ライフサイエンスコーパス: coreceptor

1 sts, it is possibly not due to its role as a coreceptor.

2 gh viral adaptation to use a drug-bound CCR5 coreceptor.

3 acement of filamentous actin from the CD4(+) coreceptor.

4 i-inflammatory effect is binding to the CD14 coreceptor.

5 (CCR5) or C-X-C chemokine receptor 4 (CXCR4) coreceptor.

6 g via a plexin receptor without a neuropilin coreceptor.

7 interactions with the cellular receptor and coreceptor.

8 ss sensitive, even in the absence of the CD8 coreceptor.

9 protein (Env) and cellular CD4 receptors and coreceptors.

10 inhibitory receptors, as well as modulating coreceptors.

11 us interactions with both the CXCR4 and CCR5 coreceptors.

12 GPR15 and CXCR6 to serve as potential entry coreceptors.

13 p120 that allow high-affinity binding to its coreceptors.

14 ding of soluble Sema3A to Neuropilin/PlexinA coreceptors.

15 that lack expression of CD4 and CD8alphabeta coreceptors.

16 y superantigens does not require CD4 and CD8 coreceptors.

17 strong for cells with low surface density of coreceptors.

18 We cloned sabaeus CD4 and 10 candidate coreceptors.

19 It enabled us to show that CCR5 coreceptor activation is rapidly reversible and to disse

20 ximately 100 times more efficiently and that coreceptor activation is reversible, enabling synchronou

21 erapeutic approach aimed at blocking the HIV coreceptor activity of CXCR4 without knocking down its c

22 ich is required to be phosphorylated for TCR coreceptor activity, and a dileucine endocytosis motif.

23 hough these DN thymocytes fail to re-express coreceptors after OP9-DL1 culture, they eventually matur

24 pt expression in testes, we show that the OR coreceptor, AgOrco, is localized to the flagella of A. g

25 e V3 loop, blocking its interaction with the coreceptor and altering the structure of the envelope sp

26 It acts as an inhibitory coreceptor and modulates B cell activation, especially o

27 ts of MIF may involve CD74 together with the coreceptor and PEC activation marker CD44.

28 upled receptor (GPCR) that serves for an HIV coreceptor and was also recently found as a novel homing

29 The Arabidopsis genome encodes nine PP2C coreceptors and 14 different RCARs, which can be divided

30 , instead, processes in the thymus involving coreceptors and other molecules select MHC-specific TCRs

31 cooperative binding between the TCR and CD4 coreceptor, and a low frequency of Ag-specific CD4(+) T

32 et a host cell protein, CCR5, an HIV-1 entry coreceptor, and not viral protein.

33 hybrid pattern recognition receptors and TCR coreceptors, and they may function as antimicrobials.

34 nes showed that this compound acts as a dual-coreceptor antagonist.

35 Moreover, the early use of coreceptor antagonists against the remaining CCR5-tropic

36 that are distinct from those of known HIV-1 coreceptor antagonists.

37 HCI-restricted TCRs (0.9 s) because more CD4 coreceptors are Lck-loaded compared to CD8.

38 RCARs and PP2C coreceptors are represented by small protein families co

39 WC1 coreceptors are scavenger receptor cysteine-rich (SRCR)

40 CCR5, which indicates that alternative entry coreceptors are used by SIV in vivo in these animals.

41 o studied species, the expression of the SIV coreceptor as well as the expression of a number of host

42 Parallel recruitment of coreceptor-associated Lck kinase to the TCR ensured Zap7

43 ired the common receptor-like protein kinase coreceptor BAK1.

44 aran sulfate proteoglycan were implicated as coreceptors because only the combination of anti-DC-SIGN

45 GFR1 at the cell-surface with or without the coreceptor betaKlotho.

46 ls along with FGF receptors and its obligate coreceptor, betaKlotho.

47 loop highly flexible, implying disruption of coreceptor binding and attachment to the target cell.

