ライフサイエンスコーパス: conjugate addition

1 an of the reaction type (e.g., substitution, conjugate addition).

2 ganocatalyst N-methylpyrrolidine catalyzes a conjugate addition.

3 intermediate that supports the Stetter-like conjugate addition.

4 mine formation and subsequent intramolecular conjugate addition.

5 e modest diastereoselectivity of the radical conjugate addition.

6 enable general oxetane construction via oxa-conjugate addition.

7 xetanes that could undergo similar retro-oxa-conjugate addition.

8 he anticipated facile ring opening retro-oxa-conjugate addition.

9 disfavor the breaking of conjugation by oxa-conjugate addition.

10 followed by a regioselective intramolecular conjugate addition.

11 nifying the mechanisms of these two kinds of conjugate addition.

12 tituted amino acid precursors via asymmetric conjugate addition.

13 alkoxy group elimination, and intramolecular conjugate addition.

14 tom-attached alkyl group affects the rate of conjugate addition.

15 addition to the quinone is favored over 1,4-conjugate addition.

16 tes an alkylmagnesium alkoxide that triggers conjugate addition.

17 ne reduction, hydration, hydroamination, and conjugate addition.

18 the Barton decarboxylation and Giese radical conjugate addition.

19 -lived state in dimethyl maleate using thiol conjugate addition.

20 rd highly efficient catalysis for asymmetric conjugate additions.

21 Highly stereoselective conjugate additions (97:3 to 99:1 dr) were observed betw

22 cid based ligands in Cu-catalyzed asymmetric conjugate addition (ACA) reactions and a relatively rare

23 nthesis highlights the utility of asymmetric conjugate additions (ACA) of alkylzincs to acyclic alpha

24 nyl monomers, proceeding exclusively through conjugate addition across the methacrylic C horizontal l

25 methodology, we developed a catalytic tandem conjugate addition-aldol cyclization of keto-enones.

26 Collectively, the conjugate addition-alkylation generates highly substitut

27 nzylic perborylation with a new deborylative conjugate addition-alkylation method enables a one-pot p

28 ega-chloroalkyl Grignard reagents triggers a conjugate addition-alkylation sequence leading exclusive

29 The first conjugate addition/alkylation to alkenyl isocyanides is

30 n to complete the 6-5-6-6 ring system, and a conjugate addition, all of which overcome considerable s

31 The reaction mechanism of a tandem conjugate addition/alpha-alkylation of enals leading to

32 eaction results in a highly enantioselective conjugate addition and a diastereoselective proton trans

33 ing blocks by the pairwise use of asymmetric conjugate addition and aldehyde dehydration protocols.

34 The enantioselective 1,4-conjugate addition and enantioselective lactone formatio

35 was competition between the desired radical conjugate addition and undesired alkene reduction mediat

36 These Abeta modifications result from 1,4 conjugate addition and/or Schiff base formation, they oc

37 rode arrays with the use of both thiol-based conjugate additions and Cu(I)-coupling reactions between

38 olecular Knoevenagel condensation, a radical conjugate addition, and a SmI(2)-mediated nitro reductio

39 e atoms, have been synthesized using Wittig, conjugate addition, and asymmetric aldol reactions and f

40 gh proton transfer vs polymerization through conjugate addition, and mapped out extensive energy prof

41 n MoOPH-mediated oxidative cyclization, then conjugate addition, and redox processes to complete the

42 misinic acid was utilized as an acceptor for conjugate addition, and the resultant homologated acids

43 tereoselectivities in Diels-Alder reactions, conjugate additions, and aldol reactions employing these

44 enic cascade reaction, iminium chemistry and conjugate additions are added to the emerging repertoire

45 1,6-Conjugate additions are otherwise limited to substrates

46 Nonetheless, catalytic enantioselective 1,6-conjugate additions are uncommon, and ones that incorpor

47 e rearrangement and a diastereoselective 1,4-conjugate addition as the key steps.

