ライフサイエンスコーパス: covalent

1 the nature of nfGNPs-VLPs interaction is non-covalent.

2 ion (DNP), provide direct evidence of shared covalent (29) Si-O-(29) Si bonds between intermediate na

3 characteristics (DeltaE<5); while acylation (covalent acid attachment) resulted in DeltaE 5-15.

4 e identified the reversible character of the covalent addition chemistry, even at temperatures below

5 Through the covalent addition of phosphate groups to certain amino-a

6 and various electrophilic compounds, through covalent adduct formation at the C7-C8 olefin of PL, whe

7 NMR reveals that the drugs form a covalent adduct near the Ub-binding pocket leading to th

8 Moreover, aS forms a covalent adduct with DHA.

9 the enzyme involved in the formation of the covalent adduct.

10 SA was immobilized onto the CMD chip through covalent amide binding formation.

11 DNA minor-groove binding agents that form a covalent aminal bond between their C11-position and the

12 Supramolecular copolymers, non-covalent analogues of synthetic copolymers, constitute a

13 The Xe-Br and Xe-Cl bonds are very weakly covalent and can be viewed as sigma-hole interactions, s

14 o the presence of distinctly coexisting weak covalent and lone-pair interactions, give rise to cooper

15 h amines, highlighting the impact of metal-S covalent and metal-NH2 dative bonds in controlling the m

16 structure-guided development of a series of covalent and mutant-selective EGFR inhibitors that effec

17 e most relevant synthetic approaches for the covalent and non-covalent functionalization and characte

18 Our FEP calculations also revealed that covalent and noncovalent binding states of an inhibitor

19 cal properties of melanins are influenced by covalent and noncovalent disorder.

20 t possibilities, such as homodimerization in covalent and noncovalent forms.

21 ich were used extensively to prepare several covalent and noncovalent heteroporphyrin-based multiporp

22 stic MD simulations to reveal the details of covalent and noncovalent protein interactions that link

23 itope peptides could be used as specific non-covalent and paratope-independent handles in targeted dr

24 The concept of forcing covalent and reversible bonds to mix at molecular scale

25 Here, we investigate the dynamic covalent assembly of short o-phenylenes, a simple class

26 e next identified residues important for the covalent attachment and selected the FrdA(E245) residue,

27 Covalent attachment of a synthetic triantennary N-acetyl

28 nalized pCB is shown to be recovered only by covalent attachment of amino acid deactivation agents to

29 Covalent attachment of antibodies on 2D PC membrane base

30 um groups with ERGO and subjected to further covalent attachment of Azure A (Azu-A) mediator or gluco

31 robe and PAMAM-Dendrimers/AuNPs was used for covalent attachment of CA125-antibody and completing the

32 describe a novel method that integrates the covalent attachment of DNA handles to target proteins wi

33 homologs, but the mechanisms underlying the covalent attachment of FAD remain to be fully elucidated

34 lso allow layer-specific postcrystallization covalent attachment of guest molecules.

35 N-myristoylation is the covalent attachment of myristic acid to the N terminus o

36 in a process referred to as pupylation, the covalent attachment of prokaryotic ubiquitin-like protei

37 O-Linked glycosylation often involves the covalent attachment of sugar moieties to the hydroxyl gr

38 ins we show the SPKTG motif is essential for covalent attachment to the cell wall.

39 Although a range of covalent azobenzene-based photoactive materials has been

40 red to native beta-Lactoglobulin and the non-covalent beta-lactoglobulin/caffeic complex (betaLg/CA).

41 Also, due to the ability of the non-covalent beta-sheet cross-links to reassemble, the hydro

42 nding free energy and the overall reversible covalent binding affinity using a two-state binding mode

43 The direct covalent binding and the detailed characterization of th

44 cation of soft organic electrophiles through covalent binding at its cysteine (Cys) thiol group, foll

45 bout 160 of the new products were formed via covalent binding of 3-QCA with DOM molecules of above-av

46 -ATP monolayers previously oxidized, and the covalent binding of amino-oligonucleotides to pure p-MBA

47 Covalent binding of capturing biomolecule (anti-TNF-alph

48 hese products were presumably formed through covalent binding of CBZ phototransformation products wit

49 ere we describe a detailed protocol based on covalent binding of nucleophilic groups on Wnt proteins

50 eaction mechanism could be inferred from the covalent binding of the proteasome-specific inhibitor ep

51 n general, can be used to predict reversible covalent binding selectivity.