48 can coordinately suppress both receptor and coreceptor binding and conformationally entrap the prote

49 D4-induced conformational changes leading to coreceptor binding and fusion, and HIV-1 Env conformatio

50 CD8 coreceptor binding and lymphocyte-specific kinase signal

51 The plasticity of the coreceptor binding cavity is shown to be essential for d

52 e cell membrane can be inhibited by blocking coreceptor binding or by preventing fusion-inducing conf

53 essibility of bNAb epitopes in the CD4bs and coreceptor binding region, thus representing a potential

54 mponent of the Env trimer contributes to the coreceptor binding site and is a target for neutralizing

55 is active and allowing mapping of the native coreceptor binding site on pMHC II.

56 rtance of V3 lies in its contribution to the coreceptor binding site on the target cell.

57 ycoproteins on these HIV-1 variants expose a coreceptor binding site that overlaps some CD4-induced (

58 xposure or the stability of the receptor and coreceptor binding site without affecting the integrity

59 (CD4) and an antibody (36D5) at part of the coreceptor binding site, we visualized multiple conforma

60 earrange and separate to allow access to the coreceptor binding site.

61 ts its neutralization effect by blocking the coreceptor binding site.

62 Ab epitopes in V3 and/or associated with the coreceptor binding site.

63 on that the antigenicity of the receptor and coreceptor binding sites can be modulated by a single gl

64 It shields V3 and the coreceptor binding sites in the prefusion state and expo

65 as insensitive to actin inhibitors, post-CD4/coreceptor binding steps during FFWO were abrogated.

66 ved CD4-induced epitope on gp120 involved in coreceptor binding.

67 he V3 region, two gp120 elements involved in coreceptor binding.

68 i) antibodies, which recognize the conserved coreceptor-binding site of the HIV-1 envelope glycoprote

69 auses gradual and reversible exposure of the coreceptor-binding site.

70 ides simultaneously target the receptor- and coreceptor-binding sites of the HIV-1 envelope glycoprot

71 The CD4- and coreceptor-binding sites serve as epitopes for two class

72 imicking sulfated tyrosines in CCR5 and anti-coreceptor-binding-site antibodies such as 412d.

73 ing between prefusion-closed, CD4-bound, and coreceptor-bound conformations by transitioning into a p

74 induced defense responses required the known coreceptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECE

75 id differentiation protein 2 (MD2) is a TLR4 coreceptor, but its role in pollen- and cat dander-induc

76 It is also used as a coreceptor by some HIV-1 strains (X4 strains), whereas o

77 species-matched CXCR6 and other alternative coreceptors by SIVagmSab, which infects sabaeus AGM.

78 regulated by the expression of a suppressive coreceptor called PD-1.

79 tilization was observed, indicating that the coreceptor can compensate for TbpA impairment.

80 p120 binds to CD4, the HIV-1 receptor, and a coreceptor, capturing an open conformational state in wh

81 y lipoprotein receptor-related protein 5 Wnt coreceptor causes constitutive activation of Wnt signali

82 sed and secreted), the ligands for HIV entry coreceptor CC chemokine receptor type 5.

83 tended to increase the expression of the HIV coreceptor CCR5 and the activation marker CD69.

84 Genetic disruption of the HIV-1 coreceptor CCR5 by nucleases in T cells is under 2 clini

85 The expression of the SIV coreceptor CCR5 on CD4+ T cells dramatically increased i

86 IV) have been described that can utilize the coreceptor CCR5 or CXCR4 in the absence of CD4, these vi

87 ntry inhibitor drug maraviroc makes the cell coreceptor CCR5 unavailable for use by HIV-1 and is now

88 erse transcriptase, protease, integrase, and coreceptor CCR5 with EC50's ranging from 0.9 to 1.5 muM.

