ライフサイエンスコーパス: corticotropin-releasing hormone

1 xytocin (OT), arginine-vasopressin (AVP), or corticotropin releasing hormone.

2 axis activity secondary to hypersecretion of corticotropin-releasing hormone.

3 evels, showing no response to stimulation by corticotropin-releasing hormone.

4 rphin in response to the usual secretagogue, corticotropin-releasing hormone.

5 s I were identified as potent antagonists of corticotropin-releasing hormone-1 receptor (CRH1-R, also

6 CRH (corticotropin-releasing hormone), a peptide released fro

7 alamic-pituitary-adrenal (HPA) axis hormones-corticotropin-releasing hormone, adrenocorticotropic hor

8 of mice homozygous for null mutations of the corticotropin-releasing hormone alleles.

9 the endogenous stress response, principally corticotropin-releasing hormone and its downstream effec

10 he mRNAs encoding the precursor peptides for corticotropin-releasing hormone and neurotensin/neuromed

11 l work has led to the proposal that in PTSD, corticotropin-releasing hormone and noradrenergic system

12 Oversecretion of corticotropin-releasing hormone and/or dysregulation of

13 ding glutamate, acetylcholine, somatostatin, corticotropin releasing hormone, and nitric oxide.

14 ernal blood (i.e., C-reactive protein (CRP), corticotropin-releasing hormone, and cytokines) were com

15 vasopressin, thyrotropin-releasing hormone, corticotropin-releasing hormone, and somatostatin, are a

16 at several peptide markers (cholecystokinin, corticotropin-releasing hormone, and tachykinin 1) label

17 omatostatin, arginine vasopressin, oxytocin, corticotropin-releasing hormone, and thyrotropin-releasi

18 e of investigation, include treatment with a corticotropin-releasing hormone antagonist and gene ther

19 Levels of corticotropin-releasing hormone are elevated in patients

20 These neurons, which synthesize and release corticotropin-releasing hormone, arginine vasopressin, a

21 , cortisol, arginine vasopressin, prolactin, corticotropin-releasing hormone, beta-endorphin, and som

22 found that the rs28365143 variant within the corticotropin-releasing hormone binding protein (CRHBP)

23 We demonstrate that corticotropin-releasing-hormone-binding protein (CRHBP),

24 somatostatin, thyrotropin-releasing hormone, corticotropin-releasing hormone), central autonomic cont

25 The intron of the corticotropin-releasing hormone (corticoliberin; CRH) ge

26 Using a corticotropin releasing hormone-cre driver X tdTomato re

27 of the vagus, DMV) to examine the effects of corticotropin releasing hormone (CRF) on the central com

28 Corticotropin releasing hormone (CRH) acts on the centra

29 duces long-lasting reduction of hypothalamic corticotropin releasing hormone (CRH) expression and upr

30 Here, we report that transcription of the corticotropin releasing hormone (CRH) gene is regulated

31 ional interaction between macroautophagy and Corticotropin Releasing Hormone (Crh) in the gut.

32 Intra-amygdala CORT or intra-LC corticotropin releasing hormone (CRH) infusion supported

33 ects of intravenous hydrocortisone and ovine corticotropin releasing hormone (CRH) infusions in patie

34 Corticotropin releasing hormone (CRH) is disrupted in in

35 erone levels and elicits c-fos expression in corticotropin releasing hormone (CRH) neurons of the hyp

36 nt male and female offspring received either corticotropin releasing hormone (CRH) or saline intraven

37 Corticotropin releasing hormone (CRH) plays a major role

38 al requires Nmu receptor 2 and signaling via corticotropin releasing hormone (Crh) receptor 1.

39 te nucleus of the hypothalamus (ARH) and the corticotropin releasing hormone (CRH) system in the para

40 Glucocorticoids and corticotropin releasing hormone (CRH) underlie the physi

41 ry-adrenal (HPA) axis through the release of corticotropin releasing hormone (CRH), leading to produc

42 Corticotropin releasing hormone (CRH), which activates a

43 , and serotonin--as well as the neuropeptide corticotropin releasing hormone (CRH).

44 d by potentiating the action of hypothalamic corticotropin releasing hormone (CRH).

