ライフサイエンスコーパス: cystathionine

1 densation of serine and homocysteine to form cystathionine.

2 t condensation of serine and homocysteine to cystathionine.

3 eine, ribosylhomocysteine, homocysteine, and cystathionine.

4 densation of homocysteine and serine to form cystathionine.

5 on of l-serine with l-homocysteine to form l-cystathionine.

6 t condenses homocysteine with serine to form cystathionine.

7 74F substitution, allowing better access for cystathionine.

8 e cycle by the conversion of homocysteine to cystathionine.

9 lation or the appearance of homocysteine and cystathionine.

10 n the classic AMC) and thence by CysK(Hp) to cystathionine and by MetB(Hp) to cysteine.

11 f homocysteine and a concomitant decrease of cystathionine and cysteine in blood and tissues.

12 and methionine and reduced concentrations of cystathionine and cysteine.

13 ysteine with serine or with cysteine to form cystathionine and either water or hydrogen sulfide, resp

14 S(Hp) mutant was restored by homocysteine or cystathionine and growth of the DeltacysK(Hp) mutant by

15 mocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.

16 teine is condensed with homocysteine to form cystathionine and H2S.

17 ensation of serine and homocysteine to yield cystathionine and is the single most common locus of mut

18 ensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position

19 ct in SAA metabolism: homocystine, cysteine, cystathionine and serine were significantly decreased in

20 Macrophages were pretreated with L-cystathionine and then treated with ox-LDL.

21 r serine or cysteine by homocysteine to give cystathionine and water or H(2)S, respectively.

22 ay, one-carbon metabolism, transsulfuration (cystathionine), and glycine decarboxylation (serine and

23 tration of a gamma-elimination reaction with cystathionine as well as the gamma-replacement reaction

24 s endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamm

25 Five-month-old cystathionine beta synthase heterozygous and wild-type C

26 and GADD153 in ethanol-treated heterozygous cystathionine beta synthase mice.

27 sensitivity to chemotherapeutic agents (eg, cystathionine beta synthase, dCMP deaminase, and CTP syn

28 yielded variant ALR(Y274F), which catalyzes cystathionine beta-elimination with a near-native Michae

29 oli alanine racemase (ALR), is a promiscuous cystathionine beta-lyase (CBL).

30 us assay for the forward reaction, employing cystathionine beta-lyase and L-lactate dehydrogenase as

31 , methionine synthase reductase (MTRR A66G), cystathionine beta-synthase (CBS exon 8, 68-base-pair in

32 nate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensit

33 and hypercholesterolemia in which the mouse cystathionine beta-synthase (CBS) and apolipoprotein E (

34 es involved in the transsulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamm

35 wo enzymes in the trans-sulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamm

36 synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamm

37 In vertebrates, cystathionine beta-synthase (CBS) and cystathionine gamm

38 zed by the transsulfuration pathway enzymes, cystathionine beta-synthase (CBS) and gamma-cystathionas

39 Hcy and hyperlipidemia mouse model, in which cystathionine beta-synthase (CBS) and low-density lipopr

40 Cystathionine beta-synthase (CBS) catalyzes the condensa

41 Cystathionine beta-synthase (CBS) catalyzes the first ir

42 Cystathionine beta-synthase (CBS) catalyzes the first of

43 Cystathionine beta-synthase (CBS) condenses homocysteine

44 Cystathionine beta-synthase (CBS) contains a prosthetic

45 Cystathionine beta-synthase (CBS) controls the flux of s

46 Untreated cystathionine beta-synthase (CBS) deficiency in humans i

47 Cystathionine beta-synthase (CBS) deficiency is a recess

48 Cystathionine beta-synthase (CBS) deficiency is a recess

49 Cystathionine beta-synthase (CBS) deficiency, a genetic

50 e setting of hyperhomocysteinemia because of cystathionine beta-synthase (CBS) deficiency, an inborn

51 Homocystinuria, which typically results from cystathionine beta-synthase (CBS) deficiency, is the mos

52 mon cause of many genetic diseases including cystathionine beta-synthase (CBS) deficiency.

