ライフサイエンスコーパス: conjugate

1 d interacted with Atg5 and also with Atg12-5 conjugate.

2 r functional properties of lysozyme-guar gum conjugate.

3 r bone mineralized matrix (BMM) or a BMM+SIM conjugate.

4 y activators involving fatty acid cysteamine conjugates.

5 c parameters of ursodeoxycholic acid and its conjugates.

6 ark contrast to that of fluorescent antibody conjugates.

7 onal antibodies (mAbs) with and without drug conjugates.

8 ersibility of the boronate/thiosemicarbazone conjugates.

9 may be a potential target for antibody-drug conjugates.

10 than free DOX and GEM and the single drug HA conjugates.

11 te, for both the lysine- and cysteine-biotin conjugates.

12 the antioxidant capacities of the resulting conjugates.

13 tubulogenic assay; furthermore, dimeric-RGD conjugate 3 strongly inhibited in vivo angiogenesis in M

14 PROTACs conjugate a target warhead to an E3 ubiquitin ligase lig

15 However, the conjugate acid would resist C-C bond breaking as that wo

16 se fundamentally important species and their conjugate acids, e.g. HNSO and HSNO, have been the focus

17 ties of the anions and the pKa values of the conjugate acids.

18 cture also reveals the 4'-phosphopantetheine-conjugated acyl-group of ACP occupies the hydrophobic co

19 iazepine (PBD)-based anti-CD19 antibody drug conjugate (ADC) being investigated for treatment of B-ce

20 ls, for example in the form of antibody-drug conjugates (ADC).

21 ategies to produce homogeneous antibody-drug conjugates (ADCs) rely on mutations or inefficient conju

22 r-vehicle basis as compared to antibody-drug conjugates (ADCs).

23 via intermediate 19 for use in antibody-drug conjugates (ADCs).

24 l substrates in contrast to more traditional conjugate addition methods.

25 talysts for the unreported, enantioselective conjugate addition reaction of the barbituric acid pharm

26 H-Pro-Pro-Xaa-NH2-type peptidic catalysts in conjugate addition reactions.

27 ) were achieved using the diastereoselective conjugate additions of lithium amide reagents in the key

28 for the environmentally benign oxidation of conjugated alkenes with H2O2.

29 lyzed conjunctive cross-coupling between non-conjugated alkenes, aryl iodides, and alkylzinc reagents

30 ybridized biotin-miRNA with streptavidin-HRP conjugates, amperometric detection at -0.20V was carried

31 sp(2)c-COF) that was designed to be fully pi-conjugated and constructed from all sp(2) carbons by C=C

32 s (1 cm(2)) and of general validity for both conjugated and non-conjugated polymers, e.g. poly(9,9-di

33 evidenced by the loss of activity of GalNAc conjugated and unconjugated ASOs in ASGR knockout mice.

34 A cholestanol-conjugated antagonist, CGRP8-37, accumulated in CLR-cont

35 idyl-hydrazinonicotinamide ((99m)Tc-S-HYNIC)-conjugated anti-FAP antibody 28H1 at 2, 5, and 9 d after

36 atment with RG-101, an N-acetylgalactosamine-conjugated anti-microRNA-122 oligonucleotide, resulted i

37 microglia in the spinal cord using a saporin-conjugated antibody to Mac1, we demonstrate a causal rol

38 ng well-defined full-length antibody-polymer conjugates (APCs).

39 ory of GO, which was the first antibody-drug conjugate approved for human use by the FDA.

40 trated that PSMA-11-derived dual-labeled dye conjugates are feasible for providing PSMA-specific pre-

41 We describe the application of Rh-catalyzed conjugate arylation to the modification of thiostrepton,

42 control, we establish heterotypic ubiquitin conjugates as important carriers of biological informati

43 The advent of antibody-drug conjugates as pharmaceuticals has fuelled a need for rel

44 e SUR1 in processing cysteine-isothiocyanate conjugates, as well as the S-methyltransferase DTCMT tha

45 ementation of N-acetylgalactosamine (GalNAc)-conjugated ASOs for Asialoglycoprotein Receptor (ASGR)-m

46 tin microarrays and lectin-magnetic particle conjugate-assisted LC-MS/MS analyses.