45 Peptide secretion stimulated by corticotropin releasing hormone (CRH; 10(-8) M) was firs

46 ethylation of the cortisol-regulating genes, corticotropin releasing hormone (CRH; P=0.05) and glucoc

47 The neuropeptide corticotropin-releasing hormone (CRH) activates locus ce

48 LIF and corticotropin-releasing hormone (CRH) also synergistical

49 luding those that encode the stress hormones corticotropin-releasing hormone (CRH) and adrenocorticot

50 Corticotropin-releasing hormone (CRH) and arginine vasop

51 Human skin is a local source of corticotropin-releasing hormone (CRH) and expresses CRH

52 stress-induced c-fos mRNA and a reduction of corticotropin-releasing hormone (CRH) and glucocorticoid

53 al (HPA) axis, including local expression of corticotropin-releasing hormone (CRH) and its receptors

54 The corticotropin-releasing hormone (CRH) and its type 1 rec

55 n-33 (IL-33), and stress molecules including corticotropin-releasing hormone (CRH) and neurotensin (N

56 ncluding mucosal release of substance P (SP) corticotropin-releasing hormone (CRH) and neutrophil tra

57 ess-induced PVN c-fos mRNA, and elevated PVN corticotropin-releasing hormone (CRH) and parvocellular

58 y-adrenal (HPA) axis, including hypothalamic corticotropin-releasing hormone (CRH) and pituitary cort

59 r (GR), the mineralocorticoid receptor (MR), corticotropin-releasing hormone (CRH) and pro-opiomelano

60 at stress may impact wake regulation through corticotropin-releasing hormone (CRH) and the orexinergi

61 skin have shown expression of the genes for corticotropin-releasing hormone (CRH) and the related ur

62 Corticotropin-releasing hormone (CRH) and urocortins (Uc

63 paired from abnormal expression of amygdalar corticotropin-releasing hormone (CRH) and/or CRH-binding

64 High densities of nerve cells containing corticotropin-releasing hormone (CRH) are located in the

65 Substance P (SP) and corticotropin-releasing hormone (CRH) are particularly p

66 s been postulated that altered expression of corticotropin-releasing hormone (CRH) can at least parti

67 Because norepinephrine (NE) and corticotropin-releasing hormone (CRH) can produce these

68 cally link the RA-associated marker with the corticotropin-releasing hormone (CRH) candidate gene, an

69 nstem adrenergic and noradrenergic inputs to corticotropin-releasing hormone (CRH) cells of the hypot

70 larval zebrafish with transgenically labeled corticotropin-releasing hormone (CRH) cells, which repre

71 the hypothesis that basal elevations in CSF corticotropin-releasing hormone (CRH) concentrations exi

72 Corticotropin-releasing hormone (CRH) coordinates multip

73 Corticotropin-releasing hormone (CRH) derived from the p

74 Intracerebroventricular administration of corticotropin-releasing hormone (CRH) elicits a constell

75 employed viral-genetic approaches to reduce corticotropin-releasing hormone (Crh) expression in the

76 ropeptide Y (NPY) expression and to decrease corticotropin-releasing hormone (CRH) expression were no

77 ce was associated with decreases in cFos and corticotropin-releasing hormone (CRH) expression.

78 rocortin and urocortin II are members of the corticotropin-releasing hormone (CRH) family of neuropep

79 tress promotes secretion of the neuropeptide corticotropin-releasing hormone (CRH) from hippocampal i

80 axis initiates the production and release of corticotropin-releasing hormone (CRH) from the paraventr

81 activity for the suppression of hypothalamic corticotropin-releasing hormone (CRH) gene expression an

82 We found increased corticotropin-releasing hormone (Crh) gene expression in

83 ion of progesterone in the regulation of the corticotropin-releasing hormone (CRH) gene.