53 e of CNNM2 (CNNM2BAT), which consists of two cystathionine beta-synthase (CBS) domains (IPR000664) an

54 Cytoplasmic cystathionine beta-synthase (CBS) domains are strategica

55 rous proteins containing pairs of regulatory cystathionine beta-synthase (CBS) domains, family II pyr

56 cleotide-binding insert comprising a pair of cystathionine beta-synthase (CBS) domains, termed a Bate

57 Cystathionine beta-synthase (CBS) effects the condensati

58 Deficiencies of the human cystathionine beta-synthase (CBS) enzyme are characteriz

59 serine hydroxymethyltransferase (SHMT), and cystathionine beta-synthase (CBS) genes and their associ

60 onine synthase (MS), MS reductase (MSR), and cystathionine beta-synthase (CBS) in the NCI60 panel of

61 Cystathionine beta-synthase (CBS) is a heme-dependent an

62 Cystathionine beta-synthase (CBS) is a key enzyme in hum

63 Cystathionine beta-synthase (CBS) is a key enzyme in sul

64 Cystathionine beta-synthase (CBS) is a pyridoxal phospha

65 Cystathionine beta-synthase (CBS) is a pyridoxal-5'-depe

66 Cystathionine beta-synthase (CBS) is a pyridoxal-5'-phos

67 Cystathionine beta-synthase (CBS) is a pyridoxal-phospha

68 Cystathionine beta-synthase (CBS) is a tetrameric heme p

69 Human cystathionine beta-synthase (CBS) is a unique pyridoxal

70 Human cystathionine beta-synthase (CBS) is a unique pyridoxal-

71 Cystathionine beta-synthase (CBS) is an enzyme that cond

72 Cystathionine beta-synthase (CBS) is an essential pyrido

73 Cystathionine beta-synthase (CBS) is the first and rate-

74 omocysteinemia due to genetic alterations in cystathionine beta-synthase (Cbs) or methylenetetrahydro

75 dition to elevating plasma Hcy, mutations in cystathionine beta-synthase (CBS) or methylenetetrahydro

76 Cystathionine beta-synthase (CBS) plays a central role i

77 nism, unique to breast cancer cells, whereby cystathionine beta-synthase (CBS) promotes elevated GSH/

78 Wild-type and cystathionine beta-synthase (CBS)(+/-) HHcy mice were tr

79 Cystathionine beta-synthase (CBS), a key enzyme in the m

80 Human cystathionine beta-synthase (CBS), a novel heme-containi

81 ine clearance converge at the active site of cystathionine beta-synthase (CBS), a pyridoxal phosphate

82 Patients with homocystinuria lack the enzyme cystathionine beta-synthase (CBS), and many of these ind

83 gen sulfide (H2S) producing enzymes, namely, cystathionine beta-synthase (CBS), cystathionine gamma l

84 d metabolism caused by deficient activity of cystathionine beta-synthase (CBS), resulting in an accum

85 mitting step in this pathway is catalyzed by cystathionine beta-synthase (CBS), which is subject to c

86 On a hyperhomocysteinemic diet, cystathionine beta-synthase (Cbs)-heterozygous mice deve

87 omocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS).

88 ionine synthase (MS) or transsulfuration via cystathionine beta-synthase (CBS).

89 ted by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS).

90 ound a single nucleotide polymorphism within cystathionine beta-synthase (CYS4) that causes multi-dru

91 Here we show that Drosophila cystathionine beta-synthase (dCBS), which catalyzes the

92 ontinuous spectrophotometric assay for human cystathionine beta-synthase (hCBS).