48 beta-unsaturated aldehydes towards selective conjugate additions as well as activation of an unsatura

49 The tandem Friedel-Crafts conjugate addition/asymmetric protonation reaction betwe

50 nCl(4), and is the first example of a tandem conjugate addition/asymmetric protonation reaction using

51 A conjugate addition/asymmetric protonation/aza-Prins casc

52 minations, 1,2-addition to carbonyl, and 1,6-conjugate addition at the spiramycin aglycone, proceeds

53 metal-free enantioselective method for boron conjugate addition (BCA) to alpha,beta-unsaturated carbo

54 Lewis base catalyzed enantioselective boryl conjugate additions (BCAs) that generate products contai

55 Rapid conjugate addition between thiol-terminated tetravalent

56 Meanwhile, the same conjugate addition but followed by enolate oxidation wit

57 uce a vinyl gold(I) carbene, which undergoes conjugate addition by the nitrogen pronucleophile.

58 PPBenzene ligand effectively promotes direct conjugate additions by perfluoroarenes.

59 reactions, Morita-Baylis-Hillman reactions, conjugate additions, carbonylations, methylations, silyl

60 on/regioselective intramolecular cyclization/conjugate addition cascade reaction and provides a strai

61 of a key strategy-level intramolecular aldol/conjugate addition cascade that led, in a single operati

62 ed ketone dehydrogenation with organocuprate conjugate addition chemistry allows for the introduction

63 Surfaces constructed with the conjugate addition chemistry were not stable at neutral

64 One is a 1,6-conjugate addition/cyclization sequence with incorporati

65 pha-functionalization of amines and ketones, conjugate additions, cycloadditions etc.

66 The scope and limitations of the tandem conjugate addition-Dieckmann condensation for the constr

67 e key element of the synthesis consists of a conjugate addition-dipolar cycloaddition of 2,3-bis(phen

68 Since catalytic enantioselective conjugate addition (ECA) reactions directly generate the

69 A new class of enantioselective conjugate addition (ECA) reactions that involve aryl- or

70 excess (ee) via allylboration, followed by a conjugate addition-elimination and ring-closing metathes

71 They can be removed highly effectively via a conjugate addition-elimination mechanism using pyrrolidi

72 th the thiol group on C319 of RAD51, using a conjugate addition-elimination mechanism.

73 ey steps in stereocontrol were an asymmetric conjugate addition employing a proline-based catalyst an

74 n a novel DNA-based catalytic Friedel-Crafts conjugate addition/enantioselective protonation reaction

75 Catalytic tandem conjugate addition-enolate trapping represents an effect

76 KODE-(E)-I adducts were confirmed to reflect conjugate addition (epoxide ring remains intact) through

77 Conjugate addition followed by enolate protonation gener

78 An alternative method to copper-catalyzed conjugate addition followed by enolate silylation for th

79 with 2,5-dimethylpyrrole through an initial conjugate addition followed by intramolecular O- and N-n

80 nd pyrrole to afford two isomeric oximes via conjugate addition followed by rearomatization of the py

81 te one quaternary stereocenter and a cuprate conjugate addition for the establishment of the other.

82 in situ oxidation of the enolate formed upon conjugate addition, giving access to the corresponding a

83 While oxa-conjugate additions have been shown to provide direct an

84 We hypothesize that a transannular oxa-conjugate addition in a macrocyclic laulimalide precurso

85 ive carbonyl anion species in situ allow for conjugate additions in good yield to sensitive nitroalke

86 etates selectively undergo two different 1,6-conjugate addition-initiated cyclization cascades.

87 lled fashion through application of a tandem conjugate addition-intramolecular cyclization method dev

88 cid which is advanced via a highly selective conjugate addition/intramolecular Friedel-Crafts acylati

89 In triflic acid-promoted reactions, conjugate addition is observed with pyrazine-, 2-pyrimid

90 Our data indicates that oxa-conjugate addition is reversible and that the stereochem

91 tically active species from solution and the conjugate addition is turned OFF.

