ライフサイエンスコーパス: disorganization

1 eriences (eg, paranoid thoughts or cognitive disorganization).

2 nitive deficits and CSF variables on network disorganization.

3 s including Grp94 potentially involved in ER disorganization.

4 oping Muller cells showed late onset retinal disorganization.

5 njury is associated with microtubule lattice disorganization.

6 n both cellulose microfibril and microtubule disorganization.

7 ation, which is correlated with cytoskeleton disorganization.

8 ower rates of homelessness, and lower social disorganization.

9 brosis, loss of exocrine pancreas, and islet disorganization.

10 of its centrosomal pool entails microtubule disorganization.

11 oma protein (Rb), where Rb causes sarcomeric disorganization.

12 vated autophagy, apoptosis and mitochondrial disorganization.

13 ive symptoms, anxiety, negative symptoms and disorganization.

14 efrontal cortex (PFC), leading to behavioral disorganization.

15 cause severe axon shortening and microtubule disorganization.

16 inje neuron spontaneous activity and pinceau disorganization.

17 prone to death and exhibited striking tissue disorganization.

18 to granule cells in the absence of neuronal disorganization.

19 ing progenitor cells and eventual primordium disorganization.

20 led to kidney cyst formation and basal body disorganization.

21 n mitochondrial morphology and cardiomyocyte disorganization.

22 ide cytoprotection, consequent to lipid raft disorganization.

23 itotic spindle apparatus, leading to spindle disorganization.

24 ed rats, ethanol metabolism results in Golgi disorganization.

25 ignificant hair cell loss and neuronal fibre disorganization.

26 rves led to either no effect or solely fibre disorganization.

27 est scores for disability/impairment (0.61), disorganization (0.60), and scholastic performance (0.51

28 olyubiquitin aggregates [6, 7] and myofibril disorganization [8, 9].

29 ositive symptoms (hallucinations, delusions, disorganization) (adjusted mean [SE], 9.4 [3.3] vs 18.2

30 spectrin are not sufficient to prevent nodal disorganization after AnkG ablation.

31 Lumen disorganization after depletion of Tuba or Cdc42 or inhi

32 duced by the BBDS mutations direct nucleolar disorganization, alter ribosome biogenesis, and activate

33 C1-/-) led to axonopathies with cytoskeletal disorganization and abnormal cargo accumulation.

34 ssed in Hoxc9 mutants, leading to motor pool disorganization and alterations in the connections by th

35 y islet hyperplasia that progresses to islet disorganization and altered vascularization, inflammatio

36 would otherwise lead to spindle microtubule disorganization and aneuploidy.

37 t cellular pathology but profound perceptual disorganization and cognitive deficits, schizophrenia is

38 Lis1 heterozygotic mice, severe hippocampal disorganization and cognitive impairment have also been

39 ciated with pathologic neurofilament network disorganization and degeneration of motor neurons.

40 th the single mutants, resulting in cortical disorganization and depletion of the progenitor pool.

41 arbonyl and carboxyl groups caused a partial disorganization and depolymerization of starch granules.

42 93L expressing mouse muscle had myofibrillar disorganization and desmin inclusions.

43 ructural major abnormalities including loss, disorganization and dilatation of cristae.

44 tube defects associated with neuroepithelial disorganization and enhanced progenitor maintenance.

45 Ihh deficiency caused condylar disorganization and growth retardation and reduced polym

46 s in this complex cause stereociliary bundle disorganization and hearing loss.

47 l ablation of LHX2 results in gross cellular disorganization and HF-SC polarization within the niche.

48 promote tumorigenesis by causing epithelial disorganization and hyperplasia.

49 enon is caused in part by actin cytoskeleton disorganization and impaired dendritic branching.

50 n disease by developing progressive vascular disorganization and leakiness culminating in massive asc

51 ion of ADAM12L in HSCs leads to cytoskeletal disorganization and loss of adhesion.

52 All three mutants display spindle disorganization and mitotic defects.

53 vimentin (VIM) in a mode which promotes VIM disorganization and phosphorylation during metaphase, ul

54 xpression attenuates stress-induced T-tubule disorganization and protects against heart failure progr

55 roscopy and western blotting revealed marked disorganization and reduced COL6A5 synthesis, respective

56 ogy and immunohistochemistry revealed tissue disorganization and reduced type I collagen in bgn(-/0)f

57 Its inhibition causes microtubule disorganization and release of centrosomal dynactin.

58 the inner retinal damage, but also permanent disorganization and scarring in the photoreceptor layer.