47 Thus, bright spots resulting from the conjugates at the bottom of the sample vials were easily

48 c 5,5-dimethylcyclopentadiene monomer into a conjugated backbone is an attractive strategy to high pe

49 lectron-poor subunits were introduced in the conjugated backbone to modulate the band gap.

50 critical requirement is the strength of the conjugate base such that an equilibrium exists between p

51 at total concentrations (uncharged acid plus conjugate base) of 257 and 27.1 mM, respectively.

52 complexes that are kappa(2)-chelated by the conjugate base.

53 We used cdN-conjugated beads to biochemically isolate host receptors

54 but completely inhibited active transport of conjugated bile acid species in OATP knockout mice.

55 nforced homeostasis in Teff cells exposed to conjugated bile acids (CBAs), a class of liver-derived e

56 CP and OATPs contribute to hepatic uptake of conjugated bile acids in mice, whereas the predominant u

57 cubation with a high concentration (1 mM) of conjugated bile acids.

58 believed to be pivotal for hepatic uptake of conjugated bile acids.

59 osteoadsorptive bisphosphonate-ciprofloxacin conjugate (BV600022), utilizing a "target and release" c

60 at C-terminus of SCRII, SCRII subunits were conjugated by sortase A to form crosslinked SCRII, mainl

61 d used to create a protherapeutic product by conjugating C1aB to a cell-penetrating domain.

62 In summary, betaLg-CA conjugates can act as effective antioxidant emulsifiers

63 est planar structures, DPT shows a curved pi-conjugated carbon skeleton.

64 o improve therapeutic efficacy, polymer drug conjugates carrying synergistic pairs of chemotherapy dr

65 We conjugated catalase to anti-ICAM-1 antibodies and admini

66 Labelling with nanogold-conjugated CBM3, which binds the hydrophobic surface of

67 Corline Heparin Conjugate (CHC), a compound of multiple unfractionated h

68 olecular heparin conjugates (Corline Heparin Conjugate, CHC).

69 ere accompanied by increased hepatic taurine-conjugated cholic acid and beta-muricholic acid as well

70 MS procedures after urine precipitation with conjugate cleavage (UglucP) or dried urine spot workup b

71 avage (UglucP) or dried urine spot workup by conjugate cleavage and liquid extraction (DUSglucE).

72 demonstrate that, upon photoactivation, the conjugate cleaves the DNA backbone specifically near the

73 it to prepare novel two-dimensional (2D) pi-conjugated COFs, as crystalline powders and exfoliated m

74 (also known as DS-8201) is an antibody-drug conjugate comprised of a humanised antibody against HER2

75 alirine (SGN-CD33A, 33A) is an antibody-drug conjugate consisting of pyrrolobenzodiazepine dimers lin

76 In this work, a polymer-catechol conjugate containing a superhydrophilic nonfouling poly(

77 PAV) and coupled with macromolecular heparin conjugates (Corline Heparin Conjugate, CHC).

78 tively, with potencies similar to chemically conjugated counterparts, and longer plasma circulation t

79 n is a novel anti-CD37 antibody-radionuclide conjugate currently in phase 1/2a.

80 O-target function is the balance between the conjugated/de-conjugated forms.

81 We show that conjugating dendritic alkyl chains to DNA creates amphip

82 le fluorescent receptor 1 was synthesized by conjugating diaminomaleonitrile (DMN) with benzothiazole

83 of the approach was performed by correlating conjugated diene concentrations measured by spectrophoto

84 al products have in common an E,Z-configured conjugated diene linked to a di- or triyne chain.

85 ene, and butylated hydroxyanisole (BHA)] for conjugated dienes (during a 90-day period) and for malon

86 ed by measuring the peroxide value, acidity, conjugated dienes and trienes.