93 1298A>C, methionine synthase [MTR] 2756A>G, cystathionine beta-synthase [CBS] 844ins68, and methioni

94 Cystathionine beta-synthase activity is also regulated i

95 zMC), serves as a highly sensitive assay for cystathionine beta-synthase activity, and is suitable fo

96 ons from the models, mutation of residues in cystathionine beta-synthase and channel domains either a

97 hide (H2S), through multiple steps involving cystathionine beta-synthase and cystathionine gamma-lyas

98 oduced endogenously by catalytic activity of cystathionine beta-synthase and cystathionine gamma-lyas

99 Renal cortical content of cystathionine beta-synthase and cystathionine gamma-lyas

100 zed by the transsulfuration pathway enzymes, cystathionine beta-synthase and cystathionine gamma-lyas

101 the human transsulfuration pathway enzymes, cystathionine beta-synthase and gamma-cystathionase (CSE

102 of MST versus the other two H2S generators, cystathionine beta-synthase and gamma-cystathionase, has

103 es the cytoplasmic transsulfuration enzymes, cystathionine beta-synthase and gamma-cystathionase, whe

104 Cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are critical enzymes in the

105 Cystathionine beta-synthase catalyzes the condensation o

106 oprotection, its chronic increase such as in cystathionine beta-synthase deficiency may pose a proble

107 n (SIS), biofilm-related region 2 (B2) and a cystathionine beta-synthase domain pair (CBS).

108 e and stability of PAE2072, a dimeric tandem cystathionine beta-synthase domain protein from the hype

109 ontain a sugar isomerase domain and a tandem cystathionine beta-synthase domain.

110 Cystathionine beta-synthase domains are found in a myria

111 -phosphate isomerases but lacking the tandem cystathionine beta-synthase domains found in the other a

112 eep in a cleft formed by ClC-1 intracellular cystathionine beta-synthase domains, and the nicotinamid

113 rase domain of E. coli KdsD, lacking the two cystathionine beta-synthase domains, demonstrated API ac

114 e potential ATP binding by the intracellular cystathionine beta-synthase domains.

115 Reactions catalyzed by the cystathionine beta-synthase enzyme (CBS) are one possibl

116 No changes were observed in cystathionine beta-synthase expression, immunolocalized

117 eterozygous for a targeted disruption of the cystathionine beta-synthase gene (Cbs+/-) and wild-type

118 The human cystathionine beta-synthase gene promoters -1a and -1b a

119 s in methylenetetrahydrofolate reductase and cystathionine beta-synthase genes, respectively.

120 treatment of diabetic rats with RA prevented cystathionine beta-synthase induction.

121 Cystathionine beta-synthase is modular and subjected to

122 vels of UNG mRNA were increased in brains of cystathionine beta-synthase knockout mice, a model for h

123 it was reversed by the inhibition of either cystathionine beta-synthase or cystathionine gamma-lyase

124 Cystathionine beta-synthase plays a key role in the intr

125 Here we express a mutant form of the human cystathionine beta-synthase protein, I278T, in Saccharom

126 Cystathionine beta-synthase regulates endothelial functi

127 xample of mutations in the catalytic core of cystathionine beta-synthase that result in failure of Ad

128 oderate (88 micromol/L) HHcy were induced in cystathionine beta-synthase wild-type (Cbs(+/+)) and het

129 ilarly, a particular M.grisea CBS1 (encoding cystathionine beta-synthase) TAGKO cDNA failed to comple

130 Expression of cystathionine beta-synthase, a key gene in the transsulf

131 osome binding site of the cbs gene, encoding cystathionine beta-synthase, an enzyme that is a part of

132 we demonstrate that inactivation of putative cystathionine beta-synthase, cystathionine gamma-lyase,

133 These include cystathionine beta-synthase, cystathionine-gamma-lyase,

134 OR1 induction resulted in down-regulation of Cystathionine beta-synthase, which is known to lead to i

135 h-density lipoprotein cholesterol (HDL-C) in cystathionine beta-synthase-/apolipoprotein E-deficient

136 Cystathionine beta-synthase-deficient homocystinuria (HC

137 The lean phenotype of cystathionine beta-synthase-deficient homocystinuria and

138 einylation impairs collagen cross-linking in cystathionine beta-synthase-deficient mice: a novel mech

139 In hyperhomocysteinemic human cells and cystathionine beta-synthase-deficient mouse brains, we f

140 PON1 affects plasma N-Hcy-protein levels in cystathionine beta-synthase-deficient patients (n=28).

141 wed little or no CSE protein but did express cystathionine beta-synthase.

