ライフサイエンスコーパス: cystathionine beta-synthase

1 ation of a full-length dimeric form of human cystathionine beta-synthase.

2 hanism for the tissue specific regulation of cystathionine beta-synthase.

3 and indispensable role in the regulation of cystathionine beta-synthase.

4 ine management, methionine synthase (MS) and cystathionine beta-synthase.

5 ndent beta-replacement reaction catalyzed by cystathionine beta-synthase.

6 ne in Escherichia coli and of purified yeast cystathionine beta-synthase.

7 n architecture of the heme-independent yeast cystathionine beta-synthase.

8 igands as cysteinate and imidazole in ferric cystathionine beta-synthase.

9 nce of heme, which is found in human and rat cystathionine beta-synthase.

10 e first characterization of the PLP bound to cystathionine beta-synthase.

11 y half of the sites activity associated with cystathionine beta-synthase.

12 or homocystinuria is inherited disorders in cystathionine beta-synthase.

13 te reductase reaction and as an activator of cystathionine beta-synthase.

14 wed little or no CSE protein but did express cystathionine beta-synthase.

15 expression of cystathionine gamma-lyase and cystathionine beta-synthase.

16 f genes localized to chromosome 21 including cystathionine-beta-synthase.

17 onine synthase reductase (MTRR) 66A-->G, and cystathionine-beta-synthase 844ins68.

18 Expression of cystathionine beta-synthase, a key gene in the transsulf

19 Cystathionine beta-synthase activity is also regulated i

20 zMC), serves as a highly sensitive assay for cystathionine beta-synthase activity, and is suitable fo

21 heme, and is accompanied by complete loss of cystathionine beta-synthase activity.

22 osome binding site of the cbs gene, encoding cystathionine beta-synthase, an enzyme that is a part of

23 ons from the models, mutation of residues in cystathionine beta-synthase and channel domains either a

24 hide (H2S), through multiple steps involving cystathionine beta-synthase and cystathionine gamma-lyas

25 oduced endogenously by catalytic activity of cystathionine beta-synthase and cystathionine gamma-lyas

26 Renal cortical content of cystathionine beta-synthase and cystathionine gamma-lyas

27 zed by the transsulfuration pathway enzymes, cystathionine beta-synthase and cystathionine gamma-lyas

28 the human transsulfuration pathway enzymes, cystathionine beta-synthase and gamma-cystathionase (CSE

29 of MST versus the other two H2S generators, cystathionine beta-synthase and gamma-cystathionase, has

30 es the cytoplasmic transsulfuration enzymes, cystathionine beta-synthase and gamma-cystathionase, whe

31 ish the overall catalytic mechanism of yeast cystathionine beta-synthase and provide a useful system

32 ysteine by reverse transsulfurylation with a cystathionine-beta-synthase and cystathionine-gamma-lyas

33 In contrast, transcripts of cystathionine-beta-synthase and deoxycytidine kinase wer

34 enotype of other folate-related genes (e.g., cystathionine-beta-synthase and methionine synthase redu

35 h-density lipoprotein cholesterol (HDL-C) in cystathionine beta-synthase-/apolipoprotein E-deficient

36 Cystathionine gamma-lyase (CSE) and cystathionine beta-synthase are critical enzymes in the

37 he conclusion that the heme and PLP sites in cystathionine beta-synthase are nonequivalent.

38 uishable states that are observed with human cystathionine beta-synthase: "basal" (i.e., wild-type en

39 omocystinuria as a result of a deficiency of cystathionine beta-synthase can be prevented by the scre

40 Cystathionine beta-synthase catalyzes the condensation o

41 Human cystathionine beta-synthase catalyzes the first step in

42 s endogenously produced from homocysteine by cystathionine beta synthase (CBS) and cystathionine gamm

43 Human cystathionine beta--synthase (CBS) is an S-adenosylmethi

44 , methionine synthase reductase (MTRR A66G), cystathionine beta-synthase (CBS exon 8, 68-base-pair in

45 We detected an interaction with cystathionine beta-synthase (CBS) [L-serine hydrolyase (

46 nate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensit

47 and hypercholesterolemia in which the mouse cystathionine beta-synthase (CBS) and apolipoprotein E (