59 felodipine treated lenses revealed extensive disorganization and swelling of cortical fiber cells res

60 the knockdown of Eps8 by RNAi led to F-actin disorganization and the mislocalization of the tight jun

61 accumulation and the endothelial cell layer disorganization and thickening in a live animal.

62 Patients with BVMD demonstrated progressive disorganization and thinning of the submacular RPE on OC

63 All eyes showed disorganization and/or loss of the IS-OS junction in the

64 ularity in articular cartilage, growth plate disorganization, and a severe reduction in bone volume.

65 g extracellular matrix defects, cytoskeletal disorganization, and aberrant epithelial movement.

66 so induced perceptual distortions, cognitive disorganization, and anhedonia (all p < 0.02).

67 e cellular and flagellar membranes, membrane disorganization, and blebbing as well as cytoplasmic vac

68 efects have been implicated in cancer, brain disorganization, and cardiomyopathies.

69 tivity and cognitive performance, behavioral disorganization, and global functioning.

70 apamycin pathway, astrogliosis, and neuronal disorganization, and increased brain size in Tsc1(GFAP)C

71 steocyte lacunocanalicular network, collagen disorganization, and matrix hypermineralization; all of

72 ated with more cell proliferation, cartilage disorganization, and new bone formation.

73 ntree into the study of system organization, disorganization, and reorganization.

74 s master regulator of Golgi organization and disorganization, and that NMIIA and giantin engage in a

75 synaptic transmission independent of laminar disorganization, and the ectopic position of adult-born

76 actomyosin complex forces EtOH-induced Golgi disorganization, and the targeting of NMIIA-P-S1943 may

77 immune regulator expression, lymphoid tissue disorganization, and virus persistence.

78 mmation, cellular infiltration, and collagen disorganization; and basement membrane preservation.

79 atin stability and highlight heterochromatin disorganization as a potential determinant of human agin

80 rts of altered limbic system microstructural disorganization as a trait feature of bipolar disorder.

81 ice was associated with progressive t-tubule disorganization, as quantified by fast-Fourier transform

82 findings, including T-tubule dilatation and disorganization, associated with defects in this additio

83 formed embryos; it also resulted in cellular disorganization at the blastoderm margin.

84 skeletal muscle development and myofibrillar disorganization at the microscopic level.

85 orphological defects, including cytoskeletal disorganization, axon beading, and defasciculation.

86 muscle cells showed dramatic disruption and disorganization before vEVT presence.

87 Loss of Nfasc186 provokes CNS paranodal disorganization, but this does not contribute to loss of

88 ular mechanism underlying actin cytoskeleton disorganization by NHERF1, a combined 2-dimensional elec

89 laminar stratification and find that laminar disorganization can be caused in a non-cell autonomous f

90 ith severe energy failure and ultrastructure disorganization can be rapidly rescued and remodeled by

91 her bag3 gene knockdown induces myofibrillar disorganization caused by mechanical stress, in vitro me

92 In addition, the EPA-induced lipid raft disorganization, caveolin-1 inactivation, and cellular c

93 sarcomeric and intercalated disk structural disorganization confirmed in CM-specific ephrin-B1 KO mi

94 Interestingly, the chromosome disorganization could be prevented by treatment with a t

95 in in C2C12 myoblasts induces desmin network disorganization, desmin aggregate formation, and a small

96 d abundant internalized nuclei, myofibrillar disorganization, desmin-positive inclusions, and thicken

97 Anterior pigmented neuroectodermal disorganization, dysgenesis of angle structures, and a h

98 ne prevented MIF-induced microtubule network disorganization, excessive tubulin polymerization, and m

99 The "low self confidence" and "disorganization" factors correlated positively with blur

100 epididymal dysfunction caused by epithelial disorganization, fibrosis and acute inflammation.

101 ntiate normally but, reflecting cytoskeletal disorganization, form small actin rings and fail to effe

102 nd migration of neurons probably cause brain disorganizations found in lamin-B null mice.

