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1  viral mRNAs, proteins, replicative DNA, and covalently closed circular DNA.
2 plete cure additionally includes loss of HBV covalently closed circular DNA.
3 easurement of HBsAg, HBeAg, and intrahepatic covalently closed circular DNA.
4 s of ATP is not inhibited by 1 microg RNA or covalently closed circular DNA.
5 wer virus replication is due to a less rapid covalently closed circular DNA amplification, leading to
6 ieving a functional cure are the presence of covalently closed circular DNA and ineffective/exhaustiv
7 ts in these strains as both low-copy-number, covalently closed circular DNA and tandemly duplicated,
8 were investigated using plasmid DNA, relaxed covalently closed circular DNA, and linear duplex DNA as
9  of HBV replicative intermediates, including covalently closed circular DNA (cccDNA) and Dane particl
10                            At the same time, covalently closed circular DNA (cccDNA) and viral mRNA l
11 here all replicative intermediates including covalently closed circular DNA (cccDNA) are present.
12  IFN-gamma treatment does not affect initial covalently closed circular DNA (cccDNA) conversion but i
13 e HBV virion assembly, capsid uncoating, and covalently closed circular DNA (cccDNA) formation.
14 gned that specifically identifies methylated covalently closed circular DNA (cccDNA) in human liver t
15 viral therapies, lies in the accumulation of covalently closed circular DNA (cccDNA) in nuclei of inf
16  by the formation of an intranuclear pool of covalently closed circular DNA (cccDNA) in the liver.
17  RNA (pgRNA) and subgenomic RNA from the HBV covalently closed circular DNA (cccDNA) minichromosome,
18 (HBV) transcriptional template, a long-lived covalently closed circular DNA (cccDNA) molecule, is deg
19 th woodchuck hepatitis virus (WHV) contained covalently closed circular DNA (cccDNA) molecules with d
20                                              Covalently closed circular DNA (cccDNA) of hepatitis B v
21                                          HBV covalently closed circular DNA (cccDNA) plays an essenti
22 nisms that control the nuclear pool of viral covalently closed circular DNA (cccDNA) transcriptional
23 tes indicated that both encapsidated DNA and covalently closed circular DNA (cccDNA) were turned over
24 nal template of the hepatitis B virus (HBV), covalently closed circular DNA (cccDNA), has been diffic
25 me, which forms a stable minichromosome, the covalently closed circular DNA (cccDNA), in the nucleus
26 n increase in the intranuclear pool of viral covalently closed circular DNA (cccDNA), resulting in a
27                                              Covalently closed circular DNA (cccDNA), the nuclear for
28 block virus replication and formation of new covalently closed circular DNA (cccDNA), the viral trans
29 ability to eradicate or inactivate the viral covalently closed circular DNA (cccDNA), which is a stab
30 ed markers of HBV replication, including the covalently closed circular DNA (cccDNA).
31 ential step in the formation of hepadnavirus covalently closed circular DNA (cccDNA).
32  cases with lower levels of intrahepatic WHV covalently closed circular DNA (cccDNA).
33  regulated number of episomal viral genomes [covalently closed circular DNA (cccDNA)] in the nuclei o
34 after stopping treatment from the stable HBV covalently-closed-circular DNA (cccDNA).
35 umulation of significantly higher amounts of covalently closed circular DNA compared with wild-type H
36 ly hybridized RNAs associated primarily with covalently closed circular DNA, consistent with this str
37                 We found that although viral covalently closed circular DNA declined 20- to 100-fold,
38          Thus, chemotherapeutic clearance of covalently closed circular DNA did not involve the repla
39  was prepared without amplification by using covalently closed circular DNA extracted from the liver
40 yrcludex B binding, taurocholate uptake, HBV covalently closed circular DNA formation, and expression
41 control of viral replication by clearance of covalently closed circular DNA from infected hepatocytes
42 s that specifically target hepatitis B virus covalently closed circular DNA (HBV cccDNA), the episoma
43 preparation could generate a small amount of covalently closed circular DNA in LMH cells, a chicken h
44 d decline in the transcriptional template or covalently closed circular DNA level.
45                           Viral antigens and covalently closed circular DNA levels in liver samples w
46 e to inhibition of virus entry since initial covalently closed circular DNA levels were not decreased
47 h an RNA intermediate produced from a stable covalently closed circular DNA molecule.
48                             We have isolated covalently closed circular DNA molecules carrying hybrid
49  was packaged with foreign, single-stranded, covalently closed, circular DNA molecules identical in l
50 rance) and complete cure (ie, eradication of covalently closed circular DNA) of CHB, several challeng
51 ive intermediates, no effect on the level of covalently closed circular DNA or HBV transcripts was ob
52 V infection as replicative intermediate DNA, covalently closed circular DNA, pregenomic RNA, and the
53 GD protein levels and impaired production of covalently closed circular DNA, the template for DHBV ge
54 aining viruses the transcriptional template, covalently closed circular DNA, was formed by circulariz
55 , core (HBc) and surface (HBs) antigens, and covalently closed circular DNA, was observed in HUHEP an

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