89 HIGH) CD4(+) T cells, do not express the HIV coreceptor CCR5 yet serve as a latent reservoir in GCs.

90 press very low levels of the canonical entry coreceptor CCR5, and recent studies have shown that CCR5

91 R3(+) cells preferentially expressed the HIV coreceptor CCR5, and vaccine-induced CXCR3(+)CXCR5(+) ce

92 memory CD4(+) T cells often express the HIV coreceptor CCR5, are significantly more proliferative, a

93 hosts have very low levels of the SIV entry coreceptor CCR5, suggesting that restricted entry may li

94 All T/F viruses used coreceptor CCR5, while no T/F viruses used CXCR4 or GPR1

95 +) FoxP3(+) CD4(+) T cells expressed the HIV coreceptor CCR5.

96 frequency of CD4(+) cells expressing the SIV coreceptor CCR5.

97 f T(SCM) cells were found to express the HIV coreceptors CCR5 and CXCR4 and were infected by HIV both

98 the viral entry receptor CD4 as well as the coreceptors CCR5 and CXCR4 from the surface of HIV-infec

99 , including the viral entry receptor CD4 and coreceptors CCR5 and CXCR4.

100 HIV-1 requires the CD4 receptor and a coreceptor (CCR5 [R5 phenotype] or CXCR4 [X4 phenotype])

101 Binding of gp120 to CD4 and a coreceptor (CCR5 or CXCR4) reduces the constraint on met

102 inal homing (beta7hi), activation, and HIV-1 coreceptor (CCR5) expression in peripheral blood.

103 ther strains (R5 strains) use an alternative coreceptor, CCR5.

104 onserved gp120 site for interaction with the coreceptors, CCR5 and CXCR4.

105 double blockade of complement C5 and the TLR coreceptor CD14 could improve survival of experimental p

106 nally, antibodies against TLR2, TLR4, or the coreceptor CD14 reduced the profibrotic responses of ure

107 d expression of TLR4, its adaptor MyD88, and coreceptors CD14 and MD2.

108 transduction by the B-cell receptor and its coreceptor CD19.

109 ceptors on the B-cell surface, including the coreceptor CD19.

110 -particle tracking, we show how the negative coreceptor CD22 works with the cortical cytoskeleton in

111 modulation of the function of the inhibitory coreceptor CD22.

112 cell antigen receptor (TCR) and required the coreceptor CD28 and the kinase TAK1.

113 on via the T cell antigen receptor (TCR) and coreceptor CD28 to accelerate and increase Mir210 expres

114 ulation with antigen or via the TCR plus the coreceptor CD28, with Lys325 and Lys506 being the main s

115 report the influence of signaling domains of coreceptors CD28 and 4-1BB on the metabolic characterist

116 substrate through the T-cell receptor (TCR) coreceptor CD3 and CD28, a costimulation signal essentia

117 T cells from CCI patients in response to TCR/coreceptor (CD3/CD28) challenge.

118 The alphabeta T-cell coreceptor CD4 enhances immune responses more than 1 mil

119 unction of Nef is the down-regulation of the coreceptor CD4 from the surface of the host cells.

120 ion of the gene encoding the T cell-specific coreceptor CD4 in helper and cytotoxic T cells exemplifi

121 Like the TCR coreceptor CD4, WC1 is endocytosed in response to PMA.

122 T cells expressed memory markers and the HIV coreceptors CD4 and CCR5; they were not detected in subj

123 seconds) interaction between CD3zeta and the coreceptor CD8 that is independent of the binding of CD8

124 is triggered by interactions of the TCR and coreceptor (CD8 or CD4) with antigenic peptides embedded

125 ion, killing stimulatory receptor Ly49s6 and coreceptor CD8alphaalpha on this cell used rat nonclassi

126 -cadherin ligation and involves the cadherin coreceptor Cdo with its downstream effector, Cdc42.

127 eptor cluster of differentiation 4 (CD4) and coreceptors chemokine receptor type 5 and chemokine-rela

128 ctor H, blocked B cell activation by the BCR coreceptor complex (CD19/CD21/CD81).

129 ates to the F-box protein COI1-JAZ jasmonate coreceptor complex and suggest that coincidence detectio

130 Auxin is perceived by a transient coreceptor complex consisting of a TIR1/AFB protein and

131 nd CD21 and preventing colocalization of the coreceptor complex with the BCR.