92 atalytic enantioselective aldol and boronate conjugate additions, is discussed and illustrated throug

93 ed on results from DBFOX/Ph-promoted radical conjugate additions, is in need of revision.

94 Stereoelectronic control favors an axial conjugate addition leading to a particularly reactive co

95 eptide mimics by means of an organocatalytic conjugate addition, leading to chiral cyclic hemiacetals

96 The stepwise trans pathway, beginning with a conjugate addition-like transition state, becomes increa

97 containing the key functional groups for oxa-conjugate addition-mediated dihydropyran formation.

98 ly, using enantioselective rhodium-catalyzed conjugate addition methodology, we developed a catalytic

99 l substrates in contrast to more traditional conjugate addition methods.

100 uran solvent provides the products of tandem conjugate addition-Michael cyclization, 2a-2e, along wit

101 on of alcohols to ynones and promotes tandem conjugate addition/Michael cascade reactions.

102 We report an enantioselective conjugate addition nitro-Mannich reaction protocol which

103 Base-mediated double conjugate addition of 1,3-propane dithiol to various sil

104 A novel gamma-selective conjugate addition of 1-silyl-substituted dienol ethers

105 Under dinuclear catalysis, the direct conjugate addition of 2(5H)-furanone to nitroalkenes inv

106 The copper-catalyzed asymmetric conjugate addition of 2-oxazoline- and 2-thiazoline 4-ca

107 0 degradable poly(beta-amino esters) via the conjugate addition of 20 primary or secondary amine mono

108 A convenient, mild and effective conjugate addition of 3-butyn-2-one to a variety of anil

109 his route involves Davies's protocol for the conjugate addition of a chiral lithium amide to alpha,be

110 (i) an asymmetric Reformatsky reaction; (ii) conjugate addition of a chiral vinyllithium reagent; (ii

111 nylene)-2-phenylallyl (BDPA) radical via the conjugate addition of a derivatized fluorene nucelophile

112 A metal-free method for enantioselective conjugate addition of a dimethylphenylsilyl group to alp

113 The key step involves intramolecular 1,4-conjugate addition of a hydroxymethyl radical generated

114 ished as turnover limiting followed by rapid conjugate addition of a nickel hydride and nonselective

115 which are united in the synthetic pathway by conjugate addition of a nucleophilic tertiary radical to

116 ne, was elaborated through an intramolecular conjugate addition of a phenol to create the dihydrofura

117 f the process is attributed to a cooperative conjugate addition of a thiourea-bound carbamate anion t

118 a-arylation of propargylic ether followed by conjugate addition of a vinyl palladium intermediate and

119 shown to very effectively promote asymmetric conjugate addition of acetylacetone to trans-beta-nitroo

120 itional type of adduct resulting from direct conjugate addition of Ade to AF followed by hydrolytic c

121 An efficient intermolecular conjugate addition of alcohols to activated alkenes cata

122 lyzed by diarylprolinol ether catalysts, the conjugate addition of aldehydes to nitro-olefins and the

123 ptoid hybrids was assessed in the asymmetric conjugate addition of aldehydes to nitroolefins, where m

124 rted zinc-copper matrix reagent promotes the conjugate addition of alkyl iodides to cyclic and acycli

125 Last, conjugate addition of alkyl iodides to Dha, promoted by

126 ny natural products and pharmaceuticals--via conjugate addition of alkylzirconium reagents to a terti

127 The enantioselective conjugate addition of alkynyl nucleophiles has been a lo

128 heterocylylacetic acid derivatives involving conjugate addition of allyl mercaptan to an acrylate con

129 per(II) triflate catalyzed tandem asymmetric conjugate addition of AlMe3 to 2-methyl-2-cyclohexen-1-o

130 nsesterification, followed by intramolecular conjugate addition of alpha,beta-unsaturated esters to p