48 synthesized by the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamm

49 In vertebrates, cystathionine beta-synthase (CBS) and cystathionine gamm

50 es involved in the transsulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamm

51 wo enzymes in the trans-sulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamm

52 zed by the transsulfuration pathway enzymes, cystathionine beta-synthase (CBS) and gamma-cystathionas

53 Hcy and hyperlipidemia mouse model, in which cystathionine beta-synthase (CBS) and low-density lipopr

54 Mutations in cystathionine beta-synthase (CBS) are known to cause hom

55 Cystathionine beta-synthase (CBS) catalyzes the condensa

56 Cystathionine beta-synthase (CBS) catalyzes the condensa

57 Cystathionine beta-synthase (CBS) catalyzes the first ir

58 Cystathionine beta-synthase (CBS) catalyzes the first of

59 Cystathionine beta-synthase (CBS) condenses homocysteine

60 Cystathionine beta-synthase (CBS) contains a prosthetic

61 Cystathionine beta-synthase (CBS) controls the flux of s

62 Untreated cystathionine beta-synthase (CBS) deficiency in humans i

63 Cystathionine beta-synthase (CBS) deficiency is a recess

64 Cystathionine beta-synthase (CBS) deficiency is a recess

65 Cystathionine beta-synthase (CBS) deficiency is an autos

66 Cystathionine beta-synthase (CBS) deficiency, a genetic

67 e setting of hyperhomocysteinemia because of cystathionine beta-synthase (CBS) deficiency, an inborn

68 Homocystinuria, which typically results from cystathionine beta-synthase (CBS) deficiency, is the mos

69 mon cause of many genetic diseases including cystathionine beta-synthase (CBS) deficiency.

70 e of CNNM2 (CNNM2BAT), which consists of two cystathionine beta-synthase (CBS) domains (IPR000664) an

71 Cytoplasmic cystathionine beta-synthase (CBS) domains are strategica

72 rous proteins containing pairs of regulatory cystathionine beta-synthase (CBS) domains, family II pyr

73 cleotide-binding insert comprising a pair of cystathionine beta-synthase (CBS) domains, termed a Bate

74 Cystathionine beta-synthase (CBS) effects the condensati

75 Deficiencies of the human cystathionine beta-synthase (CBS) enzyme are characteriz

76 n in mice heterozygous for a deletion in the cystathionine beta-synthase (CBS) gene, by studying isol

77 serine hydroxymethyltransferase (SHMT), and cystathionine beta-synthase (CBS) genes and their associ

78 onine synthase (MS), MS reductase (MSR), and cystathionine beta-synthase (CBS) in the NCI60 panel of

79 Cystathionine beta-synthase (CBS) is a heme-dependent an

80 Cystathionine beta-synthase (CBS) is a key enzyme in hum

81 Cystathionine beta-synthase (CBS) is a key enzyme in sul

82 Cystathionine beta-synthase (CBS) is a pyridoxal phospha

83 Cystathionine beta-synthase (CBS) is a pyridoxal-5'-depe

84 Cystathionine beta-synthase (CBS) is a pyridoxal-5'-phos

85 Cystathionine beta-synthase (CBS) is a pyridoxal-phospha

86 Cystathionine beta-synthase (CBS) is a tetrameric heme p

87 Human cystathionine beta-synthase (CBS) is a unique pyridoxal

88 Human cystathionine beta-synthase (CBS) is a unique pyridoxal-

89 Cystathionine beta-synthase (CBS) is an enzyme that cond

90 Human cystathionine beta-synthase (CBS) is an essential enzyme

91 Cystathionine beta-synthase (CBS) is an essential pyrido

92 The gene for cystathionine beta-synthase (CBS) is located on chromoso

93 Cystathionine beta-synthase (CBS) is the first and rate-

94 omocysteinemia due to genetic alterations in cystathionine beta-synthase (Cbs) or methylenetetrahydro

95 dition to elevating plasma Hcy, mutations in cystathionine beta-synthase (CBS) or methylenetetrahydro