84 Extrahypothalamic corticotropin-releasing hormone (CRH) has been implicate

85 ral alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone (CRH) have been implicat

86 Retrograde tracing from the LC combined with corticotropin-releasing hormone (CRH) immunohistochemist

87 of the expression of the stress neurohormone corticotropin-releasing hormone (CRH) in hypothalamic ne

88 experiments investigated the involvement of corticotropin-releasing hormone (CRH) in the BLA in modu

89 The excitatory actions of corticotropin-releasing hormone (CRH) in the brain and t

90 reduced expression of the anorectic peptide corticotropin-releasing hormone (CRH) in the paraventric

91 nstrate that a cluster of neurons expressing corticotropin-releasing hormone (Crh) in the pontine mic

92 interaction between neuropeptide Y (NPY) and corticotropin-releasing hormone (CRH) in the regulation

93 ted cytokine oncostatin M induced basal, and corticotropin-releasing hormone (CRH) induced proopiomel

94 Central administration of corticotropin-releasing hormone (CRH) induces immediate-

95 hibitory factor (LIF) to strongly potentiate corticotropin-releasing hormone (CRH) induction of POMC

96 transcription factor B (NF-kappaB), whereas corticotropin-releasing hormone (CRH) inhibited both the

97 Corticotropin-releasing hormone (CRH) is a central integ

98 Corticotropin-releasing hormone (CRH) is a central regul

99 Corticotropin-releasing hormone (CRH) is a major regulat

100 Corticotropin-releasing hormone (CRH) is a neuropeptide

101 Because corticotropin-releasing hormone (CRH) is an anxiogenic n

102 Increased corticotropin-releasing hormone (CRH) is hypothesized to

103 Corticotropin-releasing hormone (CRH) is secreted under

104 Corticotropin-releasing hormone (CRH) is secreted under

105 Corticotropin-releasing hormone (CRH) is suggested to be

106 n of the paraventricular nucleus (PVN) where corticotropin-releasing hormone (CRH) is synthesized.

107 Corticotropin-releasing hormone (CRH) is the primary hyp

108 Peripheral corticotropin-releasing hormone (CRH) is thought to have

109 Corticotropin-releasing hormone (CRH) is widely recogniz

110 amic area (LHA) show increased expression of corticotropin-releasing hormone (CRH) mRNA as a conseque

111 animals and had two components: (1) reduced corticotropin-releasing hormone (CRH) mRNA in the neuroe

112 like immunoreactivity (Fos-LI) and levels of corticotropin-releasing hormone (CRH) mRNA in the parave

113 sociated with a cocaine-induced reduction of corticotropin-releasing hormone (CRH) mRNA level in the

114 Vasoactive intestinal peptide (VIP) and corticotropin-releasing hormone (CRH) mRNA levels were u

115 Surprisingly, basal corticotropin-releasing hormone (CRH) mRNA or post-restr

116 administration on hypothalamic expression of corticotropin-releasing hormone (CRH) mRNA.

117 Paraventricular hypothalamic (PVH) corticotropin-releasing hormone (CRH) neuroendocrine neu

118 Intravenous IL-1beta activates corticotropin-releasing hormone (CRH) neurones in the pa

119 Here we demonstrate that corticotropin-releasing hormone (CRH) neurons are modula

120 affects excitatory and inhibitory inputs to corticotropin-releasing hormone (CRH) neurons in the hyp

121 Corticotropin-releasing hormone (CRH) neurons in the par

122 ormation onto paraventricular neuroendocrine corticotropin-releasing hormone (CRH) neurons is a major

123 plasma and Fos (c-fos protein) activation in corticotropin-releasing hormone (CRH) neurons of the fet

124 We found that lateral hypothalamic corticotropin-releasing hormone (CRH) neurons show exten

125 opic thyrotropin-releasing hormone (TRH) and corticotropin-releasing hormone (CRH) neurons to regulat

126 lar nucleus (PVN) of hypothalamus, including corticotropin-releasing hormone (CRH) neurons, by induci

127 tical areas transmit signals to hypothalamic corticotropin-releasing hormone (CRH) neurons, which con

128 augments excitatory synaptic strength in PVN corticotropin-releasing hormone (CRH) neurons, with GLP-

129 st physiological actions of the neuropeptide corticotropin-releasing hormone (CRH) on hippocampal pyr

130 sampling before and after administration of corticotropin-releasing hormone (CRH) on separate days.