131 menaquinone (vitamin K(2)) is a Stetter-like conjugate addition of alpha-ketoglutarate with isochoris

132 synthase, or MenD, catalyze the Stetter-like conjugate addition of alpha-ketoglutarate with isochoris

133 Conjugate addition of alpha-nitrophosphonates to enones

134 The beta-aminoester, formed by the conjugate addition of ammonia on olefinic ester, undergo

135 ated in a highly stereocontrolled fashion by conjugate addition of an alkyllithium reagent to the s-c

136 processes constitute an uncommon instance of conjugate addition of an allyl moiety and afford the des

137 Nickel-(II)-catalyzed 1,4-conjugate addition of an alpha-alkylidene-beta-dicarbony

138 efficient route was developed that involved conjugate addition of an aryl Grignard reagent to a 2-ni

139 etoester starting materials and proceeds via conjugate addition of an in situ-generated palladium eno

140 catalyst and a syn-selective intramolecular-conjugate addition of an oxygen nucleophile to an alpha,

141 a alkaloid-derived urea-catalyzed asymmetric conjugate addition of aromatic thiols to cycloalkenones

142 l cinchona alkaloids catalyze the asymmetric conjugate addition of aromatic thiols to cycloalkenones

143 ickel catalyst and Cp2TiCl allows the direct conjugate addition of aryl and alkenyl iodides, bromides

144 The synthetic sequence begins with the conjugate addition of benzeneselenol to nitroalkenes (in

145 The substrate-controlled 1,3-stereoselective conjugate addition of boronic acids and potassium triflu

146 We have applied this new strategy to the conjugate addition of C-nucleophiles to enals via iminiu

147 lex 1a catalyzes the highly enantioselective conjugate addition of carbon- and nitrogen-based nucleop

148 The conjugate addition of carbonyl anions catalyzed by thiaz

149 ) from bicyclic enone 10 was accomplished by conjugate addition of crotylsilane, photochemical hydrob

150 utyrine (Dhb), respectively, followed by the conjugate addition of Cys residues to the Dha and Dhb re

151 ismuth-mediated two-component hemiacetal/oxa-conjugate addition of delta-trialkylsilyloxy and delta-h

152 The conjugate addition of dialkylzinc reagents to allyl fuma

153 y active (1 mol % cat. loading) promoters in conjugate addition of dibenzoylmethane to various trans-

154 An enantioselective copper-catalyzed conjugate addition of diethylzinc led to highly crystall

155 ic hydroformylation of allyl cyanide and the conjugate addition of diethylzinc to cycloalkenones.

156 Copper-catalyzed conjugate addition of diorgano zinc reagents to nitroacr

157 Subsequent conjugate addition of either a PIII species or phosphoru

158 Conjugate addition of either lithium (R)-N-allyl-N-(alph

159 amidite ligand promotes the copper catalyzed conjugate addition of Et(2)Zn to a N-carbamoyl-4-pyridon

160 ion but also as a functional equivalent to a conjugate addition of fluoride, furnishing products in m

161 Copper catalysis in the conjugate addition of Grignard reagents affords modest y

162 TMSCl-mediated conjugate addition of Grignard reagents to 2-substituted

163 Sequential carbonyl addition-conjugate addition of Grignard reagents to 3-oxocyclohex

164 Sequential carbonyl addition-conjugate addition of Grignard reagents to cyclic 5-7-me

165 Chelation-controlled conjugate addition of Grignard reagents to cyclic and ac

166 each elementary step of the copper-catalyzed conjugate addition of Grignard reagents to enamides, all

167 Enantioselective conjugate addition of Grignard reagents to enones, catal

168 Conjugate addition of guanidine to a bis enone followed

169 utes a new approach for the enantioselective conjugate addition of hydrazones to enals under metal-fr

170 ort chain reductase YwfH which catalyzes the conjugate addition of hydride at the C(4) olefinic termi