52 We conclude that covalent binding state alone, in general, can be used to

53 on warhead scaffold, in both noncovalent and covalent binding states, and for two highly homologous p

54 alcohol dehydrogenase enzyme immobilised by covalent binding through an array composed of carbon Tor

55 Drug covalent binding to endogenous proteins (haptenation) is

56 atures a photoreactive moiety for UV-induced covalent binding to GSTs and GSH-binding enzymes.

57 However, the effect of non-covalent binding to Nedd8 remains unknown.

58 Baseline separation is achieved on all covalent biotin additions, for each charge state, for bo

59 We report here on the use of covalent bond formation among monomers, compensating for

60 d a validated 8-N-benzyladenosine ligand for covalent bond formation and confirmed targeted irreversi

61 chemistry the study of the interplay between covalent bond formation and noncovalent interactions has

62 Our findings document covalent bond formation between the asparagusic acid moi

63 rements together provided strong evidence of covalent bond formation between the photoacids and the p

64 Covalent bond formation to Cys-154 was confirmed by incu

65 th processes, which involve a combination of covalent bond formation, degenerate bond exchange, and n

66 lf-assembly pathways can enable control over covalent bond formation.

67 Upon blue light activation, a covalent bond is formed between VVD residue Cys108 and i

68 anic frameworks (COFs), the chemistry of the covalent bond was extended to two- and three-dimensional

69 ch exerted its inhibitory efficacy through a covalent bond with BTK Cys481.

70 ts are linked by a genuine d(10)-d(10) polar-covalent bond with ligand-unassisted Cu(I)-Au(I) distanc

71 captured HIV-1 Env trimers via a more stable covalent bond, resulting in enhanced germinal center B c

72 rst C-H functionalization could involve Ru-N covalent bond, the second C-H functionalization most lik

73 his seminal work on what became known as the covalent bond, which has since occupied a central role i

74 escent probe in tissue by the formation of a covalent bond.

75 topic abundance (4.7%) establish the through-covalent-bond (29)Si-O-(29)Si connectivities of distinct

76 cture calculations to quantify the extent of covalent bonding in-arguably-one of the most difficult s

77 e of poly(ether sulfone) (PES) membranes via covalent bonding.

78 found to sensitize ground-state Cu(I)-Au(I) covalent bonds and near-unity phosphorescence quantum yi

79 nclusion that PL inhibits GSTP1, which forms covalent bonds between GSH and various electrophilic com

80 nzymatic, or chemoenzymatic formation of new covalent bonds between two polypeptides, or between a si

81 In this context, the generation of transient covalent bonds is a fundamental tool for nonequilibrium

82 Here, organic molecules are linked by covalent bonds to yield crystalline, porous COFs from li

83 the substrate by electrostatic interactions, covalent bonds, and physical interpenetration.

84 SCAN accurately describes the balance among covalent bonds, hydrogen bonds, and van der Waals intera

85 rogen bonds, coordination bonds, and dynamic covalent bonds.

86 ognition strategy to a new family of tubular covalent cages to create both 1D porous nanotubes and 3D

87 ent linkage induced by DOPA oxidation allows covalent capture of the aligned nanofiber bundles, enhan

88 Covalent capture of these labile assemblies provides acc

89 sses three key properties: (i) an all-sp (3) covalent carbon framework that produces high-frequency p

90 Posttranslational modifications are covalent changes made to proteins that typically alter t

91 eral conditions to explore the nature of the covalent chemical bond, non-covalent interactions, bond

92 MOFs represent the development of covalent chemistry "beyond the molecule" and into extend

93 Dynamic covalent chemistry enables self-assembly of reactive bui

94 Dynamic covalent chemistry is exploited to drive morphological o

95 entation chain transfer (RAFT)-based dynamic covalent chemistry is incorporated into liquid crystalli

96 rigger morphological transitions via dynamic covalent chemistry offers considerable scope for the des

97 With the advent of reversible covalent chemistry the study of the interplay between co

98 Here we describe an on-demand covalent chemistry to address this intriguing challenge.

99 works (which are usually prepared by dynamic covalent chemistry) and for the synthesis of viologen-ba

100 ns are due to trapping and processing of the covalent cleavage intermediate.