132 ory expression of an NB2 (Contactin5)/Caspr4 coreceptor complex, together with spinal interneuron exp

133 extracellular epitopes of the HCV CD81-CLDN1 coreceptor complex.

134 ppression and whether association with other coreceptor complexes is needed have remained unknown.

135 ort that formation of the pre-fusion Env-CD4-coreceptor complexes triggers non-apoptotic cell surface

136 luenced by both auxin accumulation and F-box coreceptor concentration.

137 ingly, we used HIV envelope gp140 and CD4 or coreceptor (CoR) binding site (bs) mutant probes to eval

138 pon sequential binding of Env to CD4 and the coreceptor CXCR4 or CCR5.

139 udy, we demonstrate the efficient use of the coreceptor CXCR6 by SIVagmSab to infect sabaeus African

140 fection is mediated by the alternative entry coreceptor CXCR6, as well as CCR5.

141 r is a concern for therapies applying single-coreceptor disruption.

142 D8(+) T cells can, in the absence of the CD8 coreceptor, elicit CD4 T cell help and partially reverse

143 cells, are missing for the endothelial cell coreceptor endoglin and for the ALK1 type I receptor, wh

144 but also, critically, by promoting B7-2/CD28 coreceptor engagement, forcing the principal costimulato

145 ested downstream of CD4 binding but prior to coreceptor engagement.

146 an intermediate stage downstream of Env-CD4-coreceptor engagement.

147 Although the introduction of the CD8 coreceptor enhanced the ability of CD4(+) T cells to rec

148 with decreased phosphorylation of ErbB3, its coreceptor ErbB2, and its downstream target, AKT.

149 CD28 is a coreceptor expressed on T lymphocytes.

150 e members of the Siglec family of inhibitory coreceptors expressed on B cells that participate in enf

151 CD4-independent HIV-1 variants can infect coreceptor-expressing cells lacking CD4.

152 st-selected double-positive cells lose CD4/8 coreceptor expression and masquerade as double-negative

153 ssion status, downregulates HIV receptor and coreceptor expression and may reduce susceptibility of i

154 irus (HIV) infectivity increases as receptor/coreceptor expression levels increase.

155 ne their effects on cellular activation, HIV coreceptor expression, and innate restriction factor exp

156 re observed, along with elevated CD5 and CD8 coreceptor expression.

157 ase binding to MHC class I tetramers and CD8 coreceptor expression.

158 differ in TCR sequence motifs, affinity, and coreceptor expression.

159 sistent with the current views that HJV is a coreceptor for BMP6 in hepatocytes.

160 CCR5, a coreceptor for cellular HIV-1 entry expressed on macroph

161 Neuropilin 1 (Nrp1), a coreceptor for class 3 semaphorins and growth factors, i

162 t neuropilin 1 (Nrp1), an originally defined coreceptor for class 3 semaphorins and VEGF, plays impor

163 tients express activated forms of ERBB2 (the coreceptor for ERBB3) and cMET.

164 ng sites identified betaKlotho, an essential coreceptor for FGF21, as a direct target gene of Rev-erb

165 Membrane-bound Klotho acts as a permissive coreceptor for FGF23, and its expression was recently fo

166 ne-bound protein (mKL) and recognized as the coreceptor for fibroblast growth factor-23 (FGF23) and a

167 Cas9 RNPs allowed ablation of CXCR4, a coreceptor for HIV entry.

168 nt located in the CCR5 mRNA, which encodes a coreceptor for HIV-1 and is, to our knowledge, the first

169 CCR5 is the major coreceptor for human immunodeficiency virus (HIV).

170 xpressed on multiple cell types and can be a coreceptor for human immunodeficiency virus 1.

171 results identify SorCS2 as an indispensable coreceptor for p75(NTR) and TrkB in hippocampal neurons

172 signal-dependent cooperation between TCR and coreceptor for pMHC binding previously observed for CD8

173 y Slit/Robo1 signaling and by FLRT3, a novel coreceptor for Robo1.