103 lf-rated paranoia, hallucinations, cognitive disorganization, grandiosity, and anhedonia, as well as

104 ular impairment characterized by stereocilia disorganization, hair cell loss, and endocochlear potent

105 l center with foveal thinning and structural disorganization heralded central VA loss.

106 in the urothelium itself, led to urothelial disorganization, highlighting the importance of mesenchy

107 ction and a dual pattern of cortical network disorganization (i.e., desynchronization and hypersynchr

108 central apparatus defects with microtubular disorganization (IDA/CA/MTD; n = 40).

109 This microtubule disorganization impedes normal relaxation of the axons,

110 ation receptive field sizes, and topographic disorganization in all early visual areas.

111 Additionally, nodal disorganization in both early and late AnkG mutants is a

112 rest migration, as evident from melanophores disorganization in capzb(-/-) mutants.

113 earing nebulette mutations, a severe general disorganization in cardiomyocytes of the extrasarcomeric

114 of auditory hair cells evidenced structural disorganization in Clrn1(-/-) mice.

115 lesterol homeostasis cause mitochondrial DNA disorganization in control cells, while mitochondrial DN

116 ar morphogenesis defects characterized by EC disorganization in embryonic explants and isolated ECs.

117 We recently reported that Golgi disorganization in ethanol (EtOH)-treated hepatocytes is

118 Thus, IF disorganization in GAN fibroblasts is independent of TBC

119 CB levels are not primary determinants of IF disorganization in GAN.

120 to complete morphogenetic failure and actin disorganization in the embryonic epidermis.

121 Osx::CXCR4(fl/fl) mice displayed chondrocyte disorganization in the epiphyseal growth plate associate

122 h remarkable structural defects and cellular disorganization in the terminal end buds interrupted duc

123 Although there is cellular disorganization in the ventricular zone, gross morpholog

124 rmed small head blastemas with severe tissue disorganization, including ectopic neural spheroids cont

125 n elongated valves with extracellular matrix disorganization, including elastin fragment infiltration

126 Nfasc(NF(1)(8)(6))) in vivo results in nodal disorganization, including loss of Na(v) channel and ank

127 most organized near the disc boundary, with disorganization increasing posteriorly.

128 ss-of-function results in PSC overgrowth and disorganization, indicating that Bam plays a crucial rol

129 crease in melanophores and a pigment pattern disorganization indicative of a xanthophore- deficient p

130 CTTN) hyperacetylation associated with actin disorganization inducing important changes in the distri

131 Synaptic disorganization is a prominent feature of many neurologi

132 We further show that the onset of vorticity disorganization is delayed if the skin organization is t

133 at human AF, despite apparent spatiotemporal disorganization, is often perpetuated by a few spatially

134 he mutant exocrine tissue displays extensive disorganization leading to pancreatitis-like autodigesti

135 wn-regulation of JP2 contributes to T-tubule disorganization, loss of excitation-contraction coupling

136 t correct subsarcolemmal microtubule lattice disorganization, loss of torque production after in vivo

137 ed drug fasudil, prevented dendritic network disorganization, memory loss, and neurodegeneration.

138 The resultant disorganization mimics the effects of neural crest ablat

139 features of PYROXD1 myopathy with sarcomeric disorganization, myofibrillar aggregates, and marked swi

140 he often-reported delusions, hallucinations, disorganization, negative, and affective factors; novel

141 Such chromosome disorganization occurs with essentially no change in the

142 P3-6, the effect on IGLEs had recovered, the disorganization of antrum innervation had partially reco

143 hythmia vulnerability and promote increasing disorganization of arrhythmias in the chronic AF-remodel

144 f the neurological phenotype- in particular, disorganization of axon tracts and deficient myelination

145 rebellar granule cell migration secondary to disorganization of Bergmann glial cell fibers cause cere

146 Depletion of zeta-tubulin results in disorganization of centriole distribution and polarity i

147 ere that loss of ATX-LPA1 signaling leads to disorganization of chondrocytes, causing severe defects

148 Despite the severe disorganization of collagen fibrils in adult tissues, th

149 Histology showed disorganization of collagen fibrils, with amorphous depo

150 pias were detected in the marginal zone, and disorganization of cortical cells induced several malfor

151 ormalities, absence of cerebellar foliation, disorganization of cortical neurons, and lethality by po

152 anatomical regions) and a global functional disorganization of cortico-basal ganglia networks in pat

153 on of DCs resulted in regression of ILFs and disorganization of CPs.

