ライフサイエンスコーパス: common fragile site

1 romatin structure of breakpoint regions in a common fragile site.

2 essor gene, like FHIT and WWOX, located at a common fragile site.

3 cular demonstration of a germline break in a common fragile site.

4 kpoints of lost regions located in genes and common fragile sites.

5 demonstrate that OPT domains are enriched at common fragile sites.

6 s that resemble those of aphidicolin-induced common fragile sites.

7 ny characteristics similar to those in other common fragile sites.

8 nt known to result in chromosome breakage at common fragile sites.

9 and promotes replication of DNA lesions and common fragile sites.

10 inhibit DNA replication induce expression of common fragile sites.

11 ility regions are the most characteristic of common fragile sites.

12 n secondary structures that are hallmarks of common fragile sites.

13 it gene and asked whether it also contains a common fragile site and if it is unstable in mouse tumor

14 The tumor suppressor gene FHIT spans a common fragile site and is highly susceptible to environ

15 s evidence indicates that telomeres resemble common fragile sites and present a challenge for DNA rep

16 ty of ORC sites are strongly associated with common fragile sites and recurrent deletions in cancers.

17 toward understanding the genomic features of common fragile sites and the cellular processes that mon

18 14.2, is the most frequently expressed human common fragile site, and allelic losses at FRA3B have be

19 recessive cancer genes, 17 were of sequenced common fragile sites, and 178 were in genomic regions th

20 Common fragile sites appear to arise through incomplete

21 Common fragile sites are chromosomal loci prone to break

22 Common fragile sites are highly unstable regions of the

23 Common fragile sites are loci that form chromosome gaps

24 In contrast, common fragile sites are present in all individuals and

25 Common fragile sites are regions of human chromosomes pr

26 Common fragile sites are regions that show elevated susc

27 Our results support a model in which common fragile sites are sequences that initiate replica

28 Common fragile sites are specific regions in the human g

29 Common fragile sites are specific regions of the genome

30 Common fragile sites, as their name implies, are present

31 The common fragile site at 3p14.2 (FRA3B) is the most sensit

32 The common fragile site at chromosomal band 3p14.2 (FRA3B) i

33 FRA7G is an aphidicolin-inducible common fragile site at human chromosomal band 7q31.2.

34 highly destabilized chromosomes and specific common fragile site breakage.

35 Thus, the study of common fragile sites can provide insight not only into t

36 The cloning and characterization of the common fragile site (CFS) FRA6E (6q26) identified Parkin

37 Common fragile sites (CFS) are chromosomal regions that

38 Although distinct from late-replicating common fragile sites (CFS), the stability of ERFSs and C

39 of hard-to-replicate genomic regions, namely common fragile sites (CFS).

40 loci with DNA secondary structures, such as common fragile sites (CFSs) and palindromic repeats.

41 Chromosomal common fragile sites (CFSs) are genetically unstable reg

42 Common fragile sites (CFSs) are genomic regions that are

43 Common fragile sites (CFSs) are hot spots of chromosomal

44 Common fragile sites (CFSs) are large genomic regions pr

45 Common fragile sites (CFSs) are loci that preferentially

46 Common fragile sites (CFSs) are regions of profound geno

47 Chromosomal common fragile sites (CFSs) are unstable genomic regions

48 se cleaves late replication intermediates at common fragile sites (CFSs) during early mitosis to trig

49 n in cervical cancer and the position of the common fragile sites (CFSs) has been observed at both th

50 n in cervical cancer and the position of the common fragile sites (CFSs) has been observed at the cyt

51 Common fragile sites (CFSs) represent large, highly unst

52 from genomic deletions and duplications and common fragile sites (CFSs) seen as breaks on metaphase

53 ragile metaphase telomeres that resemble the common fragile sites (CFSs), and the association of sist

54 ol eta is also required for the stability of common fragile sites (CFSs), whose rearrangements are co

55 entially integrates at loci containing human common fragile sites (CFSs).

56 enomic regions, we assessed the stability of common fragile sites, chromosomal loci that are prone to

57 Thus, this is the largest common fragile site cloned to date.

58 With three common fragile sites cloned, their mechanism of expressi

59 We found that aphidicolin (APH)-induced common fragile sites contain more sequence segments with

60 FRA7G is a common fragile site containing the candidate tumor suppr

61 cal to prevent mitotic catastrophe following common fragile site expression.