131 These experiments examined the effects of corticotropin-releasing hormone (CRH) on single-unit ele

132 bria/fornix blocked the excitatory effect of corticotropin-releasing hormone (CRH) on startle (CRH-en

133 el synergistic actions of corticosterone and corticotropin-releasing hormone (CRH) on synaptic physio

134 PVN-NTS projection includes those expressing corticotropin-releasing hormone (CRH) or oxytocin.

135 ing hormone, oxytocin, arginine vasopressin, corticotropin-releasing hormone (CRH) or thyrotropin-rel

136 ress, adrenal corticosterone and hippocampal corticotropin-releasing hormone (CRH) permeate memory-fo

137 Corticotropin-releasing hormone (Crh) plays an important

138 could result from estrogen regulation of the corticotropin-releasing hormone (CRH) promoter via eithe

139 creening of our chemical library using a rat corticotropin-releasing hormone (CRH) receptor assay led

140 Corticotropin-releasing hormone (CRH) receptor type 1 (C

141 xpression levels of mRNA encoding the type 1 corticotropin-releasing hormone (CRH) receptor, which ha

142 The activation of corticotropin-releasing hormone (CRH) receptors within t

143 g-standing paradigm posits that hypothalamic corticotropin-releasing hormone (CRH) regulates neuroend

144 he potential for NMDA receptor regulation of corticotropin-releasing hormone (CRH) release.

145 Corticotropin-releasing hormone (CRH) released at local

146 Corticotropin-releasing hormone (CRH) released from the

147 le attention is that 5-HT regulates upstream corticotropin-releasing hormone (CRH) signaling systems

148 petrosal-to-peripheral ACTH gradients before corticotropin-releasing hormone (CRH) stimulation in six

149 e time-integrated cortisol response to human corticotropin-releasing hormone (CRH) stimulation was lo

150 The corticotropin-releasing hormone (CRH) system coordinates

151 velty have been attributed to differences in corticotropin-releasing hormone (CRH) system function.

152 The corticotropin-releasing hormone (CRH) system is implicat

153 In addition, increased activation of the corticotropin-releasing hormone (CRH) system within the

154 working memory (WM) deficits; changes to the corticotropin-releasing hormone (CRH) system; and struct

155 vasopressin (AVP) acts synergistically with corticotropin-releasing hormone (CRH) to stimulate ACTH

156 ble cAMP early repressor (ICER), in limiting corticotropin-releasing hormone (CRH) transcription duri

157 ted the effects of the lipophilic nonpeptide corticotropin-releasing hormone (CRH) type 1 receptor an

158 The possible neurotransmitter role of corticotropin-releasing hormone (CRH) was studied in the

159 e production and release of the neuropeptide corticotropin-releasing hormone (CRH) within the hippoca

160 tyric acid (GABA)(A) receptor with those for corticotropin-releasing hormone (CRH) within the rat hyp

161 Corticotropin-releasing hormone (Crh), a 41-residue poly

162 lished by blocking the receptor (CRFR(1)) of corticotropin-releasing hormone (CRH), a hippocampal neu

163 n the underlying mechanisms, but the role of corticotropin-releasing hormone (CRH), a hypothalamic ho

164 The actions of corticotropin-releasing hormone (Crh), a mediator of end

165 on the effects of ACTH on the expression of corticotropin-releasing hormone (CRH), a neuropeptide in

166 c stress wherein transgenic mice overexpress corticotropin-releasing hormone (CRH), a primary mediato

167 Although corticotropin-releasing hormone (CRH), a regulator of st

168 Extensive preclinical data implicate corticotropin-releasing hormone (CRH), acting through it

169 ormones increased expression of hypothalamic corticotropin-releasing hormone (CRH), ADP had no substa

170 was used to determine the colocalization of corticotropin-releasing hormone (CRH), enkephalin (ENK),

171 nal function, we exploited mice deficient in corticotropin-releasing hormone (CRH), IL-6, or both.

172 se of neuromodulators, including the peptide corticotropin-releasing hormone (CRH), leading to activa

173 Although corticotropin-releasing hormone (CRH), produced by parvo

174 We report that administration of corticotropin-releasing hormone (CRH), the key limbic st

175 Corticotropin-releasing hormone (CRH), the key regulator

176 Corticotropin-releasing hormone (CRH), through the hypot

177 nals were collected and processed to measure corticotropin-releasing hormone (CRH), urocortin (Ucn),

178 activities by stimulating the expression of corticotropin-releasing hormone (CRH), urocortin, proopi

179 multilabeled for vasotocin, mesotocin (MT), corticotropin-releasing hormone (CRH), vasoactive intest

180 ormone 44 (Dh44), a homolog of the mammalian corticotropin-releasing hormone (CRH), were specifically