101 in mesostructured soft solids involving non-covalent co-assembly has received little attention.

102 etastable phases were predicted, such as the covalent CO2-based layer in P1 Li(CO2)2.

103 acterized C2O4(2-) oxalate in Li2C2O4 viable covalent CO2-based nets emerge upon compression within t

104 aromatic module and the reactive group, each covalent combination of the modules yields one exclusive

105 To exploit these properties of TF, a covalent complex between FVIIa and the soluble ectodomai

106 and sTF G109C spontaneously assembled into a covalent complex with functional properties similar to t

107 The non-covalent complexes formed between the peptide and cargo

108 and mitoxantrone-induced TOP2A and TOP2B-DNA covalent complexes in cells, which are converted to DNA

109 Moreover, the non-covalent complexes were optimally detected at wavelength

110 Carbon dioxide forms covalent complexes with N-heterocyclic carbenes.

111 roteinases factor Xa and thrombin by forming covalent complexes with them.

112 ic nature but may also contain a significant covalent component.

113 The array is fabricated using non-covalent conjugation of an aptamer-anchor polynucleotide

114 nanowire surface that are effective for the covalent conjugation of antibody without further surface

115 immune responses can only be achieved by the covalent conjugation of CPSs with carrier proteins to pr

116 However, the need for covalent conjugation of small molecules to MPPs can nega

117 se results offer proof-of-concept of how the covalent conjugation of two angiogenesis-related small m

118 In contrast to their covalent counterparts, the details of their mechanism of

119 Importantly, the covalent coupling not only enhanced gp120-directed respo

120 ) molecules underwent dehydrocyclization and covalent coupling reactions on Au(111) according to scan

121 lysis, apparently resulting from significant covalent cross-linking that occurs during the treatment

122 ssembling beta-sheet peptides to provide non-covalent cross-linking through beta-sheet assembly, rein

123 all molecules and post self-assembly undergo covalent cross-linking using copper catalyzed click chem

124 Covalent cross-links are crucial for the folding and sta

125 n be well ionized via ESI MS, and the strong covalent cross-links are stable during ionization.

126 ed peptide mapping revealed as many as seven covalent cross-links in the HMW fractions, where oxidize

127 ected cells, causing subsequent formation of covalent cross-links of MAPKs.

128 with one another and allowing their dynamic covalent crosslinkers to undergo intra- to interpolymer

129 th a small-amount dynamic CB[8]-mediated non-covalent crosslinking (2.5 mol%), yields extremely stret

130 Mechanical tuning by mixing reversible covalent crosslinking kinetics is found to be independen

131 drogen bonds are often polar motifs, whereas covalent crosslinks are nonpolar motifs.

132 ork to one with larger distances between the covalent crosslinks when heated.

133 Making use of enforced covalent DDR1 dimerisation, which does not affect recept

134 SpyTag002 reaction enabled specific and covalent decoration of intimin for live cell fluorescent

135 The covalent diamantyl (C28H38) and oxadiamantyl (C26H34O2)

136 lent trimers, we found that m4-1BBL formed a covalent dimer via 2 cysteines absent in h4-1BBL.

137 e, we used rhDNase, which only forms His-His covalent dimers after light treatment to determine the f

138 show that it exists as monomers but also as covalent dimers.

139 rotein extensibility lies in the presence of covalent disulfide bonds, which significantly enhance pr

140 BaP forms covalent DNA adducts after metabolic activation and indu

141 , and unique ADME assays of our irreversible covalent drug discovery program which culminated in the

142 advantages over noncovalent or irreversible covalent drugs.

143 In this work, a covalent electron donor-acceptor-radical triad is used t

144 rt the synthesis of a full-fledged family of covalent electron donor-acceptor1-acceptor2 conjugates a

145 from 5'-triphospho-RNA (pppRNA) to GDP via a covalent enzyme-pRNA intermediate to generate a 5'-cap s

146 y factor and bound dicarboxylates, stimulate covalent flavinylation by preorganizing the active site

147 The SdhE assembly factor enhances covalent flavinylation of Complex II homologs, but the m

148 Here, we explored the mechanisms of covalent flavinylation of the E. coli QFR FrdA subunit.

149 the anticipated assembly intermediate during covalent flavinylation, FrdA(E245) variants had stabilit

150 z-protected donors revealed the formation of covalent FucN3 triflates and oxosulfonium triflates.

