ライフサイエンスコーパス: covariation

1 amino acids that appear to change together (covariation).

2 hifts in amino acid propensities due to site covariation.

3 s result in robust insights about phenotypic covariation.

4 are often residues that display evolutionary covariation.

5 sounds orthogonal or oblique to experienced covariation.

6 fect on a cell's output of manipulating such covariation.

7 rrors suffices to create all of the observed covariation.

8 volution is misperceived due to unrecognized covariation.

9 imes, and demonstrated the generality of the covariation.

10 traits that give rise to their strong global covariation.

11 nmeasured traits are required to explain LES covariation.

12 olutionarily relevant patterns of amino acid covariations.

13 omputational method, R-scape (RNA Structural Covariation Above Phylogenetic Expectation), that quanti

14 We highlight patterns of covariation across levels of organisation and conclude w

15 ndings suggest that, in healthy populations, covariation across these complex multidimensional behavi

16 We use amino acid evolutionary covariation across these ORs to define restraints on str

17 sing PCA, a color space was derived from the covariation, across voxels, in the responses to differen

18 We demonstrate that variability and covariation also apply to the biophysical properties of

19 ies often reported evidence of weak negative covariation, although more complicated patterns were als

20 ptations in the absence of information about covariation among characteristics.

21 s of interspecific patterns of variation and covariation among characters describing the stem, cup, a

22 by RNase structure probing and by nucleotide covariation among closely related group 2 coronaviruses,

23 s on cortisol coregulation suggests stronger covariation among distressed partners.

24 led HD can be used as a framework to explore covariation among DNA binding residues.

25 to be responsible for the high frequency of covariation among many of the protease residues.

26 -standing hypothesis by assessing geographic covariation among pollinator reliability, outcrossing ra

27 ographic rates, using simulated and observed covariation among rates.

28 The covariation among replicates of the three species densit

29 also providing a platform for assessments of covariation among root, leaf, and wood traits, the role

30 l component describing a pattern of positive covariation among sizes across all ages.

31 to the relationship between conflict and the covariation among the 3 disorders, and the Cholesky mode

32 cated that conflict accounted for 33% of the covariation among the disorders, via genetic and environ

33 hesis of no contribution of the locus to the covariation among the two traits.

34 Rather than the expected covariation among these measures, eyelid movement magnit

35 ell established, but its role as a source of covariation among traits (i.e., as a source of "epistati

36 The pattern of genetic covariation among traits (the G matrix) plays a central

37 between growing seasons can lead to positive covariation among virus species.

38 Genome-wide covariation analyses of pretreatment virus sequences fro

39 and is supported by combined mutagenesis and covariation analyses.

40 shown to be essential for RNA3 production by covariation analysis and in vivo selection of RNA3-expre

41 However, covariation analysis does reveal a weaker although signi

42 This reveals that covariation analysis identifies other types of structura

43 Covariation analysis is used to identify those positions

44 he existence of SL1 was further supported by covariation analysis of several PVX strains, the functio

45 Covariation analysis provides limited support for basic

46 ectation), that quantitatively tests whether covariation analysis supports the presence of a conserve

47 d coarse-grained MD simulations and sequence covariation analysis, we characterized the interface bet

48 airing constraints derived from phylogenetic covariation analysis.

49 lly identified in the 16S and 23S rRNAs with covariation analysis.

50 than sequence, which was consistent with the covariation analysis.

51 ts, in general have not exploited the global covariation and constraints characteristic of beta-sheet

52 ure improvements; for example, incorporating covariation and immunological constraints will permit mo

53 This covariation and interaction may partially explain differ

54 e play a dominant role in shaping amino acid covariation and that computational protein design method

55 fied using a combination of protein sequence covariation and TMH binding surfaces predicted from sequ

56 We conclude that covariation (and probably a tightly controlled coregulat

57 tions, patterns of segregating variation and covariation, and lines selected for late-age fertility h

58 f selection, estimated genetic variation and covariation, and predicted the response to selection for

59 ces to robustly assess the extent of residue covariation, and the larger the protein family, the more

60 The validation of covariation as a predictive tool will be dependent on mo

61 enol A (BPA) was identified by chemical:gene covariation as the most impactful estrogenic chemical ac

62 d or adapted to encode the natural kinematic covariations associated with prehension described by a l

63 global-scale models may poorly describe LES covariation at non-global scales.