171 for carrying out the stereocontrolled formal conjugate addition of hydroxycarbonyl anion equivalents

172 iodoallenolate intermediate is generated via conjugate addition of iodide to an alkynone followed by

173 Conjugate addition of LDA/HMPA to an unsaturated ester p

174 Preparatively useful conjugate addition of lithiated methyl pyridines to cycl

175 The conjugate addition of lithium (R)-N-(3-chloropropyl)-N-(

176 The conjugate addition of lithium (R)-N-benzyl-N-(alpha-meth

177 been developed, using the diastereoselective conjugate addition of lithium (S)-N-benzyl-N-(alpha-meth

178 These substrates are readily prepared via conjugate addition of lithium (S)-N-benzyl-N-(alpha-meth

179 enantioselective copper-catalyzed asymmetric conjugate addition of Me2Zn to (Z)-nitroalkenes led to t

180 The conjugate addition of N-formyl derivatives of 2-amino-3-

181 The 1,6-conjugate addition of nucleophiles to dienyl diketones p

182 d the first example of a catalytic reductive conjugate addition of organic halides that proceeds via

183 ing use of the regio- and diastereoselective conjugate addition of organolithium reagents to alpha,be

184 Kinetic studies of the conjugate addition of propanal to nitrostyrene catalyzed

185 Key steps include a stereoselective conjugate addition of pyrrolidino enedione 19 to afford

186 Conjugate addition of RP(OTMS)(2) to alpha-methylene glu

187 recedented highly enantioselective catalytic conjugate addition of simple alkyl thiols to alpha,beta-

188 Specifically, a Bronsted base catalyzed conjugate addition of substituted 2-cyanomethylpyridine

189 st-translationally modified proteins through conjugate addition of sulfur nucleophiles to dehydroalan

190 turated ester, and doubly diastereoselective conjugate addition of the antipodes of lithium N-benzyl-

191 exahydro-1H-indole-2-carboxylic acid) by the conjugate addition of the free amine to the cyclohexadie

192 mine displacement of the chlorohydrin, and a conjugate addition of the hindered secondary amine to ac

193 ne 10 under acidic conditions led to net bis-conjugate addition of the latent diol to give the thermo

194 bsequent aza-Wacker oxidative cyclization or conjugate addition of the olefinated intermediates provi

195 on of the bicyclic isoxazolidine arises from conjugate addition of the oxime onto the diene to afford

196 Subsequent conjugate addition of the requisite antipode of lithium

197 unusual 6,7-ketol moiety and stereoselective conjugate addition of vinyl cuprate to enone.

198 he installation of the C8-hydroxyl group via conjugate addition of water to a putative strained bridg

199 ed the necessary catalytic machinery for the conjugate addition of water.

200 cestor but retained the key elements for the conjugate addition of water.

201 osphite 6b catalyzes highly enantioselective conjugate additions of acyl silanes to alpha,beta-unsatu

202 Finally, a GC2 base was found to catalyze conjugate additions of alpha-aryl ester pronucleophiles,

203 Enantioselective conjugate additions of arylboronic acids to beta-substit

204 development of a highly efficient method for conjugate additions of commercially available bis(pinaco

205 n a three-component (A(3)) condensation, and conjugate additions of Cu acetylides.

206 e substrates were readily prepared using the conjugate additions of lithium (R)-N-benzyl-N-(alpha-met

207 ) were achieved using the diastereoselective conjugate additions of lithium amide reagents in the key

208 The first examples of conjugate additions of N-tert-butanesulfinyl metalloenam

209 ssible organocopper catalyst can promote 1,6-conjugate additions of propargyl and 2-boryl-substituted

210 The highly diastereoselective conjugate additions of the novel lithium amide reagents

211 mmetric alpha-alkylation of aldehydes by 1,6-conjugated addition of enamines to p-quinone methides is

212 ng position of the vinyl substituent, either conjugate addition or Markovnikov addition occurs.