96 Cystathionine beta-synthase (CBS) plays a central role i

97 nism, unique to breast cancer cells, whereby cystathionine beta-synthase (CBS) promotes elevated GSH/

98 Wild-type and cystathionine beta-synthase (CBS)(+/-) HHcy mice were tr

99 Cystathionine beta-synthase (CBS), a key enzyme in the m

100 Human cystathionine beta-synthase (CBS), a novel heme-containi

101 Cystathionine beta-synthase (CBS), a pyridoxal 5'-phosph

102 ine clearance converge at the active site of cystathionine beta-synthase (CBS), a pyridoxal phosphate

103 Patients with homocystinuria lack the enzyme cystathionine beta-synthase (CBS), and many of these ind

104 Cystathionine beta-synthase (CBS), condensing homocystei

105 gen sulfide (H2S) producing enzymes, namely, cystathionine beta-synthase (CBS), cystathionine gamma l

106 the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed i

107 d metabolism caused by deficient activity of cystathionine beta-synthase (CBS), resulting in an accum

108 of the genes for apolipoprotein E (apoE) and cystathionine beta-synthase (CBS), which converts Hcy to

109 mitting step in this pathway is catalyzed by cystathionine beta-synthase (CBS), which is subject to c

110 On a hyperhomocysteinemic diet, cystathionine beta-synthase (Cbs)-heterozygous mice deve

111 ionine synthase (MS) or transsulfuration via cystathionine beta-synthase (CBS).

112 ted by hydrogen sulfide (H2S) synthesized by cystathionine beta-synthase (CBS).

113 omocysteine (Hcy) in a reaction catalyzed by cystathionine beta-synthase (CBS).

114 >C), methionine synthase (MS 2756A-->G), and cystathionine-beta-synthase (CBS 844ins68) on risk for d

115 C57BL/6J (wild-type) and cystathionine-beta-synthase (CBS(+/-)) mice, treated wit

116 emic mice deficient in the Cbs gene encoding cystathionine-beta-synthase (Cbs(+/-)) to evaluate retin

117 The trans-sulfuration enzyme cystathionine-beta-synthase (CBS) and its product hydrog

118 levels of two chromosome 21-localized genes, cystathionine-beta-synthase (CBS) and superoxide dismuta

119 Cystathionine-beta-synthase (CBS) deficiency is a human

120 Individuals with homozygous deficiency in cystathionine-beta-synthase (CBS) develop high levels of

121 requires ATP, which binds to the C-terminal cystathionine-beta-synthase (CBS) domain of SpoIVFB.

122 Tandem cystathionine-beta-synthase (CBS) domains in the ATP-bin

123 to the transmembrane part or to cytoplasmic cystathionine-beta-synthase (CBS) domains of ClC-7.

124 The cystathionine-beta-synthase (CBS) gene (localized to chr

125 ertion in the coding region of exon 8 of the cystathionine-beta-synthase (CBS) gene in a single patie

126 ficiency or absence of the cbs gene encoding cystathionine-beta-synthase (CBS) have marked retinal di

127 ve up-regulation of the H2S-producing enzyme cystathionine-beta-synthase (CBS) in colon cancer, resul

128 e-homocysteine methyltransferase (Bhmt), and cystathionine-beta-synthase (Cbs) were up-regulated, but

129 Mice deficient in cystathionine-beta-synthase (cbs) were used as a model o

130 levels of the chromosome 21-localized gene, cystathionine-beta-synthase (CBS), in DS myeloblasts.

131 thionine adenosyltransferase 1alpha (Mat1a), cystathionine-beta-synthase (Cbs), methylenetetrahydrofo

132 heterozygous for disruption of the gene for cystathionine-beta-synthase (Cbs+/-) and C57BL/6 (Cbs+/+

133 Cystathionine beta-synthase [CBS; l-serine hydro-lyase (

134 1298A>C, methionine synthase [MTR] 2756A>G, cystathionine beta-synthase [CBS] 844ins68, and methioni

135 ntracellular carboxy-terminus containing two cystathionine-beta-synthase (CBS1 and CBS2) domains.