64 The covariation at positions (1092/1099)1072 is studied here

65 statistical coupling analysis (SCA) to infer covariations at various locations using a family of evol

66 group allows for finer distinctions between covariation based on shared severity and comorbidity pos

67 ouplings between residue pairs have rendered covariation-based contact prediction a viable means for

68 Consensus covariation-based secondary structural models for the 5'

69 n analysis of the Escherichia coli 16 S rRNA covariation-based structure model revealed a strong bias

70 y of the G, C, and U bases are paired in the covariation-based structure model.

71 s, however, little evidence of the predicted covariation between an animal's olfactory cues and its g

72 human subjects learned to shape patterns of covariation between arbitrary pairs of hand and forearm

73 thermore, our records show that the observed covariation between atmospheric CO2 concentration and ab

74 ariate models that account for the pervasive covariation between biological factors and extinction ar

75 orrelation analyses (sCCAs) to determine the covariation between brain imaging metrics of WM-network

76 Differential patterns of covariation between combat veterans with and without PTS

77 The current study investigated whether the covariation between condition and preferences for mascul

78 iases have on individual measures and on the covariation between different constructs.

79 d States, paying particular attention to how covariation between ecological benefits and economic cos

80 associated polygenic variation also captured covariation between environmental exposures and children

81 ts suggested by these experiments reflects a covariation between enzyme and tRNA that may have acted

82 Extensive covariation between floral traits and mating system amon

83 The authors examined the sources of covariation between generalized anxiety disorder and the

84 mming from life history theory (eg, negative covariation between male-female traits and flower size-f

85 n biotic interactions, may commonly underlie covariation between native and non-native faunas, especi

86 ative sample (n = 6,710), we find widespread covariation between offspring trait-associated polygenic

87 Strong covariation between our new composite ITCZ-stack and Nor

88 carbon (C) cycles; yet, the demonstration of covariation between overstory tree genetic-based traits

89 pes enable us to identify subtle patterns of covariation between peptide sequence positions; analysis

90 n utilized is to examine overall patterns of covariation between phenotypic variables of interest, su

91 Moreover, the strong covariation between residues in matrix and capsid at the

92 Poorly integrated plant CCDs (i.e. low covariation between scent compounds) support the notion

93 No covariation between self-relatedness and peripheral auto

94 we demonstrate conserved patterns of simple covariation between sequence evolution, codon usage, and

95 is does reveal a weaker although significant covariation between sets of nucleotides that are in prox

96 Nevertheless, population covariation between sexually antagonistic traits remaine

97 olution towards certain patterns of negative covariation between sizes across ages is constrained.

98 ated atmospheric CO(2) and N deposition, but covariation between species richness (S) and functional

99 s in diffuse light fields that eliminate the covariation between surface orientation and intensity, a

100 Thus, we hypothesize that there has been covariation between the amount of DNA gained by transpos

101 Here, we investigate covariation between the discriminator base (N73) element

102 stimuli embedded in noise), a trial-by-trial covariation between the neural response and the monkey's

103 f their DNA binding sites, investigating the covariation between the protein sequence and the sequenc

104 red developmental processes and include both covariation between the trait values and more complex as

105 Lastly, we found significant covariation between the volatile compounds and bacterial

106 We investigated covariation between trait-associated polygenic variation

107 shown that epistasis can produce patterns of covariation between traits that are not seen in additive

108 pt abundance; the results revealed extensive covariation between transcription and splicing in prosta

109 and how this would affect interpretation of covariation between transcriptional profiles and other p

110 ed pattern and mechanism of positive genetic covariation between virulence and pathogen load are cons

111 We also find evidence for positive genetic covariation between virulence and pathogen load, a proxy

112 we found weak but significant trial-to-trial covariations between V1 activity and behavioral choices,

113 Because of covariation, blood loss, blood transfusion, and complica

114 Here, we have separated the two types of covariation by independently recombining every naturally

115 We verify predicted theoretical covariations by contrasting empirical data and provide t

116 This covariation can arise from multiple factors, including s

117 Finally, we demonstrate that the patterns of covariation can be generalized to quantifiable biologica

118 ith a specific pattern of regional metabolic covariation, characterized by increases in the dorsal mi

119 Furthermore, we give examples of complex covariation created by simple regimes of combined direct

120 Knowledge of noise covariations did not lead to better decoding performance

121 Our study indicates that spatial climate covariation drives the global carbon cycle response.

122 However, others postulate that noise covariation effects may depend on network anisotropy/hom

123 Evolutionary rate covariation (ERC) is a phylogenetic signature that refle

124 Such evolutionary rate covariation (ERC) is a sequence-based signature of coevo

125 ruct gene networks via the evolutionary rate covariation (ERC) signature.