142 expression of cystathionine gamma-lyase and cystathionine beta-synthase.

143 ation of a full-length dimeric form of human cystathionine beta-synthase.

144 hanism for the tissue specific regulation of cystathionine beta-synthase.

145 and indispensable role in the regulation of cystathionine beta-synthase.

146 ine management, methionine synthase (MS) and cystathionine beta-synthase.

147 the abundance of the transsulfuration enzyme cystathionine beta-synthase; treatment of diabetic rats

148 ogenous hydrogen sulfide synthesizing enzyme cystathionine beta-synthetase (CBS) in sensitization of

149 approximately 150 muM), which was induced in cystathionine-beta synthase heterozygous mice fed a high

150 rreversible cystathionine-gamma-synthase and cystathionine-beta-lyase enzymes.

151 C57BL/6J (wild-type) and cystathionine-beta-synthase (CBS(+/-)) mice, treated wit

152 emic mice deficient in the Cbs gene encoding cystathionine-beta-synthase (Cbs(+/-)) to evaluate retin

153 The trans-sulfuration enzyme cystathionine-beta-synthase (CBS) and its product hydrog

154 Cystathionine-beta-synthase (CBS) deficiency is a human

155 Individuals with homozygous deficiency in cystathionine-beta-synthase (CBS) develop high levels of

156 requires ATP, which binds to the C-terminal cystathionine-beta-synthase (CBS) domain of SpoIVFB.

157 Tandem cystathionine-beta-synthase (CBS) domains in the ATP-bin

158 to the transmembrane part or to cytoplasmic cystathionine-beta-synthase (CBS) domains of ClC-7.

159 ficiency or absence of the cbs gene encoding cystathionine-beta-synthase (CBS) have marked retinal di

160 ve up-regulation of the H2S-producing enzyme cystathionine-beta-synthase (CBS) in colon cancer, resul

161 e-homocysteine methyltransferase (Bhmt), and cystathionine-beta-synthase (Cbs) were up-regulated, but

162 Mice deficient in cystathionine-beta-synthase (cbs) were used as a model o

163 thionine adenosyltransferase 1alpha (Mat1a), cystathionine-beta-synthase (Cbs), methylenetetrahydrofo

164 heterozygous for disruption of the gene for cystathionine-beta-synthase (Cbs+/-) and C57BL/6 (Cbs+/+

165 ntracellular carboxy-terminus containing two cystathionine-beta-synthase (CBS1 and CBS2) domains.

166 yperhomocysteinemia induced in wild-type and cystathionine-beta-synthase +/- mice by feeding a high-m

167 onine synthase reductase (MTRR) 66A-->G, and cystathionine-beta-synthase 844ins68.

168 ysteine by reverse transsulfurylation with a cystathionine-beta-synthase and cystathionine-gamma-lyas

169 In contrast, transcripts of cystathionine-beta-synthase and deoxycytidine kinase wer

170 Interestingly, both enzymes contain a cystathionine-beta-synthase domain (CBS).

171 rt or deletion of the last 11 amino acids of cystathionine-beta-synthase domain 1 gives rise to funct

172 zed domain of unknown function (DUF21) and a cystathionine-beta-synthase domain.

173 d large cytoplasmic C-termini containing two cystathionine-beta-synthase domains (CBS1 and CBS2) that

174 A mouse model of HHcy, in which cystathionine-beta-synthase is deficient (cbs (-/-)), wa

175 s proposed in which mutagenesis is driven by cystathionine-beta-synthase overexpression and altered f

176 that ox-LDL treatment down-regulated the H2S/cystathionine-beta-synthase pathway, with increased MCP-

177 inically relevant AML cell line models, high cystathionine-beta-synthase transcripts in DS CMK cells

178 Among these are CP12-CBS (for cystathionine-beta-synthase) domain fusions.

179 ism secondary to genes on chromosome 21 (eg, cystathionine-beta-synthase, superoxide dismutase) as po

180 ression of the gene, designated M truncatula Cystathionine-beta-Synthase-like1 (MtCBS1), using a prom

181 ate in the predicted pathways for serine and cystathionine biosynthesis.