136 The C-terminal region of human cystathionine beta-synthase contains two hydrophobic mot

137 ound a single nucleotide polymorphism within cystathionine beta-synthase (CYS4) that causes multi-dru

138 we demonstrate that inactivation of putative cystathionine beta-synthase, cystathionine gamma-lyase,

139 These include cystathionine beta-synthase, cystathionine-gamma-lyase,

140 Here we show that Drosophila cystathionine beta-synthase (dCBS), which catalyzes the

141 sensitivity to chemotherapeutic agents (eg, cystathionine beta synthase, dCMP deaminase, and CTP syn

142 erhomocysteinemia may be due to heterozygous cystathionine beta-synthase defect or B6 deficiency.

143 oprotection, its chronic increase such as in cystathionine beta-synthase deficiency may pose a proble

144 Homocystinuria due to cystathionine beta-synthase deficiency was confirmed by

145 Heterozygous cystathionine beta-synthase-deficient (CBS((-/+))) mice

146 Heterozygous cystathionine beta-synthase-deficient (CBS(+/-)) and wil

147 dilated cerebral arterioles in heterozygous cystathionine beta-synthase-deficient (CBS(+/-)) mice an

148 Cystathionine beta-synthase-deficient homocystinuria (HC

149 The lean phenotype of cystathionine beta-synthase-deficient homocystinuria and

150 einylation impairs collagen cross-linking in cystathionine beta-synthase-deficient mice: a novel mech

151 In hyperhomocysteinemic human cells and cystathionine beta-synthase-deficient mouse brains, we f

152 PON1 affects plasma N-Hcy-protein levels in cystathionine beta-synthase-deficient patients (n=28).

153 n (SIS), biofilm-related region 2 (B2) and a cystathionine beta-synthase domain pair (CBS).

154 e and stability of PAE2072, a dimeric tandem cystathionine beta-synthase domain protein from the hype

155 ontain a sugar isomerase domain and a tandem cystathionine beta-synthase domain.

156 Interestingly, both enzymes contain a cystathionine-beta-synthase domain (CBS).

157 rt or deletion of the last 11 amino acids of cystathionine-beta-synthase domain 1 gives rise to funct

158 zed domain of unknown function (DUF21) and a cystathionine-beta-synthase domain.

159 Among these are CP12-CBS (for cystathionine-beta-synthase) domain fusions.

160 Cystathionine beta-synthase domains are found in a myria

161 -phosphate isomerases but lacking the tandem cystathionine beta-synthase domains found in the other a

162 eep in a cleft formed by ClC-1 intracellular cystathionine beta-synthase domains, and the nicotinamid

163 rase domain of E. coli KdsD, lacking the two cystathionine beta-synthase domains, demonstrated API ac

164 e potential ATP binding by the intracellular cystathionine beta-synthase domains.

165 d large cytoplasmic C-termini containing two cystathionine-beta-synthase domains (CBS1 and CBS2) that

166 Reactions catalyzed by the cystathionine beta-synthase enzyme (CBS) are one possibl

167 No changes were observed in cystathionine beta-synthase expression, immunolocalized

168 properties of a truncated catalytic core of cystathionine beta-synthase extending from residues 1 th

169 Cystathionine beta-synthase found in yeast catalyzes a p

170 Our studies of the reaction mechanism of cystathionine beta-synthase from Saccharomyces cerevisia

171 Our studies of cystathionine beta-synthase from Saccharomyces cerevisia

172 Our studies of the reaction mechanism of cystathionine beta-synthase from yeast (Saccharomyces ce

173 Cystathionine beta-synthase from yeast (Saccharomyces ce

174 eterozygous for a targeted disruption of the cystathionine beta-synthase gene (Cbs+/-) and wild-type

175 tabolism is deregulated by a mutation in the cystathionine beta-synthase gene and/or by an antifolate

176 The human cystathionine beta-synthase gene promoters -1a and -1b a

177 te reductase gene or with 3 mutations of the cystathionine beta-synthase gene.

178 s in methylenetetrahydrofolate reductase and cystathionine beta-synthase genes, respectively.

