria is a subject of growing interest.

213 ntigen (glycoantigen) PSA from an intestinal commensal bacteria is able to down-regulate inflammatory

214 lthy tissue, the neutrophil response to oral commensal bacteria is associated with the select express

215 and colleagues demonstrate that tolerance to commensal bacteria is established during the neonatal pe

216 Uncontrolled APC reactivity toward commensal bacteria is implicated in the pathogenesis of

217 tion between the mammalian immune system and commensal bacteria is necessary to limit chronic inflamm

218 Whereas the symbiotic contribution of commensal bacteria is well established, the role of euka

219 ROS generation induced by the commensal bacteria Lactobacillus rhamnosus GG and the FP

220 we demonstrate that lymphoid-tissue-resident commensal bacteria (LRC) colonized murine dendritic cell

221 nction of the immune system, suggesting that commensal bacteria may influence host immunity via nutri

222 ere found using the device developed between commensal bacteria (no infection) and bacteria inoculate

223 nflammation and disrupt the intestinal niche commensal bacteria occupy.

224 Commensal bacteria of low virulence are capable of produ

225 vars and other common respiratory pathogenic/commensal bacteria of pigs.

226 It is suggested that the commensal bacteria of the digestive tract may play a rol

227 Although the effects of commensal bacteria on intestinal immune development seem

228 eliminary study examined the contribution of commensal bacteria on neutrophil location across the too

229 the local antigens seemed to be derived from commensal bacteria, on the basis of the in vitro reactiv

230 t a commensal organism) and 143 (30.2%) grew commensal bacteria only.

231 Recolonization of GF mice with commensal bacteria or administration of lipopolysacchari

232 oteins are highly enriched in pathogenic and commensal bacteria, our work indicates that CRISPR/Cas-m

233 r function of the intestine and tolerance to commensal bacteria, overlaps a QTL on Chr 12 that influe

234 Here, we report that commensal bacteria, particularly members of the genus La

235 udy investigates the interaction of tSC with commensal bacteria, pathogenic bacteria and a fungal pat

236 Commensal bacteria play an important role in formation o

237 Commensal bacteria protect against invading pathogens us

238 Site-specific commensal bacteria provide key signals ensuring host def

239 inal selection whereby MHCII(+) ILC3 deletes commensal bacteria-reactive CD4 T cells.

240 These results suggest that commensal bacteria regulate cell migration via induced g

241 However, the mechanisms by which commensal bacteria regulate protective immunity after ex

242 Here we review the current knowledge of how commensal bacteria regulate the production and bioavaila

243 ity and the mucosal immune system by sensing commensal bacteria, regulating microbial ecology, establ

244 ulation that orchestrates some of these host-commensal bacteria relationships that can impact immunit

245 al bacteria that result in dysregulated host-commensal bacteria relationships.

246 The survival of commensal bacteria requires them to evade host peptidase

247 HuNoV replicates in human B cells, and that commensal bacteria serve as a cofactor for this infectio

248 It has been shown in the mouse that oral commensal bacteria significantly contribute to clinicall

249 these results define a selection pathway for commensal bacteria-specific CD4(+) T cells in the intest

250 ng T-cell proliferation, ILCs acted to limit commensal bacteria-specific CD4(+) T-cell responses.

251 ns, the mechanisms that control selection of commensal bacteria-specific T cells remain poorly unders

252 LC3s directly induce cell death of activated commensal bacteria-specific T cells.

253 We previously demonstrated that commensal bacteria stimulate ERK pathway activity via in

254 Here, we demonstrate that natural, commensal bacteria stimulate generation of reactive oxyg

255 Further, commensal bacteria stimulate the host's immune defenses

256 ng an inflammatory response in the gut, some commensal bacteria such as E. coli can thrive and contri

257 the concept that SIgA-mediated monitoring of commensal bacteria targeting dendritic cells in the sube

258 art by the relationship of the organism with commensal bacteria that affect inflammation with both lo

259 ract is colonized by trillions of beneficial commensal bacteria that are anatomically restricted to s

260 nzae (NTHi) are closely related upper airway commensal bacteria that are difficult to distinguish phe

261 ract is colonized by trillions of beneficial commensal bacteria that are essential for promoting norm

262 an intestine harbors trillions of beneficial commensal bacteria that are essential for the developmen

263 Commensal bacteria that colonize mammalian barrier surfa

264 Staphylococci are commensal bacteria that colonize the epithelial surfaces

265 preinfection memory B cell pool triggered by commensal bacteria that cross-react with Env.

266 th our abilities to culture and sequence the commensal bacteria that dwell on and within a host, we c

267 nsal segmented filamentous bacteria or human commensal bacteria that induce intestinal TH17 cells wer

268 Commensal bacteria that interact with a eukaryotic host

269 enzymes occur in a variety of pathogenic and commensal bacteria that interact with eukaryotic hosts.

270 However, the specific commensal bacteria that promote host resistance and immu

271 017) define a precise, limited consortium of commensal bacteria that restores resistance to colonizat

272 ations in the composition or localization of commensal bacteria that result in dysregulated host-comm

273 orption of the alveolar bone and mediated by commensal bacteria that trigger host immune responses an

274 lamina propria macrophages hyporesponsive to commensal bacteria through the down-regulation of proinf

275 ens have evolved mechanisms that can utilize commensal bacteria to establish a replicative advantage

276 with impaired epithelial integrity, enables commensal bacteria to function as highly pathogenic orga

277 s, it is mutually beneficial to the host and commensal bacteria to inhibit a pathogen's ability to es

278 age populations, preventing translocation of commensal bacteria to mesenteric lymph nodes (mLNs), and

279 ng VRE, administration of obligate anaerobic commensal bacteria to mice results in a billionfold redu

280 isplayed markedly increased translocation of commensal bacteria to mLNs.

281 macromolecules are critical for adherence of commensal bacteria to mucus but structural information i

282 cellular and molecular pathways activated by commensal bacteria to protect against allergic sensitiza

283 l-host interaction, including the ability of commensal bacteria to remain immunologically silent and

284 lecule and illustrates the lifelong value of commensal bacteria to their host.

285 studies revealed that IL17A synergized with commensal bacteria to trigger Ikkepsilon phosphorylation

286 rant of foreign antigens, such as those from commensal bacteria, to prevent immunopathology such as i

287 lammatory CD4(+) T cell responses to self or commensal bacteria underlie the pathogenesis of autoimmu

288 e is known about the specific effectors that commensal bacteria use to interact with the human host.

289 We present evidence that both reducing commensal bacteria using antibiotics and neutralizing LP

290 s infectivity without affecting host cell or commensal bacteria viability.

291 between proinflammatory cytokine levels and commensal bacteria was observed in smokers but not in no

292 n gut microbiota composed of fully sequenced commensal bacteria, we elucidated the functional interac

293 Commensal bacteria were characterized in uninfected GC-C

294 population specialized in the containment of commensal bacteria when gut barriers are breached.

295 the cytokine production of PBMCs induced by commensal bacteria when these cells were primed by C. al

296 in the number and composition of intestinal commensal bacteria, which leads to susceptibility to opp

297 Overall, our data suggest that defined gut commensal bacteria with a propensity to induce TH17 cell

298 are now a handful of examples of intestinal commensal bacteria with defined immunomodulatory propert

299 iota, the presence of individual mutualistic commensal bacteria with immunomodulatory effects has bee

300 urrent study is to compare the prevalence of commensal bacteria, with beneficial properties, for heal