154 ity, promoting the displacement of ZO-1, and disorganization of cytoskeletal assembly.

155 ds to rearrangement of the cytoskeleton with disorganization of cytoskeletal elements such as actin a

156 The ensuing disorganization of E-cadherin-mediated adherens junction

157 This is preceded by disorganization of elastin, indicating defects in the ex

158 ic degradation of corneodesmosomes (CDs); 2) disorganization of extracellular lamellar bilayers; and/

159 ion of PARD6B, loss of apical cell polarity, disorganization of F-actin, and activation of HIPPO sign

160 rs, developmental abnormality of fin muscle, disorganization of facial musculature and/or degeneratio

161 cuoles in cortical fiber cells, swelling and disorganization of fiber cells, and defective fiber cell

162 ion among the precursor vitelline bodies and disorganization of follicle cell microvilli.

163 bipolar cells could not be attributed to the disorganization of inner plexiform layer cells that occu

164 em in GAN patients is accompanied by massive disorganization of intermediate filaments (IFs) both in

165 late projection and results in the permanent disorganization of its laminae.

166 yasarathy, and colleagues showed progressive disorganization of key functional elements of the synaps

167 impairment as assessed by electroretinogram, disorganization of lamination and apical junctions and r

168 rafts, and depletion of cholesterol leads to disorganization of lipid raft microdomains.

169 ovastatin and atorvastatin) led to a spatial disorganization of LOX-1 in plasma membranes and a marke

170 ouse and that Sac1 insufficiencies result in disorganization of mammalian Golgi membranes and mitotic

171 is, the meiotic spindle fails to form due to disorganization of meiotic microtubules.

172 TEM revealed disorganization of microtubules, swelling of mitochondri

173 aenorhabditis elegans gene unc-89 results in disorganization of muscle A-bands.

174 uoles with cytoplasmic inclusions, and focal disorganization of myofilaments.

175 ion or gain of function of mel-26 results in disorganization of myosin thick filaments similar to tha

176 o-1 in C. elegans adults showed a pattern of disorganization of myosin thick filaments similar to the

177 ults suggest that white matter integrity and disorganization of neuronal networks could be important

178 normal laminar cytoarchitecture and cortical disorganization of neurons, but not glia, in prefrontal

179 ageing-associated nuclear defects including disorganization of nuclear lamina and loss of heterochro

180 Disorganization of OHC stereocilia was seen as early as

181 migratory paths and division planes, causing disorganization of regenerated muscle fibers.

182 These results demonstrate that disorganization of retinal circuit development is a like

183 To determine whether disorganization of retinal inner layers (DRIL) assessed

184 etinal cysts, ellipsoid zone disruption, and disorganization of retinal inner layers (DRIL) length we

185 Disorganization of retinal lamellar structure was genera

186 Disorganization of retinal lamellar structures in the RP

187 mitant with low visual function, and a rapid disorganization of RPE cells, ultimately leading to reti

188 one leads to RPE dysfunction and concomitant disorganization of RPE layer morphology, large areas of

189 d by the presence of desmin aggregates and a disorganization of sarcomeres.

190 pment at late embryonic stages due to severe disorganization of sarcomeric actin filaments in body wa

191 These observations might account for the disorganization of secretory granules previously reporte

192 rrelates with an increased mitotic index and disorganization of seminiferous tubules.

193 ycle arrest in metaphase and causes dramatic disorganization of small nuclear ribonuclear protein and

194 s, and impaired motility and ultrastructural disorganization of spermatozoa.

195 Lack of PDZD7 leads to the disorganization of stereocilia bundles and a reduction i

196 encing promoted strong cytoskeletal changes: disorganization of stress fibers, decreased number of fo

197 filtration with atypical basal cells, severe disorganization of stromal collagen matrix, and loss of

198 ately 78% of cones had died, and progressive disorganization of synaptic ultrastructure was noted in

199 We have also shown disorganization of the actin cytoskeleton network and ch

200 immunofluorescence analysis shows a striking disorganization of the actin- cytoskeleton following RAS

201 mal aggregates of neurofilament protein, the disorganization of the axonal cytoskeleton, and the accu

202 sease gene LIS-1 in humans causes an extreme disorganization of the brain associated with significant

203 Disorganization of the collagen network, collagen type I

204 g been proposed to play an essential role in disorganization of the collagen-rich extracellular matri

205 A persistent anatomic disorganization of the corneal nerves in human grafts wa

206 is of the neural progenitor cells as well as disorganization of the cortical plate.