213 novel, one-step Diels-Alder/beta-elimination/conjugate addition organocascade sequence allowed rapid

214 ) as the allyl transfer reagent and promotes conjugate addition over 1,2-addition.

215 A merged conjugate addition/oxidative coupling sequence that repr

216 calculations and kinetics studies, support a conjugate addition pathway as more favorable energetical

217 suggest that the reaction is proceeding by a conjugate addition pathway rather than by a pathway invo

218 yclic carbene (NHC)-mediated organocatalytic conjugate-addition polymerization of acrylic monomers.

219 nd the catalytic nature of this NHC-mediated conjugate-addition polymerization.

220 Cu-catalyzed enantioselective conjugate additions proceed to completion within only 2

221 A dynamic beta-elimination/conjugate addition process was strategically applied to

222 t the stereochemical outcome of organocopper conjugate addition processes focus on the nucleophilic a

223 ions, the model under went regiospecific oxa-conjugate addition producing a stable trans oxetane as t

224 The stereochemistry of the conjugate addition product is the result of axial attack

225 ester, thioester, nitro moieties) within the conjugate addition products allowed for straightforward

226 Synthetic manipulations of the conjugate addition products are demonstrated, including

227 The conjugate addition products could rapidly be converted w

228 as a selective coupling partner to generate conjugate addition products exclusively.

229 endo-8 from the respective syn-4 and anti-7 conjugate addition products in a one-pot tandem fashion.

230 at 60 degrees C, provides the corresponding conjugate addition products in moderate to good yields.

231 tion mixture allowed a one-pot methylenation/conjugate addition protocol to be developed, which great

232 ne intermediates, consisting of the proposed conjugate addition-proton transfer-NHC release fundament

233 a highly stereoselective heteroatom-directed conjugate addition reaction and cyclopentanone ring cycl

234 sted acid-catalyzed asymmetric guanidine aza-conjugate addition reaction has been developed.

235 talysts for the unreported, enantioselective conjugate addition reaction of the barbituric acid pharm

236 the oxidized Leu66 side chain, suggesting a conjugate addition reaction of the imidazole nitrogen to

237 These fragments were linked by a challenging conjugate addition reaction that also generated the C11

238 ulfonyl anion surrogate in the DBU-catalyzed conjugate addition reaction with enones and enals for th

239 es, which involved a 6-exo-trig free-radical conjugate addition reaction.

240 e recently introduced; these boryl and silyl conjugate addition reactions (BCA and SCA, respectively)

241 Copper-catalyzed asymmetric conjugate addition reactions are a very powerful and wid

242 atalyst loadings as low as 0.1 mol%, for the conjugate addition reactions of 1,3-dicarbonyl compounds

243 e application of developments for asymmetric conjugate addition reactions of organocopper reagents wi

244 Conjugate addition reactions to enones can now be done i

245 The conjugate addition reactions used both acrylate and male

246 results of systematic studies of arylcuprate conjugate addition reactions with cis and trans gamma-al

247 lent enantiomeric ratios are obtained in the conjugate addition reactions with methyl vinyl ketone wh

248 N-carbamoyl-4-pyridones undergo conjugate addition reactions with organocuprates and org

249 Catalytic asymmetric conjugate addition reactions with organometallic reagent

250 expand the classical reactivity pattern for conjugate addition reactions.

251 ously been used to guarantee good results in conjugate addition reactions.

252 silyl donor to enals, enones, and enoates in conjugate addition reactions.

253 H-Pro-Pro-Xaa-NH2-type peptidic catalysts in conjugate addition reactions.

254 s" expands the scope of potential donors for conjugate addition reactions.

255 ligand for enantioselective nickel-catalyzed conjugate addition reactions.

256 odulate asymmetric quimioselective aldol and conjugate addition reactions.

257 ctive species in copper-catalyzed asymmetric conjugate addition reactions.