174 CD14, a coreceptor for several pattern recognition receptors and

175 CD14 is a coreceptor for several TLRs, including TLR4 and TLR2.

176 CCR5 has been described as the primary entry coreceptor for SIV in vivo, while human-derived CXCR6 an

177 We also showed that SM CXCR6 is a robust coreceptor for SIVsmm in vitro.

178 tor-related protein 6 (LRP6) is an essential coreceptor for Wnt signaling, and its genetic variants h

179 ion is the use of CXCR6 or other alternative coreceptors for entry, which may direct SIV toward CD4(+

180 rt that acidic lipids function with Ypt7p as coreceptors for HOPS, supporting membrane tethering and

181 agmVer entry in vitro and may serve as entry coreceptors for SIVagm in vivo, since their mRNAs were d

182 CD4(+) T cells and are potential alternative coreceptors for SIVagm use in vivo.

183 All bovine WC1 proteins can serve as coreceptors for the TCR in a tyrosine phosphorylation de

184 ycan motifs of gangliosides serve as initial coreceptors for these protein complexes, whereby a membr

185 nces were even more significant for usage of coreceptors FPRL1, CCR3 and APJ.

186 gnaling through promoting degradation of Wnt coreceptors Frizzled (FZD) and LRP6, and this activity i

187 ves to infect new cell types by changing the coreceptor from CCR5 to CXCR4 to infect naive T cells or

188 ficient blocking of Orco (olfactory receptor coreceptor) function.

189 n interaction that requires the nonsignaling coreceptor GDNF family receptor (GFRalpha3).

190 ch has been most notably applied to the CCR5 coreceptor gene, or the introduction of small mutations

191 he mechanoreceptor marker NF200 and the GDNF coreceptor GFRalpha1.

192 ps, via the Ret receptor tyrosine kinase and coreceptor Gfralpha1; Ret signaling up-regulates transcr

193 fusion protein specific for both the CD4 and coreceptor gp120-binding sites.

194 fusion protein specific for both the CD4 and coreceptor gp120-binding sites.

195 Two isoforms of this coreceptor have been described in humans: CXCR4-A and CX

196 ne morphogenetic protein 6 (BMP6) or the BMP coreceptor hemojuvelin (HJV) in mice leads to a similar

197 lecules and is strongly modulated by the BMP coreceptor hemojuvelin (HJV).

198 4-using virus (CXCR4 is the main alternative coreceptor HIV-1 uses, in addition to CD4).

199 RT) drug to target a human protein, the CCR5 coreceptor; however, the mechanisms of maraviroc-associa

200 promoting or repressive activity of a single coreceptor in multiple simultaneously active pathways.

201 sociated receptor kinase1 (BAK1) is a common coreceptor in plants and regulates distinct cellular pro

202 understanding the functional role of the WC1 coreceptors in the gammadelta T cell responses.

203 uch as GPR15 and CXCR6, also function as SIV coreceptors in vitro.

204 , indicating that SIVsmm can use alternative coreceptors in vivo.

205 ugh the use of the simian CD81 ortholog as a coreceptor, indicating that HCV entry is not restricted

206 rst extramembrane loop of CCR5 (the main HIV coreceptor), induce a long-lasting internalization (48 h

207 A striking feature of coreceptor-induced remission is the purging of T cells f

208 sults demonstrate that NF279 is a dual HIV-1 coreceptor inhibitor that interferes with the functional

209 sts could thus represent a new class of dual-coreceptor inhibitors with a structure and a mechanism o

210 er interfaces, areas remote from where these coreceptors interact, implying that inflammatory signali

211 region of HIV-1 gp120 is important for virus-coreceptor interaction and highly immunogenic.

212 depends on Ca(2+) signaling triggered by Env-coreceptor interactions and involves the lipid scramblas

213 al compatibility and specificity of receptor-coreceptor interactions.