87 d a lower generation of oxidation compounds (conjugated dienes in chains having also hydroperoxy/hydr

88 x-generated alpha-amino radical species with conjugated dienes using a unified cobalt and iridium cat

89 b tesirine is a first-in-class antibody-drug conjugate directed against delta-like protein 3 (DLL3),

90 of CA units coupled increases; 3) betaLg-CA conjugates displayed comparable or superior water solubi

91 bioorthogonal reactions with the fluorophore-conjugated DpTz reagents afforded the fluorescently labe

92 We found that the chemical structure of conjugated drugs could strongly influence their assemble

93 he therapeutic efficacy of site-specifically conjugated duocarmycin- and monomethyl auristatin E (MMA

94 lication of the membrane-impermeable E2 (BSA-conjugated E2; 15 min).

95 by ubiquitin activating enzyme E1, ubiquitin conjugating enzyme E2 and ubiquitin ligase E3.

96 e, we report that the stability of Ubiquitin-conjugating enzyme E2S (UBE2S) is regulated by the PTEN/

97 is dependent on the activity of E2 ubiquitin conjugating enzyme Ubc13.

98 sive enzyme-substrate interaction (ubiquitin-conjugating enzyme UBE2D3 with substrate PCNA), and endo

99 ation can be linked to reduced NCE (E2 NEDD8-CONJUGATING ENZYME) NEDD8 thioester levels, either by cr

100 1 [ubiquitin (Ub)-activating enzyme], E2 (Ub-conjugating enzyme), and E3 (Ub ligase).

101 e binding of an E3 ubiquitin ligase to an E2-conjugating enzyme, leading to prolonged inflammatory si

102 into the structural plasticity of ubiquitin-conjugating enzymes.

103 lt and triggered aftershocks along a complex conjugate fault system.

104 BP1A/TNFRSF6) 2Bck/J mice received rhodamine-conjugated ferumoxytol.

105 using an in vitro mouse model with a dextran-conjugated fluorescent calcium indicator.

106 In the free and conjugated forms, chlorogenic acid was present in 60% of

107 ion is the balance between the conjugated/de-conjugated forms.

108 and selectively remove K48-linked ubiquitin conjugates from a subpopulation of damaged lysosomes to

109 and easy production of well-defined antibody conjugates from a variety of antibody sequence and speci

110 The GE11-conjugated, GFP-siRNA-complexed NPs exhibited excellent

111 The subject of N-acyl amino acid conjugates has been rapidly growing in recent years, esp

112 Conclusion Targeted monoclonal antibody-conjugated HNPs can serve as a catalyst for photothermal

113 aches to prepare functional redox-active and conjugated homopolymers as well as the construction of c

114 en together, our results suggest that Bio-IL conjugated hydrogels could be implemented and readily ta

115 nge, in particular with respect to laterally conjugated imine-linked COFs.

116 lized with a near infrared (NIR) fluorophore-conjugated immunoassay to Carbohydrate Antigen 19-9 (CA

117 Immunological evaluations of the resultant conjugates in mice revealed that they elicited robust GM

118 alcein co-incubated with the protein-polymer conjugate increased only 5-fold.

119 ilic polyethylene glycol (PEG), a bortezomib-conjugating intermediate, and a dendritic doxorubicin-af

120 Pluronic P85 (LepNP85) and administered this conjugate intranasally using the nose-to-brain (INB) rou

121 SubPc-TCBD-aniline systems showed that each conjugate is a racemic mixture of two atropisomers resul

122 he improvement in brain accumulation of this conjugate is due to its enhanced brain absorption.

123 se, the DNA damage-responsive E3 ligase RNF8 conjugates K63-linked ubiquitin chains to tankyrase 1, w

124 o nitrostyrenes, and nitroalkane addition to conjugated ketones activated as iminium ions.

125 itable leaving group to generate the desired conjugated lactam.

126 small molecules at mild potentials based on conjugated, light element scaffolds.

127 selectivity were studied in the synthesis of conjugated linoleic acid (CLA) partial glycerides, which

128 unique 1,4-boraphosphabutadiene systems with conjugated main-group multiple bonds.