126 gnal transmission, we used Evolutionary Rate Covariation (ERC), a recently developed bioinformatic to

127 specificity of the effect was established by covariation experiments as well as by experiments with t

128 Second, comprehensive nucleotide covariation experiments demonstrate that 7S11 and its RN

129 protein structure has constrained amino acid covariation for 40 diverse protein domains.

130 e diallel, we measured genetic variation and covariation for and among performance, resistance, and t

131 airwise group differences were attenuated by covariation for symptom severity.

132 This suggests that amino acid covariation found in the subtilisin orthologs is almost

133 hat can be employed to determine patterns of covariation from both uni- and multivariate phenotypic c

134 alysis is a powerful tool for distinguishing covariation from causation in expression array studies o

135 Analysis of covariation from naturally occurring sets of orthologs c

136 ses in Australia's energy mix, this negative covariation has implications for storage capacity of exc

137 A set of 16 helices are supported by covariation (i.e. conservation of base pairing potential

138 V-Phaser uses covariation (i.e. phasing) between observed variants to

139 Analyses of phenotypic and genetic covariation identified substantial correlations among th

140 Sequence covariation implies wide conservation of structural and

141 s--unexpected floods and droughts--determine covariation in abundance of native and non-native fish s

142 nificant similarities between the amino acid covariation in alignments of natural protein sequences a

143 Moreover, we identified covariation in amino acid transport and cofactor synthes

144 Here we test a developmental model of limb covariation in anthropoid primates and demonstrate that

145 ching geometries govern much of the observed covariation in biological scaling exponents.

146 a meta-analysis to characterize patterns of covariation in CCDs and identified functional or biosynt

147 study evaluates patterns of brain anatomical covariation in chimpanzees and humans to infer their inf

148 erve that invasive cancers exhibit increased covariation in DNA methylation at the risk CpG sites rel

149 Importantly, we show that the covariation in DNA methylation at these risk CpG loci is

150 nd environmental influences on variation and covariation in EUE and EOE were established using a biva

151 ificity of GABAergic gene groups, defined by covariation in expression, for response to chronic alcoh

152 on of primary sequence elements and sequence covariation in helical domains.

153 validated technique based on across-subject covariation in magnetic resonance imaging-derived cortic

154 nents (PCs) of the G-matrix corresponding to covariation in metals response, nitrogen availability, o

155 ements and ZF genes and was not explained by covariation in other genomic features.

156 ximum entropy approach to infer evolutionary covariation in pairs of sequence positions within a prot

157 We show that amino acid covariation in proteins, extracted from the evolutionary

158 vations from across Britain), we compare the covariation in temperature and first spawning dates of t

159 Phylogenetic covariation in the P2b and P3 sequences of 35 species pr

160 del environmental filtering by variation and covariation in the responses of individual species to th

161 , His/Val, and Leu/Ile) that showed striking covariation in their concentrations across ST samples.

162 mption, the authors examined the patterns of covariation in these eyelid movement measures in acquisi

163 traits indicate that a small portion of the covariation in these traits can be explained by the repo

164 By linking estimated covariation in tree growth and mortality over time with

165 e, we introduce a general method that probes covariations in charged residues along the sequence in a

166 rvation of RNA base pairing induces pairwise covariations in sequence alignments.

167 attributes are determined by the statistical covariations in the spectral stimuli that humans have al

168 Do slow trial-by-trial noise covariations increase or decrease IT's object coding cap

169 SHAPE probing structural data and nucleotide covariation information from structure-based alignments.

170 Modeling results demonstrate that such covariation is a signature of recurrent rather than pure

171 Although covariation is not direct evidence of structural propens

172 Particularly, increased covariation is observed between subsets of characters fr

173 the similarity between natural and designed covariation is sensitive to the magnitude and mechanism

174 Our results suggest that negative covariation is widely anticipated from theory.

175 immediate 5' side, are involved in tertiary covariations, making these sites strong candidates for t

176 nal structure, the improved understanding of covariation may help identify functional residues involv

177 While covariation methods have effectively and accurately pred

178 Covariation network analysis using the fetal neocortex d

179 ork independent of the V3 loop; and (iv) the covariation network formed between the V3 loop and other

180 iii) CD4 binding sites form part of a unique covariation network independent of the V3 loop; and (iv)

181 nce and found that (i) there are complicated covariation networks, indicating frequent coevolutionary

182 e results suggest that networks of intrinsic covariation observed at multiple levels and with several

183 rmination accounts for the unique pattern of covariation observed in these two traits.