207 In contrast, tn mutants had significant disorganization of the costameric orthologs beta-integri

208 Metformin triggers the disorganization of the cristae and inner mitochondrial m

209 le organization, CEP290 knockdown causes the disorganization of the cytoplasmic microtubule network.

210 airment of ameloblastin self-assembly causes disorganization of the enamel organic matrix and yields

211 This is associated with disorganization of the extracellular matrix and increase

212 The results showed a delay in elongation and disorganization of the HERS in Tgfbr2(cko) mice.

213 urbed upon pressure overload, underscored by disorganization of the IDs in Mzp(-/-) mice.

214 oss or truncation of APC correlated with the disorganization of the IF network in glioma and carcinom

215 At high concentrations, AMBMP caused disorganization of the inner cell mass.

216 f the mesh by overexpression of TACC3 causes disorganization of the K-fiber MTs.

217 alpha helix coiled-coil and caused localized disorganization of the K1-K10 heterodimer.

218 in caused neonatal lethality associated with disorganization of the laminar patterning of the cortex.

219 eased terminal branching, and thickening and disorganization of the luminal wall.

220 KO mice have an enlarged spleen with marked disorganization of the marginal zone and red pulp.

221 unteracting ectopic microtubule assembly and disorganization of the microtubule network, this functio

222 vered a failure to shed excess cytoplasm and disorganization of the middle piece of the flagellum at

223 ation and membrane rearrangement, leading to disorganization of the muscle fibrils on the tissue leve

224 y around the myocardial cells and consequent disorganization of the myocardial epithelium.

225 ractable epilepsy in humans, due to a severe disorganization of the neocortex and hippocampus known a

226 cells disrupts adherens junctions and causes disorganization of the neuroepithelium in the developing

227 e formation of apical adherens junctions and disorganization of the neuroepithelium.

228 loss of postsynaptic membrane infoldings and disorganization of the NMJ microenvironment, including i

229 Schwann cells causes myelin instability and disorganization of the nodes of Ranvier.

230 reduced myelin sheath thickness and partial disorganization of the nodes.

231 eolar localization signal (NoLS) and induces disorganization of the nucleolus.

232 0.2 and 0.3 MPa groups showed only moderate disorganization of the odontoblast layer at 24 hours tha

233 mary and secondary follicles, and structural disorganization of the ovary, with many abnormal follicl

234 lity and/or ommatidial rotation will lead to disorganization of the photoreceptor array, misalignment

235 ning of Bruch's membrane, and shortening and disorganization of the photoreceptor outer and inner seg

236 nd global Wnt inactivation leads to dramatic disorganization of the primordium and a loss of proto-NM

237 fasc in adult Purkinje neurons leads to slow disorganization of the Purkinje AIS and pinceau morpholo

238 domain optical coherence tomography (SD-OCT) disorganization of the retinal inner layers (DRIL) is pr

239 Images were evaluated for disorganization of the retinal inner layers (DRIL), cyst

240 Disorganization of the retinal inner layers in the 1-mm

241 tructural changes such as cystoid spaces and disorganization of the retinal inner layers.

242 ssociated uniformly with the OCT findings of disorganization of the retinal inner layers.

243 emb1611-2 plants display disorganization of the shoot meristem cell layers early

244 glomerular features including effacement and disorganization of the slit diaphragm, followed by foot

245 ected either in cortical signal reduction or disorganization of the somatotopic map, such as disturbe

246 Mutations in the Trpml3 gene cause disorganization of the stereociliary hair bundle, struct

247 tro, and its absence in vivo correlates with disorganization of the subsarcolemmal microtubule lattic

248 Moreover, we demonstrate that disorganization of the T cell microtubule cytoskeleton a

249 This is correlated with a disorganization of the timing of granule cell proliferat

250 Hallmarks of HF are depletion and disorganization of the transverse tubular system (t-syst

251 the neutralization of TNF results in marked disorganization of the tuberculous granuloma, as demonst

252 This indicates that a structural disorganization of the tubular system worsens the electr

253 oblastoid cells treated with K2 siRNA showed disorganization of their actin cytoskeleton and decrease

254 or gain of function of mei-1 also results in disorganization of thick filaments similar to unc-89 mut

255 or an increased dosage of UNC-96 results in disorganization of thick filaments.