181 Corticotropin-releasing hormone (CRH), which activates t

182 ticoids and the stress-released neuropeptide corticotropin-releasing hormone (CRH), which influence t

183 evious studies have described the effects of corticotropin-releasing hormone (CRH), which is released

184 Interestingly, corticotropin-releasing hormone (CRH)-1 receptors, which

185 se is characterized by the activation of the corticotropin-releasing hormone (CRH)-adrenocorticotropi

186 Corticotropin-releasing hormone (CRH)-deficient (KO) mic

187 ts physiologic importance, we have exploited corticotropin-releasing hormone (CRH)-deficient mice gen

188 he adult brain, we have virally traced local corticotropin-releasing hormone (CRH)-expressing inhibit

189 noreactive boutons in apposition to both the corticotropin-releasing hormone (CRH)-immunoreactive cel

190 corticomedullary interface is innervated by corticotropin-releasing hormone (CRH)-like beaded fibers

191 inhibit acute inflammation via hypothalamic corticotropin-releasing hormone (CRH)-mediated secretion

192 ing the sympathetic nervous system (SNS) and corticotropin-releasing hormone (CRH).

193 P), proopiomelanocortin (POMC) products, and corticotropin-releasing hormone (CRH).

194 ion independent of the input of hypothalamic corticotropin-releasing hormone (CRH).

195 ence implicates the excitatory neuropeptide, corticotropin-releasing hormone (CRH).

196 nced vertebrate genomes for genes resembling corticotropin-releasing hormone (CRH).

197 ed subset of OXT neurons that co-express the corticotropin-releasing hormone (CRH).

198 oderate density of fibers immunoreactive for corticotropin-releasing hormone (CRH).

199 cipal effectors of the stress system include corticotropin-releasing hormone (CRH); arginine vasopres

200 Unilateral local infusion of corticotropin-releasing hormone (CRH; 0, 10, 20, 40 and

201 Corticotropin-releasing hormone (CRH; or corticotropin-r

202 Furthermore, endogenous corticotropin-releasing hormone(+) (CRH(+)) LC inputs fr

203 We used the corticotropin-releasing hormone-deficient (Crh(-/-)) mou

204 re, we asked if glucocorticoid deficiency in corticotropin-releasing hormone-deficient mice (CRH-/-)

205 abrogated in TNF-/- mice and was shown to be corticotropin-releasing hormone dependent.

206 ntrast, mRNA levels of another neuropeptide, corticotropin releasing hormone, do not change under the

207 In addition, we discovered that corticotropin-releasing hormone-expressing cells contain

208 The corticotropin-releasing hormone family mediates function

209 oked robust upregulation of cholecystokinin, corticotropin releasing hormone, galanin, neuropeptide Y

210 peptides found in the neuroendocrine system: corticotropin-releasing hormone, growth hormone-releasin

211 pheral sites and in tumors, we asked whether corticotropin-releasing hormone has angiogenic propertie

212 refrontal cortex restrains the amygdala, the corticotropin-releasing hormone/hypothalamic-pituitary-a

213 These data support the corticotropin-releasing hormone hypothesis of depression

214 Corticotropin-releasing hormone immunoreactive (CRH-ir)

215 rovide information regarding the function of corticotropin-releasing hormone in peripheral sites and

216 Stress and corticotropin-releasing hormone inhibit the reproductive

217 Corticotropin-releasing hormone is a main regulator of m

218 Corticotropin-releasing hormone is also expressed in man

219 The hypothalamic neuropeptide corticotropin-releasing hormone is the major hypothalami

220 MNL-CMR-associated PTD showed higher CRP and corticotropin-releasing hormone levels.

221 Peripheral corticotropin-releasing hormone may thus enhance local a

222 al raphe-originating serotonergic control of corticotropin-releasing hormone-mediated excitation of t

223 In stressed mice, corticotropin-releasing hormone, nerve growth factor, ne

224 way in rat paraventricular hypothalamic CRH (corticotropin-releasing hormone) neuroendocrine neurons

225 from the nucleus tractus solitarii (NTS) to corticotropin releasing hormone neurons in the paraventr

226 Low levels of corticotropin-releasing hormone neurons also expressed E

227 communicated to paraventricular hypothalamic corticotropin-releasing hormone neurons by way of subcor

228 arvocellular PVN, suggesting localization in corticotropin-releasing hormone neurons.