182 This study suggests that L-cystathionine could inhibit the expression of MCP-1 in T

183 bosylhomocysteine, homocysteine, methionine, cystathionine, cysteine, and homoserine were quantified

184 homocysteine (SAH), adenosine, homocysteine, cystathionine, cysteine, and oxidized and reduced glutat

185 entrations of methionine, SAM, homocysteine, cystathionine, cysteine, and total glutathione and signi

186 oline, phosphocholine, glyceophosphocholine, cystathionine, cysteine, hydrogen sulfide, glutathione d

187 The K Ms for cystathionine for both pathogenic mutants are comparable

188 rom the methionine cycle provides sulfur for cystathionine formation, which may subsequently be used

189 homocysteine, and cysteine, about 5% of the cystathionine formed is from cysteine.

190 In the reverse direction, CBS reacted with cystathionine, forming the aminoacrylate intermediate wi

191 P) cofactor which catalyzes the synthesis of cystathionine from homocysteine and serine.

192 , namely, cystathionine beta-synthase (CBS), cystathionine gamma lyase (CSE) and 3-mercaptopyruvate s

193 ine by cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE) enzymes.

194 H(2)S by cardiac-specific overexpression of cystathionine gamma-lyase (alpha-MHC-CGL-Tg mouse) signi

195 Cardiomyocyte-specific overexpression of cystathionine gamma-lyase (an enzyme that produces H(2)S

196 of the transsulfuration pathway (TSP) enzyme cystathionine gamma-lyase (CGL), resulting in increased

197 onia and alpha-ketobutyrate by the action of cystathionine gamma-lyase (CGL).

198 nzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL).

199 the key enzyme required for this conversion, cystathionine gamma-lyase (CGL).

200 rived vasodilator, is produced by the enzyme cystathionine gamma-lyase (CSE) and acts by hyperpolariz

201 Cystathionine gamma-lyase (CSE) and cystathionine beta-s

202 rates, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are enzymes that catalys

203 on and activity of the H2S-generating enzyme cystathionine gamma-lyase (CSE) by promoting its transla

204 ect enzymatically produced H2S from isolated cystathionine gamma-lyase (CSE) enzymes (p < 0.001) and

205 d that mice lacking the H2S-producing enzyme cystathionine gamma-lyase (CSE) exhibit elevated oxidati

206 Cystathionine gamma-lyase (CSE) is a major H(2)S-produci

207 Cystathionine gamma-lyase (CSE) is one of the major enzy

208 Cystathionine gamma-lyase (CSE) produces H2S via enzymat

209 Cystathionine gamma-lyase (CSE) produces hydrogen sulfid

210 The expression of cystathionine gamma-lyase (CSE), a major H(2)S producing

211 Both H2S production and cystathionine gamma-lyase (CSE), an H2S enzyme, levels w

212 e of O2 sensing in the carotid body, express cystathionine gamma-lyase (CSE), an H2S-generating enzym

213 thway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are believed to be chie

214 since mice lacking its biosynthetic enzyme, cystathionine gamma-lyase (CSE), display pronounced hype

215 thway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), H2S has been implicated

216 H2S), a gaseous messenger produced mainly by cystathionine gamma-lyase (CSE), is a proangiogenic vaso

217 Here we show a major depletion of cystathionine gamma-lyase (CSE), the biosynthetic enzyme

218 Experiments with several blockers of cystathionine gamma-lyase (CSE), the enzyme responsible

219 ne K(M) and V(max) for natural substrates of cystathionine gamma-lyase (CSE), the main enzyme respons

220 rom ischemia/reperfusion injury, but whether cystathionine gamma-lyase (CSE), which produces endogeno

221 treatment with Na2S or by overexpression of cystathionine gamma-lyase (CSE).