214 er, the emergence of viruses using the CXCR4 coreceptor is a concern for therapies applying single-co

215 nist Eritoran, and provide evidence that the coreceptor is a molecular switch that undergoes ligand-i

216 nteraction of the Lck kinase with CD4 or CD8 coreceptors is critical for generation of MHC specificit

217 Loss-of-function mutations in Wnt coreceptor LDL receptor-related protein 6 (LRP6) underli

218 lpha interacts with Wnt signaling at the Wnt coreceptor level.

219 Modulation of CD8 coreceptor levels can profoundly affect T-cell sensitivi

220 ent capacity for epigenetic reprogramming of coreceptor levels on effector CD8(+) T cells enables the

221 ther coreceptors when tested at limiting CD4/coreceptor levels.

222 (-/-) mice to determine contributions of Wnt coreceptor low-density lipoprotein receptor-related prot

223 ncogenic Wnt signaling by binding to the Wnt coreceptor low-density lipoprotein receptor-related prot

224 ired Wnt signaling caused by loss of the Wnt coreceptor Lrp5 in models of lung fibrosis induced by bl

225 The Wnt coreceptors Lrp5 and Lrp6 are essential for normal postn

226 We show that the Wnt coreceptor, Lrp5, is a genetic driver of lung fibrosis i

227 We show that folding of the Wnt signaling coreceptor LRP6 is promoted by ubiquitination of a speci

228 that miR-19a negatively regulates FZD4, its coreceptor LRP6, and WNT signaling, and that antagonism

229 gest that simultaneous disruption of the HIV coreceptors may provide a useful approach for the long-t

230 r 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS

231 We identified two anti-HIV-1 antibodies, the coreceptor mimicking antibody 17b and the gp120-gp41 int

232 These coreceptors modulate T cell responses upon antigen prese

233 engaged T cell receptor (TCR) scans multiple coreceptor molecules to find one that is coupled to Lck;

234 minopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid.

235 anized mouse model of HIV-1 infection, these coreceptor negative cells engraft and traffic normally,

236 s for the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular phenot

237 eptor accessory protein (IL1RAP; IL1R3) is a coreceptor of interleukin-1 receptor type 1 and has been

238 tin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health a

239 CCR5 and CXCR4, the respective cell surface coreceptors of R5 and X4 HIV-1 strains, both form hetero

240 an sulfate proteoglycans (HSPGs) function as coreceptors or modulators of Wnt activation.

241 er defects associated with loss of receptor, coreceptor, or ligand, indicating that Norrin/Frizzled4

242 ORs and the olfactory coreceptor (Orco) are with very high probability lacking

243 enes, and this inhibition depended on the JA coreceptor OsCOI1.

244 tivated receptor 4 (PAR4; Par4(-/-)), or its coreceptor, PAR3, were mated.

245 ing RNA (siRNA) suppresses activation of Wnt/coreceptor pathways.

246 We further show that the coreceptor PD-1 with its ligand PD-L1, immunotherapy tar

247 T cells with regard to the inhibitory T-cell coreceptors PD-1 and Tim-3 in patients with metastatic m

248 inactivates the phosphatase activity of the coreceptor, permitting phosphorelay of the ABA signal vi

249 expressing alphabeta TCR but lacking CD4/CD8 coreceptors play protective as well as pathogenic roles.

250 SEMA3F acts on its coreceptors, plexins and neuropilins, among which neurop

251 eratively to its cellular receptor CD4 and a coreceptor, principally CXCR4 or CCR5.

252 at synergy emerges when Env engages multiple coreceptors prior to inducing fusion and when high-affin

253 hereby the risk variant augments the BCR and coreceptor programs throughout B cell development, promo

254 B cell-activating factor receptor, and CD40 coreceptor programs, leading to broadly enhanced positiv

255 Evidence indicates that Abs binding to the coreceptors promotes T cell egress from these tissues.

256 oposed that differential kinetics of CD4/CD8 coreceptors regulate fate choice of selected thymocytes.