129 anding the conformations and arrangements of conjugated materials as solids is key to their prospecti

130 Amino acid conjugates may easily deconjugate, releasing the parent

131 We hypothesize that ASO-T3 conjugates may knock down target genes and enrich T3 act

132 ART analogue, SMART-OH, and its polymer-drug conjugate, methoxy-poly (ethylene glycol)-block-poly (2-

133 Ligand-conjugated microparticles of iron oxide (MPIO) have the

134 An MMC conjugate (MMC-TOC) was synthesized on solid-phase and c

135 cular those obtained via self-assembly of pi-conjugated molecules, are dynamic materials possessing u

136 We further show that the optimal dual drug conjugate more effectively inhibits the growth of an agg

137 Here, we develop flat and thin phase-conjugate nanostructures on low-cost ink coated glass su

138 Here, we report that nanoparticle-drug conjugates (NDCs) of monomethyl auristatin E (MMAE) sign

139 We create a palette of triple-bond-conjugated near-infrared dyes that each displays a singl

140 h chiral self-assembly of nucleobase-peptide conjugates (NPCs), where achiral nucleobases are helical

141 ynthesis and characterization of new peptide conjugates obtained by hierarchical co-assembly of L,L-d

142 A conjugate of a tris(hydroxypyridinone) (THP) chelator wi

143 in our previous study can be applied to the conjugates of this lethal pathogen.

144 A membrane-intercalating conjugated oligoelectrolyte (COE), PTTP, was designed an

145 Two conjugated oligoelectrolytes (COEs), WMG1 and WMG2, were

146 heterocycles are a ubiquitous skeleton of pi-conjugated organic compounds, and their incorporation re

147 4-fold C-H hydroarylation provided a highly conjugated organic framework in one step.

148 ctrodes by oxidative polymerizations, are pi-conjugated organic semiconductors, or which provide the

149 that the superior tumor distribution of the conjugate over nanoparticles will be accentuated in clin

150 nhanced in Esperase-derived peptides/sucrose conjugates (p<0.05).

151 ates, the amount of FCN-DNA dispensed on the conjugate pad and the dispensing cycles of the capture D

152 dy-decorated silica beads (Ab-SiO2) onto the conjugate pad and the sample flows by capillarity throug

153 very platform, (ii) polyethylene glycol-PLGA conjugate (PEG-PLGA, p) to help maintain an appropriate

154 d after tail vein injection (150 mug of each conjugate per mouse) at 1, 7 and 13 days post-injection.

155 Herein, we describe a simple histidine (H) conjugated perylene diimide (PDI) bolaamphiphile (HPH) a

156 pinpointed as being involved in binding CoA-conjugated phenylpropanoids.

157 A photoactivatable dopamine-conjugated platinum(IV) anticancer complex (Pt-DA) has b

158 c respiration of bacteria in the presence of conjugated polyelectrolytes (CPEs).

159 articles and self-assembled structures of pi-conjugated polymer are highlighted.

160 using Poly(3-thiophene acetic acid) (P3), a conjugated polymer as an immobilization matrix.

161 trated as an efficient n-type dopant for the conjugated polymer ClBDPPV.

162 perties and inherent mechanical flexibility, conjugated polymer field-effect transistors (FETs) are p

163 poly(2,5-di(hexyloxy)cyanoterephthalylidene) conjugated polymer films.

164 this review, we summarize the key aspects of conjugated polymer nanoparticles optical properties and

165 ive nonconjugated polymer that converts to a conjugated polymer via an extensive rearrangement of the

166 In the crystal the conjugated-polymer chains are extended along the long ax

167 ns in traditional Pt-bisacetylide containing conjugated polymers and small molecules.

168 ion incorporating high-performance ambipolar conjugated polymers and unipolar small molecules as the

169 ce strong memory behavior from common p-type conjugated polymers by adding n-type dopant 2-(2-methoxy

170 a of excitons in oligomers of the ubiquitous conjugated polymers poly(3-hexylthiophene) (P3HT), poly(

171 general validity for both conjugated and non-conjugated polymers, e.g. poly(9,9-di-n-octylfluorene-al

172 been reported for solution-processed n-type conjugated polymers, with a thermoelectric power factor

173 orphology and charge-transport properties of conjugated polymers.