229 the pathogenesis of IBD include substance P, corticotropin-releasing hormone, neurotensin, and vasoac

230 ds of aberrant membrane receptors but not by corticotropin-releasing hormone or dexamethasone.

231 rved in the distribution of cells containing corticotropin releasing hormone- or ERbeta-ir.

232 A possible link between placental corticotropin-releasing hormone (pCRH) and PPD incidence

233 al stress physiology, specifically placental corticotropin-releasing hormone (pCRH).

234 Urocortin is a member of the corticotropin-releasing hormone peptide family and is fo

235 YO also increased Fos in the majority of corticotropin releasing hormone-positive neurons in the

236 ly blunted Fos activation in the BNST and in corticotropin-releasing hormone-positive PVNmp neurons a

237 In conclusion, besides elements of the corticotropin-releasing hormone/proopiomelanocortin syst

238 erone levels), and alleviated by antalarmin (corticotropin releasing hormone receptor 1 antagonist).

239 cluding the membrane progestin receptor, the corticotropin releasing hormone receptor, and the 5HT1a

240 The type 1 corticotropin-releasing hormone receptor (CRH-R1) influe

241 e other ligand-binding site defined--for the corticotropin-releasing hormone receptor 1 (CRF1R)--whic

242 lation of the Crhr1 transcript, encoding the corticotropin-releasing hormone receptor 1 (CRH-R1), was

243 Corticotropin-releasing hormone receptor 1 (CRHR1) activ

244 Variations in the corticotropin-releasing hormone receptor 1 (CRHR1) gene

245 In addition, GR and corticotropin-releasing hormone receptor 1 (CRHR1) genot

246 Variation in one gene, corticotropin-releasing hormone receptor 1 (CRHR1) was c

247 ment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1)

248 elch-like protein 2)), chromosome 17 (CRHR1 (corticotropin-releasing hormone receptor 1) and MAPT (mi

249 Activation of corticotropin-releasing hormone receptor 2 (CRHR2) in th

250 e UCN3 (Urocortin 3) and its receptor CRHR2 (corticotropin-releasing hormone receptor 2) genes.

251 5'-untranslated region (UTR) of the mRNA on corticotropin-releasing hormone receptor type 1 (CRHR1)

252 5-2 muM) for 6 hours significantly increases corticotropin-releasing hormone receptor-1 (CRHR-1) mRNA

253 found a significant three-way interaction on corticotropin-releasing hormone receptor-1 (Crhr1) gene

254 ally stimulates endothelial chemotaxis via a corticotropin-releasing hormone receptor-dependent mecha

255 bellar Purkinje cells, and co-localized with corticotropin-releasing hormone receptors in the latter.

256 stress-coping responses by binding to type 2 corticotropin-releasing hormone receptors.

257 The corticotropin releasing hormone-related ligand, urocorti

258 xpression of genes relevant to emotionality: corticotropin-releasing hormone, serotonin, norepinephri

259 in both the initial and replication samples: corticotropin-releasing hormone signaling, cardiac beta-

260 l enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signalin

261 In vitro, we found that human corticotropin-releasing hormone specifically stimulates

262 sulted in higher (125)I-Tyr-oCRH binding and corticotropin-releasing hormone-stimulated cAMP producti

263 utaneous expression of a proopiomelanocortin/corticotropin-releasing hormone system, we investigated

264 y outcomes, including repeated dexamethasone-corticotropin-releasing hormone tests, and psychiatric r

265 cellular oxytocin neurons, and parvicellular corticotropin-releasing hormone, thyrotropin-releasing h

266 ibitory glucocorticoid regulation, including corticotropin-releasing hormone-, thyrotropin-releasing

267 16,311, a selective nonpeptide antagonist of corticotropin-releasing hormone type 1 (CRH(1)) receptor

268 a indicate that genetic variation within the corticotropin-releasing hormone type 1 receptor gene (CR

269 not GABAergic, and do not express oxytocin, corticotropin-releasing hormone, vasopressin, or prodyno

270 epithelial tumor cells engineered to secrete corticotropin-releasing hormone was associated with sign

271 kephalin-containing cells; coexpression with corticotropin-releasing hormone was rare.