258 density functional theory calculations, of a conjugate addition-rearrangement sequence that leads to

259 on to eleven carbonyl acceptors (X-CHO), two conjugate addition sites (X-CH=CH2; X = CHO, NO2), eight

260 in good to excellent yields through a tandem conjugate addition/Smiles rearrangement involving aryl a

261 cantly more stereoselective than the radical conjugate addition step.

262 suggest a new mechanism involving sequential conjugate addition steps to explain these copolymerizati

263 tudy, we demonstrate that a transannular oxa-conjugate addition strategy is a viable approach to the

264 This oxa-conjugate addition strategy should provide a viable rout

265 of Michael acceptors is amenable to this new conjugate addition strategy.

266 olefin geometry was discovered using a silyl conjugate addition strategy: aldehydes and ketones were

267 The conjugate addition takes place smoothly in toluene at ro

268 s introduced by means of an enantioselective conjugate addition that forms an all-carbon quaternary c

269 exchange, thiolate-disulfide interchange and conjugate addition) that displays bistability and oscill

270 etone oxidation, aryl-halide activation, and conjugate addition through a single catalytic cycle.

271 ng an alternative disconnection, a hemiketal conjugate addition to a naphthaquinone electrophile was

272 relative stereochemistry; a malonate enolate conjugate addition to a nitrosoalkene in order to instal

273 enter and the a/d rings, 2) a malonate anion conjugate addition to a transient nitrosoalkene to insta

274 tereochemistry was established by asymmetric conjugate addition to an alpha,beta-unsaturated ester (6

275 ty and stereocontrol in catalytic asymmetric conjugate addition to enamides, the method is distinguis

276 strated in a Rh(I)-catalyzed decarboxylative conjugate addition to form a C-C bond at a meta position

277 ters that react constructively via thiol-ene conjugate addition to form sulfide functionalized copoly

278 n intermolecular ester enolate/nitrosoalkene conjugate addition to form the C-15/16 bond, followed by

279 a highly anti-diastereoselective arylcuprate conjugate addition to gamma-alkoxy-alpha,beta-enoates an

280 licits a highly stereoselective allyl silane conjugate addition to produce a trichlorotitanium enolat

281 The conjugate addition to the alpha-alkyl cyclohexenone 10 p

282 1,6-conjugate addition to the quinone is favored over 1,4-co

283 substituted benzenesulfonamide followed by a conjugate addition to the resulting 2H-pyridone and subs

284 ivatives are obtained in excellent yields by conjugate addition to tosylacetylene (ethynyl p-tolyl su

285 Conjugate additions to acyclic and cyclic 5-7-membered a

286 ted as promoters of enantioselective radical conjugate additions to alpha,beta-unsaturated alpha-nitr

287 Diastereoselective conjugate additions to alpha,beta-unsaturated sulfones h

288 ction: See text] Lewis acid promoted radical conjugate additions to beta-substituted alpha,beta-unsat

289 rategy addresses the challenge of performing conjugate additions to disubstituted alkenenitriles and

290 nucleophiles in intramolecular Michael-type conjugate additions to in situ generated nitrosoalkenes

291 ered protic environment that readily undergo conjugate additions to substituted alpha,beta-unsaturate

292 talyzed method for enantioselective boronate conjugate additions to trisubstituted alkenes of acyclic

293 enantioselective catalytic methods including conjugate addition under metal-free conditions with an N

294 ion (>4 A) and products that are reactive to conjugate additions under mild conditions.

295 ormed by an organocatalytic enantioselective conjugate addition using the respective trifluoroborate

296 Conjugate additions utilizing the simple monosilylcuprat

297 exhibited by the metal-free approach (e.g., conjugate addition vs reaction with an alkyne, allene, o

298 proceeds via sequential Michael and Mannich conjugate additions whereby the primary amine activates

299 his process merged an intramolecular radical conjugate addition with an enolate hydroxylation and cre

300 amides 1 were subjected to rhodium-catalyzed conjugate addition with arylboronic acids providing high