174 general method to induce memory behavior in conjugated polymers.

175 rategy, based on the use of light-sensitive, conjugated polymers.

176 developed porphyrin-peptoid (pigment-helix) conjugates (PPCs) that can modulate the donor-acceptor e

177 Total conjugated primary BAs were significantly higher in NASH

178 The lipid-conjugated prodrug of cidofovir, brincidofovir, has impr

179 urodegenerative diseases; accordingly, these conjugates promote rapid proteasomal clearance of aggreg

180 We demonstrate that chemically-conjugated Qbeta VLPs elicited the highest quantity of a

181 Aptamer-conjugated Quantum dots (QDs) are adsorbed to Au nanopar

182 en and ibuprofen, in their parent form, were conjugated quickly and directly with glutamic acid and g

183 The cysteine-biotin conjugates remained fully intact, demonstrating the abil

184 geting and endosomal escape, and cholesterol-conjugated RNAi triggers, which together result in HBV g

185 Using the fluorescent-dye conjugate, [S14R, W50Pra(Bodipy)]Ts1, we confirmed its b

186 ry antibody and horseradish peroxidase (HRP)-conjugated secondary antibody onto AgNPs-rGO modified-SP

187 In this paper we report a coumarin-conjugated self-assembling system adorned with valuable

188 A high-performance conjugated semiconductor (an indacenodithiophene-benzoth

189 es, semiconductor-metal heterostructures, pi-conjugated semiconductor nanoparticles, organic-inorgani

190 ght-harvesting systems based on dye-doped pi-conjugated semiconductor polymer nanoparticles and self-

191 The conjugates showed potent biological activities against a

192 The conjugate shows weak luminescence when free in solution

193 The aptamer-conjugated silver nanoclusters (Apt@AgNCs) were synthesi

194 the trivalent N-acetylgalactosamine (GalNAc)-conjugated siRNA in mice relative to the un-modified siR

195 e role of protein oligonucleotide number and conjugate size on this observation, which revealed the i

196 a series of novel Pt-bisacetylide containing conjugated small molecules possessing an unconventional

197 By conjugating SN-38 to the dendrimer via different linker

198 ically inhibit this pathological pathway, we conjugated SOD with antibodies (Ab/SOD, size 10nm) to p

199 fission in a pentacene dimer linked by a non-conjugated spacer.

200 ASGR for the effective uptake of GalNAc-ASO conjugates, suggesting broad opportunities to exploit re

201 The elongation of the pi-conjugated system via additional ethenylene linker resul

202 Brentuximab vedotin (BV) is an antibody-drug conjugate targeting CD30.

203 he therapeutic potential of an antibody-drug conjugate targeting GPC2.

204 Bortezomib-conjugated telodendrimers, together with doxorubicin, se

205 he synthesis and excited state dynamics of a conjugated tetracene homopolymer are studied.

206 Using HLA-B*14/peptide-saporin-conjugated tetramers, we show that HLA-B*14-EL9 is subst

207 ly, we develop a GPC2-directed antibody-drug conjugate that is potently cytotoxic to GPC2-expressing

208 To circumvent these limitations, we conjugated the chemotherapy paclitaxel (PTX) to a dendri

209 er, chlorin e6, can be repurposed for PCI by conjugating the chlorin to a cell penetrating peptide, u

210 This is accomplished by conjugating the IDO inhibitor, indoximod (IND), to a pho

211 a membrane-activatable polymeric nanodrug by conjugating the photosensitizer protoporphyrin IX (PpIX)

212 DNA probe used in the preparation of FCN-DNA conjugates, the amount of FCN-DNA dispensed on the conju

213 In all conjugates, the ligand binding competence toward alphaVb

214 ification occurring during inflammation, and conjugated them to virus-like particles, followed by imm

215 ors by dimerizing the F-derived peptides and conjugating them to cholesterol.

216 nd quantify for the first time a dipeptide S-conjugate to 3MH, the gammaGluCys-3MH, in Sauvignon B.