184 The pattern of genetic covariation observed in this study is similar to that ob

185 dies have demonstrated that such patterns of covariation occur, although these are often between samp

186 Furthermore, covariations occurring in the helices of these conserved

187 The conservation and covariation of 19,241 pairs in 219 sequence alignments w

188 arations that permit measurement of both the covariation of a neuron's input signals and the effect o

189 The covariation of a number of mechanical of properties, and

190 s a phylogenetic signature that reflects the covariation of a pair of proteins over evolutionary time

191 subjective visual perception was related to covariation of activity in multiple extrastriate ventral

192 s demonstrate that the observed compensatory covariation of amino acids in eukaryotic loop 2 is essen

193 ural insights from an unexpected source: the covariation of amino acids in sequences of different cur

194 from the right hemisphere with only moderate covariation of amplitude, and drive CA1 pyramidal units

195 Decomposing variance revealed that covariation of bacterial clades within human body sites

196 lly in nucleotide sequence, and evolutionary covariation of bases to maintain G.

197 Intrinsic covariation of brain activity has been studied across ma

198 The covariation of carbon dioxide (CO(2)) concentration and

199 his effect, we derive a new estimate for the covariation of CO2 and temperature, of r2 = 0.89 for the

200 low relatedness, but none have measured the covariation of colony fitness and relatedness.

201 then used this decomposition to explain why covariation of correlations with firing rate-a relations

202 The covariation of dissolved nitrate and phosphate is mainta

203 Thus, covariation of excitatory and inhibitory inputs can be a

204 We analyze covariation of fungal and bacterial taxa, and find that

205 orks derived from analysis of inter-regional covariation of gray matter volume in MRI data on 259 hea

206 ore, we developed a predictive model for the covariation of H, D, and stem volume V scaling relations

207 letal muscle fibers are defined by patterned covariation of key traits that determine contractile and

208 ssibility that the visual system may use the covariation of local surface orientation and intensity a

209 Thus, the ubiquity in mammals of the covariation of longer cortical neurogenesis and increase

210 l framework for understanding the origin and covariation of many allometric traits within a complex i

211 trolled and field conditions and examine the covariation of mesophyll conductance with photosynthetic

212 up, sparse partial least squares analysis of covariation of microbial, inflammatory, and clinical par

213 We examined the covariation of mind perception with three subclinical sy

214 Despite these selection pressures, genetic covariation of morphology, phenology and lifespan appear

215 To examine covariation of mutations between two different sites usi

216 Covariation of nucleotides in two distantly spaced unpai

217 vironmental) influences to the variation and covariation of obesity with snoring and daytime sleepine

218 We examined covariation of pathogen infection and bacterial microbio

219 fied 11 pleiotropic hQTLs that determine the covariation of shoot and taproot growth.

220 uterium palaeothermometer reveal significant covariation of temperature and atmospheric CO2 concentra

221 rall, the weak evolutionary conservation and covariation of the beta-sheet pairs indicates that sheet

222 he secondary structure deduced from sequence covariation of the bulge in the context of the functiona

223 any RNA substrate sequences via Watson-Crick covariation of the DNA binding arms that interact direct

224 Here we introduce a method to measure covariation of the excitatory and inhibitory inputs a ce

225 on methods; heritability of brain variation; covariation of the sizes of brain regions; and correlati

226 oxygen perturbations-precisely mirroring the covariation of these parameters upon transitions between

227 Extensive QTL co-localization suggests that covariation of these traits is likely due to pleiotropy,

228 is analysis expands our understanding of the covariation of UV-B irradiance and UV floral pigmentatio

229 We propose that the covariation of voltage dependences of ion channels repre

230 ay be a useful way in obtaining evolutionary covariations of amino acid residues on a genome wide lev

231 ng that limitation in mind, it is shown that covariations of cloud and environmental properties in th

232 Here, we examined trial-to-trial covariations of concurrently recorded EEG and fMRI in a

233 results suggest that changes in gm depend on covariations of multiple leaf (S(mes)) and M cell (inclu

234 re protein and could be overcome by a G1899A covariation, or by nonsense or frameshift mutation in th

235 how the study of changes in DNA methylation covariation patterns across normal, intra-epithelial neo

236 S) method, processed to systematically infer covariation patterns among biochemically related metabol

237 Mfold and phylogenetic covariation patterns among similarly grouped betacoronav

238 th the removal of Arctic populations turning covariation patterns compatible with evolution by geneti

239 cts on the default-mode network by examining covariation patterns in functional connectivity among 33

240 ides a general tool to identify evolutionary covariation patterns in small sets of close sequence hom

241 nds revealed biosynthetic constraints in the covariation patterns of plant CCDs.