256 in patient muscle resulted in shortening and disorganization of thin filaments.

257 nerated by NSD2 and demonstrate that genomic disorganization of this canonical chromatin mark by NSD2

258 of Huwe1 in Bergmann glia leads to extensive disorganization of this cell population with layering ab

259 s, provokes misrecruitment of gamma-tubulin, disorganization of this microtubule framework emanating

260 of pigmentation and photosynthetic activity, disorganization of thylakoid membranes, accumulation of

261 ional homeostasis has been proposed to drive disorganization of tissues and promote progression of di

262 AR function during development result in the disorganization of topographic axonal projections.

263 f pregnancy, including implantation defects, disorganization of trophoblast cells, fewer uterine natu

264 ng that over-expression of SCPL-1 results in disorganization of UNC-89 at M-lines.

265 ortex, Bhlhb5 null mice display postsynaptic disorganization of vibrissal barrels.

266 These findings implicate disorganization of white-matter tracts involved in motor

267 nd diffusion tractography demonstrated broad disorganization of white-matter tracts throughout the hu

268 No effect was observed on the dimensions of disorganization or grandiosity/excitement.

269 l tracts in regions of high axon overlap and disorganization, or is our current perception of axon ar

270 ributions to paranoid thoughts and cognitive disorganization persisted for 5 years.

271 Furthermore, tissue disorganization phenotypes were most pronounced in anima

272 ial Hazards Scale, designed to assess social disorganization, physical disorder, public safety, and e

273 kinje soma/AIS, leading to extensive pinceau disorganization, Purkinje neuron degeneration, and sever

274 rated increased susceptibility to sarcomeric disorganization (RBM20: 86 +/- 10.5% versus control: 40

275 chizophrenia consistent with microstructural disorganization (reduced fractional anisotropy (FA)) and

276 Rp1L1-/- mice display scattered OS disorganization, reduced electroretinogram amplitudes, a

277 ed motility of endothelial cells, leading to disorganization/regression of tubes in vitro.

278 atchy aggregates of abnormal cells and fiber disorganization related to inhomogeneity of intracortica

279 ormal neuronal migration and severe neuronal disorganization resulting from Lis1 (lissencephaly) hapl

280 over, deletion of atf1 results in nucleosome disorganization specifically at stress coding regions an

281 Poor CC was associated with poverty and disorganization symptoms across patient groups.

282 al noise and the psychosis-like positive and disorganization symptoms induced by Delta(9)-THC, which

283 d brain activity may result in the disabling disorganization symptoms related to impaired cognition i

284 e encoding retinoschisin (RS1) cause retinal disorganization that leads to early onset of macular deg

285 The degeneration also accompanies drastic ER disorganization, that is, an aberrant increase in riboso

286 Despite cytoskeletal disorganization, the capacity of VCL(-/-) osteoclastic c

287 Drawing from social disorganization theory, we explored 3 types of contextua

288 actin stress fiber formation and claudin 18 disorganization through suppression of NFkappaB activity

289 -dosage prednisone, with long-term cognitive disorganization, vulnerability to stress, and personalit

290 or apoptosis was detected; and outer segment disorganization was observed in some cones.

291 Collagen fiber disorganization was the earliest and most prevalent chan

292 ringed fibres, sarcoplasmic masses or Z-band disorganization, which are characteristic features of dy

293 signaling leads to kidney cysts and otolith disorganization, which can be attributed to a loss of fo

294 and Src64B to promote hyperplasia and tissue disorganization, which results in cell cycle perturbatio

295 mice progressively developed cardiac tissue disorganization with loss of adult CM rod-shape and sarc

296 OCT and histopathology showed patchy retinal disorganization with pseudorosettes more pronounced in v

297 increased backscatter, and severe structural disorganization, with 3 eyes showing macular pseudocolob

298 natal day 60 it also caused CA1 histological disorganization, with a selective decline in parvalbumin

299 y diminished motor function and myofibrillar disorganization, with nemaline body formation, the patho

300 SCD mouse spleens exhibited histological disorganization, with reduction of defined lymphoid foll