222 activity of cystathionine beta-synthase and cystathionine gamma-lyase (CSE).

223 of the trans-sulfuration pathway, including cystathionine gamma-lyase (CSE).

224 d by hydrogen sulfide (H(2)S) synthesized by cystathionine gamma-lyase (CSE).

225 way enzymes, cystathionine beta-synthase and cystathionine gamma-lyase (CSE).

226 beta-elimination product of MSC catalyzed by cystathionine gamma-lyase (gamma-cystathionase).

227 A recombinant putative cystathionine gamma-lyase (smCSE) mineralizes CdS from a

228 atio and lower cystathione beta-synthase and cystathionine gamma-lyase activity.

229 ls to make H(2)S via increased expression of cystathionine gamma-lyase and cystathionine beta-synthas

230 bited transcriptional activation of Bhmt and cystathionine gamma-lyase by FOXA1.

231 s the transcriptional activation of Bhmt and cystathionine gamma-lyase by FOXA1.

232 Inhibition of cystathionine gamma-lyase causes rapid necrosis of TR/GR

233 The H2S-producing capacity of cystathionine gamma-lyase may be regulated in response t

234 genous expression of various KAT enzymes and cystathionine gamma-lyase present in target tissue coupl

235 Deletion of the CYS3 gene encoding cystathionine gamma-lyase resulted in the highest resist

236 evented by propargylglycine, an inhibitor of cystathionine gamma-lyase that catalyzes H(2)S formation

237 Expression of Bhmt and cystathionine gamma-lyase was decreased when mice were f

238 uation, immunohistochemistry (nitrotyrosine, cystathionine gamma-lyase, activated caspase-3, and extr

239 l content of cystathionine beta-synthase and cystathionine gamma-lyase, hydrogen sulfide-generating e

240 ion of putative cystathionine beta-synthase, cystathionine gamma-lyase, or 3-mercaptopyruvate sulfurt

241 ps involving cystathionine beta-synthase and cystathionine gamma-lyase.

242 ion of either cystathionine beta-synthase or cystathionine gamma-lyase.

243 s of peptidases, glutamate dehydrogenase and cystathionine gamma-lyase.

244 i) seeds with lower transcript expression of CYSTATHIONINE gamma-SYNTHASE (AtCGS), Met's main regulat

245 duces O-phospho-l-homoserine (HserP) used by cystathionine gamma-synthase (CGS) for Met synthesis and

246 Cystathionine gamma-synthase (CGS) is a pyridoxal phosph

247 079, annotated metB, was predicted to encode cystathionine gamma-synthase (CGS), but demonstration of

248 Human cystathionine-gamma-lyase (CGL) is a pyridoxal-5'-phosph

249 1,25(OH)(2)D(3) also caused cystathionine-gamma-lyase (CSE) activation and H(2)S for

250 sent study aimed to identify the presence of cystathionine-gamma-lyase (CSE) and 3-mercaptopyruvate s

251 overexpression of the H(2)S-producing enzyme cystathionine-gamma-lyase (CSE) attenuated the hyperglyc

252 e in vascular beds, and its synthetic enzyme cystathionine-gamma-lyase (CSE) is down-regulated in gro

253 Cystathionine-gamma-lyase (CSE) is the predominant endot

254 etic ablation of the H2S-synthesizing enzyme cystathionine-gamma-lyase (CSE) normalized breathing in

255 The H2S-producing enzyme cystathionine-gamma-lyase (CSE) was expressed in both ne

256 7 and propargylglycin (PAG), an inhibitor of cystathionine-gamma-lyase (CSE), a key enzyme that produ

257 hydrogen sulphide (H2S)-synthesizing enzyme cystathionine-gamma-lyase (CSE).

258 abolism: cystathionine-ss-synthase (CBS) and cystathionine-gamma-lyase (CSE).