217 anti-ICAM-1 antibodies and administered the conjugate to 8 wk old C57BL/6J mice 30 min after moderat

218 We synthesized siRNA conjugated to a diacyl lipid moiety (siRNA-L2), which ra

219 gh signal characteristics were retained when conjugated to a large protein, indicating potential for

220 enzene derivative in which the nucleobase is conjugated to a phenyldiazene tail is studied in view of

221 The ribosome-inhibiting protein saporin was conjugated to a Siglec-8-specific antibody to examine th

222 each comprising an anti-CD3 scFv covalently conjugated to a stabilized dimer of different antitumor

223 D2 receptors (D1R and D2R) when the PTL was conjugated to an engineered cysteine near the dopamine b

224 ced by exploiting the same targeting ligand, conjugated to an imaging agent, to select patients whose

225 DNA probes conjugated to AuNPs were used to detect a DNA target seq

226 response to (4-hydroxy-3-nitrophenyl)acetyl conjugated to chicken gamma globulin and found a similar

227 an-binding malachite green (MG-dextran), was conjugated to concanavalin A (Con A), an enzyme with spe

228 Daratumumab was conjugated to DFO-p-benzyl-isothiocyanate (DFO-Bz-NCS) f

229 The kinase inhibitor crizotinib was directly conjugated to Dha through its piperidine motif, and its

230 study was to demonstrate whether L1 peptides conjugated to FHs promote tissue regeneration in a wound

231 The EdU-labeled DNA was conjugated to fluor- or biotin-azide and visualized by c

232 a methodology using antibody fragments (Fab) conjugated to gold nanoparticles (immunogold) to map the

233 MHC class II loading compartment, as does Ag conjugated to H4B4.

234 ction consists of a melittin-derived peptide conjugated to N-acetylgalactosamine for hepatocyte targe

235 based and protein-based hosts that have been conjugated to near-infrared-absorbing Au nanoshells (SiO

236 imately 6) tumor microenvironment, PNAs were conjugated to pH-low insertion peptide (pHLIP).

237 assessing the translocation of drug cargoes conjugated to pHLIP.

238 to carboxylic acid; the resulting DA-TAT is conjugated to poly(ethylene glycol)-poly(epsilon-caprola

239 amma-peptide nucleic acid (gamma-PNA) probes conjugated to polystyrene beads have been reported for t

240 odynamic diameter, DH of 105.12 +/- 1.13 nm) conjugated to recombinant scavenger receptor class B, me

241 Hapten 1 was conjugated to tetanus toxoid and mixed with liposomes co

242 ion, LC3 is cleaved by the protease ATG4 and conjugated to the autophagosomal membrane; however, its

243 Fluorescent beads were conjugated to the sample surface and imaged before and d

244 A bifunctional analogue, macropa-NCS, was conjugated to trastuzumab as well as to the prostate-spe

245 NASH had higher conjugated to unconjugated chenodeoxycholate (P = 0.04),

246 gy transfer efficiency from the various AuNP conjugates to pendant ytterbium(III) cations, a Dexter-t

247 The ability of the prepared conjugates to release the free drug was verified using d

248 The antibody-drug conjugate trastuzumab emtansine is indicated for the tre

249 se serum and 100 mM EDTA, whereas the nickel-conjugated trimers were not stable under these condition

250 E2s through a RING/HECT hybrid mechanism to conjugate Ub to target proteins.

251 We conjugated unimNPs with the cholera toxin B domain (CTB)

252 desaturation of N-protected lactams to their conjugated unsaturated counterparts under mildly acidic

253 teasomes hydrolyzed the associated ubiquitin conjugates, Usp14 and Ube3c dissociated rapidly (unlike

254 untries to study the benefit of pneumococcal conjugate vaccine (PCV) in protecting against invasive p

255 a introduced universal 7-valent pneumococcal conjugate vaccine (PCV7) from 2005, replaced by 13-valen

256 Introduction of the heptavalent pneumococcal conjugate vaccine (PCV7) in 2000 reduced macrolide-resis

257 ction of MenAfriVac, a meningococcal group A conjugate vaccine developed for the African meningitis b