62 Common fragile sites form gaps at characteristic chromos

63 es of RET/PTC rearrangements, are located in common fragile sites FRA10C and FRA10G, and undergo DNA

64 ative tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1, i

65 the cloning of WWOX, a gene that maps to the common fragile site FRA16D region in chromosome 16q23.3-

66 e that WWOX may span the yet uncharacterized common fragile site FRA16D region.

67 3.3-24.1, a chromosome region that spans the common fragile site FRA16D.

68 ontig of >1 Mb across the second most active common fragile site, FRA16D (16q23.2).

69 omain containing oxidoreductase) gene at the common fragile site, FRA16D, is altered in many types of

70 The 16q23.2 breakpoint transects the common fragile site, FRA16D, providing a molecular demon

71 The FHIT gene, which spans the common fragile site FRA3B, has been shown to produce abe

72 scripts in a variety of tumors and spans the common fragile site FRA3B.

73 e gaps and breaks and breaks at the specific common fragile sites FRA3B and FRA16D were significantly

74 such independent integrations into 3p14.2, a common fragile site (FRA3B).

75 One putative target, 3p14.2, contains the common fragile site, FRA3B, a hereditary renal carcinoma

76 tidine triad gene (FHIT) encompasses a human common fragile site, FRA3B, that is susceptible to envir

77 involved in the fragility of the most active common fragile site, FRA3B.

78 within the FHIT gene, which encompasses the common fragile site, FRA3B.

79 ated that the DNA probe for D7S522 spans the common fragile site FRA7G at 7q31.

80 Thus for the first two cloned common fragile sites, FRA7G and FRA3B, there is an assoc

81 31.1-31.2, a region that contains one of the common fragile sites, FRA7G.

82 Common fragile sites frequently coincide with the locati

83 The study of common fragile sites has its roots in the early cytogene

84 romosome structure, no biological effects of common fragile sites have been convincingly shown, altho

85 f cell cycle checkpoints and DNA repair, and common fragile sites have provided insight into understa

86 ntriguing component of chromosome structure, common fragile sites have taken on novel significance as

87 teresting component of chromosome structure, common fragile sites have taken on novel significance as

88 somal band 3p14.2, FRA3B, is the most active common fragile site in the human genome.

89 FRA3B, has been described as the most active common fragile site in the human genome.

90 chromosomal band 3p14.2, is the most active common fragile site in the human genome.

91 n chromosomal band 3p14.2 is the most active common fragile site in the human genome.

92 FRA3B at 3p14.2 is the most active of the common fragile sites in the human genome and is expresse

93 Parkin maps to FRA6E, one of the most active common fragile sites in the human genome, it represents

94 orts the role of DNA secondary structures in common fragile site instability, provides a systematic m

95 Thus, the physical relationship of Fhit to a common fragile site is similar to that observed with the

96 f CCG repeats, the mechanism responsible for common fragile sites is unknown.

97 FRA3B is the most frequently expressed common fragile site localized within human chromosomal b

98 This work further demonstrates that the common fragile sites may play an important role in cance

99 Recent findings suggest that common fragile sites may serve as markers of chromosome

100 Correspondingly, genes at common fragile sites may sustain elevated levels of DNA

101 ues were associated with cancer breakpoints, common fragile sites, microRNA, and cancer-related genes

102 gene and is the most highly expressed of the common fragile sites observed when DNA replication is pe

103 t 3p14.2 is the most highly expressed of the common fragile sites observed when DNA replication is pe

104 3p14-p12 interval known to contain the most common fragile site of the human genome (FRA3B), the FHI

105 The 3p14.2 region spans the most active common fragile site of the human genome, encompassing a

106 oxidoreductase (WWOX) spans the second most common fragile site of the human genome, FRA16D, located

107 The distribution of common fragile sites parallels the positions of neoplasi

108 Common fragile sites predispose to specific chromosomal

109 rspersed nuclear element 1s, suggesting that common fragile sites serve a function.

110 l cycle checkpoint kinases, CHK1 and CHK2 on common fragile site stability in human cells.

111 ing chromosome stability, and in particular, common fragile site stability.

112 wn genomic loci/regions include centromeres, common fragile sites, subtelomeres, and telomeres.

113 dentification of a sequence element within a common fragile site that increases chromosome fragility.

114 ristics are possibly intrinsic properties of common fragile sites that may affect their replication a

115 mal abnormalities occurred preferentially at common fragile sites upon conditional Hus1 inactivation.

116 o learn about the general characteristics of common fragile sites, we investigated the chromatin stru

117 ngements in tumors are often associated with common fragile sites, which are specific genomic loci pr