259 This study investigated the activities of cystathionine-gamma-lyase (CSE, the enzyme that catalyze

260 In contrast to CBS, silencing of cystathionine-gamma-lyase (the expression of which was u

261 ocker, 1 mg/kg) or dl-propargylglycine (PAG, Cystathionine-gamma-lyase [CSE, H(2)S-producing enzyme]

262 ely, silencing of the H(2)S-producing enzyme cystathionine-gamma-lyase abolishes NO-stimulated cGMP a

263 responsible for endogenous H2 S production, cystathionine-gamma-lyase and 3-mercaptopyruvate sulphur

264 the carotid body requires the interaction of cystathionine-gamma-lyase with haem oxygenase-2, which g

265 These include cystathionine beta-synthase, cystathionine-gamma-lyase, paraxonase 1, 5,10-methylenet

266 e carotid body, express haem oxygenase-2 and cystathionine-gamma-lyase, the enzymes which catalyse th

267 ation with a cystathionine-beta-synthase and cystathionine-gamma-lyase.

268 hese reactions are catalyzed by irreversible cystathionine-gamma-synthase and cystathionine-beta-lyas

269 ds expressing a feedback-insensitive form of CYSTATHIONINE-gamma-SYNTHASE, a key enzyme of Met synthe

270 his study aimed to explore whether and how L-cystathionine had any regulatory effect on the inflammat

271 tabolites S-adenosylmethionine, betaine, and cystathionine in MS gray matter.

272 omocysteine in the DeltacysK(Hp) mutant, and cystathionine in the DeltametB(Hp) mutant.

273 splaced by the thiol of L-cysteine to form L-cystathionine, in the first step of the bacterial transs

274 t condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a h

275 and cell-culture models, we have found that cystathionine is capable of blocking the induction of he

276 In mammals, cystathionine is formed as an intermediate of the transs

277 Cystathionine is subsequently converted to cysteine plus

278 of the first of two enzymes in this pathway, cystathionine, is present at higher levels in brain as c

279 y the thiol of homocysteine (L-Hcys) to form cystathionine (L-Cth) in the first step of the trans-sul

280 ysis indicate that the protective effects of cystathionine occur without any obvious alteration of th

281 ne and growth of the DeltacysK(Hp) mutant by cystathionine only.

282 Currently there is no known function for cystathionine other than serving as an intermediate in t

283 c acid (P<0.01-0.04), homocysteine (P<0.01), cystathionine (P<0.01), and the decreased S-adenosylmeth

284 e from serine, and rates of homocysteine and cystathionine production were assessed.

285 Cystathionine (R-S-(2-amino-2-carboxyethyl)-l-homocystei

286 l as the gamma-replacement reaction yielding cystathionine showed it encodes a bifunctional CGL/CGS e

287 he ox-LDL group, 0.3 mmol/L and 1.0 mmol/L L-cystathionine significantly inhibited the expression of

288 t enzymes involved in L-cysteine metabolism: cystathionine-ss-synthase (CBS) and cystathionine-gamma-

289 Mechanistically, 0.3 mmol/L and 1.0 mmol/L L-cystathionine suppressed phosphorylation and nuclear tra

290 experimental evidence that the abolition of cystathionine synthesis may contribute to the pathology

291 he possible contribution of the abolition of cystathionine synthesis to pathogenesis in HCU has not b

292 ine-synthesis reaction than in the canonical cystathionine-synthesis reaction.

293 CBS condenses homocysteine and serine to cystathionine that is then converted to cysteine.

294 regulates these competing reactions where by cystathionine, the product of CBS, inhibits H2S synthesi

295 ion of homocysteine into Dha formed a stable cystathionine (thioether) analogue of the complement inh

296 This metabolite switch from cystathionine to cysteine and/or homocysteine renders H2

297 1, flip the operating preference of CSE from cystathionine to cysteine, transiently stimulating H2S p

298 ha-ketoglutarate, asparagine, aspartic acid, cystathionine, total cysteine, glutamic acid, glutamine,

299 homoserine via its sulfhydryl group to form cystathionine, which is cleaved to yield homocysteine.

300 CBS condenses serine and homocysteine to cystathionine with the help of three cofactors, heme, py