151 on nanotube nested in a charged, impermeable covalent functional shell, Tube(wedge)2 allows the semic

152 ynthetic approaches for the covalent and non-covalent functionalization and characterization of GBMs.

153 Examples of these processes range from covalent functionalization of graphene to modify its pro

154 ility of these probes is further enhanced by covalent functionalization with bisphosphonate.

155 protein carriers, however they often require covalent fusion to the protein for efficient delivery.

156 LuPc2 incorporated SiO2 and PANI(PVIA); (ii) covalent grafting of PANI(PVIA) onto the surface of SiO2

157 nd CcmH reduces this disulfide bond to allow covalent heme ligation.

158 nderlying chromatin structure, especially on covalent histone modifications.

159 Both noncovalent and covalent hits emerge from such endeavors.

160 The developed approach is based on the covalent immobilization of a coating antibody (Ab), a po

161 -antibody detection was demonstrated via the covalent immobilization of bovine serum albumin antibody

162 made to explore the CHO-IL platform for the covalent immobilization of GOx enzyme which served well

163 sensor detection was improved with efficient covalent immobilization of purified single-stranded DNA

164 ed onto screen-printed carbon electrodes and covalent immobilization of the specific antibody for TGF

165 The covalent immobilization of Wnt proteins can also be used

166 ith both protein and oligonucleotide through covalent immobilization.

167 t sensory perception of EOCs decreases after covalent immobilization.

168 The concept of covalent inhibition of c-Jun N-terminal kinase 3 (JNK3)

169 These findings establish a new modality for covalent inhibition of fibril formation and illuminate a

170 We show this allylic covalent inhibitor has different catalytic proficiencies

171 nthesis of a new carbocyclic mechanism-based covalent inhibitor of an alpha-glucosidase.

172 -dependent kinases (CDK), especially THZ1, a covalent inhibitor of CDK7.

173 geting drugs, and, in particular, to THZ1, a covalent inhibitor of cyclin-dependent kinase 7 (CDK7).

174 Our goal was to develop an irreversible covalent inhibitor of FGFR1-4 for use in oncology indica

175 K27 is a potent, non-covalent inhibitor of nucleotide exchange, showing consi

176 Upon addition of a covalent inhibitor that mimics one of the reaction inter

177 Herein, we present a series of targeted covalent inhibitors (TCIs) based on our previously repor

178 Targeted covalent inhibitors have gained widespread attention in

179 Reversible covalent inhibitors have many clinical advantages over n

180 We report covalent inhibitors of Tyr181Cys RT (CRTIs) that can com

181 resented a unique challenge in the design of covalent inhibitors with appropriate pharmacodynamics pr

182 the fact that pressure cannot compromise the covalent integrity of DNA.

183 l disulfide bridges are reoxidized to reform covalent inter- and intrachain bonds.

184 een a growing interest in exploring this non-covalent interaction in nanoscale drug delivery systems

185 er for assembly, the contribution of the non-covalent interaction is to direct the molecular-level ar

186 ults provide additional understanding of the covalent interaction of aromatic amine metabolites with

187 ich achieves JAK isoform specificity through covalent interaction with a unique JAK3 residue Cys-909.

188 tain B-Ng bonds with a substantial degree of covalent interaction.

189 e rational manipulation of these complex non-covalent interactions and their direct incorporation int

190 wo diverse catalytic systems with unique non-covalent interactions at the heart of each process.

191 er levels of aggregated protein, due to more covalent interactions between proteins, than the heated

192 bly of binary systems driven by specific non-covalent interactions can greatly expand the structural

193 is validated by directly connecting the non-covalent interactions defined through empirical data set

194 otin interaction is one of the strongest non-covalent interactions in the nature.

195 ested the late actinides participate in more covalent interactions than the earlier actinides, yet th

196 bsequently quantify the strengths of the non-covalent interactions using Kohn-Sham density functional

197 ed guest molecules demonstrates that the non-covalent interactions with the host hardly affect the di

198 are assembled into regular structures by non-covalent interactions, attract tremendous interests beca

199 he nature of the covalent chemical bond, non-covalent interactions, bond formation, and exotic 3-cent

200 By using specific, dynamic, and tunable non-covalent interactions, engineered approaches to drug del

201 to cell behavior as a result of dynamic non-covalent interactions.