242 We expect computation of covariation patterns to complement experimental structur

243 rotein families significant conservation and covariation patterns were detected for some of the resid

244 both performance and evolutionary signals on covariation patterns.

245 important in the maintenance of established covariation patterns.

246 inson's disease-related pattern of metabolic covariation (PDRP) that had been identified in earlier F

247 A study of the cortical covariation produced by these activations revealed that

248 It has been shown that natural variation and covariation provide valuable insights into the developme

249 This covariation provides compelling evidence that CO2 is an

250 or neurons with correlated tuning, and noise covariations reduced object encoding capability, includi

251 The overall pattern of covariation reflects the developmental origins of brain

252 etwork anisotropy/homogeneity and on how the covariation relates to representation.

253 atory analyses of interregional resting rCBF covariation revealed a specific and significant diagnosi

254 These results (1) support a totally new covariation scaling model, (2) indicate that differences

255 cular modeling, tryptophan fluorescence, and covariation sequence alignment indicate that the Crk-SH3

256 ctions are often inaccurate because the true covariation signal in the MSA is often masked by biases

257 ines three distinct approaches for inferring covariation signals from multiple sequence alignments, c

258 strands showed a degree of conservation and covariation similar to that of well-separated residues o

259 oncluded that an unmeasured trait drives LES covariation, sparking efforts to identify the latent phy

260 er, and model simulations confirmed that the covariation suffices to normalize the somatic AP wavefor

261 tegrated than those of plants (i.e. stronger covariation), suggesting that animals communicate via fi

262 This covariation suggests that the fine-scale distribution of

263 bsets of neurons may be more immune to noise covariation than others.

264 bsets of neurons may be more immune to noise covariation than others.

265 ng free from the constraints associated with covariation that have been observed between certain kine

266 five multidimensional patterns of attribute covariation that reflect polarity, secondary structure,

267 activity at the same sites exhibited spatial covariation that reflected the tonotopic map of the STP.

268 t the full extent of macroecological pattern covariations, the role of the constraints imposed by fin

269 Of the PE that showed covariation, this appeared to be due to shared genetic i

270 Pseudomonas syringae and investigated their covariation to determine the relative importance of resi

271 ltaneously and examined their trial-to-trial covariations to gain insight into these attentional cont

272 Analysis of sequence covariation using the entire RNase P RNA data set reveal

273 und to be the most conserved, while stronger covariation was detected in the solvent-exposed pairs.

274 Unexpectedly, amino acid covariation was highest between VP4 and VP2, which are s

275 ons 789 and 791 were invariant and extensive covariation was observed among the nucleotides at the ba

276 A highly significant covariation was observed between nucleotides 690 and 697

277 No unanticipated nucleotide covariation was observed between the E class and the AA-

278 This covariation was only weakly related to the preferred dir

279 ison analysis suggested that this structural covariation was sufficient to account for the behavioral

280 Covariations were predominantly positive (> 80%), sugges

281 ally distinct lines of mice, finding minimal covariation when comparing synaptically connected or dev

282 Amino acid covariation, where the identities of amino acids at diff

283 analysis can identify those synthetase-tRNA covariations which are needed to preserve the genetic co

284 N:P and stem diameter (D) showed significant covariations, which indicates that leaf N and W, N:P and

285 would be particularly likely to show genetic covariation with ADHD.

286 ified a unique pattern of regional metabolic covariation with an expression which accurately discrimi

287 rater effects, clinical referral biases, or covariation with antisocial behavior.

288 f abundance can be explained entirely by its covariation with geographic range.

289 Fecal microbiota showed covariation with mucosal adherent microbiota.

290 dala responses exhibited condition-dependent covariation with neural activity in the posterior thalam

291 ines both predicted free energy and sequence covariation with optimized weightings.

292 ubregions of the dorsal cingulate cortex and covariation with rated pain.

293 ting method (PEC) for quantifying positional covariation with the Gutell lab's new RNA Comparative An

294 Second, we report a significant covariation with the level of AED load and a wake-depend

295 may affect hearing capacity or could reflect covariation with the surrounding temporal bone.

296 esent a quantitative algorithm for assessing covariation with this approach, based on explicit likeli

297 cterize natural polymorphisms and amino acid covariation within an inhibitor-naive sequence set spann

298 ortance of epistatic pleiotropy in producing covariation within early and late-developing skull trait

299 Jaccard index was used to analyze amino acid covariation within HIV-1 integrase.

300 chemes are disallowed by lack of surrounding covariation within the hormone's hidden receptor-binding