1 edominantly expressed in ciliated cells, and deltaF508 CFTR pathogenesis in native tissues, like hete

2 log enhanced the activities of wild-type and deltaF508-CFTR channels both in excised membrane patches

3  describe potent activators of wild-type and deltaF508-CFTR channels that are structurally related to

4 ietary compound recently reported to augment deltaF508-CFTR function in mice by an unknown mechanism.

5 nction in vivo in individuals homozygous for deltaF508-CFTR.

6 ggest that cell-type specific differences in deltaF508 CFTR processing are likely to complicate effor

7                        Curcumin treatment in deltaF508-CFTR mice partially reversed the defect in ATP

8                 The most common CF mutant is deltaF508-CFTR, which inefficiently traffics to the surf

9                                           No deltaF508 CFTR mature protein or function could be detec

10  the differences in rescue and activation of deltaF508 CFTR in the two cell lines suggest that cell-t

11  normal airways and 2) the metabolic fate of deltaF508 CFTR and associated ERM proteins in the cystic

12  functional assays confirmed the presence of deltaF508 CFTR at the cell surface in both cell lines af

13 compound increased the open probabilities of deltaF508-CFTR channels in excised membrane patches by 1

14                                      Rescued deltaF508 CFTR could be stimulated with genistein indepe

15 receptor agonists failed to activate rescued deltaF508 CFTR in CFBE41o- monolayers.

16 essing and function of wild-type and rescued deltaF508 CFTR at the cell surface under non-polarized a

17                       Interestingly, rescued deltaF508 CFTR in HeLa cells could be efficiently stimul

18                  These results indicate that deltaF508 CFTR, when rescued in CFBE41o- human airway ep