202 rrelations is introduced for postulating non-covalent interactions.

203 materials that adhere primarily through non-covalent interactions.

204 renewed their interest in water-mediated non-covalent interactions.

205 eric complex exhibits the involvement of non-covalent intermolecular interactions that are localized

206 bitors promote mitochondrial turnover, while covalent Keap1 modifiers, including sulforaphane (SFN) a

207 cin SV and doxycycline), we demonstrate that covalent labeling and mass spectrometry (MS) can be used

208 We expect that this combined covalent labeling approach will be applicable to other p

209 The results demonstrated that covalent labeling followed by MS markedly increased the

210 Here we show that covalent labeling of solvent accessible residues followe

211 ilar bioactivation mechanism concluding with covalent labeling of the PLP cofactor.

212 Specifically, three different covalent labeling reagents, namely diethylpyrocarbonate,

213 The methodology combines covalent labeling, mass spectrometry, and kinetic analys

214 o-acid nucleophiles have been used to create covalent ligands and drugs, but have, so far, been mainl

215 These highly covalent ligands are found in metalloproteins and are al

216 porphyrin nanohybrid materials with a direct covalent linkage between the graphene carbon network and

217 This result suggests that the covalent linkage between the growing polyketide chain an

218 Furthermore, the covalent linkage induced by DOPA oxidation allows covale

219 sing in vitro potential was developed by the covalent linkage of an oxime nucleophile and a periphera

220 les on carbon nanotubes was achieved through covalent linkage of phage capsid onto the carbon nanotub

221 ordingly, we tested both cobalt coupling and covalent linkage of the trimers to the liposomes by reen

222 protomer of model BG505 NFL trimers to allow covalent linkage.

223 The covalent linkages are visualized by scanning probe techn

224 gated platform is constructed on a series of covalent linkages between lectin molecules and a cystein

225 from WPM, stronger interactions, possibly by covalent linkages, are involved, providing new insights

226 IP.664 and native Env trimers but includes a covalent linker between gp120 and gp41, an engineered 20

227 r of o-, m-, or p-xylylene (o-, m-, or p-Xy) covalent linkers to produce o-ExBox(4+) (3.5 A), m-ExBox

228 ver drugs specifically to mitochondria is by covalent linking a lipophilic cation such as an alkyltri

229 lf-labelling enzyme tag, which catalyses the covalent linking of exogenously supplemented synthetic l

230 Surface-assisted covalent linking of precursor molecules enables the fabr

231 After thermally induced covalent-linking through aryl-aryl coupling, well-ordere

232 h a pressure induced transition is known for covalent liquids, but has not been observed for metallic

233 nthetic biology, nanodisc-technology and non-covalent mass spectrometry provides excellent synergies

234 er exploration of this novel superconducting covalent metal.

235 ed to activate IKs channels depends on their covalent modification by small ubiquitin-like modifier (

236 bit the protein-protein interactions through covalent modification of cysteine residues within the RG

237 city is believed to occur mainly through its covalent modification of DNA, resulting in the formation

238 Covalent modification of protein by drugs may disrupt se

239 The covalent modification of protein substrates by ubiquitin

240 Covalent modification of the pi-electron basal planes of

241 sting change in receptor molecules, either a covalent modification or conformation that enhances thei

242 Among different covalent modifications found on p53 the most controversi

243 Covalent modifications of histones have an established r

244 oduce silyl ether linkage as a novel dynamic covalent motif for dynamic material design.

245 el highly functionalized N-azoles via direct covalent N-H bond transformations onto N-C bonds.