179 h purified mammalian methionine synthase and cystathionine beta-synthase have revealed the oxidative

180 Two classes of cystathionine beta-synthases have been identified in euk

181 ontinuous spectrophotometric assay for human cystathionine beta-synthase (hCBS).

182 Five-month-old cystathionine beta synthase heterozygous and wild-type C

183 approximately 150 muM), which was induced in cystathionine-beta synthase heterozygous mice fed a high

184 B(6)-responsive phenotype associated with a cystathionine beta-synthase-impaired homocystinuric geno

185 ed with a 4-fold lower steady-state level of cystathionine beta-synthase in a fibroblast cell line th

186 Fibroblasts from cystathionine beta-synthase -/- individuals also showed

187 treatment of diabetic rats with RA prevented cystathionine beta-synthase induction.

188 y absorption data reveal that iron in ferric cystathionine beta-synthase is 6-coordinate, with 1 high

189 Human cystathionine beta-synthase is a heme protein that catal

190 Human cystathionine beta-synthase is a hemeprotein that cataly

191 Cystathionine beta-synthase is a tetrameric hemeprotein

192 Cystathionine beta-synthase is a unique heme protein tha

193 Cystathionine beta-synthase is an unusual enzyme that re

194 The heme Soret peak of ferric cystathionine beta-synthase is at 428 nm and shifts to a

195 Cystathionine beta-synthase is modular and subjected to

196 Human cystathionine beta-synthase is one of two key enzymes in

197 PLP bound to cystathionine beta-synthase is weakly fluorescent and ex

198 A mouse model of HHcy, in which cystathionine-beta-synthase is deficient (cbs (-/-)), wa

199 vels of UNG mRNA were increased in brains of cystathionine beta-synthase knockout mice, a model for h

200 like the homologous mammalian enzymes, yeast cystathionine beta-synthase lacks a second cofactor, hem

201 ransferase and transsulfuration catalyzed by cystathionine beta-synthase leading to cystathionine.

202 ression of the gene, designated M truncatula Cystathionine-beta-Synthase-like1 (MtCBS1), using a prom

203 genetic defects resulting in deficiencies in cystathionine beta synthase, methylenetetrahydrofolate r

204 and GADD153 in ethanol-treated heterozygous cystathionine beta synthase mice.

205 yperhomocysteinemia induced in wild-type and cystathionine-beta-synthase +/- mice by feeding a high-m

206 Binding of both CO and cyanide to ferrous cystathionine beta-synthase occurs in two distinct isoth

207 it was reversed by the inhibition of either cystathionine beta-synthase or cystathionine gamma-lyase

208 s proposed in which mutagenesis is driven by cystathionine-beta-synthase overexpression and altered f

209 that ox-LDL treatment down-regulated the H2S/cystathionine-beta-synthase pathway, with increased MCP-

210 PC in hyperhomocysteinemic mice deficient in cystathionine beta-synthase (plasma tHcy, 93 +/- 16 micr

211 Cystathionine beta-synthase plays a key role in the intr

212 Here we express a mutant form of the human cystathionine beta-synthase protein, I278T, in Saccharom

213 Cystathionine beta-synthase regulates endothelial functi

214 ism secondary to genes on chromosome 21 (eg, cystathionine-beta-synthase, superoxide dismutase) as po

215 ilarly, a particular M.grisea CBS1 (encoding cystathionine beta-synthase) TAGKO cDNA failed to comple

216 xample of mutations in the catalytic core of cystathionine beta-synthase that result in failure of Ad

217 inically relevant AML cell line models, high cystathionine-beta-synthase transcripts in DS CMK cells

218 the abundance of the transsulfuration enzyme cystathionine beta-synthase; treatment of diabetic rats

219 irst evidence for redox-linked regulation of cystathionine beta-synthase which is heme-dependent.

220 OR1 induction resulted in down-regulation of Cystathionine beta-synthase, which is known to lead to i

221 oderate (88 micromol/L) HHcy were induced in cystathionine beta-synthase wild-type (Cbs(+/+)) and het

222 Treatment of cystathionine beta-synthase with hydroxylamine releases

223 We compare our results with cystathionine beta-synthase with those of related invest