257 am of Lrp5, but not the closely related Lrp6 coreceptor, regulate the activation of beta-catenin and

258 nd its interaction with CD44 (a putative MET coreceptor regulated by Wnt signaling and highly express

259 a (TGF-beta) receptors and its modulation by coreceptors represent an important level of regulation f

260 substrate), a receptor tyrosine kinase (RTK) coreceptor required for cellular migration, and pro-NRG1

261 and transcriptional silencing of CD8 or CD4 coreceptors, respectively, in MHC class II or I (MHCII o

262 Auxin binding to the coreceptor results in degradation of the Aux/IAAs and de

263 g requires the interaction of GFRAL with the coreceptor RET.

264 g, thereby abrogating Env's interaction with coreceptor(s).

265 Monoclonal antibodies (mAbs) against the HCV coreceptor scavenger receptor class B type I (SR-BI) inh

266 -glycan branching of TCR and the CD4 and CD8 coreceptors separately altered the upper and lower affin

267 rmline encoded TCR bias for MHC, and for the coreceptor sequestration model in the context of allorea

268 early actin activity by hijacking chemokine coreceptor signaling, which activates a host dependency

269 D4 engagement appear to be restricted to the coreceptor site.

270 nhibitors suppresses binding at both CD4 and coreceptor sites on Env and triggers gp120 shedding, lea

271 Mice lacking the Lrp5 coreceptor specifically in osteoblasts and osteocytes ex

272 neic transplantation with nonfunctional CCR5 coreceptor stem cells.

273 umbers of CTLA-4-containing vesicles and its coreceptor surface expression.

274 heir interactions with the type III TGF-beta coreceptor (TbetaRIII) in live cells and their effects o

275 ernalize Tf-bound iron in the absence of the coreceptor TbpB.

276 receptor kinases (SERKs) are ligand-binding coreceptors that are able to combine with different liga

277 The present study examined how coreceptor therapy affects the migration of CD4(+) T cel

278 We reported that coreceptor therapy reverses diabetes in new onset NOD mi

279 f their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or

280 tion of the retinoid X receptor-alpha (RXRA) coreceptor to PML/RARA is required for transformation, w

281 -associated minor H antigen, HA-1; (2) a CD8 coreceptor to promote function of the class I-restricted

282 t a model in which TIM4 engages integrins as coreceptors to evoke the signal transduction needed to i

283 sion level is low, the use of CXCR6 or other coreceptors to mediate infection may target SIV toward d

284 nce in the env and pol genes, and determined coreceptor tropism and the frequency of drug resistance

285 Coreceptor tropism can be assessed by either phenotypic

286 neutralizing antibodies (bNab), determining coreceptor tropism of the virus, identifying compartment

287 vorable to its subsequent association with a coreceptor, typically CCR5 or CXCR4.

288 CD3(+) cells expressed CD4 and CD8 coreceptors, underwent antigen receptor gene rearrangeme

289 at the modest but significant differences in coreceptor usage efficiency, IFN-alpha sensitivity and v

290 Importantly, the levels of coreceptor usage efficiency, resistance to IFN-alpha and

291 t manner that is independent of receptor and coreceptor usage.

292 pic predictions and phenotypic assessment of coreceptor usage.

293 ogous and heterologous plasma, and chemokine coreceptor usages for cell entry, suggesting similar abi

294 presenting different clades, tissue origins, coreceptor usages, and neutralization sensitivities.

295 Furthermore, we also show that coreceptor use is the determining factor for differentia

296 ed sabaeus AGM and found similar patterns of coreceptor use.

297 through the TCR itself, rather than the CD3 coreceptor, was tested.

298 XCR6 and CCR5 were more efficient than other coreceptors when tested at limiting CD4/coreceptor level

299 due to preexisting virus that uses the CXCR4 coreceptor, while true resistance occurs through viral a

300 myeloid differentiation factor-2 (MD-2), the coreceptor within the TLR4/MD-2 receptor complex, as the