246 Smurf1 and its homologue Smurf2 carry a non-covalent Nedd8-binding site within its catalytic HECT do

247 ked polymer networks, we demonstrate dynamic covalent network polymers displaying both malleability a

248 Covalent nucleotide modifications in noncoding RNAs affe

249 s in line with a parallel study showing that covalent oligomerization of ILEI is essential for EMT an

250 PDI oxidation, nitration, inactivation, and covalent oligomerization.

251 A spiropyran-decorated covalent organic cage (PC2) has been designed, employing

252 nt the stereoselective synthesis of a chiral covalent organic cage consisting of three redox-active n

253 nthesized a two-dimensional (2D) crystalline covalent organic framework (sp(2)c-COF) that was designe

254 Imine-linked two-dimensional covalent organic frameworks (2D COFs) are crystalline po

255 Covalent organic frameworks (COFs) are crystalline, perm

256 Porous materials such as covalent organic frameworks (COFs) are good candidates f

257 ABSTARCT: Covalent organic frameworks (COFs) are network polymers

258 Covalent organic frameworks (COFs) are promising for cat

259 ntial of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) as platforms for the

260 Research on covalent organic frameworks (COFs) has recently gathered

261 veloped a facile, salt-mediated synthesis of covalent organic frameworks (COFs) in the presence of p-

262 Most covalent organic frameworks (COFs) to date are made from

263 With the advent of covalent organic frameworks (COFs), the chemistry of the

264 urally complex yet robust materials, such as covalent organic frameworks (COFs).

265 Two-dimensional covalent organic frameworks often pi stack into crystall

266 le Si-O chemistry for the crystallization of covalent organic frameworks, we demonstrate the simple o

267 larities result in the formation of a robust covalent organic gel framework (COGF) that is organized

268 l or microwave conditions, a viologen-linked covalent organic network in the form of hollow particles

269 e repertoire of tools for the fabrication of covalent organic networks (which are usually prepared by

270 Morphology influences the functionality of covalent organic networks and determines potential appli

271 rous acid in vitro, we identified additional covalent oxidative modifications on four tyrosine residu

272 ospholipids (dithranol, THAP, HABA), and non-covalent peptide-peptide and protein-peptide complexes (

273 mechanism, which involves the formation of a covalent phosphoramidate histidine-DNA adduct for cell-t

274 at support a ping-pong mechanism involving a covalent phosphosugar intermediate for PglC.

275 The existence of a covalent phosphosugar intermediate provides strong suppo

276 rategy for precise tuning of loop defects in covalent polymer gel networks.

277 e combined with Glaser coupling to fabricate covalent polymers via a cascade process.

278 Unlike classical covalent polymers, one-dimensionally (1D) elongated supr

279 catalyze ADP-ribosylation, a reversible and covalent post-translational modification (PTM).

280 Covalent postsynthetic modification (PSM) of metal-organ

281 an be carefully adjusted to lower energy via covalent postsynthetic modification at the amino group s

282 eties in these polymeric mimics improves non-covalent protein delivery, providing crucial design para

283 ide synthesis involves the interplay between covalent protein modifications, conformational fluctuati

284 These covalent protein-DNA complexes are reversible (t1/2 =1.8

285 The outer radius is the atomic (covalent) radius, and the inner is that of the underlyin

286 sory adaptation involves feedback control of covalent receptor modifications by two enzymes: CheR, a

287 e not observed directly, but rather leave a "covalent record" of the interaction that is measured wit

288 Thus, PDH-E1alpha expression and covalent regulation, and hence the tricarboxylic acid cy

289 Covalent, reversible, post-translational modification of

290 provide a basis for the design of optimized covalent-reversible inhibitors aimed at emerging flavivi

291 phy confirmed the formation of the predicted covalent S-homopyruvoyl adduct of the active-site Cys191

292 Cl2Sb(IV)Pd(I)Cl(o-dppp)2], a complex with a covalent Sb-Pd bond.

293 mediating targeted cell penetration and non-covalent self-assembly with therapeutic cargo, forming H

294 losure of microcracks formed parallel to the covalent-sp(2)-bonded graphene layers at higher temperat

295 onships requires precise manipulation of the covalent structure of chromatin.

296 (110) on the formation of organometallic and covalent structures for Ullmann-type coupling reactions.

297 As(H)K and ThAsTh linkages exhibit polarized-covalent thorium-arsenic multiple bonding interactions,

298 Covalent triazine frameworks (CTFs) are normally synthes

299 gy domain (THD) of human (h)4-1BBL forms non-covalent trimers, we found that m4-1BBL formed a covalen

300 DFT calculations reveal a polarized-covalent Zr=P double bond, with a Mayer bond order of 1.