258 ed persons with a quadrivalent meningococcal conjugate vaccine in accordance with Advisory Committee

259 full extent to which childhood pneumococcal conjugate vaccines (PCV) can indirectly reduce illness i

260 Pneumococcal conjugate vaccines (PCVs) are being used worldwide.

261 Pneumococcal conjugate vaccines (PCVs) are highly effective in preven

262 h, even though highly effective pneumococcal conjugate vaccines (PCVs) are used in national immunizat

263 OM) burden following rollout of pneumococcal conjugate vaccines (PCVs) have exceeded predictions of v

264 ciated with the introduction of pneumococcal conjugate vaccines (PCVs) in five countries in the Ameri

265 t the capsule are protective, polysaccharide conjugate vaccines, which are constructed against the mo

266 th age but not by serotypes in the different conjugate vaccines.

267 emissivity into the "backward" (i.e., phase-conjugated) version of that beam; another gives the over

268 In addition, antimicrobial activity of the conjugate was determined against two gram positive (Stap

269 yl lipid A-Thomson-Friedenreich (TF) antigen conjugate was obtained to demonstrate the feasibility of

270 The synthesized mitoxantrone conjugate was oil at physiological temperatures and demo

271 tags, and cytotoxic behavior of the designed conjugate was studied in normal and cancer cell lines.

272 A novel mitoxantrone conjugate was synthesized by coupling mitoxantrone with

273 The conjugates were compared in vitro and in vivo.

274 Flavanol monomers and glucoside conjugates were not recovered in the ileum in agreement

275 The conjugates were prepared through a two-step sequential c

276 ling due to the high atomic complexity of Ub conjugates, where Ub is attached to other Ub molecules a

277 tes the initial formation of a semicarbazone conjugate, which rearranges into a stable diazaborine.

278 Several classes of glucuronide conjugates, which include acyl glucuronides, ether glucu

279 ss to a new set of nucleic acid-nanoparticle conjugates, which may be useful as programmable material

280 ful for building a homogeneous antibody-drug conjugate with a precise drug-to-antibody ratio of 2.

281 a first-in-class DLL3-targeted antibody-drug conjugate with encouraging initial safety and efficacy p

282 n, we have generated a novel FA-Qdot 605 dye conjugate with superior sensitivity and flexibility to a

283 er, poly(beta-amino ester) (PBAE), with PBAE conjugated with 5kDa polyethylene glycol (PEG) molecules

284 therapy based on a monoclonal antibody (mAb) conjugated with a near-infrared (NIR) phthalocyanine dye

285 luronan and heparosan were then successfully conjugated with Alexa Fluor 488 DIBO alkyne, demonstrati

286 rapeutic and diagnostic multifunctional HNPs conjugated with anti-MG1 monoclonal antibodies were synt

287 Trastuzumab was conjugated with deferoxamine and radiolabeled with (89)Z

288 Pertuzumab was conjugated with deferoxamine and radiolabeled with (89)Z

289 ate of micelles of a recombinant polypeptide conjugated with doxorubicin via an acid-labile hydrazone

290 nslational modification of cellular proteins conjugated with either ubiquitin (Ub) or Ub-like interfe

291 Antibody probes were conjugated with gold nanoparticles that were sputtered o

292 -based immunoassay multi-arrayed fiberoptics conjugated with rolling circle amplification.

293 sativum) using cleavage by bound preproteins conjugated with the artificial protease FeBABE and cyste

294 After being conjugated with the glucosamine, insulin can efficiently

295 The conjugates with 2.5 and 72h release half-lives did not a

296 mple functionalization allows preparation of conjugates with fluorophore, affinity handle, and pharma

297 escribe "semisynthetic" pH-sensitive protein conjugates with organic fluorophores, carbofluorescein,

298 Three conjugates with plasma release half-lives of 2.5h, 21h,

299 ility for both mycotoxins and mycotoxin-AITC conjugates, with duodenal fractions representing 63.5% o

300 secondary and tertiary amine-linked protein conjugates without affecting the structure and function